Chenodeoxycholic acid supplier

Name
Chenodeoxycholic acid
EINECS 207-481-8
CAS No. 474-25-9
Article Data72
CAS DataBase
Density 1.129 g/cm³
Solubility practically insoluble in water
Melting Point 165-167 °C(lit.)
Formula C₂₄H₄₀O₄
Boiling Point 547.148 °C at 760 mmHg
Molecular Weight 392.579
Flash Point 298.8 °C
Transport Information
Appearance Off-white solid
Safety 22-24/25-45-36/37
Risk Codes 63
Molecular Structure
Hazard Symbols Xn
Synonyms Anthropodeoxycholic acid;Cholan-24-oic acid,3,7-dihydroxy-,(3R,5a,- 7R)-;Chenodiol [USAN];7-alpha-Hydroxylithocholic acid;Anthropododesoxycholic acid;Acido chenodeoxicholico [INN-Spanish];Chenodesoxycholic acid;Cholan-24-oic acid, 3,7-dihydroxy-, (3-.alpha., 5-.beta., 7-.alpha.)-;Acidum chenodeoxycholicum [INN-Latin];Anthropodesoxycholic acid;Chenodeoxycholic acid (JAN);(4R)-4-[(3R,5S,7R,8R,9S,10R,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate;Chendol;3-alpha,7-alpha-Dihydroxy-5-beta-cholan-24-oic acid;Prestwick_553;3-alpha,7-alpha-Dihydroxycholanic acid;Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-alpha)- (9CI);Chenodiol;Chenodesoxycholsaeure [German];5-beta-Cholan-24-oic acid, 3-alpha,7-alpha-dihydroxy-;(4R)-4-[(3R,5S,7R,8S,9S,10R,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid;Chenodeoxycholate;
PSA 77.76000
LogP 4.47790

Synthetic route

: 3α,7α-Dihydroxy-chol-11-ensaeure

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In methanol at 70℃; under 30003 Torr; for 12h;	99%

: 19684-68-5
(4R)-methyl 4-((3R,5R,7R,10S,13R,17R)-3-acetoxy-7-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With water; sodium hydroxide In methanol for 1h; Reflux;	97%
With water; sodium hydroxide In methanol; water for 2h; Reagent/catalyst; Reflux;	97%
With sodium hydroxide In tetrahydrofuran; methanol; water at 70℃; for 3h;	95%

: 4651-67-6
7-Ketolithocholic acid

A: 474-25-9
chenodeoxycholic acid

B: 128-13-2
ursodeoxycholic acid

Conditions

Conditions	Yield
Stage #1: 7-Ketolithocholic acid With potassium tert-butylate; palladium(II) hydroxide; potassium hydroxide In isopropyl alcohol at 20℃; for 0.166667h; Stage #2: With hydrogen In isopropyl alcohol at 40 - 80℃; Reagent/catalyst; Temperature;	A n/a B 95%
With sodium tetrahydroborate; sodium hydrogencarbonate In water at 20℃; for 0.5h; var. reducing agents;	A 94% B 2%
With potassium In tert-butyl alcohol for 0.5h; Heating; var. reducing agents;	A 6% B 94%

: 4651-67-6
7-Ketolithocholic acid

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 0℃; for 2h;	93%

: 93701-16-7
(4R)-methyl 4-((3R,5S,7R,10S,13R,17R)-7-acetoxy-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With water; sodium hydroxide In methanol for 6h; Reflux;	90.9%

: 2458-08-4
3α,7α-dihydroxy-12-oxo-5β-cholan-24-oic acid

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With potassium hydroxide; hydrazine In 2-methoxy-ethanol; water at 110 - 135℃; for 12h; Wolff-Kishner reduction;	90%
With potassium hydroxide; ethylene glycol weiteres Reagens: N2H4;
With potassium hydroxide; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol weiteres Reagens: N2H4;

: 2616-71-9
methyl 3α,7α-diacetoxy-5β-cholan-24-oate

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
Stage #1: methyl 3α,7α-diacetoxy-5β-cholan-24-oate With sodium hydroxide In dichloromethane at 20 - 30℃; for 1h; Stage #2: With sulfuric acid	87.8%
In methanol; isopropyl alcohol reflux 4 h then RT;	69%
With potassium hydroxide

: 28535-81-1
methyl 3α,7α-diacetoxy-12-one-5β-cholest-24-carboxylate

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With hydrazine hydrate; potassium hydroxide In ethylene glycol at 120 - 210℃; for 5h;	86.6%
With sodium ethanolate; hydrazine hydrate at 160℃;
With hydrazine hydrate; potassium hydroxide In 2,2'-[1,2-ethanediylbis(oxy)]bisethanol at 120 - 210℃; for 4h; Wolff-Kishner Reduction; Large scale;
Stage #1: methyl 3α,7α-diacetoxy-12-one-5β-cholest-24-carboxylate With hydrazine hydrate; potassium hydroxide In 2,2'-[1,2-ethanediylbis(oxy)]bisethanol at 120℃; for 2h; Stage #2: at 210℃; for 3h;
Multi-step reaction with 2 steps 1: Alkaline conditions View Scheme

: ethyl 3α-benzoyloxy-7α-hydroxy-chol-5-en-24-oate

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
Stage #1: ethyl 3α-benzoyloxy-7α-hydroxy-chol-5-en-24-oate With palladium 10% on activated carbon; hydrogen; acetic acid In ethanol under 2844.39 Torr; for 24h; Stage #2: With methanol; sodium hydroxide for 18h; Reflux;	82%

: C29H48O5

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With water; sodium hydroxide In methanol at 80℃; for 4h;	30%

: ethyl chenodeoxycholate acid 7-acetate

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With water; sodium hydroxide In methanol at 75℃; for 6h;	28%

: C29H46O5

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With water; sodium hydroxide In methanol at 75℃; for 5h;	28%

: C33H48O5

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With water; sodium hydroxide In methanol at 60℃; for 8h;	26%

: 859-97-2
3,7-diketocholanic acid

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With ethanol; platinum Hydrogenation;
With acetic acid; platinum Hydrogenation;
With sodium tetrahydroborate; water; sodium hydroxide

: 859-97-2
3,7-diketocholanic acid

A: 474-25-9
chenodeoxycholic acid

B: 128-13-2
ursodeoxycholic acid

Conditions

Conditions	Yield
With aluminum isopropoxide; isopropyl alcohol

: 4651-67-6
7-Ketolithocholic acid

: 141-52-6
sodium ethanolate

A: 474-25-9
chenodeoxycholic acid

B: 128-13-2
ursodeoxycholic acid

Conditions

Conditions	Yield
at 200℃;

...Expand

: 71837-87-1
methyl 3α-hydroxy-7α-acetoxy-12-oxocholanate

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With potassium hydroxide; ethylene glycol weiteres Reagens: N2H4;
With potassium hydroxide; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol weiteres Reagens: N2H4;

: 859-97-2
3,7-diketocholanic acid

: 555-31-7
aluminum isopropoxide

: 67-63-0
isopropyl alcohol

A: 474-25-9
chenodeoxycholic acid

B: 128-13-2
ursodeoxycholic acid

...Expand

: 79580-95-3
3α,7α-dihydroxy-12-oxocholanic acid tosylhydrazone

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With sodium tetrahydroborate In acetic acid for 3h; Ambient temperature;

: 64520-49-6, 68780-68-7, 68780-73-4, 68833-02-3, 124815-69-6, 59132-32-0
7-hydroxy-3-(sulfooxy)-(3α,5β,7α)-cholan-24-oic acid

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With hydrogenchloride In methanol; acetone at 37℃; for 18h; Product distribution; solvolyse methods, var. of temp., solvent, reagent and time;

: 59132-31-9
chenodeoxycholic acid 7-sulfate

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With hydrogenchloride; 2,2-dimethoxy-propane In methanol; ethyl acetate at 25℃; for 24h; Product distribution; solvolyse methods, var. of temp., solvent, reagent and time;

: 3α,7α-dihydroxy-5β-cholan-24-oic acid 3-β-D-glucuronide

A: 6556-12-3, 489-91-8, 528-16-5, 552-12-5, 577-46-8, 643-33-4, 2240-07-5, 6294-16-2, 10133-02-5, 18402-78-3, 18968-14-4, 21179-08-8, 23018-83-9, 33599-45-0, 33599-46-1, 46171-67-9, 46171-69-1, 46172-26-3, 70021-34-0, 71031-08-8, 104195-06-4, 106499-29-0, 124817-72-7
D-glucuronic acid

B: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With acetate buffer; glycyrrhizinic acid hydrolase at 45℃; hydrolysis; other enzyme (β-glucuronidase);

: 17974-66-2
(25RS)-3α,7α-dihydroxy-5β-cholestan-26-oic acid

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
rat liver homogenate, NAD, pH=8.5;

: 3α,7α,24-trihydroxy-5β-cholestan-26-oic acid

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
rat liver homogenate, NAD, pH=8.5;

: (E)-(R)-6-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-2-methyl-hept-2-enoic acid

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
rat liver homogenate, NAD, pH=8.5;

6A,6C-bis(2-naphthylsulfonyl)-γ-cyclodextrin chenodeoxycholic acid 1:1 complex: 6A,6C-bis(2-naphthylsulfonyl)-γ-cyclodextrin chenodeoxycholic acid 1:1 complex

A: 474-25-9
chenodeoxycholic acid

B 6A,6C-bis(2-naphthylsulfonyl)-γ-cyclodextrin: 6A,6C-bis(2-naphthylsulfonyl)-γ-cyclodextrin

Conditions

Conditions	Yield
In water; ethylene glycol at 25℃; Equilibrium constant; decomplexation;

6A,6D-bis(2-naphthylsulfonyl)-γ-cyclodextrin chenodeoxycholic acid 1:1 complex: 6A,6D-bis(2-naphthylsulfonyl)-γ-cyclodextrin chenodeoxycholic acid 1:1 complex

A: 474-25-9
chenodeoxycholic acid

B 6A,6D-bis(2-naphthylsulfonyl)-γ-cyclodextrin: 6A,6D-bis(2-naphthylsulfonyl)-γ-cyclodextrin

Conditions

Conditions	Yield
In water; ethylene glycol at 25℃; Equilibrium constant; decomplexation;

6A,6E-bis(2-naphthylsulfonyl)-γ-cyclodextrin chenodeoxycholic acid 1:1 complex: 6A,6E-bis(2-naphthylsulfonyl)-γ-cyclodextrin chenodeoxycholic acid 1:1 complex

A: 474-25-9
chenodeoxycholic acid

B 6A,6E-bis(2-naphthylsulfonyl)-γ-cyclodextrin: 6A,6E-bis(2-naphthylsulfonyl)-γ-cyclodextrin

Conditions

Conditions	Yield
In water; ethylene glycol at 25℃; Equilibrium constant; decomplexation;

3α,7α-diacetoxy-12-oxo-5β-cholan-24-oic acid methyl ester: 3α,7α-diacetoxy-12-oxo-5β-cholan-24-oic acid methyl ester

: 474-25-9
chenodeoxycholic acid

Conditions

Conditions	Yield
With potassium hydroxide; ethylene glycol weiteres Reagens: N2H4;
With potassium hydroxide; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol weiteres Reagens: N2H4;

: 67-56-1
methanol

: 474-25-9
chenodeoxycholic acid

: 3057-04-3
chenodeoxycholic acid methyl ester

Conditions

Conditions	Yield
With thionyl chloride	100%
With toluene-4-sulfonic acid at 20℃; for 1h;	100%
With toluene-4-sulfonic acid for 2h; Reflux; Inert atmosphere;	100%

: 474-25-9
chenodeoxycholic acid

: 4185-00-6
Dehydrochenodeoxycholic acid

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate; D-glucose; Pseudomonas paucimobilis; yeast extracxt; peptone In water at 28℃; for 24h;	100%

: 474-25-9
chenodeoxycholic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 3057-04-3
chenodeoxycholic acid methyl ester

Conditions

Conditions	Yield
In methanol; hexane; toluene at 20℃;	100%

: 107-68-6
N-Methyltaurine

: 474-25-9
chenodeoxycholic acid

: 93790-68-2
3α,7α-dihydroxy-5β-cholan-24-oyl-N-methyltaurine

Conditions

Conditions	Yield
With triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In N,N-dimethyl-formamide at 20℃; for 1h;	100%

: 67-56-1
methanol

: 474-25-9
chenodeoxycholic acid

: C26H44O4

Conditions

Conditions	Yield
	100%

: 474-25-9
chenodeoxycholic acid

: 108-24-7
acetic anhydride

: 33628-52-3
3α,7α-diacetoxy-24-phenyl-5β-cholan-24-oic acid

Conditions

Conditions	Yield
With pyridine at 20℃; for 24h;	99%
With pyridine at 20℃; for 3h;	97%
With pyridine at 20℃; for 15h;	95%

: 64-17-5
ethanol

: 474-25-9
chenodeoxycholic acid

: ethyl 3α,7α-dihydroxy-5β-cholan-24-oate

Conditions

Conditions	Yield
With Candida antarctica lipase B In hexane at 55℃; for 24h; Reagent/catalyst; Solvent; Temperature; Time; Enzymatic reaction;	99%
With heterologous Rhizopus oryzae lipase immobilized on Octadecyl Sepabeads In di-isopropyl ether at 55℃; Enzymatic reaction;	87%

: 101-70-2
bis(4-methoxyphenyl)amine

: 474-25-9
chenodeoxycholic acid

: (3R,5S,7R,8R,9S,10S,13R,14S,17R)-17-((R)-4-(bis(4-methoxyphenyl)amino)butan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol

Conditions

Conditions	Yield
With 9-(2-chlorophenyl)acridine; di-tert-butyl peroxide; copper(II) hexafluoroacetylacetonate In ethyl acetate at 35℃; for 24h; Inert atmosphere; Irradiation;	99%

: 474-25-9
chenodeoxycholic acid

: 4651-67-6
7-Ketolithocholic acid

Conditions

Conditions	Yield
With dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride In dichloromethane at -30℃; for 1.5h; Temperature; Swern Oxidation;	98.6%
With sodium bromate; sulfuric acid; sodium bromide In dichloromethane at 20 - 30℃; for 6h;	96.1%
With N-Bromosuccinimide In water; acetone at 20℃; for 2h; Darkness;	94%

: 64-18-6
formic acid

: 474-25-9
chenodeoxycholic acid

: 6159-50-8, 6058-15-7
3α,7α-diformyloxy-5β-cholan-24-oic acid

Conditions

Conditions	Yield
With perchloric acid In tetrahydrofuran at 50℃; for 15h;	98%
With perchloric acid In tetrahydrofuran; water at 54℃; Inert atmosphere;	96%
at 55℃; for 20h;	95%

: 474-25-9
chenodeoxycholic acid

: 2,2,2,-trichloroethoxycarbonyl azide

: 2,2,2-trichloroethyl ((3R)-3-((3R,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)butyl)carbamate

Conditions

Conditions	Yield
With dmap; copper diacetate In acetonitrile at 80℃; for 0.166667h; Schlenk technique; Sealed tube;	98%

: 474-25-9
chenodeoxycholic acid

: 14034-59-4
ethylene diamine mono-p-toluenesulfonic acid salt

: 23-(4,5-dihydroimidazol-2-yl)-24-nor-5β-cholan-3α,7α-diol

Conditions

Conditions	Yield
at 220 - 225℃; for 0.75h;	97%

: 474-25-9
chenodeoxycholic acid

: 5680-79-5
glycine ethyl ester hydrochloride

: 69320-16-7
[(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoylamino]-acetic acid methyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide	97%

: 474-25-9
chenodeoxycholic acid

: 859-97-2
3,7-diketocholanic acid

Conditions

Conditions	Yield
With sodium bromate; ammonium cerium (IV) nitrate In water; acetonitrile at 80℃; Green chemistry;	96%
With potassium bromate; phosphoric acid; potassium bromide In tetrahydrofuran; water; acetonitrile at 20℃; for 3h; Reagent/catalyst; Solvent; Temperature;	90.6%
With aluminium(III) chloride hexahydrate; potassium peroxymonosulfate In water at 50℃; for 0.166667h; Microwave irradiation;	83%
With chromium(VI) oxide; acetic acid

: 474-25-9
chenodeoxycholic acid

: (2-(3)H(N))taurine

: C26H44(3)HNO6S

Conditions

Conditions	Yield
With hydrogenchloride; tributyl-amine; chloroformic acid ethyl ester In 1,4-dioxane for 0.25h; Ambient temperature;	95%

: 474-25-9
chenodeoxycholic acid

: (1,2-(14)C)taurine

: C24(14)C2H45NO6S

Conditions

Conditions	Yield
With hydrogenchloride; tributyl-amine; chloroformic acid ethyl ester In 1,4-dioxane for 0.25h; Ambient temperature;	95%

: 474-25-9
chenodeoxycholic acid

: ferric chenodeoxycholate

Conditions

Conditions	Yield
With iron(III) chloride; sodium hydroxide In water at 35℃; pH=8;	95%

: 474-25-9
chenodeoxycholic acid

: 114459-62-0
tri-Boc-spermine

: 287964-36-7
N1-(3α,7α-dihydroxy-5β-cholan-24-carbonyl)-(N4,N9N12-tri-tert-butoxycarbonyl)-1,12-diamino-4,9-diazadodecane

Conditions

Conditions	Yield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 25℃; for 24h; Acylation;	93%

: 107-35-7
Tau

: 474-25-9
chenodeoxycholic acid

: 6009-98-9
sodium taurochenodeoxycholate

Conditions

Conditions	Yield
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; sodium hydroxide In water; acetonitrile; tert-butyl alcohol at 20 - 80℃;	93%

: 474-25-9
chenodeoxycholic acid

: 100-39-0
benzyl bromide

: 111992-94-0
benzyl 3α,7α-dihydroxy-5β-cholan-24-oate

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile Reflux;	92%
With caesium carbonate In acetonitrile for 4h; Reflux;	80%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 55℃;
With caesium carbonate In acetonitrile Reflux;

: TMSCH2N2

: 474-25-9
chenodeoxycholic acid

: 14773-00-3
methyl (5β,7α)-12-hydroxy-3-oxo-cholan-24-oate

Conditions

Conditions	Yield
In methanol; diethyl ether; toluene at 20℃; for 0.333333h;	91%

: 109-01-3
1-methyl-piperazine

: 474-25-9
chenodeoxycholic acid

: 86678-67-3
N1<(3α,5β,7α)3,7-dihydroxy-24-oxo-cholan-24-yl>N4methyl-piperazine

Conditions

Conditions	Yield
With tributyl-amine; chloroformic acid ethyl ester In 1,4-dioxane 10 deg C, 10 min then rt., 1 h;	90%

: 474-25-9
chenodeoxycholic acid

: 74-89-5
methylamine

: 86678-62-8
N methyl(3α,5β,7α)3,7-dihydroxy-cholan-24-amide

Conditions

Conditions	Yield
With tributyl-amine; chloroformic acid ethyl ester In 1,4-dioxane 10 deg C, 10 min then rt., 1 h;	90%
With tributyl-amine; chloroformic acid ethyl ester Multistep reaction;

: 474-25-9
chenodeoxycholic acid

: 100-46-9
benzylamine

: 86678-64-0
N benzyl (3α,5β,7α)3,7-dihydroxy-cholan-24-amide

Conditions

Conditions	Yield
With tributyl-amine; chloroformic acid ethyl ester In 1,4-dioxane 10 deg C, 10 min then rt., 1 h;	90%
With ammonium hydroxide; tributyl-amine; chloroformic acid ethyl ester Multistep reaction;

Chenodeoxycholic acid Chemical Properties

Structure of Chenodeoxycholic acid (CAS NO.474-25-9):

IUPAC Name: (4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,
3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
Empirical Formula: C₂₄H₄₀O₄
Molecular Weight: 392.572
EINECS: 207-481-8
Index of Refraction: 1.543
Molar Refractivity: 109.65 cm³
Molar Volume: 347.8 cm³
Polarizability: 43.46×10^-24cm³
Surface Tension: 46 dyne/cm
Density: 1.128 g/cm³
Flash Point: 298.8 °C
Enthalpy of Vaporization: 95.01 kJ/mol
Melting Point: 165-167 °C(lit.)
Boiling Point: 547.1 °C at 760 mmHg
Vapour Pressure: 2.98E-14 mmHg at 25°C
Water Solubility: PRACTICALLY INSOLUBLE
Physical Appearance: Off-White Solid
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Intracellular receptor

Chenodeoxycholic acid Uses

A major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion.

Chenodeoxycholic acid Toxicity Data With Reference

1.	mmo-sat 20 mg/L	MUREAV Mutation Research. 158 (1985),45.
2.	sln-smc 100 mg/L	CRNGDP Carcinogenesis. 5 (1984),447.
3.	orl-wmn TDLo:24 g/kg/5Y-C:CAR	CLONEA Clinics in Oncology. 7 (1981),245.
4.	orl-rat LD50:4000 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 13 (1982),1128.
5.	ipr-rat LD50:105 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 15 (1978),915.
6.	ivn-rat LD50:106 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 15 (1978),915.
7.	orl-mus LD50:3000 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 13 (1982),1128.
8.	ipr-mus LD50:86 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 15 (1978),915.
9.	ivn-mus LD50:100 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 20 (1970),323.

Chenodeoxycholic acid Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Questionable human carcinogen producing liver tumors. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes.
Hazard Codes: Harmful Xn
Risk Statements: 63
R63:Possible risk of harm to the unborn child.
Safety Statements: 22-24/25-45-36/37
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37:Wear suitable protective clothing and gloves.
WGK Germany: 2
RTECS: FZ1980000

Chenodeoxycholic acid Specification

Chenodeoxycholic acid , its cas register number is 474-25-9. It also can be called 3-alpha,7-alpha-Dihydroxy-5-beta-cholan-24-oic acid ; 3-alpha,7-alpha-Dihydroxycholanic acid ; 3-alpha,7-alpha-Dihydroxycholansaeure ; 3alpha,7alpha-Dihydroxy-5beta-cholan-24-oic acid ; 7-alpha-Hydroxylithocholic acid ; Acide chenodeoxycholique ; Acido chenodeoxicholico ; Anthropodeoxycholic acid ; Anthropododesoxycholic acid ; Chenic acid ; Chenix ;
Chenodesoxycholsaeure ; Chenodiol ; Gallodesoxycholic acid .

Product Name

Chenodeoxycholic acid

Synthetic route

Chenodeoxycholic acid Chemical Properties

Chenodeoxycholic acid Uses

Chenodeoxycholic acid Toxicity Data With Reference

Chenodeoxycholic acid Safety Profile

Chenodeoxycholic acid Specification

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