Product Name

  • Name

    Benzenesulfonyl chloride

  • EINECS 202-636-6
  • CAS No. 98-09-9
  • Article Data146
  • CAS DataBase
  • Density 1.4 g/cm3
  • Solubility may decompose with water
  • Melting Point 14.5 °C
  • Formula C6H5ClO2S
  • Boiling Point 251.5 °C at 760 mmHg
  • Molecular Weight 176.624
  • Flash Point 105.9 °C
  • Transport Information UN 2225 8/PG 3
  • Appearance clear liquid
  • Safety 23-26-36/37/39-45
  • Risk Codes 20/22-34-42/43-29
  • Molecular Structure Molecular Structure of 98-09-9 (Benzenesulfonyl chloride)
  • Hazard Symbols CorrosiveC
  • Synonyms Benzenesulfochloride;Benzenesulfonic chloride;NSC 2864;Phenylsulfonyl chloride;
  • PSA 42.52000
  • LogP 2.69490

Synthetic route

benzenesulfonic acid
98-11-3

benzenesulfonic acid

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With trichloroacetonitrile; triphenylphosphine In dichloromethane for 1h; Heating;100%
With thionyl chloride99%
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine; potassium chloride at 25℃; for 0.0333333h; Neat (no solvent);95%
phenyl thiobenzoate
884-09-3

phenyl thiobenzoate

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With N-chloro-succinimide; ammonium chloride In water; acetonitrile at 0℃; for 0.333333h; pH=0 - 2;100%
S-Phenyl benzenethiosulfonate
1212-08-4

S-Phenyl benzenethiosulfonate

A

thiophenol
108-98-5

thiophenol

B

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With hydrogenchloride In waterA 100%
B 100%
thiophenol
108-98-5

thiophenol

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With thionyl chloride; dihydrogen peroxide In water; acetonitrile at 25℃; for 0.0166667h;99%
With dihydrogen peroxide; zirconium(IV) chloride In water; acetonitrile at 25℃; for 0.0166667h;98%
With N,N,N',N'-tetrachlorobenzene-1,3-disulphonamide; tetrabutyl-ammonium chloride; water In acetonitrile at 0 - 20℃; for 0.333333h;98%
diphenyldisulfane
882-33-7

diphenyldisulfane

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With N,N,N',N'-tetrachlorobenzene-1,3-disulphonamide; tetrabutyl-ammonium chloride; water In acetonitrile at 0 - 20℃; for 0.333333h;99%
With trichloroisocyanuric acid; tetrabutylammomium bromide; water In acetonitrile at 0 - 20℃; for 0.333333h;99%
With dihydrogen peroxide; trichlorophosphate In water at 25℃; for 0.5h; Micellar solution;96%
methyl carbamothioic acid S-phenyl ester
13509-39-2

methyl carbamothioic acid S-phenyl ester

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With hydrogenchloride; N-chloro-succinimide In acetonitrile at 10℃;96.6%
S-phenyl thioacetate
934-87-2

S-phenyl thioacetate

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With hydrogenchloride; N-chloro-succinimide In acetonitrile at 10℃; for 0.166667h;96.3%
Benzyl phenyl sulfide
831-91-4

Benzyl phenyl sulfide

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With hydrogenchloride; iodosylbenzene for 0.0833333h;96%
With hydrogenchloride; iodosylbenzene for 0.0833333h; Chlorination; oxidation;96%
With 1,3-dichloro-5,5-dimethylhydantoin; acetic acid In dichloromethane; water at 0 - 5℃; Inert atmosphere;90%
With N-chloro-succinimide In dichloromethane; benzyl alcohol for 18h; Ambient temperature;62%
sodium phenylsulfonate
515-42-4

sodium phenylsulfonate

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With 1,3,5-trichloro-2,4,6-triazine; 18-crown-6 ether In acetone for 20h; Heating;94%
Stage #1: sodium phenylsulfonate With potassium phosphate; bis(trichloromethyl) carbonate In dichloromethane at 0 - 5℃; for 0.0833333h;
Stage #2: With triethylamine In dichloromethane at 20℃; for 0.5h;		91%
With phosphorus pentachloride Man giesst in Wasser und destilliert das hierbei sich abscheidende Benzolsulfochlorid mit Wasser unter vermindertem Druck;
methoxymethyl phenyl sulfide
13865-50-4

methoxymethyl phenyl sulfide

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With water; chlorine In dichloromethane at 5 - 10℃; for 1h;94%
toluene-4-sulfonic acid phenyl ester
640-60-8

toluene-4-sulfonic acid phenyl ester

phenylboronic acid
98-80-6

phenylboronic acid

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With phenylchlorosulfate; C43H43NO3PPdS; sodium carbonate In acetone at 20 - 50℃; Inert atmosphere; Sealed tube;90%
S-Phenyl benzenethiosulfonate
1212-08-4

S-Phenyl benzenethiosulfonate

benzenesulfenyl chloride
931-59-9

benzenesulfenyl chloride

A

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

B

diphenyldisulfane
882-33-7

diphenyldisulfane

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 115℃; for 24h; Mechanism;A n/a
B 88.7%
...Expand
chloroamine-T
127-65-1

chloroamine-T

thiophenol
108-98-5

thiophenol

A

N-chloro-N-(4-methylbenzenesulfonyl)benzenesulfinamide

N-chloro-N-(4-methylbenzenesulfonyl)benzenesulfinamide

B

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With N-chloro-succinimide In water; acetonitrile at 35℃; for 0.25h; Solvent; Temperature; Reagent/catalyst;A 78%
B 17%
...Expand
thiophenol
108-98-5

thiophenol

A

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

B

diphenyldisulfane
882-33-7

diphenyldisulfane

Conditions
ConditionsYield
With potassium chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In water at 20℃; for 10h; Reagent/catalyst;A 22%
B 68%
dibenzyl disulphide
150-60-7

dibenzyl disulphide

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With hydrogenchloride; iodosylbenzene for 0.0833333h;56%
sulfinothioyldibenzene

sulfinothioyldibenzene

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With hydrogenchloride; iodosylbenzene for 0.0833333h; Chlorination; oxidation;56%
aniline
62-53-3

aniline

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
Stage #1: aniline With hydrogenchloride; acetic acid
Stage #2: With sodium nitrite In water at -10 - -5℃; for 0.75h;
Stage #3: With hydrogenchloride; sulfur dioxide; acetic acid; copper(l) chloride In water at 10℃; for 0.5h;		53%
With hydrogenchloride; sodium nitrite In acetic acid
Stage #1: aniline With hydrogenchloride; sodium nitrite
Stage #2: With sulfur dioxide; copper(l) chloride In acetone
methyl-phenyl-thioether
100-68-5

methyl-phenyl-thioether

A

Methyl phenyl sulfone
3112-85-4

Methyl phenyl sulfone

B

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With hydrogenchloride; iodosylbenzene for 0.0833333h;A 47%
B 4%
With hydrogenchloride; iodosylbenzene for 0.0833333h; Chlorination; oxidation;A 47%
B 4%
N-chloro-succinimide
128-09-6

N-chloro-succinimide

Benzyl phenyl sulfide
831-91-4

Benzyl phenyl sulfide

benzyl alcohol
100-51-6

benzyl alcohol

A

Succinimide
123-56-8

Succinimide

B

benzyl chloride
100-44-7

benzyl chloride

C

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
In dichloromethane for 18h; Product distribution; Ambient temperature;A n/a
B n/a
C 42%
...Expand
nitrostyrene
5153-67-3

nitrostyrene

benzene diazonium chloride
100-34-5

benzene diazonium chloride

A

(2-nitro-1-(phenylsulfonyl)ethyl)benzene
87015-49-4

(2-nitro-1-(phenylsulfonyl)ethyl)benzene

B

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With sulfur dioxide In acetic acid; acetone at 15 - 20℃;A 35%
B n/a
...Expand
benzene
71-43-2

benzene

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With chlorosulfonic acid at 20℃; Cooling with ice;34%
With chlorosulfonic acid; sulfuric acid
With chlorosulfonic acid; sodium chloride
N-chloro-succinimide
128-09-6

N-chloro-succinimide

ethanol
64-17-5

ethanol

Benzyl phenyl sulfide
831-91-4

Benzyl phenyl sulfide

A

Succinimide
123-56-8

Succinimide

B

ethyl benzenesulfinate
1859-03-6

ethyl benzenesulfinate

C

benzyl chloride
100-44-7

benzyl chloride

D

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
In dichloromethane for 18h; Product distribution; Ambient temperature;A n/a
B 30%
C n/a
D n/a
...Expand
benzenediazonium tetrafluoroborate
369-57-3

benzenediazonium tetrafluoroborate

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With thionyl chloride; tris(bipyridine)ruthenium(II) dichloride hexahydrate In water; acetonitrile at 20℃; for 20h; Sealed tube; Irradiation;30%
benzene diazonium chloride
100-34-5

benzene diazonium chloride

(E)-benzalacetone
1896-62-4

(E)-benzalacetone

A

4-benzenesulfonyl-4-phenyl-butan-2-one
62692-46-0

4-benzenesulfonyl-4-phenyl-butan-2-one

B

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With sulfur dioxide In acetic acid; acetoneA 14%
B n/a
...Expand
N,N-dimethyl-aniline
121-69-7

N,N-dimethyl-aniline

A

N,N,N',N'-tetramethylbenzidine
366-29-0

N,N,N',N'-tetramethylbenzidine

B

4-fluoro-N,N-dimethylaniline
403-46-3

4-fluoro-N,N-dimethylaniline

C

2-fluoro-N,N-dimethylaniline
393-56-6

2-fluoro-N,N-dimethylaniline

D

1-chloro-2-(dimethylamino)benzene
698-01-1

1-chloro-2-(dimethylamino)benzene

E

4-(methylamino)benzaldehyde
556-21-8

4-(methylamino)benzaldehyde

F

4,4'-methylene-bis(N,N-dimethylaniline)
101-61-1

4,4'-methylene-bis(N,N-dimethylaniline)

G

4-dimethylamino-benzaldehyde
100-10-7

4-dimethylamino-benzaldehyde

H

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With zirconium(IV) chloride; N-fluorobis(benzenesulfon)imide In chloroform for 5h; Reflux;A n/a
B n/a
C n/a
D n/a
E n/a
F n/a
G n/a
H 6%
...Expand
N,N-Dichlorobenzenesulfonamide
473-29-0

N,N-Dichlorobenzenesulfonamide

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
at 200℃;
1,2-bis(phenylsulfonyl)ethane
599-94-0

1,2-bis(phenylsulfonyl)ethane

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With chlorine
diphenyl sulphone
127-63-9

diphenyl sulphone

A

chlorobenzene
108-90-7

chlorobenzene

B

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With phosphorus pentachloride at 160 - 170℃;
With chlorine at 120 - 130℃;
N,N-dimethylbenzenesulfonamide
14417-01-7

N,N-dimethylbenzenesulfonamide

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Conditions
ConditionsYield
With chlorosulfonic acid at 130 - 150℃;
1-indoline
496-15-1

1-indoline

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

1-benzenesulfonyl-2,3-dihydro-1H-indole
81114-41-2

1-benzenesulfonyl-2,3-dihydro-1H-indole

Conditions
ConditionsYield
With triethylamine In 1,2-dichloro-ethane at 0 - 20℃; for 1h;100%
With potassium trimethylsilonate In water at 20℃; for 0.5h; Concentration; Inert atmosphere;97%
With dmap; triethylamine In dichloromethane at 0 - 20℃;96%
isobutylamine
78-81-9

isobutylamine

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

N-(iso-butyl)benzenesulfonamide
23705-39-7

N-(iso-butyl)benzenesulfonamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at -25 - 20℃; Inert atmosphere;100%
With N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide In tetrahydrofuran at 20℃; for 1h;80%
With picoline In dichloromethane at 20℃; for 1h;71%
2-methoxy-phenylamine
90-04-0

2-methoxy-phenylamine

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

N-(2-methoxyphenyl)benzenesulfonamide
21226-32-4

N-(2-methoxyphenyl)benzenesulfonamide

Conditions
ConditionsYield
With pyridine for 12h; Ambient temperature;100%
With sodium hydroxide at 20℃; for 1h; Addition;85%
51%
4-nitro-aniline
100-01-6

4-nitro-aniline

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

N-(4-nitrophenyl)benzenesulfonamide
1829-81-8

N-(4-nitrophenyl)benzenesulfonamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 24h;100%
With pyridine In dichloromethane at 20℃;92%
With pyridine for 13h; Ambient temperature;83%
aniline
62-53-3

aniline

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

N-phenylbenzenesulfonamide
1678-25-7

N-phenylbenzenesulfonamide

Conditions
ConditionsYield
With pyridine at 0 - 25℃;100%
With pyridine at 20℃;98%
With Fe3O4-supported (diisopropylamino)acetamide In dichloromethane at 25℃;98%
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

p-aminoethylbenzoate
94-09-7

p-aminoethylbenzoate

ethyl 4-benzoate
89113-18-8

ethyl 4-benzoate

Conditions
ConditionsYield
Stage #1: benzenesulfonyl chloride; p-aminoethylbenzoate With pyridine for 18h;
Stage #2: With ammonia In methanol at 90℃; for 0.5h; Microwave irradiation;		100%
With pyridine In tetrahydrofuran at 20℃; for 1.5h;100%
With pyridine at 5 - 20℃; for 1h; sulfonylation;70%
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

o-toluidine
95-53-4

o-toluidine

N-o-tolyl-benzenesulfonamide
18457-86-8

N-o-tolyl-benzenesulfonamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 3h;100%
86%
With pyridine for 4h; Heating;81%
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

benzylamine
100-46-9

benzylamine

N-benzylbenzenesulfonamide
837-18-3

N-benzylbenzenesulfonamide

Conditions
ConditionsYield
With triethylamine In dichloromethane 1) 0 deg C, 1 h, 2) room temperature;100%
With sodium hydroxide In water at 25℃; for 2h; pH 9.6;99.9%
With Fe3O4-supported (diisopropylamino)acetamide In dichloromethane at 25℃;98%
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

3,4-dimethoxyaniline
6315-89-5

3,4-dimethoxyaniline

N-(3,4-dimethoxyphenyl)benzenesulfonamide
62035-67-0

N-(3,4-dimethoxyphenyl)benzenesulfonamide

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 0.0833333h;100%
With pyridine; dmap In tetrahydrofuran Ambient temperature;65%
With potassium hydroxide at 30 - 40℃; zuletzt bei 75grad;
With sodium hydroxide In acetone
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

diphenyldisulfane
882-33-7

diphenyldisulfane

Conditions
ConditionsYield
With trimethylsilyl iodide In dichloromethane at 25℃; for 16h;100%
With tungsten(VI) chloride; sodium iodide In acetonitrile for 16h; Ambient temperature;97%
With Silphos; iodine In acetonitrile for 10h; Heating;96%
cyclohexylamine
108-91-8

cyclohexylamine

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

N-cyclohexylbenzenesulfonamide
3237-31-8

N-cyclohexylbenzenesulfonamide

Conditions
ConditionsYield
With picoline In dichloromethane at 20℃; for 1h;100%
With pyridine In dichloromethane at 0 - 20℃;85%
With pyridine
tert-butylamine
75-64-9

tert-butylamine

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

N-tert-butylbenzenesulfonamide
2512-24-5

N-tert-butylbenzenesulfonamide

Conditions
ConditionsYield
In chloroform at 0℃;100%
With hydrogenchloride In dichloromethane at 0 - 20℃; for 0.666667h;97%
With triethylamine In dichloromethane at 20℃;95%
piperidin-2-one
675-20-7

piperidin-2-one

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

1-Benzenesulfonyl-3,4,5,6-tetrahydropyridin-2-one
7744-25-4

1-Benzenesulfonyl-3,4,5,6-tetrahydropyridin-2-one

Conditions
ConditionsYield
Stage #1: piperidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
Stage #2: benzenesulfonyl chloride In tetrahydrofuran; hexane at -78℃; for 4h; Inert atmosphere;		100%
With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 3h;94%
With n-butyllithium 1.) THF, hexane, -60 deg C, 20 min, 2.) THF, hexane, from -60 deg C to 0 deg C, 2.5 h; Yield given. Multistep reaction;
indole
120-72-9

indole

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

1-benzenesulfonylindole
40899-71-6

1-benzenesulfonylindole

Conditions
ConditionsYield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane at 0 - 20℃; for 3h;100%
Stage #1: indole With sodium hydride In tetrahydrofuran for 0.25h; Cooling with ice bath;
Stage #2: benzenesulfonyl chloride In tetrahydrofuran at 20℃;		100%
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane99%
pyrrole
109-97-7

pyrrole

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

N-phenylsulfonylpyrrole
16851-82-4

N-phenylsulfonylpyrrole

Conditions
ConditionsYield
With potassium hydroxide; 1-butyl-3-methylimidazolium Tetrafluoroborate at 80℃; for 1h;100%
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In dichloromethane; water at 20℃; Inert atmosphere; Cooling;99%
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 18.5h;98%
5,6-methylenedioxyindole
267-48-1

5,6-methylenedioxyindole

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

5-(benzenesulfonyl)-[1,3]dioxolo[4,5-f]indole
100587-74-4

5-(benzenesulfonyl)-[1,3]dioxolo[4,5-f]indole

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In dichloromethane at 20℃; Cooling with ice;100%
With n-butyllithium 1.) THF, hexane, from -70 deg C to 0 deg C, 45 min, 2.) from -70 deg C to room temperature, 2 h; Multistep reaction;
5-chloro-1H-indole
17422-32-1

5-chloro-1H-indole

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

5-chloro-1-(phenylsulfonyl)-1H-indole
78329-47-2

5-chloro-1-(phenylsulfonyl)-1H-indole

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; Reflux;100%
Stage #1: 5-chloro-1H-indole With sodium hydride In tetrahydrofuran at 20℃; for 1h;
Stage #2: benzenesulfonyl chloride In tetrahydrofuran for 1h;		96%
Stage #1: 5-chloro-1H-indole With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.333333h; Inert atmosphere;
Stage #2: benzenesulfonyl chloride In tetrahydrofuran; mineral oil at 0 - 20℃; Inert atmosphere;		96.3%
4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

4-hydroxybenzaldehyde benzenesulfonate ester
13493-50-0

4-hydroxybenzaldehyde benzenesulfonate ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;100%
With triethylamine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere;99%
With triethylamine In dichloromethane at 20℃; for 2h;98%
2-methyl-1-buten-4-ol
763-32-6

2-methyl-1-buten-4-ol

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

3-methyl-3-butenyl-1-benznesulfonate
90545-36-1

3-methyl-3-butenyl-1-benznesulfonate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0℃; for 4h;100%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 4.33333h;
4-methyl-5-nitrophenol
2042-14-0

4-methyl-5-nitrophenol

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

4-benzenesulfonyloxy-2-nitrotoluene
92059-54-6

4-benzenesulfonyloxy-2-nitrotoluene

Conditions
ConditionsYield
With potassium carbonate In acetone for 2h;100%
2-(3-methoxyanilino)acetaldehyde diethyl acetal
32431-44-0

2-(3-methoxyanilino)acetaldehyde diethyl acetal

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

N-(2,2-diethoxyethyl)-N-(3-methoxyphenyl)-benzene-sulfonamide
99546-93-7

N-(2,2-diethoxyethyl)-N-(3-methoxyphenyl)-benzene-sulfonamide

Conditions
ConditionsYield
With pyridine In dichloromethane 1.) 0 deg C, 1 h, 2.) 25 deg C, overnight;100%
1-benzenesulfonamido-2,4-diaminonaphthalene
85218-98-0

1-benzenesulfonamido-2,4-diaminonaphthalene

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

1,2,4-tris(benzenesulfonamido)naphthalene
85218-99-1

1,2,4-tris(benzenesulfonamido)naphthalene

Conditions
ConditionsYield
With pyridine for 10h;100%
N-(5-hexen-1-yl)aniline
105971-30-0

N-(5-hexen-1-yl)aniline

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

N-(hex-5-enyl)-N-phenylbenzenesulfonamide
157099-71-3

N-(hex-5-enyl)-N-phenylbenzenesulfonamide

Conditions
ConditionsYield
In pyridine for 10h; Heating;100%
R-(+)-4-methyl-6-(tert-butyldimethylsiloxy)-1-hexanol
87921-27-5

R-(+)-4-methyl-6-(tert-butyldimethylsiloxy)-1-hexanol

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

R-(+)-4-methyl-6-(tert-butyldimethylsiloxy)-1-hexyl benzenesulphonate
87921-28-6

R-(+)-4-methyl-6-(tert-butyldimethylsiloxy)-1-hexyl benzenesulphonate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane for 3h; Ambient temperature;100%
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

L-proline
147-85-3

L-proline

N-benzenesulfonyl-L-proline
88425-46-1

N-benzenesulfonyl-L-proline

Conditions
ConditionsYield
With sodium carbonate In water for 5h;100%
With sodium carbonate In water for 4h;100%
With sodium carbonate In water at -5 - 20℃; for 4h; Inert atmosphere;100%
5-Hydroxy-2-methylpyridine
1121-78-4

5-Hydroxy-2-methylpyridine

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

5-(benzenesulfonyloxy)-2-methylpyridine
173913-74-1

5-(benzenesulfonyloxy)-2-methylpyridine

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
With triethylamine In dichloromethane at 0℃; for 2h;95%
With triethylamine
L-phenylalanine
63-91-2

L-phenylalanine

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

Nα-benzenesulfonyl-L-phenylalanine
40279-95-6

Nα-benzenesulfonyl-L-phenylalanine

Conditions
ConditionsYield
With sodium carbonate In water for 5h;100%
With sodium carbonate In water for 4h;100%
With sodium hydroxide for 2h; Ambient temperature; pH=10;
With sodium hydroxide for 2.5h; Ambient temperature;
With N-ethyl-N,N-diisopropylamine; sodium hydroxide In acetone at 0 - 20℃; for 6h; Inert atmosphere;
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

5-(4-methylphenoxy)tetrazole
4612-90-2

5-(4-methylphenoxy)tetrazole

NI-(benzenesulfonyl)(4-methylphenoxy)imidoyl azide

NI-(benzenesulfonyl)(4-methylphenoxy)imidoyl azide

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 20℃; Ring cleavage;100%
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

5-(2,6-dimethoxy-phenoxy)-2H-tetrazole

5-(2,6-dimethoxy-phenoxy)-2H-tetrazole

NI-(benzenesulfonyl)(2,6-dimethoxyphenoxy)imidoyl azide

NI-(benzenesulfonyl)(2,6-dimethoxyphenoxy)imidoyl azide

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 20℃; Ring cleavage;100%
(+/-)-trans-2-butyl-5-heptylpyrrolidine
116558-84-0

(+/-)-trans-2-butyl-5-heptylpyrrolidine

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

(2R,5R)-1-Benzenesulfonyl-2-butyl-5-heptyl-pyrrolidine
95513-29-4, 95587-13-6, 95587-18-1, 129446-24-8

(2R,5R)-1-Benzenesulfonyl-2-butyl-5-heptyl-pyrrolidine

Conditions
ConditionsYield
With sodium hydroxide In chloroform Substitution;100%

Benzenesulfonyl chloride Chemical Properties

Product Name: Benzenesulfonyl chloride (CAS NO.98-09-9)
IUPAC Name: Benzenesulfonyl chloride
CAS NO: 98-09-9
Molecular Formula: C6H5ClO2S
Molecular Weight :176.6207
Molecular Structure :
EINECS: 202-636-6
Index of Refraction: 1.553
Surface Tension: 42.6 dyne/cm 
Density: 1.4 g/cm3 
Flash Point: 105.9 °C 
Enthalpy of Vaporization: 46.9 kJ/mol 
Boiling Point: 251.5 °C at 760 mmHg 
Vapour Pressure: 0.0324 mmHg at 25°C 
Melting point: 14.5 °C
Water Solubility:  may decompose
Sensitive : Moisture Sensitive
Product Categories: Pharmaceutical Intermediates; Organics; Sulfonyl Halides; Sulfonyl HalidesDerivatization Reagents; Derivatization Reagents HPLC; Organic Building Blocks; Sulfur Compounds; UV-VIS;A-B, Puriss p.a.; Analytical Reagents for General Use; Puriss p.a.

Benzenesulfonyl chloride Uses

 Benzenesulfonyl chloride (CAS NO.98-09-9) is used for intermediates of medicines and dyes , mainly forsulfa drugs, is also used to identify a variety of amine.

Benzenesulfonyl chloride Production

Benzene and Chlorosulfonic acid for reaction in 1:3 (mol) at 20 ~ 30°C about 2h, which are crude Benzene chloride, Benzenesulfonyl chloride (CAS NO.98-09-9) is obtained by the refining of the crude product.

Benzenesulfonyl chloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 828mg/kg (828mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 36(6), Pg. 19, 1971.
mouse LD50 oral 828mg/kg (828mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 36(6), Pg. 19, 1971.
rabbit LD50 oral 828mg/kg (828mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 36(6), Pg. 19, 1971.
rat LCLo inhalation 1870mg/m3/1H (1870mg/m3) SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Office of Toxic Substances Report. Vol. OTS0510391,
rat LD50 intraperitoneal 76mg/kg (76mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Medycyna Pracy. Industrial Medicine. Vol. 20, Pg. 513, 1969.
rat LD50 oral 1960mg/kg (1960mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Medycyna Pracy. Industrial Medicine. Vol. 20, Pg. 513, 1969.

Benzenesulfonyl chloride Safety Profile

Poison by intraperitoneal route. A dangerous storage hazard. It may explode in a sealed bottle. Explosive reaction with dimethyl sulfoxide. Reacts vigorously with methyl formamide. When heated to decomposition it emits toxic fumes of Cl− and SOx. See also SULFONATES.
Hazard Codes CorrosiveC
Risk Statements  20/22-34-42/43-29
R20/22:Harmful by inhalation and if swallowed. 
R34:Causes burns. 
R42/43:May cause sensitization by inhalation and skin contact. 
R29:Contact with water liberates toxic gas.
Safety Statements  23-26-36/37/39-45
S23:Do not breathe vapour. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR  UN 2225 8/PG 3
WGK Germany  1
RTECS  DB8750000
F  21
HazardClass  8
PackingGroup  III

Benzenesulfonyl chloride Specification

 Benzenesulfonyl chloride , its CAS NO. is 98-09-9, the synonyms are  Benezenesulfochloride ; Benzene sulfonechloride .

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