DL-Malic acid supplier | CasNO.617-48-1

Name
Malic acid
EINECS 210-514-9
CAS No. 617-48-1
Article Data154
CAS DataBase
Density 1.641 g/cm3
Solubility 558 g/L (20℃)
Melting Point 130-132oC
Formula C4H6O5
Boiling Point 306.4oC at 760 mmHg
Molecular Weight 134.089
Flash Point 203oC
Transport Information
Appearance White to nearly white crystals or crystal powder
Safety
Risk Codes Xi:Irritant;
Molecular Structure
Hazard Symbols R22:; R34:; R42/43:;
Synonyms DL-Hydroxysuccinic acid;DL-2-Hydroxybutanedioic acid;DL-Apple acid;
PSA 94.83000
LogP -1.09340

Synthetic route

: 110-16-7
maleic acid

A: 109-99-9
tetrahydrofuran

B: 96-48-0
4-butanolide

C: 67-56-1
methanol

D: 110-63-4
Butane-1,4-diol

E: 617-48-1
malic acid

F: 110-15-6
succinic acid

G: 64-19-7
acetic acid

H: 71-36-3
butan-1-ol

Conditions

Conditions	Yield
With hydrogen; 0.5percent Pd on Rutile TiO2 at 110℃; Product distribution / selectivity;	A 0.45% B 0.06% C 0% D 0.21% E 0.36% F 98.73% G 0.04% H 0.08%

...Expand

: 110-17-8
(2E)-but-2-enedioic acid

: 617-48-1
malic acid

Conditions

Conditions	Yield
With sodium; iron	97%
With water at 150 - 200℃;
With sodium hydroxide; water at 100℃;

: 97-99-4
Tetrahydrofurfuryl alcohol

: 150-90-3
sodium succinate

A: 617-48-1
malic acid

B: (tetrahydrofuran-2-ylmethoxy)butanedioic acid

Conditions

Conditions	Yield
With lanthanum(III) chloride at 116℃; for 19h; Product distribution; also with other alcohols; variation of reaction time, temperature and proportion of reagents;	A 3% B 95%

...Expand

: 67-56-1
methanol

: 16090-09-8, 17229-80-0, 29126-50-9
lithium succinate

A: 617-48-1
malic acid

B: 1726-80-3
2-methoxy succinic acid

Conditions

Conditions	Yield
With lanthanum(III) chloride; trimethyl orthoformate In water at 150℃; for 6h;	A 1.5 % Chromat. B 91%

...Expand

: 110-16-7
maleic acid

A: 109-99-9
tetrahydrofuran

B: 96-48-0
4-butanolide

C: 110-63-4
Butane-1,4-diol

D: 591-81-1
4-hydroxybutanoic acid

E: 617-48-1
malic acid

F: 110-15-6
succinic acid

G: 64-19-7
acetic acid

Conditions

Conditions	Yield
With hydrogen; 0.5percent Pd/2.0percent Re on Rutile TiO2 at 110℃; Product distribution / selectivity;	A 1.27% B 4.78% C 1.55% D 1.24% E 0.48% F 90.6% G 0.08%

...Expand

: 110-16-7
maleic acid

A: 109-99-9
tetrahydrofuran

B: 96-48-0
4-butanolide

C: 110-63-4
Butane-1,4-diol

D: 617-48-1
malic acid

E: 110-15-6
succinic acid

F: 64-19-7
acetic acid

G: 71-36-3
butan-1-ol

Conditions

Conditions	Yield
With hydrogen; 0.5percent Pd on Rutile TiO2 at 110℃; for 96 - 238h; Product distribution / selectivity;	A 0.6% B 0.04% C 0.62% D 0.19% E 88.49% F 0.12% G 0.11%

...Expand

: 110-16-7
maleic acid

A: 109-99-9
tetrahydrofuran

B: 96-48-0
4-butanolide

C: 110-63-4
Butane-1,4-diol

D: 591-81-1
4-hydroxybutanoic acid

E: 617-48-1
malic acid

F: 110-15-6
succinic acid

G: 100-21-0
terephthalic acid

H: 64-19-7
acetic acid

I: 802294-64-0
propionic acid

J: 110-17-8
(2E)-but-2-enedioic acid

Conditions

Conditions	Yield
With hydrogen; 0.5percent Pd/0.2percent Re on Rutile TiO2 at 110℃; for 170 - 1009h; Product distribution / selectivity;	A 0.86% B 4.34% C 0.28% D 1.24% E 0% F 85.51% G 0% H 0.04% I 0% J 0%

...Expand

: 1631-28-3
N-p-tolylphenylmaleimide

: 617-48-1
malic acid

Conditions

Conditions	Yield
Stage #1: N-p-tolylphenylmaleimide With potassium carbonate; isopropyl alcohol for 1h; oxa-Michael addition; Heating; Stage #2: With hydrogenchloride; acetic acid for 10h; Heating;	85%

: 98-01-1
furfural

A: 617-48-1
malic acid

B: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; acetic acid; 5 weight percent methyltrioxorhenium on polystyrene In water at 20℃; Product distribution / selectivity;	A 9% B 84%

: 108-31-6
maleic anhydride

A: 617-48-1
malic acid

B: 110-17-8
(2E)-but-2-enedioic acid

Conditions

Conditions	Yield
With water at 190℃; for 1h; Temperature; Concentration; Time; Sealed tube; Green chemistry;	A n/a B 72%

: 64-17-5
ethanol

: 16090-09-8, 17229-80-0, 29126-50-9
lithium succinate

A: 617-48-1
malic acid

B: 1726-75-6
(R,S)-ethoxybutanedioic acid

Conditions

Conditions	Yield
With lanthanum(III) chloride; trimethyl orthoformate In water at 175℃; for 24h;	A 15.5 % Chromat. B 70%

...Expand

: 98-01-1
furfural

A: 88-14-2
2-furanoic acid

B: 617-48-1
malic acid

C: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; methyltrioxorhenium(VII) In dichloromethane; water; acetonitrile at 20℃;	A 10% B 8% C 66%

...Expand

: 98-01-1
furfural

A: 14032-66-7
5-hydroxy-2-(5H)-furanone

B: 64-18-6
formic acid

C: 617-48-1
malic acid

D: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 49.84℃; for 24h; Catalytic behavior; Temperature; Concentration;	A n/a B n/a C n/a D 57%

...Expand

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 79-14-1
glycolic Acid

B: 617-48-1
malic acid

C: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; methyltrioxorhenium(VII) In water; acetic acid at 20℃;	A 55% B 29% C 14%

...Expand

: 98-01-1
furfural

A: 88-14-2
2-furanoic acid

B: 617-48-1
malic acid

C: 110-15-6
succinic acid

D: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; methyltrioxorhenium(VII) In ethanol; water at 20℃; Product distribution / selectivity;	A 20% B 6% C 8% D 49%
With dihydrogen peroxide; 5 weight percent methyltrioxorhenium on polystyrene In dichloromethane; water; acetonitrile at 20℃; Product distribution / selectivity;	A 10% B 11% C 10% D 44%
With dihydrogen peroxide; methyltrioxorhenium(VII) In water at 20℃; Product distribution / selectivity;	A 12% B 6% C 26% D 44%

...Expand

: potassium bisulfite

: 923-06-8, 584-98-5
bromosuccinic acid

A: 617-48-1
malic acid

B: 5138-18-1
sulfosuccinic acid

C: 110-17-8
(2E)-but-2-enedioic acid

Conditions

Conditions	Yield
heating, 18 h;	A n/a B 40% C n/a
heating, 18 h;	A n/a B 40% C n/a

...Expand

: 98-01-1
furfural

A: 14032-66-7
5-hydroxy-2-(5H)-furanone

B: 88-14-2
2-furanoic acid

C: 64-18-6
formic acid

D: 617-48-1
malic acid

E: 110-15-6
succinic acid

F: 497-23-4
2-buten-4-olide

G: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dihydrogen peroxide at 49.84℃; for 24h;	A n/a B n/a C n/a D n/a E 38% F 26% G 19.7%
With dihydrogen peroxide In water at 49.84℃; for 3h;	A n/a B n/a C n/a D n/a E 12.2% F 16.9% G 7.3%

...Expand

: 98-01-1
furfural

A: 14032-66-7
5-hydroxy-2-(5H)-furanone

B: 88-14-2
2-furanoic acid

C: 64-18-6
formic acid

D: 617-48-1
malic acid

E: 110-15-6
succinic acid

F: 497-23-4
2-buten-4-olide

G: 110-16-7
maleic acid

H: 110-17-8
(2E)-but-2-enedioic acid

Conditions

Conditions	Yield
With sulfuric acid; dihydrogen peroxide In water at 49.84℃; for 3h; Reagent/catalyst;	A n/a B n/a C n/a D n/a E 9.1% F 16.6% G 34.4% H 5.8%

...Expand

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 79-14-1
glycolic Acid

B: 6338-41-6
5-hydroxymethyl-furan-2-carboxylic acid

C: 617-48-1
malic acid

D: 110-15-6
succinic acid

E: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; methyltrioxorhenium(VII) In ethanol; water at 20℃;	A 23% B 6% C 11% D 16% E 29%

...Expand

: 124-38-9
carbon dioxide

: 127-17-3
2-oxo-propionic acid

: 617-48-1
malic acid

Conditions

Conditions	Yield
With mercaptoethyl alcohol; tris(2,2’-bipyridine)ruthenium(II); Tris buffer; Paraquat; nicotinamide adenine dinucleotide phosphate; sodium hydrogencarbonate; manganese(ll) chloride In water under 767.6 Torr; for 8h; Irradiation; ferredoxin-NADP(1+) reductase, malic enzyme;	24%
With Tris buffer; Paraquat; NADP; 2-hydroxyethanethiol; cadmium(II) sulphide at 25℃; for 5h; Mechanism; Product distribution; Irradiation; malic enzyme, ferredoxin-NADP+-reductase; other photocatalyst;
With mercaptoethyl alcohol; tris(2,2’-bipyridine)ruthenium(II); malic enzyme; ferredoxin-NADP(+) reductase; Tris buffer; Paraquat; nicotinamide adenine dinucleotide phosphate; sodium hydrogencarbonate; manganese(ll) chloride In water under 767.6 Torr; Mechanism; Product distribution; Irradiation; rate of CO2 fixation as a function of illumination time;
With tris(2,2’-bipyridine)ruthenium(II); 1.9E-4 M MV(2+); NADP+; sodium hydrogencarbonate; 2-hydroxyethanethiol; manganese(ll) chloride; malic enzyme In water Irradiation;
With Tris buffer; Paraquat; NADP; 2-hydroxyethanethiol; cadmium(II) sulphide at 25℃; Irradiation; malic enzyme, ferredoxin-NADP+-reductase;

: 110-16-7
maleic acid

A: 617-48-1
malic acid

B: 110-17-8
(2E)-but-2-enedioic acid

Conditions

Conditions	Yield
With water; palladium(II) bis(phosphine)monosulphide at 100℃; for 24h;	A 7% B 8%

: 110-16-7
maleic acid

: 617-48-1
malic acid

Conditions

Conditions	Yield
With water for 0.333333h; argon plasma-jet;	5.5%

: 6628-21-3
ethyl 2,3-dichloropropionate

: 64-17-5
ethanol

: 151-50-8
potassium cyanide

A: 617-48-1
malic acid

B: 110-17-8
(2E)-but-2-enedioic acid

Conditions

Conditions	Yield
man kocht das Produkt mit Aetzkali;

...Expand

: 13159-46-1
4,4,4-trichloro-3-hydroxybutyric acid

: 617-48-1
malic acid

Conditions

Conditions	Yield
With potassium hydroxide
With potassium hydroxide

: 70-47-3
L-asparagine

A: 617-48-1
malic acid

B: 110-15-6
succinic acid

C: 64-19-7
acetic acid

D: 110-17-8
(2E)-but-2-enedioic acid

Conditions

Conditions	Yield
bei der Einw. von Bac.fluorescens; Produkt5:Kohlendioxyd;

...Expand

: 97-67-6
(S)-Malic acid

A: 617-48-1
malic acid

B: 110-17-8
(2E)-but-2-enedioic acid

Conditions

Conditions	Yield
Gleichgewicht;

: 16045-92-4
chlorosuccinic acid

A: 617-48-1
malic acid

B: 110-17-8
(2E)-but-2-enedioic acid

Conditions

Conditions	Yield
Dinatriumsalz reagiert.Hydrolysis; l(-)-chlorosuccinic acid;

: 923-06-8, 584-98-5
bromosuccinic acid

: 617-48-1
malic acid

Conditions

Conditions	Yield
With water
With water; silver(l) oxide
With quinoline; water
With TlOH; water

: 923-06-8, 584-98-5
bromosuccinic acid

A: 617-48-1
malic acid

B: 5138-18-1
sulfosuccinic acid

Conditions

Conditions	Yield
With potassium disulphite; water at 100℃;
With potassium disulphite; water at 100℃; inactive sulfosuccinic acid;

: 20629-30-5
iodo-succinic acid

: 617-48-1
malic acid

Conditions

Conditions	Yield
With silver(l) oxide des Lacton entsteht;
With silver(l) oxide des Lacton entsteht;

: 617-48-1
malic acid

: 77-76-9
2,2-dimethoxy-propane

: 114458-03-6
5(R,S)-Carboxymethyl-2,2-dimethyl-4-oxo-1,3-dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid	100%
With pyridinium p-toluenesulfonate at 20℃; for 32h;	90.7%
With toluene-4-sulfonic acid In dichloromethane at 25℃; for 4h;	52.4%

: 617-48-1
malic acid

: 1115-70-4
metformin hydrochloride

: metformin malate (2:1)

Conditions

Conditions	Yield
Stage #1: metformin hydrochloride With sodium hydroxide In water; acetonitrile at 20℃; Stage #2: malic acid In water; acetonitrile at 20℃; Product distribution / selectivity;	100%
Stage #1: metformin hydrochloride With sodium hydroxide In tetrahydrofuran; water at 20℃; Stage #2: malic acid In water; acetone at 20℃; Product distribution / selectivity;	100%
Stage #1: metformin hydrochloride With sodium hydroxide In water; acetonitrile at 20℃; Stage #2: malic acid In water; acetonitrile at 20℃; Product distribution / selectivity;	100%

: 617-48-1
malic acid

: 71125-38-7
meloxicam

: meloxicam:DL-malic acid

Conditions

Conditions	Yield
In tetrahydrofuran for 0.5h;	100%
In tetrahydrofuran Product distribution / selectivity;

: 141-86-6
2,6-Diaminopyridine

: 617-48-1
malic acid

: 1931-44-8
2-amino-8H-7-oxo-[1,8]-naphthyridine

Conditions

Conditions	Yield
With sulfuric acid at 110℃; for 3h; Inert atmosphere; Cooling with ice;	100%
With sulfuric acid at 80 - 90℃; for 3h;	92%
Stage #1: 2.6-diaminopyridine; malic acid With sulfuric acid at 110℃; Inert atmosphere; Cooling with ice; Stage #2: With ammonium hydroxide In water pH=8; Cooling with ice;	87%

: 617-48-1
malic acid

: (2S,4S)-1 [2-[[(3aR,6aS)-5-hydroxy-2-methyl-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-yl]amino]acetyl]-4-fluoro-pyrrolidine-2-carbonitrile

: (2S,4S)-1-[2-[[(3aR,6aS)-5-hydroxy-2-methyl-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-yl]amino]acetyl]-4-fluoro-pyrrolidine-2-carbonitrile hydrogen malate

Conditions

Conditions	Yield
In ethanol; dichloromethane at 20℃; for 2h;	100%

: 617-48-1
malic acid

: 154323-57-6
almotriptan

: 181183-52-8
almotriptan malate

Conditions

Conditions	Yield
In methanol for 1h; Product distribution / selectivity; Reflux;	99.51%
In methanol at 40℃;	93%
In methanol at 20 - 40℃; for 2h; Large scale;	93%

: 617-48-1
malic acid

: 1130137-76-6
(R,Z)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-5-(2-hydroxy-3-morpholin-4-ylpropyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

: 1130138-22-5
(R,Z)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-5-(2-hydroxy-3-morpholin-4-yl-propyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one malate

Conditions

Conditions	Yield
In methanol; water; acetonitrile at 20 - 50℃; Darkness;	99%

: 617-48-1
malic acid

: 11113-50-1
boric acid

: potassium hydroxide

: K[B[malate]2]

Conditions

Conditions	Yield
In water at 95℃;	99%

...Expand

: 446292-08-6
2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

: 617-48-1
malic acid

: 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one malic acid

Conditions

Conditions	Yield
Stage #1: 2-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione With methylamine In ethanol; water at 60℃; for 2h; Stage #2: malic acid In ethanol; water	98.8%

: 141-86-6
2,6-Diaminopyridine

: 617-48-1
malic acid

: 1931-44-8
2-amino-7-hydroxy-1,8-naphthyridine

Conditions

Conditions	Yield
With sulfuric acid at 0 - 120℃; for 12h;	98%
With sulfuric acid at 110℃; for 3h;	97%
With sulfuric acid at 110℃; for 3h; Cooling with ice;	97%

: 141-86-6
2,6-Diaminopyridine

: 617-48-1
malic acid

: 49655-93-8
2,7-dihydroxy-1,8-naphthyridine

Conditions

Conditions	Yield
Stage #1: 2.6-diaminopyridine; malic acid With sulfuric acid at 110℃; Stage #2: With sodium nitrite at 0 - 5℃; Cooling with ice;	98%

: 617-48-1
malic acid

: 107534-96-3
tebuconazole

: (RS)-1-(4-chlorophenyl)-4,4-dimethyl-3-[(1H-1,2,4-triazol-4-ium)-1-ylmethyl]pentan-3-ol malate

Conditions

Conditions	Yield
In methanol at 20℃;	98%

: 617-48-1
malic acid

: 482-20-2, 25908-92-3, 101984-34-3, 111408-21-0
(R)-tylophorine

A: tylophorine malate

B: C4H6O5*C24H27NO4

Conditions

Conditions	Yield
In methanol; dichloromethane at 20℃;	A 98% B 97%

...Expand

: 617-48-1
malic acid

: 1044642-88-7
tegaserod

: 3-(5-methoxy-1H-indol-3-ylmethylene)-N-pentylcarbazimidamide malate

Conditions

Conditions	Yield
In ethanol at 20 - 60℃;	97.6%

: 3-fluoropyridine-2,6-diamine

: 617-48-1
malic acid

: 7-amino-6-fluoro-1,8-naphthyridin-2(1H)-one

Conditions

Conditions	Yield
With sulfuric acid at 115℃; for 1h;	97%

: 25908-92-3
2,3,6,7-Tetramethoxy-9,10,11,12,12a,13-hexahydro-9a-aza-cyclopenta[b]triphenylene

: 617-48-1
malic acid

: 1203657-55-9
NK-007

Conditions

Conditions	Yield
In methanol; chloroform at 40 - 45℃;	97%
In methanol; chloroform	97%
In methanol; chloroform at 40 - 50℃; for 2h; Inert atmosphere;

: 41744-75-6
isostearyl Alcohol

: 617-48-1
malic acid

: diisostearyl malate

Conditions

Conditions	Yield
In n-heptane at 100 - 120℃; for 6h; Inert atmosphere;	97%
In n-heptane at 100 - 120℃; for 8h; Inert atmosphere;	374 g

: 617-48-1
malic acid

: 100-51-6
benzyl alcohol

: 4-(benzyloxy)-2-hydroxy-4-oxobutanoic acid

Conditions

Conditions	Yield
Stage #1: malic acid With trifluoroacetic anhydride at 0℃; for 3h; Inert atmosphere; Stage #2: benzyl alcohol at 20℃; for 4h; Inert atmosphere;	96.7%

: 617-48-1
malic acid

: 110-17-8
(2E)-but-2-enedioic acid

Conditions

Conditions	Yield
	96%
In neat (no solvent) at 200℃; for 4h; Inert atmosphere;	96.6%
at 180℃; for 4h; Temperature; Inert atmosphere;	88%

: 617-48-1
malic acid

: 1044642-88-7
tegaserod

: 3-(5-methoxy-1H-indol-3-ylmethylene)-N-pentylcarbazimidamide hydrogenmalate

Conditions

Conditions	Yield
In isopropyl alcohol at 20 - 75℃; for 20h;	96.3%

: 302-17-0
chloral hydrate

: 617-48-1
malic acid

: 5050-56-6
Chloralide of malic acid

Conditions

Conditions	Yield
With sulfuric acid	96%
With sulfuric acid at 20℃; -chloralide;

: 67-56-1
methanol

: 617-48-1
malic acid

: 38115-87-6
malic acid dimethyl ester

Conditions

Conditions	Yield
With hydroxy-substituted sulfonic acid-functionalized silica (HO-SAS) at 110℃; Fischer-Speier Esterification; Flow reactor;	96%
With acetyl chloride at 20℃; Esterification;	90%
With carbon dioxide at 180℃; under 20686.5 Torr; for 5h;	86.3%

: 617-48-1
malic acid

: 630-19-3
pivalaldehyde

: (2RS,5RS)-5-bromo-2-(1,1-dimethylethyl)-4-oxo-1,3-dioxolane-5-acetic acid

Conditions

Conditions	Yield
With sulfuric acid; toluene-4-sulfonic acid In pentane for 36h; Heating;	96%

: 118-71-8
Maltol

: 617-48-1
malic acid

: 3-hydroxy-2-methyl-4-pyrone/malic acid 1:1 cocrystals

Conditions

Conditions	Yield
In methanol at 64℃; for 1h;	96%

: 617-48-1
malic acid

: 3040-38-8
Acetyl-L-carnitine

: 1351564-17-4
acetyl-L-carnitine malate

Conditions

Conditions	Yield
In ethanol at 0℃; for 2h; Product distribution / selectivity;	95.51%

: 617-48-1
malic acid

: 100-51-6
benzyl alcohol

: 56977-10-7
dibenzyl 2-hydroxysuccinate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 4h; Heating;	95%
With 5-sulfosalicylic Acid In benzene

DL-Malic acid Chemical Properties

The Molecular Structure of DL-Malic acid (CAS NO.617-48-1):

Empirical Formula: C₄H₆O₅
Molecular Weight: 134.0874
IUPAC Name: 2-hydroxybutanedioic acid
Appearance:  white crystalline powder
Nominal Mass: 134 Da
Average Mass: 134.0874 Da
Monoisotopic Mass: 134.021523 Da
Index of Refraction: 1.529
Molar Refractivity: 25.2 cm³
Molar Volume: 81.6 cm³
Surface Tension: 86.2 dyne/cm
Density: 1.641 g/cm³
Flash Point: 153.4 °C
Enthalpy of Vaporization: 63.43 kJ/mol
Boiling Point: 306.4 °C at 760 mmHg
Vapour Pressure: 7.19E-05 mmHg at 25°C
Product Categories: MalicAcidSeries
Solubility methanol: 0.1 g/mL, clear, colorless
Stability: Stable. Incompatible with strong oxidizing agents, strong bases, amines, alkali metals, carbonates
Synonyms: (+/-)-2-Hydroxysuccinic acid ; (+/-)-Hydroxybutanedioic acid ; (+/-)-Hydroxysuccinic acid ; Dl-2-hydroxybutanedioic acid ; Dl-hyroxybutanedioic acid ; Dl-hydroxysuccinic acid ; Dl-hydroxysucoinic acid ; Dl(+/-)-malic acid

DL-Malic acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	50mg/kg (50mg/kg)	"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4937, 1982.
mouse	LD50	oral	1600mg/kg (1600mg/kg)	Kodak Company Reports. Vol. #82-0458,
rat	LD50	intraperitoneal	100mg/kg (100mg/kg)	"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4937, 1982.

LD50/LC50: RTECS:
CAS# 6915-15-7: Draize test, rabbit, eye: 750 ug/24H Severe;
Draize test, rabbit, skin: 20 mg/24H Moderate;
Oral, mouse: LD50 = 1600 mg/kg;
Carcinogenicity: DL-Malic acid - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other: The toxicological properties have not been fully investigated. See actual entry in RTECS for complete information.

DL-Malic acid Safety Profile

Hazard Codes: Harmful Xn
Risk Statements: 22-37/38-41-42/43-34
R22: Harmful if swallowed
R37/38: Irritating to respiratory system and skin
R41: Risk of serious damage to the eyes
R42/43: May cause sensitization by inhalation and skin contact
R34: Causes burns
Safety Statements: 26-39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S39: Wear eye / face protection
WGK Germany: 1
RTECS: ON7175000

DL-Malic acid Specification

Product Categories: MalicAcidSeries
Personal Protection:Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Fire Fighting:Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Product Name

Malic acid

Synthetic route

DL-Malic acid Chemical Properties

DL-Malic acid Toxicity Data With Reference

DL-Malic acid Safety Profile

DL-Malic acid Specification

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