5-Ethyl-2-vinylpyridine supplier

Name
5-ETHYL-2-VINYL PYRIDINE
EINECS 226-475-6
CAS No. 5408-74-2
Article Data13
CAS DataBase
Density 0.941 g/cm³
Solubility
Melting Point
Formula C₉H₁₁ N
Boiling Point 208.5ºC at 760 mmHg
Molecular Weight 133.193
Flash Point 76.2 ºC
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Pyridine,5-ethyl-2-vinyl- (6CI,7CI,8CI);5-Ethyl-2-vinylpyridine;NSC 8395;
PSA 12.89000
LogP 2.28700

Synthetic route

: 646519-88-2
5-{4-[2-chloro-2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-2,4-thiazolidene dione

A: 5408-74-2
5-ethyl-2-vinyl-pyridine

B: 105355-27-9
Pioglitazone

C: 74772-78-4
5-(4-hydroxybenzyl)-2,4-thiazolidinedione

Conditions

Conditions	Yield
With acetic acid; zinc In ethyl acetate at 25 - 35℃; for 9h; Product distribution / selectivity;	A n/a B 41% C n/a
With acetic acid; zinc at 25 - 30℃; for 15h;	A 10% B 25% C 12%
Stage #1: 5-{4-[2-chloro-2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-2,4-thiazolidene dione With acetic acid; zinc at 5 - 30℃; for 15h; Stage #2: With sodium carbonate In water; acetic acid Product distribution / selectivity;	A 10% B 20% C 12%

...Expand

: 104-90-5
5-ethyl-2-methyl-pyridine

: 50-00-0
formaldehyd

A: 5408-74-2
5-ethyl-2-vinyl-pyridine

B: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; ethanol at 220℃;
In water at 155℃; under 4500.45 Torr; for 4h; Pressure; Autoclave;	A n/a B 70 g

...Expand

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
With aluminum oxide at 420℃;
With potassium hydroxide at 175℃; Erhitzen unter vermindertem Druck;
With potassium hydroxide Heating; Yield given;

: 7647-01-0
hydrogenchloride

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
at 160 - 170℃; nachfolgenden Erwaermen mit Natronlauge;

5-ethyl-2-<β-oxy-ethyl>-pyridine: 5-ethyl-2-<β-oxy-ethyl>-pyridine

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
With hydrogenchloride at 160 - 170℃; im Rohr; Erwaermen mit Natronlauge;
With hydrogenchloride at 160 - 170℃; im Rohr; Destillieren ueber Kaliumhydroxyd;

: 5223-06-3
5-ethyl-2-(2-hydroxyethyl)pyridine

potassium hydroxide: potassium hydroxide

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
Destillation;

: 104-90-5
5-ethyl-2-methyl-pyridine

pyridine-homologous/ues: pyridine-homologous/ues

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: formic acid, tert-butylcatechol / ethanol / 120 h / Heating 2: KOH / Heating View Scheme

: 104-90-5
5-ethyl-2-methyl-pyridine

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium peroxo disulfate; ethanol / 220 °C 2: potassium hydroxide / 175 °C / Erhitzen unter vermindertem Druck View Scheme
Multi-step reaction with 2 steps 1: formic acid; water / 240 °C / 139011 Torr 2: potassium hydroxide / 175 °C / Erhitzen unter vermindertem Druck View Scheme
Multi-step reaction with 3 steps 1: water / 3 h / 150 - 160 °C / 3750.38 - 4500.45 Torr / Autoclave 2: triethylamine; p-toluenesulfonyl chloride / toluene / 0 - 5 °C 3: potassium carbonate / toluene / 10 h / Reflux View Scheme
Multi-step reaction with 3 steps 1: water / 4 h / 155 °C / 4500.45 Torr / Autoclave 2: triethylamine; p-toluenesulfonyl chloride / toluene / 0 - 5 °C 3: potassium carbonate / toluene / 10 h / Reflux View Scheme

: 646519-89-3
5-{4-[2-chloro-2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-2,4-thiazolidene dione hydrochloride

A: 5408-74-2
5-ethyl-2-vinyl-pyridine

B: 105355-27-9
Pioglitazone

C: 74772-78-4
5-(4-hydroxybenzyl)-2,4-thiazolidinedione

Conditions

Conditions	Yield
With acetic acid; zinc In methanol Product distribution / selectivity; Industry scale;

...Expand

: 768-61-6
2-hydroxymethyl-5-ethyl pyridine

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
With potassium hydroxide

: 646519-94-0
5-{4-[2-chloro-2-(5-ethylpyridn-2-yl)ethoxy]benzylidene}-2,4-thiazolidene dione

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen / tetrahydrofuran / 12 h 2: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme

: 90643-32-6
2-(5-ethyl-1-oxypyridin-2-yl)ethanol

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1: 0.5 h / 120 °C 2: sodium hydroxide / water / 2 h / 40 °C 3: thionyl chloride; triethylamine / dichloromethane / 1.25 h / 0 - 5 °C 4: N,N-dimethyl-formamide / 14 h / 80 °C 5: thionyl chloride / chloroform / 1 h / Reflux 6: acetic acid; piperidine / toluene / Heating 7: hydrogen / tetrahydrofuran / 12 h 8: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
Multi-step reaction with 8 steps 1: 0.5 h / 120 °C 2: sodium hydroxide / water / 2 h / 40 °C 3: thionyl chloride; triethylamine / dichloromethane / 1.25 h / 0 - 5 °C 4: N,N-dimethyl-formamide / 14 h / 80 °C 5: pyrrolidine / methanol / 2 h / 50 - 55 °C / Large scale 6: thionyl chloride / chloroform / 3 h / Reflux 7: hydrogen / tetrahydrofuran / 12 h 8: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
Multi-step reaction with 8 steps 1: 0.5 h / 120 °C 2: sodium hydroxide / water / 2 h / 40 °C 3: thionyl chloride; triethylamine / dichloromethane / 1.25 h / 0 - 5 °C 4: N,N-dimethyl-formamide / 14 h / 80 °C 5: pyrrolidine / methanol / 2 h / 50 - 55 °C / Large scale 6: sodium tetrahydroborate; butane-2,3-dione dioxime; cobalt(II) chloride hexahydrate / water; N,N-dimethyl-formamide / 4 h / 65 - 85 °C / Large scale 7: thionyl chloride / chloroform / 2 h / Reflux 8: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme

: 1-(5-ethylpyridin-2-yl)ethan-1,2-diol

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: thionyl chloride; triethylamine / dichloromethane / 1.25 h / 0 - 5 °C 2: N,N-dimethyl-formamide / 14 h / 80 °C 3: thionyl chloride / chloroform / 1 h / Reflux 4: acetic acid; piperidine / toluene / Heating 5: hydrogen / tetrahydrofuran / 12 h 6: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
Multi-step reaction with 6 steps 1: thionyl chloride; triethylamine / dichloromethane / 1.25 h / 0 - 5 °C 2: N,N-dimethyl-formamide / 14 h / 80 °C 3: pyrrolidine / methanol / 2 h / 50 - 55 °C / Large scale 4: sodium tetrahydroborate; butane-2,3-dione dioxime; cobalt(II) chloride hexahydrate / water; N,N-dimethyl-formamide / 4 h / 65 - 85 °C / Large scale 5: thionyl chloride / chloroform / 2 h / Reflux 6: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
Multi-step reaction with 6 steps 1: thionyl chloride; triethylamine / dichloromethane / 1.25 h / 0 - 5 °C 2: N,N-dimethyl-formamide / 14 h / 80 °C 3: pyrrolidine / methanol / 2 h / 50 - 55 °C / Large scale 4: thionyl chloride / chloroform / 3 h / Reflux 5: hydrogen / tetrahydrofuran / 12 h 6: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme

: 5-ethyl-2-[2-oxo-(1,3,2)dioxathiolan-4-yl]pyridine

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: N,N-dimethyl-formamide / 14 h / 80 °C 2: thionyl chloride / chloroform / 1 h / Reflux 3: acetic acid; piperidine / toluene / Heating 4: hydrogen / tetrahydrofuran / 12 h 5: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
Multi-step reaction with 5 steps 1: N,N-dimethyl-formamide / 14 h / 80 °C 2: pyrrolidine / methanol / 2 h / 50 - 55 °C / Large scale 3: sodium tetrahydroborate; butane-2,3-dione dioxime; cobalt(II) chloride hexahydrate / water; N,N-dimethyl-formamide / 4 h / 65 - 85 °C / Large scale 4: thionyl chloride / chloroform / 2 h / Reflux 5: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
Multi-step reaction with 5 steps 1: N,N-dimethyl-formamide / 14 h / 80 °C 2: pyrrolidine / methanol / 2 h / 50 - 55 °C / Large scale 3: thionyl chloride / chloroform / 3 h / Reflux 4: hydrogen / tetrahydrofuran / 12 h 5: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme

: 4-[2-chloro-2-(5-ethyl-2-pyridyl)ethoxy]benzaldehyde

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: acetic acid; piperidine / toluene / Heating 2: hydrogen / tetrahydrofuran / 12 h 3: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme

: 471295-98-4
4-[2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy]benzaldehyde

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: thionyl chloride / chloroform / 1 h / Reflux 2: acetic acid; piperidine / toluene / Heating 3: hydrogen / tetrahydrofuran / 12 h 4: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
Multi-step reaction with 4 steps 1: pyrrolidine / methanol / 2 h / 50 - 55 °C / Large scale 2: thionyl chloride / chloroform / 3 h / Reflux 3: hydrogen / tetrahydrofuran / 12 h 4: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
Multi-step reaction with 4 steps 1: pyrrolidine / methanol / 2 h / 50 - 55 °C / Large scale 2: sodium tetrahydroborate; butane-2,3-dione dioxime; cobalt(II) chloride hexahydrate / water; N,N-dimethyl-formamide / 4 h / 65 - 85 °C / Large scale 3: thionyl chloride / chloroform / 2 h / Reflux 4: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme

: acetic acid 2-acetoxy-2-(5-ethyl-1-pyridin-2-yl)ethyl ester

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: sodium hydroxide / water / 2 h / 40 °C 2: thionyl chloride; triethylamine / dichloromethane / 1.25 h / 0 - 5 °C 3: N,N-dimethyl-formamide / 14 h / 80 °C 4: thionyl chloride / chloroform / 1 h / Reflux 5: acetic acid; piperidine / toluene / Heating 6: hydrogen / tetrahydrofuran / 12 h 7: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
Multi-step reaction with 7 steps 1: sodium hydroxide / water / 2 h / 40 °C 2: thionyl chloride; triethylamine / dichloromethane / 1.25 h / 0 - 5 °C 3: N,N-dimethyl-formamide / 14 h / 80 °C 4: pyrrolidine / methanol / 2 h / 50 - 55 °C / Large scale 5: thionyl chloride / chloroform / 3 h / Reflux 6: hydrogen / tetrahydrofuran / 12 h 7: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
Multi-step reaction with 7 steps 1: sodium hydroxide / water / 2 h / 40 °C 2: thionyl chloride; triethylamine / dichloromethane / 1.25 h / 0 - 5 °C 3: N,N-dimethyl-formamide / 14 h / 80 °C 4: pyrrolidine / methanol / 2 h / 50 - 55 °C / Large scale 5: sodium tetrahydroborate; butane-2,3-dione dioxime; cobalt(II) chloride hexahydrate / water; N,N-dimethyl-formamide / 4 h / 65 - 85 °C / Large scale 6: thionyl chloride / chloroform / 2 h / Reflux 7: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme

: 646519-84-8
5-{4-[2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy]benzylidene}-2,4-thiazolidene dione

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: thionyl chloride / chloroform / 3 h / Reflux 2: hydrogen / tetrahydrofuran / 12 h 3: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
Multi-step reaction with 3 steps 1: sodium tetrahydroborate; butane-2,3-dione dioxime; cobalt(II) chloride hexahydrate / water; N,N-dimethyl-formamide / 4 h / 65 - 85 °C / Large scale 2: thionyl chloride / chloroform / 2 h / Reflux 3: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme

: 646519-81-5
2-bromo-1-(5-ethylpyridin-2-yl)ethanol

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: potassium carbonate / tert-butyl alcohol / 1.17 h / Reflux 1.2: 11 h / Reflux 2.1: thionyl chloride / chloroform / 1 h / Reflux 3.1: acetic acid; piperidine / toluene / Heating 4.1: hydrogen / tetrahydrofuran / 12 h 5.1: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
Multi-step reaction with 5 steps 1.1: potassium carbonate / tert-butyl alcohol / 1.17 h / Reflux 1.2: 11 h / Reflux 2.1: pyrrolidine / methanol / 2 h / 50 - 55 °C / Large scale 3.1: thionyl chloride / chloroform / 3 h / Reflux 4.1: hydrogen / tetrahydrofuran / 12 h 5.1: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme
Multi-step reaction with 5 steps 1.1: potassium carbonate / tert-butyl alcohol / 1.17 h / Reflux 1.2: 11 h / Reflux 2.1: pyrrolidine / methanol / 2 h / 50 - 55 °C / Large scale 3.1: sodium tetrahydroborate; butane-2,3-dione dioxime; cobalt(II) chloride hexahydrate / water; N,N-dimethyl-formamide / 4 h / 65 - 85 °C / Large scale 4.1: thionyl chloride / chloroform / 2 h / Reflux 5.1: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme

: 101931-00-4
5-{4-[2-(5-ethyl-pyridin-2-yl)-2-hydroxyethoxy]benzyl}-2,4-thiazolidinedione

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: thionyl chloride / chloroform / 2 h / Reflux 2: zinc; acetic acid / 15 h / 25 - 30 °C View Scheme

: 144809-27-8
toluene-4-sulfonic acid 2-(5-ethylpyridin-2-yl)ethyl ester

: 5408-74-2
5-ethyl-2-vinyl-pyridine

Conditions

Conditions	Yield
With potassium carbonate In toluene for 10h; Reflux;

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 1193-02-8
4-aminotiophenol

: 136401-93-9
4-[2-(5-Ethyl-pyridin-2-yl)-ethylsulfanyl]-phenylamine

Conditions

Conditions	Yield
Ambient temperature;	95%

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 646519-81-5
2-bromo-1-(5-ethylpyridin-2-yl)ethanol

Conditions

Conditions	Yield
With N-Bromosuccinimide; water In tert-butyl alcohol at 25 - 30℃; for 1.16667h; Reagent/catalyst; Solvent; Temperature; Time;	95%
With water; bromine; potassium bromide at 60 - 65℃; for 0.666667h; Product distribution / selectivity;	86%
With N-Bromosuccinimide; water In 1,4-dioxane at 25 - 30℃; for 4h; Product distribution / selectivity;	85%
With N-Bromosuccinimide; water In tetrahydrofuran at 25 - 30℃; for 4h; Product distribution / selectivity;	82%

: 5408-74-2
5-ethyl-2-vinyl-pyridine

A: 286411-85-6
1-(5-ethyl-2-pyridinyl)ethanone

B: 646519-81-5
2-bromo-1-(5-ethylpyridin-2-yl)ethanol

C: 2-(1-bromovinyl)-5-ethylpyridine

Conditions

Conditions	Yield
With N-Bromosuccinimide; water In tert-butyl alcohol at 25 - 30℃; for 1h; Product distribution / selectivity;	A n/a B 93% C n/a
With N-Bromosuccinimide; water In dimethyl sulfoxide at -5 - 0℃; for 0.5h; Product distribution / selectivity;	A 5% B 88% C 6%

...Expand

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 5-ethyl-2-oxiran-2-ylpyridine

Conditions

Conditions	Yield
Stage #1: 5-ethyl-2-vinyl-pyridine With N-Bromosuccinimide; water In tert-butyl alcohol at 25 - 30℃; for 1.5h; Stage #2: With sodium hydroxide In water; tert-butyl alcohol for 0.75h; Product distribution / selectivity;	92%
Stage #1: 5-ethyl-2-vinyl-pyridine With N-Bromosuccinimide; water In dimethyl sulfoxide at -5 - 0℃; for 1h; Stage #2: With potassium carbonate In methanol; water; dimethyl sulfoxide at 25 - 30℃; for 1h; Product distribution / selectivity;	80%
With N-Bromosuccinimide; acetic acid In water; tert-butyl alcohol at 10℃; for 1h; Reagent/catalyst; Solvent; Inert atmosphere; Large scale;
Multi-step reaction with 2 steps 1: water; N-Bromosuccinimide / tert-butyl alcohol / 1.17 h / 25 - 30 °C 2: potassium carbonate / tert-butyl alcohol; water / 1 h / 25 - 30 °C View Scheme
Multi-step reaction with 2 steps 1: water; N-Bromosuccinimide / dimethyl sulfoxide / 0.5 h / -5 - 0 °C 2: potassium carbonate / tert-butyl alcohol; water / 1 h / 25 - 30 °C View Scheme

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 83-12-5
phenindione

: 2-phenyl-2-[-(5-ethyl-2-pyridyl)ethyl]indane-1,3-dione

Conditions

Conditions	Yield
In ethanol for 40h; Heating;	90%

: 5408-74-2
5-ethyl-2-vinyl-pyridine

A: 646519-81-5
2-bromo-1-(5-ethylpyridin-2-yl)ethanol

B: 2-(1-bromovinyl)-5-ethylpyridine

Conditions

Conditions	Yield
With N-Bromosuccinimide; water In dimethyl sulfoxide at -5 - 0℃; for 0.5h;	A 88% B 6%

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 123-08-0
4-hydroxy-benzaldehyde

A: 471295-98-4
4-[2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy]benzaldehyde

B: 471296-00-1
4-[1-(5-ethyl-pyridin-2-yl)-2-hydroxy-ethoxy]-benzaldehyde

Conditions

Conditions	Yield
Stage #1: 5-ethyl-2-vinyl-pyridine With N-Bromosuccinimide; water In tert-butyl alcohol at 25 - 30℃; for 1.5h; Industry scale; Stage #2: With sodium hydroxide In water; tert-butyl alcohol for 0.75h; Industry scale; Stage #3: 4-hydroxy-benzaldehyde With PEG 4000; sodium hydroxide In water; toluene at 78℃; for 17h; Product distribution / selectivity;	A 84% B n/a
Stage #1: 5-ethyl-2-vinyl-pyridine With N-Bromosuccinimide; water In tert-butyl alcohol at 25℃; for 1.5h; Industry scale; Stage #2: With sodium hydroxide In water; tert-butyl alcohol for 0.75h; Stage #3: 4-hydroxy-benzaldehyde With sodium hydroxide In water; toluene at 78℃; for 17h; Product distribution / selectivity;	A 83% B n/a
Stage #1: 5-ethyl-2-vinyl-pyridine With N-Bromosuccinimide; water; 18-crown-6 ether In tert-butyl alcohol at 25 - 30℃; for 1.5h; Stage #2: With sodium hydroxide In water; tert-butyl alcohol for 0.75h; Stage #3: 4-hydroxy-benzaldehyde With sodium hydroxide; 18-crown-6 ether In water; toluene at 78℃; for 24h; Product distribution / selectivity;	A 81% B n/a
Stage #1: 5-ethyl-2-vinyl-pyridine With N-Bromosuccinimide; water In tert-butyl alcohol at 25 - 30℃; for 2.5h; Stage #2: 4-hydroxy-benzaldehyde With potassium carbonate In tert-butyl alcohol at 75 - 80℃; for 18h; Product distribution / selectivity;	A 79% B n/a

...Expand

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 123-08-0
4-hydroxy-benzaldehyde

: 471295-98-4
4-[2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy]benzaldehyde

Conditions

Conditions	Yield
Stage #1: 5-ethyl-2-vinyl-pyridine With N-Bromosuccinimide In water; tert-butyl alcohol at 25℃; for 1.5h; Large scale; Stage #2: With sodium hydroxide In water; tert-butyl alcohol for 0.75h; Large scale; Stage #3: 4-hydroxy-benzaldehyde With sodium hydroxide In water; toluene at 78℃; for 17h; Reagent/catalyst; Solvent; Temperature; Time; Large scale;	84%

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 58765-11-0
4-hydroxybenzaldehyde potassium salt

: 471295-98-4
4-[2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy]benzaldehyde

Conditions

Conditions	Yield
Stage #1: 5-ethyl-2-vinyl-pyridine With N-Bromosuccinimide; water In tert-butyl alcohol at 25 - 30℃; for 2.5h; Stage #2: 4-hydroxybenzaldehyde potassium salt In tert-butyl alcohol at 75 - 80℃; for 18h;	79%

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 110-17-8
(2E)-but-2-enedioic acid

: 90126-10-6
1-(2-methoxyphenyl)-4-<2-<2-(5-ethyl)pyridyl>ethyl>piperazine fumarate

Conditions

Conditions	Yield
With acetic acid 1.) ethanol, 5 h, reflux; 2.) acetone;	64%

...Expand

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 137729-45-4
[(hydridotris(pyrazolyl)borato)RuCl2(NO)]

: (BH(C3H3N2)3)RuCl(NOC2H2NC5H3C2H5)

Conditions

Conditions	Yield
With triethylamine In dichloromethane treatment of Ru-complex with 2-vinylpyridine in the presence of excess of triethylamine in refluxing CH2Cl2;	56%

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 2-bromo[5-ethylpyridin-2-yl]ethyl bromide

Conditions

Conditions	Yield
With bromine In tetrachloromethane for 2h; Product distribution / selectivity;	43%
With bromine In tetrachloromethane at 0 - 5℃; for 2h;

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 76162-64-6
3-Ethyl-5-(5-ethyl-pyridin-2-yl)-5,6,7,8-tetrahydro-quinoline

Conditions

Conditions	Yield
With PPA In phosphoric acid at 180 - 200℃; for 8h;	42%

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 941-69-5
N-phenyl-maleimide

: 5-(2,5-Dioxo-1-phenyl-pyrrolidin-3-yl)-8-ethyl-2-phenyl-3a,4,5,9b-tetrahydro-pyrrolo[3,4-f]quinoline-1,3-dione

Conditions

Conditions	Yield
In acetic anhydride for 15h; Heating;	30%

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 1477-55-0
1,3-di(aminomethyl)benzene

: 147151-69-7
[3-({Bis-[2-(5-ethyl-pyridin-2-yl)-ethyl]-amino}-methyl)-benzyl]-bis-[2-(5-ethyl-pyridin-2-yl)-ethyl]-amine

Conditions

Conditions	Yield
With acetic acid In methanol for 168h; Heating;	18%

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 157072-60-1, 166941-05-5, 16971-33-8, 61521-25-3
carbonylchlorohydridotris(triphenylphosphine)ruthenium(II)

: Ru(CH2CH2(C2H5C5H3N))Cl(CO)(P(C6H5)3)2

Conditions

Conditions	Yield
In tetrahydrofuran under N2, a THF suspn. of 1 equiv of Ru-complex and 1.5 equiv of 5-ethyl-2-vinylpyridine was stirred at room temp. for 10 h; elem. anal.;	17%

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 154743-00-7
bis<2-(2-(5-ethylpyridyl)ethyl)>amine

Conditions

Conditions	Yield
With ammonium chloride In methanol for 48h; Heating;	16.5%

: 123-75-1
pyrrolidine

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 91904-22-2
5-ethyl-2-(2-pyrrolidino-ethyl)-pyridine

Conditions

Conditions	Yield
With acetic acid

: 110-89-4
piperidine

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 43058-52-2
5-ethyl-2-(2-piperidino-ethyl)-pyridine

Conditions

Conditions	Yield
With acetic acid

: 110-91-8
morpholine

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 91904-47-1
4-[2-(5-ethyl-pyridin-2-yl)-ethyl]-morpholine

Conditions

Conditions	Yield
With acetic acid

: 7774-74-5
Thiophene-2-thiol

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 100373-67-9
5-ethyl-2-(2-[2]thienylmercapto-ethyl)-pyridine

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 119-65-3
isoquinoline

: 21364-46-5
isoquinoline hydrochloride

: 2-[2-(5-ethyl-[2]pyridyl)-ethyl]-isoquinolinium; chloride

Conditions

Conditions	Yield
at 140℃;

...Expand

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 120-72-9
indole

: 16571-55-4
3-[2-(5-ethyl-pyridin-2-yl)-ethyl]-indole

Conditions

Conditions	Yield
With acetic acid

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 123-56-8
Succinimide

: 97030-49-4
N-[2-(5-ethyl-[2]pyridyl)-ethyl]-succinimide

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 67-56-1
methanol

: 5-ethyl-2-(2-methoxy-ethyl)-pyridine

Conditions

Conditions	Yield
With potassium hydroxide at 150℃; unter Druck;

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 603-76-9
1-methylindole

: 16568-58-4
3-[2-(5-ethyl-pyridin-2-yl)-ethyl]-1-methyl-indole

Conditions

Conditions	Yield
With acetic acid

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 136918-14-4
phthalimide

: 17624-24-7
N-[2-(5-ethyl-pyridin-2-yl)-ethyl]-phthalimide

Conditions

Conditions	Yield
With acetic acid at 140℃;

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 5344-20-7
4-methyl pentanamine

: 131241-20-8
[2-(5-ethyl-[2]pyridyl)-ethyl]-isohexyl-amine

Conditions

Conditions	Yield
With acetic acid

: 5408-74-2
5-ethyl-2-vinyl-pyridine

: 507-09-5
thioacetic acid

: thioacetic acid S-[2-(5-ethyl-[2]pyridyl)-ethyl ester]

Conditions

Conditions	Yield
anfangs bei -40grad;

5-Ethyl-2-vinylpyridine Chemical Properties

IUPAC Name:   2-Ethenyl-5-ethylpyridine
Synonyms： Pyridine 2-vinyl-5-ethyl- ; 3-Ethyl-6-vinylpyridine ; 5-Ethyl-2-vinyl-pyridin ; 2-Vinyl-5-ethylpyridine
The Molecular Formula of 5-Ethyl-2-vinylpyridin (5408-74-2) : C₉H₁₁N
The Molecular Weight of   5-Ethyl-2-vinylpyridin (5408-74-2):133.190340g/mol
The Molecular Structure of   5-Ethyl-2-vinylpyridin (5408-74-2):
Index of Refraction: 1.546
Molar Refractivity: 44.81 cm³
Molar Volume: 141.4 cm³
Surface Tension: 34.5 dyne/cm
Density: 0.941 g/cm³
Flash Point: 76.2 °C
Enthalpy of Vaporization: 42.66 kJ/mol
Boiling Point: 208.5 °C at 760 mmHg
Vapour Pressure: 0.307 mmHg at 25°C

5-Ethyl-2-vinylpyridine Uses

5-Ethyl-2-vinylpyridin (5408-74-2) can be used for bioactivity analysis.

5-Ethyl-2-vinylpyridine Toxicity Data With Reference

1.	skn-rbt 10 mg/24H open	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
2.	skn-rbt 5 mg/24H SEV	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,847.
3.	eye-rbt 20 mg open	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
4.	eye-rbt 100 mg/24H MOD	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,847.
5.	orl-rat LD50:1230 mg/kg	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
6.	ihl-rat LCLo:8000 ppm/4H	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
7.	skn-rbt LD50:890 mg/kg	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.

5-Ethyl-2-vinylpyridine Safety Profile

Moderately toxic by ingestion and skin contact. Mildly toxic by inhalation. An eye and severe skin irritant. When heated to decomposition it emits toxic fumes of NO_x.

Product Name

5-ETHYL-2-VINYL PYRIDINE

Synthetic route

5-Ethyl-2-vinylpyridine Chemical Properties

5-Ethyl-2-vinylpyridine Uses

5-Ethyl-2-vinylpyridine Toxicity Data With Reference

5-Ethyl-2-vinylpyridine Safety Profile

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