Adenine supplier | CasNO.73-24-5

Name
Adenine
EINECS 200-796-1
CAS No. 73-24-5
Article Data80
CAS DataBase
Density 1.612 g/cm³
Solubility 0.5 g/L at 20 °C in water
Melting Point >360 °C(lit.)
Formula C₅H₅N₅
Boiling Point 553.491 °C at 760 mmHg
Molecular Weight 135.128
Flash Point 322.71 °C
Transport Information UN 2811 6.1/PG 3
Appearance white to almost white crystalline powder
Safety 26-36
Risk Codes 22-20/21/22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms USAF CB-18;1,6-Dihydro-6-iminopurine;Adenine [JAN];ADE;Pedatisectine B;6-Amino-1H-purine;Vitamin B4;6-Aminopurine;1H-Purine, 6-amino-;6-Amino-7H-purine;3, 6-Dihydro-6-iminopurine;9H-purin-6-amine;Adenine (8CI);Adeninimine;9H-Purine, 1, 6-dihydro-6-imino-;Purine, 6-amino-;Adenine (JAN/USP);6-Amino-9H-purine;Leuco-4;Adenin;Crytidine;6-Aminopurine (Adenine);5H-purin-6-amine;6-Amino-3H-purine;
PSA 80.48000
LogP 0.51630

Synthetic route

: 118-70-7
4,5,6-triaminopyrimidine

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
at 140 - 150℃; for 4h;	81.8%
at 140 - 150℃; for 4h;	81.8%

: 1198-83-0
2-(methylthio)-7H-purin-6-amine

: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
With water; nickel

: 6-azidopurine

: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
With water; nickel Hydrogenation;

: 5122-36-1
N-(4,6-diaminopyrimidin-5-yl)formamide

: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
at 230℃;

: 409110-30-1
N-(4,6-diamino-pyrimidin-5-yl)-thioformamide

: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
With water
With pyridine
With quinoline

: 3647-48-1
6-amino-3,7-dihydro-purine-2-thione

: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
With water; nickel

: 64-18-6
formic acid

: 98022-70-9
4,5,6-triamino-pyrimidine-2-sulfinic acid

: 73-24-5
7H-purin-6-ylamine

: 49721-45-1
4,5,6-triaminopyrimidine sulfate

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 73-24-5
7H-purin-6-ylamine

: 623-11-0
1-methyl-4-nitrosobenzene

: 60-92-4
cAMP

: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
at 98℃; zeitlicher Verlauf.Hydrolysis;
at 100℃; zeitlicher Verlauf.Hydrolysis;

: 65758-94-3
2-amino-malonamidine; dihydrochloride

: 122-51-0
orthoformic acid triethyl ester

: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
With N,N-dimethyl-formamide
With acetonitrile

: 56-40-6
glycine

A: 73-24-5
7H-purin-6-ylamine

B: 73-40-5
guanine

Conditions

Conditions	Yield
durch Hefe;

: 64-19-7
acetic acid

: 5957-04-0
[3']adenylic acid monobenzyl ester

A: 84-21-9
adenosine monophosphate

B: 73-24-5
7H-purin-6-ylamine

...Expand

: 64-19-7
acetic acid

: [2']adenylic acid monobenzyl ester

A: 73-24-5
7H-purin-6-ylamine

B: 130-49-4
adenosine 2'-monophosphate

...Expand

: 911667-45-3
N6,O3'-diacetyl-O5'-trityl-2'-deoxy-adenosine

A: 6612-73-3
3'-O-acetyl-2'-deoxyadenosine

B: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
With palladium on activated charcoal; ethanol Hydrogenation;
With ethanol; palladium Hydrogenation;

: 5667-20-9
N-(7(9)H-purin-6-yl)-hydroxylamine

: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
With alkaline Na2S2O4
With palladium on activated charcoal; water Hydrogenation;

: 3-methyladeninium iodide

A: 700-00-5
3-methyladenine

B: 73-24-5
7H-purin-6-ylamine

C: 443-72-1
N-methyladenine

Conditions

Conditions	Yield
at 270℃; for 0.25h;

...Expand

: 1-methyladeninium iodide

A: 700-00-5
3-methyladenine

B: 73-24-5
7H-purin-6-ylamine

C: 443-72-1
N-methyladenine

Conditions

Conditions	Yield
at 290℃; for 0.25h;

...Expand

: 81090-75-7
5'-amino-5'-deoxyadenosine p-toluenesulfonic acid salt

A: (3R,4S,5R)-5-Aminomethyl-tetrahydro-furan-2,3,4-triol; hydrochloride

B: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
With hydrogenchloride In water at 88℃; Rate constant;

: 1-<(2'S)-2',3'-dihydroxypropyl>cytosine-2'-O-phosphorylyl-(2',5')-adenosine

A: 73-24-5
7H-purin-6-ylamine

B: 1-<(2'S)-2',3'-dihydroxypropyl>cytosine 2',3'-cyclic monophosphate

C: 151425-33-1
1-<(2'S)-2',3'-dihydroxypropyl>cytosine 2'-monophosphate

D: 67770-92-7
1-<(2'S)-2',3'-dihydroxypropyl>cytosine 3'-monophosphate

E: 1-<(2'S)-2',3'-dihydroxypropyl>cytosine-3'-O-phosphorylyl-(3',5')-adenosine

F: 58-61-7
adenosine

Conditions

Conditions	Yield
With hydrogenchloride at 90.1℃; for 0.222222h; Product distribution; Rate constant;

...Expand

: 58-61-7
adenosine

A: 532-20-7, 613-83-2, 7261-25-8, 7687-39-0, 13221-22-2, 14795-83-6, 15761-67-8, 20074-49-1, 25545-03-3, 25545-04-4, 32445-75-3, 34436-17-4, 36441-93-7, 36468-53-8, 37110-85-3, 37388-49-1, 38029-69-5, 40461-77-6, 40461-89-0, 41546-19-4, 41546-20-7, 41546-21-8, 41546-26-3, 41546-29-6, 41546-30-9, 41546-31-0, 126872-16-0, 131064-98-7
D-Ribose

B: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
With hydrogenchloride In water at 99℃; Rate constant; other temp.;

: 6698-26-6
2' 5'-dideoxyadenosine

A: 36792-88-8
2-deoxy-D-ribose

B: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
With hydrogenchloride In water at 20℃; Kinetics; varying pH;

: 3647-48-1
6-amino-3,7-dihydro-purine-2-thione

: 7664-93-9
sulfuric acid

: 7722-84-1
dihydrogen peroxide

: 73-24-5
7H-purin-6-ylamine

...Expand

: 7647-01-0
hydrogenchloride

: 362-75-4
2',3'-isopropylidene adenosine

: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
Kinetics; Geschwindigkeit der Hydrolyse in wss.HCl (0.1n und 1n).Hydrolysis;

: 7647-01-0
hydrogenchloride

: 60-92-4
cAMP

: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
at 92℃; zeitlicher Verlauf.Hydrolysis;
at 100℃; zeitlicher Verlauf.Hydrolysis;

5-formylamino-1(3)H-imidazole-4-carboxamidine: 5-formylamino-1(3)H-imidazole-4-carboxamidine

: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
With potassium hydrogencarbonate

: 118076-30-5
6-amino-2-chloro-7,9-dihydro-purin-8-one

: 10025-87-3, 12599-09-6, 63736-95-8
trichlorophosphate

: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
at 140℃; anschliessend Behandeln des Reaktionsprodukts mit Jodwasserstoffsaeure und Phosphoniumjodid bei 60grad;

: 13039-55-9
[5']adenylic acid monobenzyl ester

phosphodiesterase-I: phosphodiesterase-I

: 73-24-5
7H-purin-6-ylamine

Conditions

Conditions	Yield
Phosphodiesterase-I aus Schlangengift (Crotalus adamanteus).Hydrolysis;

: 2914-09-2
2,8-dichloro-7(9)H-purin-6-ylamine

: 10034-85-2
hydrogen iodide

phosphonium iodide: phosphonium iodide

: 73-24-5
7H-purin-6-ylamine

...Expand

: 7647-01-0
hydrogenchloride

: 7732-18-5
water

: 2457-80-9
5'-Deoxy-5'-methylthioadenosine

A: 23656-67-9
S-methyl-5-thio-D-ribose

B: 73-24-5
7H-purin-6-ylamine

...Expand

: 73-24-5
7H-purin-6-ylamine

: 140-88-5
ethyl acrylate

: N-(9H-purin-6-yl)-β-alanine ethyl ester

Conditions

Conditions	Yield
With N-benzyl-trimethylammonium hydroxide In N,N-dimethyl-formamide at 110℃; for 0.5h;	98%

: 32837-87-9
3-hydroxy-3-methyl-1-cyano-1-butyne

: 73-24-5
7H-purin-6-ylamine

: 1218924-50-5
(Z)-3-(6-amino-9H-purin-9-yl)-4-hydroxy-4-methyl-2-pentenenitrile

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.166667h; diastereospecific reaction;	98%

: 32837-90-4
3-hydroxy-3-tetramethylene-1-propynecarbonitrile

: 73-24-5
7H-purin-6-ylamine

: 1218924-52-7
(Z)-3-(6-amino-9H-purin-9-yl)-3-(1-hydroxycyclopentyl)-2-propenenitrile

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.166667h; diastereospecific reaction;	97%

: 32837-89-1
3-(1-hydroxycyclohexyl)prop-2-ynenitrile

: 73-24-5
7H-purin-6-ylamine

: 1218924-53-8
(Z)-3-(6-amino-9H-purin-9-yl)-3-(1-hydroxycyclohexyl)-2-propenenitrile

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.166667h; diastereospecific reaction;	96%

: 32837-90-4
3-hydroxy-3-tetramethylene-1-propynecarbonitrile

: 73-24-5
7H-purin-6-ylamine

A: 1218924-52-7
(Z)-3-(6-amino-9H-purin-9-yl)-3-(1-hydroxycyclopentyl)-2-propenenitrile

B: 98698-56-7
2,2,5,5-di(tetramethylene)-3,6-di(cyanomethylene)-1,4-dioxane

Conditions

Conditions	Yield
With triethylamine at 20℃; for 26h;	A 96% B 30%

...Expand

: 1-(2-bromoethoxy)-2-(trifluoromethoxy)benzene

: 73-24-5
7H-purin-6-ylamine

: C14H12F3N5O2

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;	95.8%

: 32837-88-0
4-hydroxy-4-methylhex-2-ynenitrile

: 73-24-5
7H-purin-6-ylamine

: 1218924-51-6
(Z)-3-(6-amino-9H-purin-9-yl)-4-hydroxy-4-methyl-2-hexenenitrile

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.166667h; diastereospecific reaction;	95%

: zinc(II) acetate hexahydrate

: 1141-38-4
2,6-Naphthalenedicarboxylic acid

: 7732-18-5
water

: 73-24-5
7H-purin-6-ylamine

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 8Zn(2+)*4C5H4N5(1-)*6C12H6O4(2-)*2HO(1-)*2H(1+)*2C2H7N*35C3H7NO*23H2O

Conditions

Conditions	Yield
at 90℃; for 24h; Sealed tube;	95%

...Expand

: 73-24-5
7H-purin-6-ylamine

: 140-88-5
ethyl acrylate

: 7083-40-1
3-(6-aminopurine-9-yl)-propionic acid ethyl ester

Conditions

Conditions	Yield
With sodium hydride In ethanol; benzene Reflux;	95%

: C10H10BrClO2

: 73-24-5
7H-purin-6-ylamine

: C15H14ClN5O2

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;	94.4%

: C11H12BrNO3

: 73-24-5
7H-purin-6-ylamine

: C16H16N6O3

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;	94.4%

: 1189816-63-4
1-(5-bromo-2-(2-bromoethoxy)phenyl)ethanone

: 73-24-5
7H-purin-6-ylamine

: C15H14BrN5O2

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;	94.1%

: nickel(II) perchlorate hexahydrate

: 4097-89-6
2,2',2''-triaminotriethylamine

: 73-24-5
7H-purin-6-ylamine

: 952227-47-3
[Ni(tris(2-aminoethyl)amine)(adeninato)(ClO4)]

Conditions

Conditions	Yield
With NaOH In methanol; water an aq. soln. of adenine and a MeOH soln. of N(C2H4NH2)3 and Ni salt mixed, pH adjusted to 8-9 with NaOH soln.; crystd. at room temp. for 3 wk; elem. anal.;	91%

...Expand

: 32837-89-1
3-(1-hydroxycyclohexyl)prop-2-ynenitrile

: 73-24-5
7H-purin-6-ylamine

A: 1218924-55-0
2-amino-1-oxaspiro[4.5]dec-2-en-4-one

B: 1218924-53-8
(Z)-3-(6-amino-9H-purin-9-yl)-3-(1-hydroxycyclohexyl)-2-propenenitrile

Conditions

Conditions	Yield
With lithium hydroxide In ethanol; water at 50 - 55℃; for 7h;	A 8% B 91%

...Expand

: 108-24-7
acetic anhydride

: 118-92-3
anthranilic acid

: 73-24-5
7H-purin-6-ylamine

: 1377584-88-7
2-methyl-3-(7H-purin-6-yl)quinazolin-4(3H)-one

Conditions

Conditions	Yield
With titanium dioxide nanoparticles at 80℃; for 10h; Neat (no solvent);	89%

...Expand

: [OsHCl(κ1-acetone)(CCHC19H26O)(triisopropylphosphine)2]PF6

: 73-24-5
7H-purin-6-ylamine

: [OsHCl(7H-amino-adenine)(CCHC19H26O)(triisopropylphosphine)2]PF6

Conditions

Conditions	Yield
In acetone using Schlenk techniques; treatment of soln. of Os(P(i-Pr)3)2HCl(acetone)(CCHC17H20OMe2) in acetone with 1.1 equiv. of adenine for 15 min at room temp.; filtration through Celite; removal of solvent in vac.; dissolving in CH2Cl2; filtration through Celite; evapn. of solvent to dryness, treatment with Et2O; pptn., sepn. by decantation, washing with Et2O; drying in vac., elem. anal.;	88%

: 877864-62-5
[(η5-cyclopentadienyl)Ru(1,3,5-triaza-7-phosphaadamantane)(PPh3)Cl]

: 73-24-5
7H-purin-6-ylamine

: [RuCp(adeninate-κN9)(PPh3)(1,3,5-triaza-7-phosphaadamantane)]

Conditions

Conditions	Yield
Stage #1: 7H-purin-6-ylamine With potassium hydroxide In ethanol at 20℃; for 0.25h; Inert atmosphere; Schlenk technique; Stage #2: [(η5-cyclopentadienyl)Ru(1,3,5-triaza-7-phosphaadamantane)(PPh3)Cl] In ethanol for 4h; Reflux; Inert atmosphere; Schlenk technique;	88%

: 123-08-0
4-hydroxy-benzaldehyde

: 73-24-5
7H-purin-6-ylamine

: 4-((7H-purin-6-ylimino)methyl)phenol

Conditions

Conditions	Yield
In ethanol for 6h; Dean-Stark; Reflux;	87%

: C30H35ClN3P2Ru(2+)*2CF3O3S(1-)

: 73-24-5
7H-purin-6-ylamine

: [RuCp(Adeninate-κN)(methyl-N-1,3,5-triaza-7-phosphaadamantane)(PPh3)](CF3SO3)

Conditions

Conditions	Yield
Stage #1: 7H-purin-6-ylamine With potassium hydroxide In ethanol at 20℃; for 0.25h; Inert atmosphere; Schlenk technique; Stage #2: C30H35ClN3P2Ru(2+)*2CF3O3S(1-) In ethanol at 20℃; for 4.16h; Inert atmosphere; Schlenk technique;	87%

: r-2-benzyloxymethyl-c,t-1-bromo-c,t-1-bromomethyl-t-fluorocyclopropane

: 73-24-5
7H-purin-6-ylamine

: c,t-9-{[c,t-1-bromo-t-3-fluoro-r-2-(benzyloxymethyl)cyclopropyl]methyl}adenine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 40℃; for 10h;	86%

: 73-24-5
7H-purin-6-ylamine

: 609344-64-1
(2R,3S)-1,2-O-isopropylidene-1,2,3,4-tetrol 3,4-cyclic carbonate

: 609344-65-2
(2'S,3'R)-9-(3',4'-O-isopropylidene-2',3',4'-trihydroxybutyl)adenine

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide at 120℃; for 38h;	85%

: [Au(acac)(1,3,5-triaza-7-phosphatricyclo[3.3.1.13.7]decane)]

: 73-24-5
7H-purin-6-ylamine

: [Au(9N-adeninate)(1,3,5-triaza-7-phosphaadamantane)]

Conditions

Conditions	Yield
In ethanol for 6h;	85%

: 1016495-38-7
C10H11BrO2

: 73-24-5
7H-purin-6-ylamine

: C15H15N5O2

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;	84.2%

: 1303556-41-3
C24(13)C5H34O4SeSi

: 73-24-5
7H-purin-6-ylamine

: 1303556-44-6
C27(13)C5H35N5O2SeSi

Conditions

Conditions	Yield
Stage #1: 7H-purin-6-ylamine With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane for 1.5h; Inert atmosphere; Reflux; Stage #2: C24(13)C5H34O4SeSi With trimethylsilyl trifluoromethanesulfonate In 1,2-dichloro-ethane at -25 - 20℃; for 0.916667h; Inert atmosphere;	84%

: 141-90-2
2-thiouracil

: 504-17-6
4,6-dihydroxy-2-mercaptopyrimidine

: 555-16-8
4-nitrobenzaldehdye

: 73-24-5
7H-purin-6-ylamine

: 5,7,8,9,9a,10-hexahydro-5-(4-nitrophenyl)-10-(7H-purin-6-yl)-8-thioxopyrido[2,3-d:6,5-d’]dipyrimidine-2,4,6(1H,3H,5aH)trione

Conditions

Conditions	Yield
With phosphotungstic acid In ethanol for 6h; Reflux;	84%

...Expand

: 55-22-1
pyridine-4-carboxylic acid

: zinc(II) nitrate hexahydrate

: 73-24-5
7H-purin-6-ylamine

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 1309885-99-1
Zn(adeninate)(isonicotinate)(N,N'-dimethylformamide)

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 120℃; for 0.5h; Time; Temperature;	83.2%

...Expand

: 104-24-5
4-phenylazobenzoyl chloride

: 73-24-5
7H-purin-6-ylamine

: (E)-4-(phenyldiazenyl)-N-(9H-purin-6-yl)benzamide

Conditions

Conditions	Yield
With pyridine at 20 - 100℃; for 18.5h;	83%

: 3-acetyl-8-chloro-2-phenyl-1(2H)-isoquinolinone

: 73-24-5
7H-purin-6-ylamine

: 3-[1-(7H-purin-6-yl)iminoethyl]-8-chloro-2-phenyl-1(2H)-isoquinolinone

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 105 - 115℃; for 24h;	82.1%

: 17039-17-7
2-deoxy–α-D-ribose 1-phosphate

: 73-24-5
7H-purin-6-ylamine

: 958-09-8
2'-deoxy-D-adenosine

Conditions

Conditions	Yield
With purine nucleoside phosphorylase	82%

Adenine History

Adenine was also called Vitamin B4.It is no longer considered a true vitamin or part of the Vitamin B complex. However, two B vitamins, niacin and riboflavin, bind with adenine to form the essential cofactors nicotinamide adenine dinucleotide and flavin adenine dinucleotide , respectively. Hermann Emil Fischer was one of the early scientists to study Adenine.Some think that, at the origin of life on Earth, the first adenine was formed by the polymerization of five hydrogen cyanide molecules. However, this has been criticized by some chemists.

Adenine Specification

The IUPAC name of Adenine is 7H-purin-6-amine. With the CAS registry number 73-24-5, it is also named as 1,6-Dihydro-6-iminopurine. The product's categories are Pyrimidine; Pharmaceutical Intermediates; Purines; Plant Growth Regulator; Nucleobases and their Analogs; Biochemistry; Cytokinins; Nucleosides, Nucleotides & Related Reagents; Nutritional Supplements; Nucleic Acids; Nucleic Acid Purification; Vitamin Ingredients, and the other registry numbers are 22051-90-7; 42911-33-1; 42911-34-2; 520-75-2; 66224-65-5. Besides, it is white to almost white crystalline powder, which should be stored in a cool, ventilated, dry place. This chemical is stable, and incompatible with strong oxidizing agents. In addition, its molecular formula is C₅H₅N₅ and molecular weight is 135.13.

The other characteristics of this product can be summarized as: (1)EINECS: 200-796-1; (2)ACD/LogP: 0.02; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 7.4): 0.021; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 21.974; (8)ACD/KOC (pH 7.4): 24.421; (9)#H bond acceptors: 5; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 0; (12)Index of Refraction: 1.837; (13)Molar Refractivity: 37.039 cm³; (14)Molar Volume: 83.823 cm³; (15)Surface Tension: 122.712 dyne/cm; (16)Density: 1.612 g/cm³; (17)Flash Point: 322.71 °C; (18)Melting Point: 360-365 °C; (19)Water solubility: 0.5 g/L at 20 °C; (20)Sublimation: 220 °C; (21)Enthalpy of Vaporization: 83.432 kJ/mol; (22)Boiling Point: 553.491 °C at 760 mmHg; (23)Vapour Pressure: 0 mmHg at 25 °C.

Preparation of Adenine: this chemical can be derived from the nucleotide inosine monophosphate (IMP) by using atoms from the amino acids glycine, glutamine, and aspartic acid, as well as fused with the enzyme tetrahydrofolate. Additionally, you can use 4,6-Dichloro-5-nitropyrimidine to produce 4,6-Diamino-5-nitropyrimidine by reaction with Ammonia. And then you would obtain this chemical by the cyclization of 4,6-Diamino-5-nitropyrimidine with Formamide, Formic acid and Sodium thiosulfate.

Uses of Adenine: this chemical is used in forming nucleotides of the nucleic acids. Furthermore, it can bind to Thymine via two hydrogen bonds to assist in stabilizing the nucleic acid structures in DNA. And it is used for protein synthesis, adenine binds to uracil in RNA. It also can be used to produce Adenosine, Adenosine triphosphate (ATP). Similarly, it can react with Fluoromethyl-oxirane to get 1-(6-Amino-purin-9-yl)-3-fluoro-propan-2-ol.

This reaction needs K₂CO₃ and Dimethylformamide at temperature of 70-75 °C for 6 hours. The yield is 63 %.

When you are using this chemical, please be cautious about it as the following: it is harmful by inhalation, in contact with skin and if swallowed. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing.

People can use the following data to convert to the molecule structure.
(1)SMILES: c1[nH]c2c(ncnc2n1)N
(2)InChI: InChI=1/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)
(3)InChIKey: GFFGJBXGBJISGV-UHFFFAOYAT

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	100mg/kg (100mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	intravenous	> 30mg/kg (30mg/kg)		Drugs in Japan Vol. 6, Pg. 20, 1982.
mouse	LD50	oral	783mg/kg (783mg/kg)		Drugs in Japan Vol. 6, Pg. 19, 1982.
mouse	LDLo	subcutaneous	1gm/kg (1000mg/kg)		Annals of the New York Academy of Sciences. Vol. 60, Pg. 251, 1954.
rat	LD50	intraperitoneal	198mg/kg (198mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Pharmacology and Experimental Therapeutics. Vol. 104, Pg. 20, 1952.
rat	LD50	oral	227mg/kg (227mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Toxicology and Applied Pharmacology. Vol. 47, Pg. 229, 1979.

Product Name

Adenine

Synthetic route

Adenine History

Adenine Specification

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