Cyproheptadine supplier | CasNO.129-03-3

Name
Cyproheptadine
EINECS 204-928-9
CAS No. 129-03-3
Article Data10
CAS DataBase
Density 1.115g/cm³
Solubility 317.6ug/L(22.5 oC)
Melting Point 112.3-113.3°
Formula C21H21 N
Boiling Point 440.1°Cat760mmHg
Molecular Weight 287.404
Flash Point 194.5°C
Transport Information
Appearance Colorless liquid, sweet, almond odor.
Safety Poison by ingestion, intraperitoneal, subcutaneous and intravenous routes. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 1-Methyl-4-(5H-dibenzo[a,d]cycloheptenylidene)piperidine;1-Methyl-4-(dibenzo[a,e]cycloheptatrien-5-ylidene)piperidine;4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine; Cycloheptadine;Cyproheptadine; Periactinol
PSA 3.24000
LogP 5.43780

Synthetic route

: 3967-32-6
5-(1-methyl-4-piperidyl)-5H-dibenzocyclohepten-5-ol

: 129-03-3
cyproheptadine

Conditions

Conditions	Yield
With formic acid at 100℃; for 2h;	99%
With hydrogenchloride; acetic acid at 120℃; for 2h;	83%
With formic acid for 1h; Heating; Yield given;

: 121138-82-7
ethyl 4-(5H-dibenzocyclohepten-5-ylidene)-1-piperidinecarboxylate

: 129-03-3
cyproheptadine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Heating; Yield given;

: 63463-36-5
(1-methyl-4-piperidyl)magnesium chloride

: 129-03-3
cyproheptadine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 76 percent / tetrahydrofuran / 70 °C 2: 83 percent / HOAc, conc. HCl / 2 h / 120 °C View Scheme

: 2222-33-5
dibenzosuberenon

: 129-03-3
cyproheptadine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 76 percent / tetrahydrofuran / 70 °C 2: 83 percent / HOAc, conc. HCl / 2 h / 120 °C View Scheme
Multi-step reaction with 2 steps 1: 60 percent / TiCl3 / 1,2-dimethoxy-ethane 2: LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 129-03-3
cyproheptadine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 60 percent / TiCl3 / 1,2-dimethoxy-ethane 2: LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme

: 129-03-3
cyproheptadine

: 541-41-3
chloroformic acid ethyl ester

: 121138-82-7
ethyl 4-(5H-dibenzocyclohepten-5-ylidene)-1-piperidinecarboxylate

Conditions

Conditions	Yield
In toluene for 5h; Heating;	94%
In hexane; toluene
In toluene for 3h; Reflux;

: 129-03-3
cyproheptadine

ether-pet ether: ether-pet ether

: 21081-07-2
4-(10,11-dihydro-5H-dibenzocyclohepten-5-ylidene)-1-methylpiperidine

Conditions

Conditions	Yield
With hydrogen In ethanol; acetic acid	94%

: 129-03-3
cyproheptadine

: 3972-65-4
1-bromo-4-tert-butylbenzene

: C31H33N

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 48h; regioselective reaction;	72%

: 129-03-3
cyproheptadine

: 591-17-3
meta-bromotoluene

: C28H27N

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 48h; regioselective reaction;	63%

: 129-03-3
cyproheptadine

: 95-46-5
2-methylphenyl bromide

: C28H27N

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 48h; regioselective reaction;	55%

: 108-86-1
bromobenzene

: 129-03-3
cyproheptadine

: C27H25N

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 4h; regioselective reaction;	51%

: 104-92-7
1-bromo-4-methoxy-benzene

: 129-03-3
cyproheptadine

: C28H27NO

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 4h; regioselective reaction;	48%

: 129-03-3
cyproheptadine

: 2398-37-0
3-methoxyphenyl bromide

: C28H27NO

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 48h; regioselective reaction;	47%

: 129-03-3
cyproheptadine

: 92-66-0
4-bromo-1,1'-biphenyl

: C33H29N

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 16h; regioselective reaction;	45%

: 129-03-3
cyproheptadine

: 90-11-9
1-Bromonaphthalene

: C31H27N

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 48h; regioselective reaction;	44%

: 129-03-3
cyproheptadine

: 108-37-2
1-bromo-3-chlorobenzene

: C27H24ClN

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 48h; regioselective reaction;	41%

: 129-03-3
cyproheptadine

: 341-41-3
1-bromo-4-fluoronaphthalene

: C31H26FN

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 48h; regioselective reaction;	41%

: 129-03-3
cyproheptadine

: 106-38-7
para-bromotoluene

: C28H27N

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 48h; Catalytic behavior; Reagent/catalyst; Solvent; Time; regioselective reaction;	41%

: 129-03-3
cyproheptadine

: 586-77-6
4-bromo-N,N-dimethylaniline

: C29H30N2

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 4h; regioselective reaction;	38%

: 129-03-3
cyproheptadine

: 402-43-7
p-trifluoromethylphenyl bromide

: C28H24F3N

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 16h; regioselective reaction;	38%

: 129-03-3
cyproheptadine

: 460-00-4
1-Bromo-4-fluorobenzene

: C27H24FN

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 16h; regioselective reaction;	38%

: 15231-91-1
6-bromo-naphthalen-2-ol

: 129-03-3
cyproheptadine

: C31H27NO

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 4h; regioselective reaction;	34%

: 129-03-3
cyproheptadine

: 2859-78-1
4-Bromoveratrole

: C29H29NO2

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 48h; regioselective reaction;	34%

: 129-03-3
cyproheptadine

: 29558-77-8
4-bromo-4'-hydroxybiphenyl

: C33H29NO

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 4h; regioselective reaction;	32%

: 106-39-8
bromochlorobenzene

: 129-03-3
cyproheptadine

: C27H24ClN

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 16h; regioselective reaction;	31%

: 129-03-3
cyproheptadine

: 106-43-4
para-chlorotoluene

: C28H27N

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 16h; regioselective reaction;	19%

: 129-03-3
cyproheptadine

: 401-78-5
3-bromo-1-trifluoromethylbenzene

: C28H24F3N

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 48h; regioselective reaction;	15%

: 129-03-3
cyproheptadine

: 624-31-7
4-tolyl iodide

A: 613-33-2
(4,4'-dimethyl-1,1'-biphenyl)

B: C28H27N

Conditions

Conditions	Yield
With PdCl(1,4-bis(diphenylphosphino)butane)(C3H5); potassium acetate In N,N-dimethyl acetamide at 150℃; for 16h; regioselective reaction;	A n/a B 11%

...Expand

: 129-03-3
cyproheptadine

: 54191-04-7
cyproheptadine 10,11-epoxide

Conditions

Conditions	Yield
With sodium hydroxide; dihydrogen peroxide In acetone; acetonitrile

: 129-03-3
cyproheptadine

: 50893-53-3
carbonochloridic acid 1-chloro-ethyl ester

: 4-Dibenzo[a,d]cyclohepten-5-ylidene-piperidine-1-carboxylic acid 1-chloro-ethyl ester

Conditions

Conditions	Yield
With sodium carbonate In 1,2-dichloro-ethane 1) 0 deg C, 2) reflux;

: 129-03-3
cyproheptadine

: 14051-46-8
4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)piperidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Na2CO3 / 1,2-dichloro-ethane / 1) 0 deg C, 2) reflux 2: 1) CH3OH, 2) NaOH / 1) r.t., 15 min, 50 deg C, 15 min, 2) water View Scheme
Multi-step reaction with 2 steps 1: toluene / 3 h / Reflux 2: potassium hydroxide; water / ethanol / Reflux View Scheme

: 129-03-3
cyproheptadine

: 175692-31-6
4-(4-Dibenzo[a,d]cyclohepten-5-ylidene-piperidin-1-yl)-butylamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: Na2CO3 / 1,2-dichloro-ethane / 1) 0 deg C, 2) reflux 2: 1) CH3OH, 2) NaOH / 1) r.t., 15 min, 50 deg C, 15 min, 2) water 3: 80 percent / Na2CO3, KI / acetonitrile; dimethylformamide / Heating 4: 62 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 2 h / Ambient temperature View Scheme

Cyproheptadine Chemical Properties

Product Name: Cyproheptadine
CAS: 129-03-3
Formula: C₂₁H₂₁N
Molecular Weight: 287.4
Molecular Structure of Cyproheptadine (CAS NO.129-03-3):

Density: 1.115 g/cm³
Flash Point: 194.5 °C
Boiling Point: 440.1 °C at 760 mmHg
Index of Refraction: 1.629
Molar Refractivity: 91.59 cm³
Molar Volume: 257.5 cm³
Polarizability: 36.31×10^-24cm³
Surface Tension: 45.6 dyne/cm
Enthalpy of Vaporization: 69.72 kJ/mol
Vapour Pressure: 6.03E-08 mmHg at 25°C
Water Solubility: 1.135(mg/L) at 25°C

Cyproheptadine Toxicity Data With Reference

1.	orl-rat LD50:295 mg/kg	27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,69.
2.	ipr-rat LD50:52 mg/kg	27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,69.
3.	orl-mus LD50:106 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 25 (1975),1723.
4.	scu-mus LD50:107 mg/kg	27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,69.
5.	orl-dog LDLo:50 mg/kg	27ZIAQ Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,82.
6.	ivn-rbt LDLo:3500 µg/kg	27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,69.

Cyproheptadine Consensus Reports

EPA Genetic Toxicology Program.

Cyproheptadine Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous and intravenous routes. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.
Safety Information about Cyproheptadine (CAS NO.129-03-3):
HS Code: 29143900

Cyproheptadine Specification

The chemical synonyms of Cyproheptadine (CAS NO.129-03-3) are 1-Methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine ; 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine ; 4-(5-Dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine ; 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidene ; 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine ; 5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene ; 5-20-08-00500 (Beilstein Handbook Reference) ; BRN 1685976 ; CCRIS 5232 ; Ciproheptadina ; Ciproheptadina [INN-Spanish] ; Cyproheptadine ; Cyproheptadinum ; Cyproheptadinum [INN-Latin] ; Dronactin ; EINECS 204-928-9 ; Eiproheptadine ; HSDB 3048 ; MK 141 ; Periactin ; Periactinol ; UNII-2YHB6175DO .

Product Name

Cyproheptadine

Synthetic route

Cyproheptadine Chemical Properties

Cyproheptadine Toxicity Data With Reference

Cyproheptadine Consensus Reports

Cyproheptadine Safety Profile

Cyproheptadine Specification

Related Products

Hot Products