Betaine supplier | CasNO.107-43-7

Name
Betaine
EINECS 203-490-6
CAS No. 107-43-7
Article Data70
CAS DataBase
Density 1.00 g/mL at 20 °C
Solubility 160 g/100 mL in water
Melting Point 301-305 °C (dec.)
Formula C₅H₁₁NO₂
Boiling Point 218.95°C (rough estimate)
Molecular Weight 117.148
Flash Point
Transport Information 25kgs
Appearance white cryst. powder
Safety 24/25-36-26
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms glycine betaine;Trimethylaminoacetate;trimethylammonioacetate;(Carboxymethyl)trimethylammonium hydroxide inner salt;2-trimethylammonioacetate;methanaminium, carboxy-N,N,N-trimethyl-, inner salt;Greenstim;FinnStim;Glycine, trimethylbetaine;(trimethylammoniumyl)acetate;alpha-Earleine;2-(Trimethylammonio)ethanoic acid, hydroxide, inner salt;Aquadew AN 100;Trimethylglycocoll;trimethylglycocoll anhydride;Loramine AMB-13;Trimethylglycine(betaine);Methanaminium, 1-carboxy-N,N,N-trimethyl-, hydroxide, inner salt;Trimethylaminoacetic acid;Methanaminium, 1-carboxy-N,N, N-trimethyl-, hydroxide, inner salt;Methanaminium, 1-carboxy-N,N,N-trimethyl-, inner salt (9CI);Betaine Anhydrous Feed Grade;Trimethyl Glycine;Betaine; Trimethylammonioacetate;Lycium Chinense Extract Powder;wolfberry;
PSA 40.13000
LogP -1.55750

Synthetic route

: 67-48-1
choline chloride

: 107-43-7
betaine

Conditions

Conditions	Yield
With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In acetonitrile for 10h; Solvent;	90.1%
With choline oxidase; oxygen; pyrophosphoric acid at 25℃; pH=6.5; Enzyme kinetics; Further Variations:; Temperatures; pH-values;
With choline oxidase; oxygen In aq. phosphate buffer at 37℃; for 312h; Enzymatic reaction;
With choline oxidase; oxygen

: 186581-53-3, 908094-01-9
diazomethane

: 60-29-7
diethyl ether

: 56-40-6
glycine

: 107-43-7
betaine

Conditions

Conditions	Yield
bei Gegenwart von Wasser;

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 56-40-6
glycine

: 107-43-7
betaine

Conditions

Conditions	Yield
intermediaere Bildung von Glycin-methylester;
With diethyl ether; water

: 74-87-3
methylene chloride

: 7148-06-3
N,N-dimethylglycine methyl ester

: 107-43-7
betaine

Conditions

Conditions	Yield
With benzene Man erhitzt im geschlossenen Gefaess auf ca. 90grad und verseift den ausgeschiedenen Betainester mit verd. Salzsaeure im geschlossenen Gefaess bei 100-150grad;

: 80-68-2
DL-threonine

: 623-11-0
1-methyl-4-nitrosobenzene

: 107-43-7
betaine

Conditions

Conditions	Yield
bei der Methylierung;

: 4385-04-0
N,N-dimethylhexylamine

: 7748-25-6
potassium chloroacetate

: 107-43-7
betaine

Conditions

Conditions	Yield
at 80 - 90℃;

: 62-49-7
choline

: 107-43-7
betaine

Conditions

Conditions	Yield
With alkali durch Einwirkung von Leber- und Nieren-Praeparaten unter aeroben Bedingungen;
With potassium permanganate; sulfuric acid
With sulfuric acid; permanganate(VII) ion
With choline dehydrogenase Enzymatic reaction;
With choline oxidase

: 7148-06-3
N,N-dimethylglycine methyl ester

: 107-43-7
betaine

Conditions

Conditions	Yield
at 170 - 200℃; in geschlossenem Rohr;

: 7418-61-3
betaine aldehyde

: 107-43-7
betaine

Conditions

Conditions	Yield
With alkali durch Einwirkung von Leber- und Nieren-Praeparaten unter aeroben Bedingungen;

: 51-84-3
acetylcholine

: 107-43-7
betaine

Conditions

Conditions	Yield
With potassium permanganate; sulfuric acid

: 74-87-3
methylene chloride

: 96-34-4
methyl chloroacetate

: 124-40-3
dimethyl amine

: 107-43-7
betaine

Conditions

Conditions	Yield
With benzene Man erhitzt im geschlossenen Gefaess auf ca. 90grad und verseift den ausgeschiedenen Betainester mit verd. Salzsaeure im geschlossenen Gefaess bei 100-150grad;

...Expand

: 105-39-5
chloroacetic acid ethyl ester

: 75-50-3
trimethylamine

: 107-43-7
betaine

: 79-11-8
chloroacetic acid

: 75-50-3
trimethylamine

: 107-43-7
betaine

: 56-40-6
glycine

: 107-43-7
betaine

Conditions

Conditions	Yield
mit Weizenkeimlingen;
mit Weizenkeimlingen; ueber den Verlauf dieser Reaktion;

: 302-84-1
serin

: 623-11-0
1-methyl-4-nitrosobenzene

: 77-78-1
dimethyl sulfate

: 107-43-7
betaine

...Expand

: 80-68-2
DL-threonine

: 77-78-1
dimethyl sulfate

: 107-43-7
betaine

Conditions

Conditions	Yield
With sodium hydroxide

: 533-62-0, 5985-23-9, 6208-97-5, 6208-98-6, 6208-99-7, 6209-00-3, 10303-67-0, 13593-84-5, 17093-76-4, 17598-55-9, 18304-61-5, 25541-20-2, 50896-27-0
erythro-3-hydroxyglutamic acid

: 623-11-0
1-methyl-4-nitrosobenzene

: 77-78-1
dimethyl sulfate

A: 107-43-7
betaine

: (+/-)-erythro-2-trimethylammonio-3-methoxy-glutaric acid-betaine

Conditions

Conditions	Yield
at 50℃;

...Expand

: 533-62-0, 5985-23-9, 6208-97-5, 6208-98-6, 6208-99-7, 6209-00-3, 10303-67-0, 13593-84-5, 17093-76-4, 17598-55-9, 18304-61-5, 25541-20-2, 50896-27-0
erythro-3-hydroxyglutamic acid

: 77-78-1
dimethyl sulfate

A: 107-43-7
betaine

: (+/-)-erythro-2-trimethylammonio-3-methoxy-glutaric acid-betaine

Conditions

Conditions	Yield
With sodium hydroxide at 50℃;

...Expand

: 107-97-1
sarcosine

: 74-88-4
methyl iodide

A: 107-43-7
betaine

B: 22041-26-5
betain methyl ester iodide

Conditions

Conditions	Yield
at 160℃;

...Expand

: 36701-37-8
silver(I) glycinate

: 74-88-4
methyl iodide

: 107-43-7
betaine

: Ethoxycarbonylmethyl-trimethyl-ammonium; hydroxide

: 107-43-7
betaine

Conditions

Conditions	Yield
In water at 50 - 70℃;

: 3032-10-8
(carboxymethyl)trimethylammonium chloride methyl ester

A: 67-56-1
methanol

B: 107-43-7
betaine

Conditions

Conditions	Yield
With sodium hydroxide; lithium chloride In water at 25℃; Rate constant; other salts, MTACl or CTACl wer used;

: 3032-11-9
N-<(ethoxycarbonyl)methyl>trimethylammonium chloride

: 107-43-7
betaine

Conditions

Conditions	Yield
With sodium hydroxide In water at 18℃; Rate constant; Thermodynamic data; var. temps., var. solvents; ΔH(activ.), ΔS(activ.), (δΔHS1->S2), ΔHS;

: 186581-53-3, 908094-01-9
diazomethane

: 60-29-7
diethyl ether

: 7732-18-5
water

: 56-40-6
glycine

: 107-43-7
betaine

Conditions

Conditions	Yield
b.Behand.mit ueberschuess.Diazomethan entstehen entsprech.Betaine;analoge Reakt.mit Aminosaeuren,die in wss.Loesung als Zwitterionen vorliegen;

...Expand

: 56-40-6
glycine

: 74-88-4
methyl iodide

methanol.alkali: methanol.alkali

: 107-43-7
betaine

...Expand

: 461-06-3
CARNITINE

KMnO4: KMnO4

aqueous H2SO4: aqueous H2SO4

: 107-43-7
betaine

...Expand

: 7418-61-3
betaine aldehyde

silver oxide: silver oxide

: 107-43-7
betaine

: 6027-13-0
L-homocysteine

A: 4727-41-7
dimethylsulfonioacetate

B: 107-43-7
betaine

C 3-dimethylsulfonio-proionoic acid betaine: 3-dimethylsulfonio-proionoic acid betaine

Conditions

Conditions	Yield
ueber die Methylierung in Gegenwart von Transmethylase-Praeparaten aus Leber und Niere unter anaeroben Bedingungen;

...Expand

: 107-43-7
betaine

: 99-73-0
para-bromophenacyl bromide

: [2-(4-bromo-phenyl)-2-oxo-ethoxycarbonylmethyl]-trimethyl-ammonium

Conditions

Conditions	Yield
With potassium dihydrogenphosphate; 18-crown-6 ether In acetonitrile at 90℃; for 0.5h;	100%

: 13956-29-1
CBD

: 107-43-7
betaine

: C21H30O2*C5H11NO2

Conditions

Conditions	Yield
for 0.75h;	100%
In n-heptane at 20℃; for 15h; Solvent; Temperature; Inert atmosphere;	50%

: 107-43-7
betaine

: nicotinic acid riboside 5'-monophosphate

: 1-carboxy-N,N,N-trimethylmethanaminium 1-((2R,3R,4S,5R)-5-(((hydrogenphosphonato)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)pyridin-1-ium-3-carboxylate

Conditions

Conditions	Yield
In water at 10℃; for 0.166667h;	100%

: 32819-50-4
trifluoro-N-(fluorosulfonyl)methanesulfonylamide

: 107-43-7
betaine

: trimethylglycinium (fluorosulfonyl)(trifluoromethylsulfonyl)imide

Conditions

Conditions	Yield
at 20 - 70℃; for 0.5h; Temperature; Inert atmosphere;	99.5%

: 107-43-7
betaine

: trimethylglycinium bis(fluorosulfonyl)imide

Conditions

Conditions	Yield
With bis(fluorosulfonyl)amide In water at 40℃; for 0.5h; Temperature; Concentration;	99%

: 107-43-7
betaine

: 112-82-3
hexadecanyl bromide

: (2-hexadecyloxy-2-oxoethyl)trimethylammonium bromide

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 72h;	99%
In acetonitrile at 80℃; Green chemistry;	91%

: 107-43-7
betaine

: 112-89-0
1-Bromooctadecane

: (2-octadecyloxy-2-oxoethyl)trimethylammonium bromide

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 72h;	99%
In acetonitrile at 80℃; Green chemistry;	88%

: 107-43-7
betaine

: 70-11-1
α-bromoacetophenone

: Trimethylammoniumessigsaeurebetain-phenacylester-bromid

Conditions

Conditions	Yield
In ethanol at 40℃; for 24h;	97%

: 107-43-7
betaine

: 590-17-0
cyanomethyl bromide

A: 60379-56-8
Trimethylammoniumessigsaeurebetain-ethylester-bromid

B: 107-16-4
glycolonitrile

Conditions

Conditions	Yield
In ethanol at 40℃; for 72h; Yields of byproduct given;	A 97% B n/a

...Expand

: 107-43-7
betaine

: 1094-61-7
nicotinamide mononucleotide

: 1-carboxy-N,N,N-trimethylmethanaminium ((2R,35,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Conditions

Conditions	Yield
In water at 10℃; for 0.166667h;	97%

: 112-29-8
1-bromo dodecane

: 107-43-7
betaine

: (2-decyloxy-2-oxoethyl)trimethylammonium bromide

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 16h;	97%
In acetonitrile at 80℃; Green chemistry;	92%

: 81-25-4
cholic acid

: 107-43-7
betaine

: betainium cholate

Conditions

Conditions	Yield
In ethanol at 25℃; for 0.5h;	97%

: 526-95-4
gluconic acid

: 107-43-7
betaine

: betainium D-gluconate

Conditions

Conditions	Yield
In ethanol at 25℃; for 0.5h;	97%

: 112-71-0
1-Bromotetradecane

: 107-43-7
betaine

: (2-tetradecyloxy-2-oxoethyl)trimethylammonium bromide

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 24h;	96%
In acetonitrile at 80℃; Green chemistry;	90%

: 111-83-1
1-bromo-octane

: 107-43-7
betaine

: (2-octyloxy-2-oxoethyl)trimethylammonium bromide

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 16h;	96%
In acetonitrile at 80℃; Green chemistry;	94%

: 107-43-7
betaine

: 1-carboxy-N,N,N-trimethylmethanaminium hydrogenosulfate

Conditions

Conditions	Yield
With sulfuric acid at 20℃; for 0.333333h;	95%
With sulfuric acid at 60℃;

: 75-75-2
methanesulfonic acid

: 107-43-7
betaine

: 111-27-3
hexan-1-ol

: hexylbetainium methanesulfonate

Conditions

Conditions	Yield
at 160℃; for 25h; Dean-Stark; Green chemistry;	95%

...Expand

: 109-65-9
1-bromo-butane

: 107-43-7
betaine

: butoxycarbonylmethyl-trimethyl-ammonium; bromide

Conditions

Conditions	Yield
In acetonitrile at 80℃; Green chemistry;	95%
In acetonitrile at 100℃; for 24h;

: 107-43-7
betaine

: 104-15-4
toluene-4-sulfonic acid

: 1-carboxy-N,N,N-trimethylmethanaminium p-toluenesulfonate

Conditions

Conditions	Yield
at 20℃; for 0.333333h;	95%

: 75-75-2
methanesulfonic acid

: 107-43-7
betaine

: 1-carboxy-N,N,N-trimethylmethanaminium methanesulfonate

Conditions

Conditions	Yield
at 20℃; for 0.333333h;	95%

: 1493-13-6
trifluorormethanesulfonic acid

: 107-43-7
betaine

: 1-carboxy-N,N,N-trimethylmethanaminium trifuoromethanesulfonate

Conditions

Conditions	Yield
at 20℃; for 0.333333h;	95%

: 107-43-7
betaine

: 143-15-7
1-dodecylbromide

: (2-dodecyloxy-2-oxoethyl)trimethylammonium bromide

Conditions

Conditions	Yield
In acetonitrile at 80℃; Green chemistry;	95%
In acetonitrile at 80℃; for 24h;	95%

: 110-53-2
1-Bromopentane

: 107-43-7
betaine

: C10H22NO2(1+)*Br(1-)

Conditions

Conditions	Yield
In acetonitrile at 80℃; Green chemistry;	95%

: 107-43-7
betaine

: 98-79-3
L-Pyroglutamic acid

: betainium L-pyroglutamate

Conditions

Conditions	Yield
In ethanol at 25℃; for 0.5h;	95%

: 298-07-7
Bis(2-ethylhexyl)phosphoric acid

: 107-43-7
betaine

: betainium bis(2-ethylhexyl)phosphate

Conditions

Conditions	Yield
In ethanol at 25℃; for 0.5h;	94%

: 530-57-4
3,5-dimethoxy-4-hydroxybenzoic acid

: 107-43-7
betaine

: betaine syringate

Conditions

Conditions	Yield
In methanol at 50℃; for 12h; Inert atmosphere;	93.51%

: 149-91-7
3,4,5-trihydroxybenzoic acid

: 107-43-7
betaine

: betaine gallate

Conditions

Conditions	Yield
In methanol at 60℃; for 12h; Inert atmosphere;	93.32%

: 121-34-6
3-methoxy-4-hydroxybenzoic acid

: 107-43-7
betaine

: betaine vanillate

Conditions

Conditions	Yield
In methanol at 65℃; for 12h; Inert atmosphere;	93.23%

: 75-75-2
methanesulfonic acid

: 112-72-1
1-Tetradecanol

: 107-43-7
betaine

: tetradecylbetainium methanesulfonate

Conditions

Conditions	Yield
at 130 - 140℃; under 37.5038 - 75.0075 Torr; for 8h; Green chemistry;	93%

...Expand

: 111-25-1
1-bromo-hexane

: 107-43-7
betaine

: C11H24NO2(1+)*Br(1-)

Conditions

Conditions	Yield
In acetonitrile at 100℃; for 24h;	93%
In acetonitrile at 80℃; Green chemistry;	89%

Betaine Specification

The Betaine, with the CAS registry number 107-43-7,is also known as Methanaminium; Trimethylammonioacetate. It belongs to the product categories of Molecular Biology Reagents;PCR Reaction Components;PCR/Amplification. This chemical's molecular formula is C₅H₁₁NO₂ and molecular weight is 117.15.Its EINECS number is 203-490-6. What's more,Its systematic name is Betaine. It is a white crystal powder which is stable, hygroscopic and incompatible with strong oxidizing agents.It is a naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. Betaine can be used to treat high homocysteine levels. Its alkylated derivates are used as quaternary ammonium zwitterionic surfactants.

Physical properties about Betaine are:
(1)ACD/LogP: -3.228; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.63; (4)ACD/LogD (pH 7.4): -2.63; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.66; (8)ACD/KOC (pH 7.4): 1.66; (9)#H bond acceptors: 3; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2;

You can still convert the following datas into molecular structure:
(1)SMILES:C[N+](C)(C)CC(=O)[O-];
(2)Std. InChI:InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3;
(3)Std. InChIKey:KWIUHFFTVRNATP-UHFFFAOYSA-N.

Safety Information of Betaine:
The Betaine is harmful by inhalation, in contact with skin and if swallowed, and irritating to eyes, respiratory system and skin. When you use it ,you should avoid contact with skin and eyes.,and wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

The toxicity data of Betaine are as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	830mg/kg (830mg/kg)		Medicina et Pharmacologia Experimentalis. Vol. 16, Pg. 529, 1967.
mouse	LD50	subcutaneous	10800mg/kg (10800mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: FLUID INTAKE LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Acta Biologica et Medica Germanica. Vol. 3, Pg. 28, 1959.

Product Name

Betaine

Synthetic route

Betaine Specification

Related Products

Hot Products