stigmast-5-en-3-yl acetate
β-sitosterol
Conditions | Yield |
---|---|
With methanol; potassium carbonate In dichloromethane at 20℃; for 12h; | 98% |
With potassium hydroxide In methanol; diethyl ether at 20℃; for 15h; Inert atmosphere; | 93.6% |
With potassium hydroxide In methanol for 1h; Heating; | 89% |
With di(n-butyl)tin oxide In methanol; chloroform at 50℃; for 6h; | 10% |
With oxo[hexa(trifluoroacetato)]tetrazinc; ethanol In ethanol for 18h; Reflux; Inert atmosphere; | 83 %Spectr. |
β-sitosterol trimethylsilyl ether
β-sitosterol
Conditions | Yield |
---|---|
With montmorillonite K-10 In methanol for 0.2h; Ambient temperature; | 98% |
β-sitosterol
Conditions | Yield |
---|---|
With montmorillonite K-10 In methanol at 40 - 50℃; for 0.5h; | 96% |
β-sitosterol
Conditions | Yield |
---|---|
With potassium fluoride; chloro-trimethyl-silane In acetonitrile at 60℃; for 0.333333h; | 90% |
(24E)-<28-(2)H>ergosta-5,24(28)-dien-3β-ol
A
β-sitosterol
B
cholesterol
C
Campesterol
D
isofucosterol
Conditions | Yield |
---|---|
With Morus alba Methylation; | A 81% B 7% C 4% D 8% |
Conditions | Yield |
---|---|
With hydrogen; Raney-Nickel W2 In ethyl acetate at 20℃; for 15h; Product distribution; Further Variations:; molar ratios; atmospheric pressure; | A 76% B 11% |
β-sitosterol
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In 1,4-dioxane; water at 80℃; for 5h; | 33% |
Conditions | Yield |
---|---|
With diethyl ether; magnesium anschliessendes Behandeln mit Sauerstoff; |
methyl-(3α.5α-cyclo-stigmasten-(22t)-yl-(6β))-ether
β-sitosterol
Conditions | Yield |
---|---|
With palladium; ethyl acetate Hydrogenation.Kochen des Reaktionsprodukts mit Zinkacetat in Essigsaeure und Behandlung des erhaltenen 3β-Acetoxy-stigmastens-(5) mit aethanol. KOH; |
acetic acid stigmasteryl ester
β-sitosterol
Conditions | Yield |
---|---|
With palladium; ethyl acetate Hydrogenation.Behandlung des Reaktionsprodukts mit aethanol. KOH; |
(10R)-3c-Acetoxy-10r.13c-dimethyl-17c-((R)-1-methyl-4-isopropyl-hexen-(4t)-yl)-(8cH.9tH.14tH)-Δ5-tetradecahydro-1H-cyclopenta[a]phenanthren
β-sitosterol
Conditions | Yield |
---|---|
With palladium; ethyl acetate; acetone Hydrogenation.Behandlung des erhaltenen Reaktionsprodukts mit aethanol. KOH; |
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol acidic hydrolysis for structure determination; | |
With hydrogenchloride In methanol for 5h; Heating; | |
With sulfuric acid |
Daucosterol
A
2,3,4,6-tetra-O-methyl-D-glucopyranose
B
β-sitosterol
Conditions | Yield |
---|---|
With sulfuric acid for 4h; Heating; hydrolysis; |
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane; water for 2h; Heating; | |
With hydrogenchloride In ethanol for 6h; Heating; | |
With sodium acetate-acetic acid buffer | 12 mg |
With hydrogenchloride In methanol for 6h; Reflux; | |
With sulfuric acid In methanol for 3h; Reflux; |
Conditions | Yield |
---|---|
With hydrogen | |
Multi-step reaction with 3 steps 1: 98 percent / p-toluenesulfonic acid monohydrate / acetic acid / 1 h / Heating 2: 86 percent / H2 / PtO2 / ethyl acetate / 3 h 3: 89 percent / potassium hydroxide / methanol / 1 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: dmap / pyridine / 6 h / 23 °C 2: potassium acetate / 3 h / 65 °C 3: 5%-palladium/activated carbon; hydrogen / methanol; dichloromethane / 24 h / 23 °C / 10343.2 Torr 4: water; toluene-4-sulfonic acid / 1,4-dioxane / 3 h / 80 °C View Scheme | |
Multi-step reaction with 5 steps 1: pyridine / 24 h / 20 °C / Inert atmosphere 2: potassium acetate / 2 h / Reflux; Inert atmosphere 3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / Inert atmosphere 4: zinc diacetate / 2 h / Inert atmosphere; Reflux 5: potassium hydroxide / methanol; diethyl ether / 15 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: dmap; pyridine / 24 h / 20 °C 2.1: pyridine; hydrogen / methanol / 6 h / Reflux 2.2: 20 h / 2585.81 Torr / Inert atmosphere 3.1: toluene-4-sulfonic acid / water; 1,4-dioxane / 5 h / 80 °C View Scheme |
β-sitosterol-D-glucoside
A
D-Glucose
B
β-sitosterol
Conditions | Yield |
---|---|
With hydrogenchloride In methanol |
Conditions | Yield |
---|---|
With cultured cells of Rabdosia japonica Hara for 96h; Mechanism; labelling studies; |
Conditions | Yield |
---|---|
With β-glucosidase Product distribution; other reaction partner - 1percent aq.HCl; |
6β-methoxy-3α,5-cyclo-5α-stigmastane
β-sitosterol
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In 1,4-dioxane; water for 3h; Heating; Yield given; | |
With water; toluene-4-sulfonic acid In 1,4-dioxane at 80℃; for 3h; | 36 mg |
(3S,8S,9S,10R,13R,14S,17R)-17-((1R,4R)-4-Ethyl-1,5-dimethyl-hexyl)-3-methoxymethoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene
β-sitosterol
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran for 1h; Ambient temperature; Yield given; |
A
β-sitosterol
Conditions | Yield |
---|---|
With hydrogenchloride; lithium aluminium tetrahydride Product distribution; 1.)THF, reflux 2.)MeOH, 75 deg C, 2 h; |
A
2,3,4-tri-O-methyl-D-glucose
B
β-sitosterol
C
1-hexadecylcarboxylic acid
Conditions | Yield |
---|---|
With sulfuric acid In water for 0.5h; Heating; |
β-sitosterol-3-O-β-D-glucoside
A
D-glucose
B
β-sitosterol
Conditions | Yield |
---|---|
With hydrogenchloride Hydrolysis; Acid hydrolysis; |
β-sitosterol
Conditions | Yield |
---|---|
With potassium acetate; acetic acid Hydrolyse des erhaltenen O-Acetyl-Derivats; |
Conditions | Yield |
---|---|
With hydrogenchloride; ethanol for 4h; Heating; | A n/a B 95 % Chromat. |
A
β-sitosterol
B
7α-hydroxysitosterol
Conditions | Yield |
---|---|
With diethyl ether; magnesium anschliessendes Behandeln mit Sauerstoff; |
β-sitosterol
Conditions | Yield |
---|---|
Alkaline hydrolysis; |
22,23-dihydro-i-stigmasterol methyl ether
β-sitosterol
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In 1,4-dioxane at 80℃; for 3h; |
stigmasteryl tosylate
β-sitosterol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: pyridine / 6 h / Heating 1.2: H2 / Pd/C / ethanol / 16 h / 20 °C / 2585.74 Torr 2.1: aq. TsOH / dioxane / 3 h / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium acetate / 3 h / 65 °C 2: 5%-palladium/activated carbon; hydrogen / methanol; dichloromethane / 24 h / 23 °C / 10343.2 Torr 3: water; toluene-4-sulfonic acid / 1,4-dioxane / 3 h / 80 °C View Scheme | |
Multi-step reaction with 4 steps 1: potassium acetate / 2 h / Reflux; Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / Inert atmosphere 3: zinc diacetate / 2 h / Inert atmosphere; Reflux 4: potassium hydroxide / methanol; diethyl ether / 15 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: pyridine; hydrogen / methanol / 6 h / Reflux 1.2: 20 h / 2585.81 Torr / Inert atmosphere 2.1: toluene-4-sulfonic acid / water; 1,4-dioxane / 5 h / 80 °C View Scheme |
24-ethylcholesta-5,22-dien-3β-ol
β-sitosterol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 90 percent / 4-DMAP; pyridine / 6 h / 20 °C 2.1: pyridine / 6 h / Heating 2.2: H2 / Pd/C / ethanol / 16 h / 20 °C / 2585.74 Torr 3.1: aq. TsOH / dioxane / 3 h / 80 °C View Scheme |
Conditions | Yield |
---|---|
With pyridine at 20℃; for 12h; | 99.6% |
β-sitosterol
5α,6α- and 5β,6β-Epoxystigmastan-3β-ol
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane for 1.5h; Ambient temperature; | 98% |
With 3-chloro-benzenecarboperoxoic acid In dichloromethane for 1h; Ambient temperature; | |
With magnesium bis(monoperoxyphthalate)hexahydrate In acetone at 57℃; for 0.5h; |
succinic acid anhydride
β-sitosterol
succinic acid mono-[17-(4-ethyl-1,5-dimethylhexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] ester
Conditions | Yield |
---|---|
With triethylamine In toluene at 60℃; Time; | 98% |
With dmap In toluene for 24h; Heating; | 88% |
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 14h; | 77% |
Conditions | Yield |
---|---|
With pyridine | 97.5% |
at 160℃; | |
With pyridine |
β-sitosterol
acetic anhydride
stigmast-5-en-3-yl acetate
Conditions | Yield |
---|---|
montmorillonite acid clay for 0.0166667h; microwave irradiation; | 97% |
With sodium hydroxide for 0.05h; Irradiation; | 95% |
With pyridine In toluene for 4h; Reflux; | 94.3% |
Conditions | Yield |
---|---|
With sulfuric acid modified bentonite In N,N-dimethyl-formamide at 20℃; for 5.5h; Sonication; | 95.39% |
β-sitosterol
(E)-3-(4-acetoxy-3-methoxyphenyl)acrylic acid
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 100℃; under 13501.4 Torr; for 0.25h; Microwave irradiation; | 95% |
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere; |
β-sitosterol
Conditions | Yield |
---|---|
With dmap In toluene at 0 - 20℃; for 48h; Inert atmosphere; | 95% |
β-sitosterol
4,5-dichloroisothiazole-3-carboxylic acid chloride
Conditions | Yield |
---|---|
With pyridine In diethyl ether at 20 - 23℃; | 94% |
Conditions | Yield |
---|---|
With pseudomonas lipase In water at 40℃; for 24h; Esterification; Enzymatic reaction; | 92.7% |
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In ethyl acetate for 24h; Inert atmosphere; | 92% |
With ammonium formate; palladium on activated charcoal In dichloromethane for 5h; Irradiation; | 91% |
With 5% Pd/C; hydrogen In ethyl acetate at 50℃; under 3750.38 Torr; | 77% |
Conditions | Yield |
---|---|
Stage #1: β-sitosterol With 1-Methyl-4-piperidone In toluene for 1h; Reflux; Inert atmosphere; Stage #2: With aluminum isopropoxide In toluene for 6h; Inert atmosphere; Reflux; | 92% |
With aluminum tri-tert-butoxide; acetone In benzene at 75 - 85℃; for 8h; | 89% |
With pyridinium chlorochromate In benzene for 4h; Heating; | 80% |
Conditions | Yield |
---|---|
With pseudomonas lipase In water at 40℃; for 24h; Esterification; Enzymatic reaction; | 91.5% |
Conditions | Yield |
---|---|
With pseudomonas lipase In water at 40℃; for 24h; Esterification; Enzymatic reaction; | 91.2% |
(9Z,12Z,15Z)-octadeca-9-12,15-trienoic acid
β-sitosterol
β-sitosteryl linolenate
Conditions | Yield |
---|---|
at 140℃; for 166.667h; Product distribution / selectivity; | 91% |
β-sitosterol
Conditions | Yield |
---|---|
With carbon tetrabromide; triphenylphosphine In dichloromethane at 0 - 20℃; for 4.5h; Inert atmosphere; | 91% |
β-sitosterol
methanesulfonyl chloride
17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[α]phenanthren-3-yl methanesulfonate
Conditions | Yield |
---|---|
With dmap; triethylamine at 0℃; for 24h; Schlenk technique; | 90% |
With triethylamine In dichloromethane at 4 - 22℃; for 16.5h; | 69% |
With triethylamine In dichloromethane at 4 - 22℃; for 16.5h; Inert atmosphere; | 69% |
With pyridine unter Kuehlung; |
β-sitosterol
acetyl chloride
stigmast-5-en-3-yl acetate
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 25℃; for 1h; | 90% |
Conditions | Yield |
---|---|
With pyridine In benzene Heating; | 90% |
Conditions | Yield |
---|---|
In pyridine | 89% |
With pyridine for 48h; Ambient temperature; | 63% |
With pyridine In chloroform for 21h; Ambient temperature; | |
With pyridine | |
With pyridine at 20℃; for 20h; Tosylation; |
β-sitosterol
1,1,1,3,3,3-hexamethyl-disilazane
β-sitosterol trimethylsilyl ether
Conditions | Yield |
---|---|
With montmorillonite K-10 In dichloromethane for 0.5h; Ambient temperature; | 89% |
With phosphomolybdic acid In dichloromethane at 20℃; for 0.833333h; | 84% |
With silica sulfate In dichloromethane at 20℃; for 0.833333h; | 84% |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 35℃; for 72h; | 89% |
all cis-5,8,11,14,17-eicosapentaenoic acid
β-sitosterol
Conditions | Yield |
---|---|
With pseudomonas lipase In water at 40℃; for 24h; Esterification; Enzymatic reaction; | 88% |
2-bromo-3,4,4-trichloro-3-butenoyl chloride
β-sitosterol
Conditions | Yield |
---|---|
With pyridine In benzene at 20 - 23℃; | 88% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 88% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In 1,4-dioxane at 20℃; for 0.333333h; Microwave irradiation; | 87% |
1. Introduction of Beta-sitosterol
The Beta-sitosterol, with the CAS registry number 83-46-5, is a kind of white powder with no odour. It is widely distributed in the plant kingdom and found in Nigella sativa, pecans, Serenoa repens (saw palmetto), avocados, Cucurbita pepo (pumpkin seed), Pygeum africanum, cashew fruit. Beta-sitosterol is insoluble in water while soluble in chloroform and carbon disulfide. As to its usage, it is widely applied in many ways. Beta-sitosterol could be used as the Lipid-lowering drugs, and it could also be used as the acridine and health food.
2. Properties of Beta-sitosterol
(1)ACD/LogP: 10.73; (2)# of Rule of 5 Violations: 1; (3)#H bond acceptors: 1; (4)#H bond donors: 1; (5)#Freely Rotating Bonds: 7; (6)Polar Surface Area: 9.23; (7)Index of Refraction: 1.521; (8)Molar Refractivity: 129.21 cm3; (9)Molar Volume: 424.3 cm3; (10)Polarizability: 51.22 ×10-24 cm3; (11)Surface Tension: 37.6 dyne/cm; (12)Density: 0.97 g/cm3; (13)Flash Point: 220.4 °C; (14)Enthalpy of Vaporization: 88.77 kJ/mol; (15)Boiling Point: 501.9 °C at 760 mmHg; (16)Vapour Pressure: 3.53E-12 mmHg at 25°C; (17)Exact Mass: 414.386166; (18)MonoIsotopic Mass: 414.386166; (19)Topological Polar Surface Area: 20.2; (20)Heavy Atom Count: 30; (21)Complexity: 634.
3. Structure Descriptors of Beta-sitosterol
(1)Canonical SMILES: CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C
(2)Isomeric SMILES: CC[C@H](CC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)C(C)C
(3)InChI: InChI=1S/C29H50O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h10,19-21,23-27,30H,7-9,11-18H2,1-6H3/t20-,21-,23+,24+,25-,26+,27+,28+,29-/m1/s1
(4)InChIKey: KZJWDPNRJALLNS-VJSFXXLFSA-N
4. Preparation of Beta-sitosterol
Beta-sitosterol has been synthesized from stigmasterol 1, which involves a specific hydrogenation of the side-chain of stigmasterol (See Figure Below). The first step in the synthesis forms stigmasterol tosylate 2 from stigmasterol 1 (95% purity) using p-TsCl, DMAP, and pyridine (90% yield). The tosylate 2 then undergoes solvolysis as it is treated with pyridine and anhydrous MeOH to give a 5:1 ratio of i-stigmasterol methyl ether 3 (74% yield) to stigmasterol methyl ether 4, which is subsequently removed by chromatography. The hydrogenation step of a previously proposed synthesis involved the catalyst Pd/C and the solvent ethyl acetate. However, due to isomerisation during hydrolysis, other catalysts, such as PtO2, and solvents, such as ethanol, were tested. There was little change with the use of a different catalyst. Ethanol, however, prevented isomerisation and the formation of the unidentified impurity to give compound 5. The last step of the synthesis is deprotection of the β-ring double bond of 5 with p-TsOH, aqueous dioxane, and heat (80 °C) to yield β-sitosterol 6. The cumulative yield for the final two steps was 55%, and the total yield for the synthesis was 37%
5. Side effects of Beta-sitosterol
Beta-Sitosterol should be avoided during pregnancy and breast-feeding, since not enough is known about its effects on unborn and newborn children. β-Sitosterol is also not recommended for individuals with sitosterolemia, a rare inherited fat storage disease. Because people with this condition have too much β-sitosterol and related fats in their system, taking β-sitosterol will only worsen this condition. In addition, high levels of β-sitosterol concentrations in blood have been correlated with increased severity of heart disease in men having previously suffered from heart attacks
6. Use of Beta-sitosterol
Alone and in combination with similar phytosterols, β-sitosterol reduces blood levels of cholesterol, and is sometimes used in treating hypercholesterolemia.[medical citation needed] β-Sitosterol inhibits cholesterol absorption in the intestine. When the sterol is absorbed in the intestine, it is transported by lipoproteins and incorporated into the cellular membrane. Phytosterols and phytostanols both inhibit the uptake of dietary and biliary cholesterol, decreasing the levels of LDL and serum total cholesterol. Because the structure of β-sitosterol is very similar to that of cholesterol, β-sitosterol takes the place of dietary and biliary cholesterol in micelles produced in the intestinal lumen. This causes less cholesterol absorption in the body
7. Other details of Beta-sitosterol
When you deal with beta-sitosterol, you should be careful. For one thing, beta-sitosterol is irritant to eyes, respiratory system and skin, which may also cause inflammation to the skin or other mucous membranes. For another thing, it is harmful which may cause damage to health, and it may have danger of serious damage to health by prolonged exposure through inhalation and if swallowed. Besides, it has the limited evidence of a carcinogenic effect. Therefore, you should take the following instructions to protect yourself. Wear suitable protective clothing, then avoid contacting with skin and eyes. If in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In addition, remember not to breathe dust.
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