Product Name

  • Name

    5-Bromouracil

  • EINECS 200-084-0
  • CAS No. 51-20-7
  • Article Data61
  • CAS DataBase
  • Density 1.965 g/cm3
  • Solubility soluble in cold water
  • Melting Point >300 °C(lit.)
  • Formula C4H3BrN2O2
  • Boiling Point 384oC
  • Molecular Weight 190.984
  • Flash Point
  • Transport Information
  • Appearance White powder.
  • Safety 36/37-53-45
  • Risk Codes 22-46
  • Molecular Structure Molecular Structure of 51-20-7 (5-Bromouracil)
  • Hazard Symbols HarmfulXn
  • Synonyms 2,4 (1H, 3H)-Pyrimidinedione, 5-bromo-;5-Bromo-2,4-dihydroxypyrimidine;Bromouracil;5-bromo-1H-pyrimidine-2,4-dione;Uracil, 5-bromo-;5-Bromo-pyrimidin-2,4-diol;2,4-dihydroxy-5-Bromo-pyrimidine;5-Bromouracil;5-Bromo uracil;5-bromopyrimidine-2,4-diol;
  • PSA 65.72000
  • LogP -0.17430

Synthetic route

uracil
66-22-8

uracil

5-bromouracil
51-20-7

5-bromouracil

Conditions
ConditionsYield
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; acetic anhydride; acetic acid at 50℃; for 1.5h; Temperature; Reagent/catalyst;99.9%
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; acetic anhydride; acetic acid at 50℃; for 1.5h; Temperature; Reagent/catalyst;99.9%
With N-Bromosuccinimide; montmorillonite K-10; tetrabutylammomium bromide for 0.0666667h; microwave irradiation;96%
5,5'-mercuribis(uracil)
97759-31-4

5,5'-mercuribis(uracil)

5-bromouracil
51-20-7

5-bromouracil

Conditions
ConditionsYield
With bromine; potassium bromide In water at 80℃; for 0.5h;84%
5-bromo-2,4-bis(4-methoxybenzyloxy)pyrimidine
664988-37-8

5-bromo-2,4-bis(4-methoxybenzyloxy)pyrimidine

5-bromouracil
51-20-7

5-bromouracil

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 0.25h;84%
5-bromo-2,4-dimethoxypyrimidine
56686-16-9

5-bromo-2,4-dimethoxypyrimidine

5-bromouracil
51-20-7

5-bromouracil

Conditions
ConditionsYield
With hydrogenchloride83%
1-Acetyl-5-trifluoroacetoxymercuriuracil

1-Acetyl-5-trifluoroacetoxymercuriuracil

5-bromouracil
51-20-7

5-bromouracil

Conditions
ConditionsYield
With bromine; potassium bromide In water; acetonitrile at 80℃; for 0.5h;77%
uracil
66-22-8

uracil

A

5-bromouracil
51-20-7

5-bromouracil

5,6-dibromo-5,6-dihydrouracil

5,6-dibromo-5,6-dihydrouracil

Conditions
ConditionsYield
With Bromoform In dichloromethane for 40h; Irradiation;A 7%
B 53%
sodium isoorotate
3252-17-3

sodium isoorotate

5-bromouracil
51-20-7

5-bromouracil

Conditions
ConditionsYield
With bromine In water for 7h; Heating;40%
3-(3,4-dihydro-5-bromo-2,4-dioxo-(2H)pyrimidin-1-yl)propanoic acid methyl ester
22384-59-4

3-(3,4-dihydro-5-bromo-2,4-dioxo-(2H)pyrimidin-1-yl)propanoic acid methyl ester

ethanolamine
141-43-5

ethanolamine

A

5-bromouracil
51-20-7

5-bromouracil

B

3-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2-hydroxyethyl)-propanamide
1174386-67-4

3-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(2-hydroxyethyl)-propanamide

C

N-(2-hydroxyethyl)-3-[5-(2-hydroxyethylamino)-2,4-dioxo-3,4-dihydro(2H)pyrimidin-1-yl]propanamide
1174386-68-5

N-(2-hydroxyethyl)-3-[5-(2-hydroxyethylamino)-2,4-dioxo-3,4-dihydro(2H)pyrimidin-1-yl]propanamide

Conditions
ConditionsYield
In methanol for 12h; Reflux;A 32%
B 30%
C 35%
...Expand
4-Decylsulfanyl-1H-pyrimidin-2-one

4-Decylsulfanyl-1H-pyrimidin-2-one

A

5-bromouracil
51-20-7

5-bromouracil

B

C14H23BrN2OS
856766-62-6

C14H23BrN2OS

Conditions
ConditionsYield
With bromine In tetrachloromethane at 20℃;A 30%
B 20%
4-Dodecylsulfanyl-1H-pyrimidin-2-one

4-Dodecylsulfanyl-1H-pyrimidin-2-one

A

5-bromouracil
51-20-7

5-bromouracil

B

C16H27BrN2OS
856766-63-7

C16H27BrN2OS

Conditions
ConditionsYield
With bromine In tetrachloromethane at 20℃;A 30%
B 18%
C18H32N2OS

C18H32N2OS

A

5-bromouracil
51-20-7

5-bromouracil

B

C18H31BrN2OS
856766-64-8

C18H31BrN2OS

Conditions
ConditionsYield
With bromine In tetrachloromethane at 20℃;A 30%
B 21%
4-Hexadecylsulfanyl-1H-pyrimidin-2-one

4-Hexadecylsulfanyl-1H-pyrimidin-2-one

A

5-bromouracil
51-20-7

5-bromouracil

B

C20H35BrN2OS
856766-65-9

C20H35BrN2OS

Conditions
ConditionsYield
With bromine In tetrachloromethane at 20℃;A 30%
B 22%
4-Octadecylsulfanyl-1H-pyrimidin-2-one

4-Octadecylsulfanyl-1H-pyrimidin-2-one

A

5-bromouracil
51-20-7

5-bromouracil

B

C22H39BrN2OS

C22H39BrN2OS

Conditions
ConditionsYield
With bromine In tetrachloromethane at 20℃;A 30%
B 20%
5,5-dibromo-6-hydroxy-5,6-dihydrouracil
1124-83-0

5,5-dibromo-6-hydroxy-5,6-dihydrouracil

A

5-bromouracil
51-20-7

5-bromouracil

B

[5,5']bipyrimidinyl-2,4,6,2',4',6'-hexaone
476-61-9

[5,5']bipyrimidinyl-2,4,6,2',4',6'-hexaone

Conditions
ConditionsYield
With water
1-acetyl-5-bromo-1H-pyrimidine-2,4-dione

1-acetyl-5-bromo-1H-pyrimidine-2,4-dione

5-bromouracil
51-20-7

5-bromouracil

Conditions
ConditionsYield
With hydrogenchloride
5-bromo-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
15018-62-9

5-bromo-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid

5-bromouracil
51-20-7

5-bromouracil

Cytosine
71-30-7

Cytosine

A

5-bromouracil
51-20-7

5-bromouracil

B

5-bromocytosine
2240-25-7

5-bromocytosine

Conditions
ConditionsYield
With bromine In tetrachloromethane; water at 25℃; for 1h; Title compound not separated from byproducts;A 17 % Spectr.
B 73 % Spectr.
5-Bromo-6-hydroxyamino-dihydro-pyrimidine-2,4-dione

5-Bromo-6-hydroxyamino-dihydro-pyrimidine-2,4-dione

5-bromouracil
51-20-7

5-bromouracil

Conditions
ConditionsYield
With hydroxylamine at 25℃; Equilibrium constant; var. pH;
hydrogenchloride
7647-01-0

hydrogenchloride

5,5-dibromo-6-hydroxy-5,6-dihydrouracil
1124-83-0

5,5-dibromo-6-hydroxy-5,6-dihydrouracil

water
7732-18-5

water

5-bromouracil
51-20-7

5-bromouracil

Conditions
ConditionsYield
at 25℃; Rate constant;
...Expand
5-bromo-2-ethylsulfanyl-pyrimidone-(4)

5-bromo-2-ethylsulfanyl-pyrimidone-(4)

5-bromouracil
51-20-7

5-bromouracil

Conditions
ConditionsYield
With hydrogenchloride
5-bromo-2-methoxy-1H-pyrimidin-4-one

5-bromo-2-methoxy-1H-pyrimidin-4-one

5-bromouracil
51-20-7

5-bromouracil

Conditions
ConditionsYield
With hydrogenchloride
cytidine nitrate

cytidine nitrate

A

5-bromouracil
51-20-7

5-bromouracil

B

D-ribonic acid
642-98-8

D-ribonic acid

Conditions
ConditionsYield
With hydrogen bromide; bromine
uracil
66-22-8

uracil

water

water

bromine

bromine

5-bromouracil
51-20-7

5-bromouracil

Conditions
ConditionsYield
Mechanism;
...Expand
2,4-dichloro-5-bromopyrimidine
36082-50-5

2,4-dichloro-5-bromopyrimidine

antimony(III) fluoride
7783-56-4

antimony(III) fluoride

A

5-fluorouracil
51-21-8

5-fluorouracil

B

5-bromouracil
51-20-7

5-bromouracil

...Expand
2,4-dichloro-5-bromopyrimidine
36082-50-5

2,4-dichloro-5-bromopyrimidine

A

5-bromouracil
51-20-7

5-bromouracil

B

uracil
66-22-8

uracil

tetrabromo aurate (III) (1-)
14337-14-5

tetrabromo aurate (III) (1-)

uracil
66-22-8

uracil

A

5-bromouracil
51-20-7

5-bromouracil

B

dibromidoaurate(I)

dibromidoaurate(I)

Conditions
ConditionsYield
In dimethylsulfoxide-d6; water Kinetics; byproducts: 5-bromo-6-hydroxy-5,6-dihydrouracil; reduction reaction at 25°C; monitored by NMR-spectroscopy;
In dimethylsulfoxide-d6 Kinetics; reduction reaction at 25°C; monitored by (1)H-NMR-spectroscopy;
...Expand
5-bromouridine
957-75-5

5-bromouridine

A

5-bromouracil
51-20-7

5-bromouracil

B

C5H9O8P(2-)*2K(1+)

C5H9O8P(2-)*2K(1+)

Conditions
ConditionsYield
With potassium dihydrogenphosphate; E-pyrimidine nucleoside phosphorylase-0002 In aq. buffer at 40℃; for 0.666667h; pH=9; Equilibrium constant; Thermodynamic data; Temperature; Enzymatic reaction;
5-bromo-2'-deoxyuridine
59-14-3

5-bromo-2'-deoxyuridine

A

5-bromouracil
51-20-7

5-bromouracil

B

C5H9O7P(2-)*2K(1+)

C5H9O7P(2-)*2K(1+)

Conditions
ConditionsYield
With potassium dihydrogenphosphate; E-pyrimidine nucleoside phosphorylase-0002 In aq. buffer at 40℃; for 0.666667h; pH=9; Equilibrium constant; Thermodynamic data; Temperature; Enzymatic reaction;
1-methyl-piperazine
109-01-3

1-methyl-piperazine

5-bromouracil
51-20-7

5-bromouracil

5-(4-methylpiperazin-1-yl) pyrimidine-2,4(1H,3H)-dione
141692-30-0

5-(4-methylpiperazin-1-yl) pyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With pyridine at 150℃; for 0.75h; Microwave irradiation;100%
In neat (no solvent) at 120℃; Microwave irradiation;91%
for 0.25h; Heating;65%
5-bromouracil
51-20-7

5-bromouracil

C4H4BrN2O2
78907-31-0

C4H4BrN2O2

Conditions
ConditionsYield
With H2SO4 glasses Product distribution; Irradiation;100%
5-bromouracil
51-20-7

5-bromouracil

2,4-dichloro-5-bromopyrimidine
36082-50-5

2,4-dichloro-5-bromopyrimidine

Conditions
ConditionsYield
With phosphorus pentachloride In 1,1,2-trichloroethane Reagent/catalyst; Solvent; Reflux;99.5%
With N,N-dimethyl-aniline; trichlorophosphate at 120 - 130℃; for 1.33333h;96.6%
With phosgene; Tributylphosphine oxide at -5 - 125℃; for 1.83333h; Inert atmosphere;89.7%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

5-bromouracil
51-20-7

5-bromouracil

2,4-bis-(trimethylsilyloxy)-5-bromopyrimidine
33282-64-3

2,4-bis-(trimethylsilyloxy)-5-bromopyrimidine

Conditions
ConditionsYield
With 1,1,1,3,3,3-hexamethyl-disilazane Ambient temperature;99%
With 1,1,1,3,3,3-hexamethyl-disilazane at 140 - 150℃; for 5h;
With 1,1,1,3,3,3-hexamethyl-disilazane
With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane for 18h; Heating;
5-bromouracil
51-20-7

5-bromouracil

ethyl acrylate
140-88-5

ethyl acrylate

3-(5-bromo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)propionic acid ethyl ester

3-(5-bromo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)propionic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 60℃; Aza-Micheal reaction;99%
With tetrabutylammomium bromide; zinc(II) oxide at 100℃; for 0.416667h; Michael addition; microwave irradiation;90%
With tetrabutylammomium bromide at 100℃; for 0.416667h; Microwave irradiation; Neat (no solvent);84%
With Bacillus subtilis alkaline protease EC 3.4.21.14 In dimethyl sulfoxide at 50℃; for 24h; Michael addition;68.5%
5-bromouracil
51-20-7

5-bromouracil

cyclohexylamine
108-91-8

cyclohexylamine

5-(N-cyclohexylamino)uracil
5177-53-7

5-(N-cyclohexylamino)uracil

Conditions
ConditionsYield
at 110℃; for 0.116667h; microwave irradiation;98%
5-bromouracil
51-20-7

5-bromouracil

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

3-(3,4-dihydro-5-bromo-2,4-dioxo-(2H)pyrimidin-1-yl)propanoic acid methyl ester
22384-59-4

3-(3,4-dihydro-5-bromo-2,4-dioxo-(2H)pyrimidin-1-yl)propanoic acid methyl ester

Conditions
ConditionsYield
Stage #1: 5-bromouracil With triethylamine In N,N-dimethyl-formamide for 0.0833333h; Michael-type addition;
Stage #2: acrylic acid methyl ester In N,N-dimethyl-formamide at 20℃; for 24h; Michael-type addition; regioselective reaction;		98%
With triethylamine In N,N-dimethyl-formamide at 60℃; Aza-Micheal reaction;97%
With acylase Amano from Aspergillus oryzae In dimethyl sulfoxide at 50℃; for 3h; Michael addition reaction;91 % Chromat.
With triethylamine In N,N-dimethyl-formamide at 20℃; for 24h; Michael condensation;
5-bromouracil
51-20-7

5-bromouracil

acrylic acid n-butyl ester
141-32-2

acrylic acid n-butyl ester

3-(5-bromo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)propionic acid butyl ester
1370413-76-5

3-(5-bromo-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)propionic acid butyl ester

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 60℃; Aza-Micheal reaction;98%
5-bromouracil
51-20-7

5-bromouracil

benzyl-methyl-amine
103-67-3

benzyl-methyl-amine

5-[benzyl(methyl)amino]-1H-pyrimidine-2,4-dione
141692-27-5

5-[benzyl(methyl)amino]-1H-pyrimidine-2,4-dione

Conditions
ConditionsYield
at 120℃; for 0.0833333h; microwave irradiation;97%
In neat (no solvent) at 120℃; for 1h; Microwave irradiation;86%
at 120℃; for 1h; Microwave irradiation;86%
at 120℃; for 1h; Microwave irradiation;86%
for 0.25h; Heating;
5-bromouracil
51-20-7

5-bromouracil

parabanic acid
120-89-8

parabanic acid

Conditions
ConditionsYield
With oxygen; ozone In acetic acid at 20℃; for 0.75h; Product distribution;97%
morpholine
110-91-8

morpholine

5-bromouracil
51-20-7

5-bromouracil

5-morpholinopyrimidine-2,4(1H,3H)-dione
37454-52-7

5-morpholinopyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
at 90℃; for 0.0833333h; microwave irradiation;96%
at 130℃; for 0.25h;96%
at 100℃; for 0.166667h; Microwave irradiation;89%
In neat (no solvent) at 120℃; Microwave irradiation;78%
5-bromouracil
51-20-7

5-bromouracil

N-butylamine
109-73-9

N-butylamine

5-butylaminouracil

5-butylaminouracil

Conditions
ConditionsYield
at 90℃; for 0.166667h; microwave irradiation;96%
5-bromouracil
51-20-7

5-bromouracil

ethanolamine
141-43-5

ethanolamine

5-(2'-hydroxyethylamino)uracil
55476-33-0

5-(2'-hydroxyethylamino)uracil

Conditions
ConditionsYield
In ethanol for 24h; Reflux;96%
5-bromouracil
51-20-7

5-bromouracil

5-Bromo-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one
72812-45-4

5-Bromo-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one

Conditions
ConditionsYield
With diphosphorus pentasulfide; sodium hydrogencarbonate In diethylene glycol dimethyl ether at 110℃; for 2h;95%
5-bromouracil
51-20-7

5-bromouracil

benzylamine
100-46-9

benzylamine

5-(benzylamino)dihydropyrimidine-2,4(1H,3H)-dione
28485-19-0

5-(benzylamino)dihydropyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
at 110℃; for 0.2h; microwave irradiation;95%
at 160℃; for 2h;90%
for 0.666667h; Inert atmosphere; Heating; neat (no solvent);84%
Heating; Yield given;
at 160℃; for 3h;
piperidine
110-89-4

piperidine

5-bromouracil
51-20-7

5-bromouracil

5-(N-piperidino)uracil
37454-53-8

5-(N-piperidino)uracil

Conditions
ConditionsYield
at 90℃; for 0.15h; microwave irradiation;95%
5-bromouracil
51-20-7

5-bromouracil

vinyl acrylate
2177-18-6

vinyl acrylate

3-(5-bromouracil-1-yl)propionic acid vinyl ester
1217794-07-4

3-(5-bromouracil-1-yl)propionic acid vinyl ester

Conditions
ConditionsYield
With D-aminoacylase from Escherichia coli In dimethyl sulfoxide at 25℃; for 0.416667h; Michael addition; Enzymatic reaction; regioselective reaction;95%
5-bromouracil
51-20-7

5-bromouracil

ethyl bromoacetate
105-36-2

ethyl bromoacetate

5-bromo-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidineacetic acid ethyl ester
381710-01-6

5-bromo-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidineacetic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 5-bromouracil With 1,1,1,3,3,3-hexamethyl-disilazane Heating;
Stage #2: ethyl bromoacetate In acetonitrile Heating; Further stages.;		94%
With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; potassium iodide In acetonitrile at 120℃; for 1h; Time; Hilbert-Johnson Synthesis; Microwave irradiation; Autoclave; regioselective reaction;62%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;55%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;
1,2,3,5-tetra-O-acetyl-3-C-ethynyl-D-ribo-pentofuranose
848644-37-1

1,2,3,5-tetra-O-acetyl-3-C-ethynyl-D-ribo-pentofuranose

5-bromouracil
51-20-7

5-bromouracil

1-[2,3,5-tri-O-acetyl-3-C-ethynyl-β-D-ribo-pentofuranosyl]-5-bromouracil
848644-42-8

1-[2,3,5-tri-O-acetyl-3-C-ethynyl-β-D-ribo-pentofuranosyl]-5-bromouracil

Conditions
ConditionsYield
With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate In acetonitrile at 50℃; for 23h;94%
5-bromouracil
51-20-7

5-bromouracil

2-fluorobenzylamine
89-99-6

2-fluorobenzylamine

5-[(2-fluorobenzyl)amino]dihydropyrimidine-2,4(1H,3H)-dione
867151-45-9

5-[(2-fluorobenzyl)amino]dihydropyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
at 160℃; for 2h;94%
5-bromouracil
51-20-7

5-bromouracil

uracil
66-22-8

uracil

Conditions
ConditionsYield
With N,N-dimethyl acetamide at 180℃; for 7h;93.8%
With isopropyl alcohol Product distribution; Mechanism; Quantum yield; Irradiation; deuterated 2-propanol solvents;
In ethanol Product distribution; Quantum yield; Mechanism; Irradiation; further solvent;
5-bromouracil
51-20-7

5-bromouracil

2,4-Difluoro-benzylamine
72235-52-0

2,4-Difluoro-benzylamine

5-[(2,4-difluorobenzyl)amino]dihydropyrimidine-2,4(1H,3H)-dione
867151-48-2

5-[(2,4-difluorobenzyl)amino]dihydropyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
at 160℃; for 6h;93%
at 160℃; for 2h;91%
5-bromouracil
51-20-7

5-bromouracil

2-chloromethyl-1,3,5-trimethylbenzene
1585-16-6

2-chloromethyl-1,3,5-trimethylbenzene

5-bromo-1-(mesitylmethyl)pyrimidine-2,4(1H,3H)-dione
1056025-50-3

5-bromo-1-(mesitylmethyl)pyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
Stage #1: 5-bromouracil With benzenesulfonamide In acetonitrile for 0.25h;
Stage #2: 2-chloromethyl-1,3,5-trimethylbenzene In acetonitrile for 20h; Heating; Further stages.;		93%
5-bromouracil
51-20-7

5-bromouracil

aniline
62-53-3

aniline

5-(phenylamino)uracil
4870-31-9

5-(phenylamino)uracil

Conditions
ConditionsYield
at 180℃; for 0.25h; microwave irradiation;92%
at 195 - 200℃; for 1h;77%
In ethylene glycol Reflux;68%
With hydroquinone In ethylene glycol at 200℃; for 2h; Heating / reflux;55%
5-bromouracil
51-20-7

5-bromouracil

para-fluorobenzylamine
140-75-0

para-fluorobenzylamine

5-[(4-fluorobenzyl)amino]dihydropyrimidine-2,4(1H,3H)-dione
867151-47-1

5-[(4-fluorobenzyl)amino]dihydropyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
at 160℃; for 2h;92%
5-bromouracil
51-20-7

5-bromouracil

1-chloro-2,4-dinitro-benzene
97-00-7

1-chloro-2,4-dinitro-benzene

1-(2,4-dinitro-phenyl)-5-bromo-1H-pyrimidine-2,4-dione

1-(2,4-dinitro-phenyl)-5-bromo-1H-pyrimidine-2,4-dione

Conditions
ConditionsYield
With zinc(II) oxide at 130℃; for 0.5h; Ionic liquid;92%
5-bromouracil
51-20-7

5-bromouracil

phenethylamine
64-04-0

phenethylamine

5-[(2-phenylethyl)amino]dihydropyrimidine-2,4(1H,3H)-dione
25912-34-9

5-[(2-phenylethyl)amino]dihydropyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
at 160℃; for 2h;91%
5-bromouracil
51-20-7

5-bromouracil

2-methoxyethylamine
109-85-3

2-methoxyethylamine

5-(2-methoxyethylamino)pyrimidine-2,4(1H,3H)-dione

5-(2-methoxyethylamino)pyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
In ethanol at 100℃; for 16h;90.4%
With potassium carbonate In tetrahydrofuran
5-bromouracil
51-20-7

5-bromouracil

ethyl 6-O-(tert-butyldimethylsilyl)-4-O-methoxycarbonyl-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside
187990-50-7

ethyl 6-O-(tert-butyldimethylsilyl)-4-O-methoxycarbonyl-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside

C18H29BrN2O5Si

C18H29BrN2O5Si

Conditions
ConditionsYield
With 1,4-di(diphenylphosphino)-butane; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 50℃; for 2h;90%

5-Bromouracil Chemical Properties

Structure of 5-Bromouracil (CAS NO.51-20-7):

IUPAC Name: 5-bromo-1H-pyrimidine-2,4-dione 
Empirical Formula: C4H3BrN2O2
Molecular Weight: 190.9828 
EINECS: 200-084-0 
Index of Refraction: 1.59
Molar Refractivity: 32.78 cm3
Molar Volume: 97.1 cm3
Polarizability: 12.99×10-24cm3
Surface Tension: 54.6 dyne/cm
Density: 1.965 g/cm3 
Melting Point: >300 °C(lit.)
Physical Appearance: White powder
Water Solubility: SOLUBLE IN COLD WATER 
Product Categories: Pyrimidine series;Detergents;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Nucleic acids;Bases & Related Reagents;Mutagenesis Research Chemicals;Nucleotides 
Synonyms of 5-Bromouracil (CAS NO.51-20-7): 5-Bromo-2,4(1H,3H)-pyrimidinedione ; Bromouracil  ; 2,4(1H,3H)-Pyrimidinedione, 5-bromo- ; Uracil, 5-bromo-

5-Bromouracil Uses

A major chemical mutagen. Incorporates into DNA, altering base-pair sequencing by replacing thymine.

5-Bromouracil Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1400mg/kg (1400mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Proceedings of the Society for Experimental Biology and Medicine. Vol. 93, Pg. 124, 1956.
rat LD50 intraperitoneal 1700mg/kg (1700mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Proceedings of the Society for Experimental Biology and Medicine. Vol. 93, Pg. 124, 1956.

5-Bromouracil Safety Profile

Hazard Codes: HarmfulXn
Risk Statements: 22-46 
R22:Harmful if swallowed. 
R46:May cause heritable genetic damage.
Safety Statements: 36/37-53-45 
S36/37:Wear suitable protective clothing and gloves. 
S53:Avoid exposure - obtain special instructions before use. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: YQ9060000
HS Code: 29335995

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View