Dichloromethane supplier

Name
Dichloromethane
EINECS 200-838-9
CAS No. 75-09-2
Article Data291
CAS DataBase
Density 1.252 g/cm³
Solubility Water solubility: 20 g/L (20 °C)
Melting Point -97 °C
Formula CH₂Cl₂
Boiling Point 39.6 °C at 760 mmHg
Molecular Weight 84.9329
Flash Point 39-40 °C
Transport Information UN 1593 6.1/PG 3
Appearance colorless liquid
Safety 23-24/25-36/37-45-16-7
Risk Codes 40-39/23/24/25-23/24/25-11
Molecular Structure
Hazard Symbols Xn,T,F
Synonyms Dichloromethane [UN1593] [Poison];methane, dichloro-;Methylene chloride (NF);Aerothene MM;Methylene Chloride;
PSA 0.00000
LogP 1.42150

Synthetic route

: 84101-40-6
tris(cyclopentadienyl)hafnium hydride

A: 75-09-2
dichloromethane

B: ((C5H5)2HfCl)2O*C4H8O

Conditions

Conditions	Yield
With chloroform In toluene under Ar; stirred at 20°C for 5 h; stored overnight at 0-5°C; evaporated, extracted (THF); elem. anal.;	A 57% B 88%

: 540-59-0
1,2-Dichloroethylene

A: 75-09-2
dichloromethane

B: 2504-64-5
1,2-bis(trichlorosilyl)ethane

C: 692-52-4
1,2-bis(trichlorosilyl)ethene

D: 4142-85-2
1,1,1,3,3,3-hexachloro-1,3-disilapropane

Conditions

Conditions	Yield
With hexachlorodisilane at 550℃; for 0.00833333h;	A n/a B n/a C 83% D n/a

...Expand

: 2943-70-6
1,3-bis-dichloromethyl-1,1,3,3-tetramethyl-disiloxane

: 75-09-2
dichloromethane

Conditions

Conditions	Yield
With KOH In water; butan-1-ol heating of (CH3)2(CHCl2)SiOSi(CH3)2(CHCl2) and 10% KOH in n-butanol/H2O at 45°C under reduced pressure;;	78%
With KOH In potassium hydroxide aq. KOH; (CH3)2(CHCl2)SiOSi(CH3)2(CHCl2) and 40% aq. KOH;;
With potassium hydroxide In potassium hydroxide (CH3)2(CHCl2)SiOSi(CH3)2(CHCl2) and 40% aq. KOH;;

: tris(cyclopentadienyl)zirconiumhydride

A: 75-09-2
dichloromethane

B: ((C5H5)2ZrCl)2O*2C4H8O

Conditions

Conditions	Yield
With chloroform In toluene under Ar; excess of CHCl3 added to suspension of Cp3ZrH in PhMe; stirred at about 20°C for 5 h; stored overnight at 0-5°C; evaporated, extracted (THF), filtered; filtrate evapd.; elem. anal.;	A 70% B 42%

: 34557-54-5
methane

A: 75-09-2
dichloromethane

B: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With sulfur dioxide; chlorine at 25℃; under 2250.23 Torr; for 1h; Concentration; Wavelength; Irradiation;	A n/a B 69%

: Schwartz's reagent

A: 1291-32-3
zirconocene dichloride

B: 75-09-2
dichloromethane

Conditions

Conditions	Yield
With chloroform In toluene under Ar; elem. anal.;	A 67% B 43%

: 34557-54-5
methane

A: 56-23-5
tetrachloromethane

B: 74-87-3
methylene chloride

C: 75-09-2
dichloromethane

D: 67-66-3
chloroform

E: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; sulfur dioxide; chlorine at 63 - 67℃; under 6750.68 Torr; Photolysis;	A n/a B n/a C n/a D n/a E 55%

...Expand

: 34557-54-5
methane

A: 75-09-2
dichloromethane

B: 67-66-3
chloroform

C: 124-63-0
methanesulfonyl chloride

Conditions

Conditions	Yield
With sulfur dioxide; chlorine at 65℃; under 2250.23 Torr; for 1h; Temperature; Irradiation;	A n/a B n/a C 54.9%

...Expand

: 56-23-5
tetrachloromethane

A: 75-09-2
dichloromethane

B: 67-66-3
chloroform

Conditions

Conditions	Yield
With tetra-n-butylphosphonium formate In water at -20 - 22℃; for 1.33333h; Reagent/catalyst;	A 26% B 52%
With [RuCl(1-butyl-3-methyl-imidazole)(1,3,5-triaza-7-phosphatricyclo[3.3.1.1]3,7decane)(η6-p-cymene)]Cl; hydrogen; sodium formate In water at 80℃; under 7500.75 Torr; for 2h; Schlenk technique; Sealed tube;	A 12.9% B 29%
With isopropyl alcohol; dimanganese decacarbonyl at 120℃; Product distribution; catalyst and temperature effects;

: 75-11-6
diiodomethane

A: 75-09-2
dichloromethane

B: 593-71-5
Chloroiodomethane

Conditions

Conditions	Yield
With iodine trichloride Product distribution; further iodoalkanes;	A 34% B 50%

: 75-43-4
Dichlorofluoromethane

: 1076-43-3
benzene-d6

: 1188-14-3
Triethylgerman

A: 593-70-4
R32

B: 75-09-2
dichloromethane

C: 35782-14-0
bis-pentadeuteriophenyl-methane

D: 994-28-5
triethylchlorogermane

Conditions

Conditions	Yield
With ACF. Et3GeH In benzene-d6 at 70℃; for 216h; Schlenk technique; Inert atmosphere;	A 50% B 11% C 39% D n/a

...Expand

: 75-77-4
chloro-trimethyl-silane

: 67-66-3
chloroform

A: 75-09-2
dichloromethane

B: 5936-98-1
trichloromethyltrimethylsilane

Conditions

Conditions	Yield
With hexaethylphosphoric triamide In acetonitrile at 20℃; for 144h;	A n/a B 47%

...Expand

: 67-66-3
chloroform

A: 75-09-2
dichloromethane

B: 18171-02-3
(dichlorosilylmethyl)trichlorosilane

C: 4142-85-2
1,1,1,3,3,3-hexachloro-1,3-disilapropane

Conditions

Conditions	Yield
With trichlorosilane at 100℃; for 8h;	A 42% B 5% C 42%

...Expand

: 75-45-6
Chlorodifluoromethane

: 1188-14-3
Triethylgerman

A: 74-87-3
methylene chloride

B: 75-09-2
dichloromethane

C: 75-46-7
trifluoromethan

D: 994-28-5
triethylchlorogermane

Conditions

Conditions	Yield
With ACF. Et3GeH at 25℃; for 72h; Schlenk technique; Inert atmosphere;	A 41% B 32% C 27% D n/a

...Expand

: 67-66-3
chloroform

: 62-53-3
aniline

A: 75-09-2
dichloromethane

B: 1197040-29-1
phenyl isocyanate

C: 1227476-15-4
Azobenzene

D: 101-54-2
N-phenylphenylene-1,4-diamine

E: 534-85-0
N-phenyl-1,2-benzenediamine

F: 79-34-5
1,1,2,2-tetrachloroethane

Conditions

Conditions	Yield
at 15℃; for 24h; Product distribution; Mechanism; Irradiation;	A n/a B 30.2% C 12.5% D 10.5% E 18.4% F n/a

...Expand

: 67-66-3
chloroform

: 1188-14-3
Triethylgerman

A: 74-87-3
methylene chloride

B: 75-09-2
dichloromethane

C: 994-28-5
triethylchlorogermane

Conditions

Conditions	Yield
With ACF. Et3GeH at 70℃; Schlenk technique; Glovebox;	A 22% B n/a C n/a

...Expand

: 75-43-4
Dichlorofluoromethane

: 1188-14-3
Triethylgerman

A: 75-10-5
Difluoromethane

B: 75-09-2
dichloromethane

C: 75-46-7
trifluoromethan

D: 75-45-6
Chlorodifluoromethane

E: 994-28-5
triethylchlorogermane

Conditions

Conditions	Yield
With ACF. Et3GeH at 25℃; for 72h; Schlenk technique; Inert atmosphere;	A n/a B n/a C 22% D 16% E n/a

...Expand

: 66793-25-7
methylenesulfurtetrafluoride

A: 75-09-2
dichloromethane

B: 753-79-7
Methylschwefelpentafluorid

C: 72161-32-1, 119616-12-5
cis-Methylschwefelchloridtetrafluorid

D: 72161-34-3
cis-(Chlormethyl)schwefelchloridtetrafluorid

E SF4: SF4

Conditions

Conditions	Yield
With chlorine In trichlorofluoromethane at -78℃;	A n/a B n/a C n/a D 20% E n/a

...Expand

: 67-66-3
chloroform

: 1076-43-3
benzene-d6

: 1188-14-3
Triethylgerman

A: 75-09-2
dichloromethane

B: 35782-14-0
bis-pentadeuteriophenyl-methane

C: 994-28-5
triethylchlorogermane

Conditions

Conditions	Yield
With ACF. Et3GeH at 70℃; Schlenk technique; Glovebox;	A n/a B 18% C n/a

...Expand

: 34557-54-5
methane

A: 56-23-5
tetrachloromethane

B: 74-87-3
methylene chloride

C: 75-09-2
dichloromethane

D: 67-66-3
chloroform

Conditions

Conditions	Yield
With chlorine for 4h; Product distribution; Ambient temperature; var. catalysts and times;	A 4.8% B 6.5% C 15% D 14%
With molybdenum(V) chloride at 699.9℃; Product distribution; Mechanism; var. time, temp., and transition-metal chlorides; var. methane and argon flow rates;
With copper dichloride In melt at 449.9℃; Kinetics; Product distribution; further temperatures and concentrations;

...Expand

: 56-23-5
tetrachloromethane

: 1188-14-3
Triethylgerman

A: 75-09-2
dichloromethane

B: 67-66-3
chloroform

C: 994-28-5
triethylchlorogermane

Conditions

Conditions	Yield
With ACF. Et3GeH at 70℃; Schlenk technique; Glovebox;	A 8% B n/a C n/a

...Expand

: 56-23-5
tetrachloromethane

: 1076-43-3
benzene-d6

: 1188-14-3
Triethylgerman

A: 75-09-2
dichloromethane

B: 67-66-3
chloroform

C: 35782-14-0
bis-pentadeuteriophenyl-methane

D: 994-28-5
triethylchlorogermane

Conditions

Conditions	Yield
With ACF. Et3GeH at 70℃; Schlenk technique; Glovebox;	A 7% B n/a C 6% D n/a

...Expand

: 37823-96-4
pentacarbonyl(methoxyphenylmethylene)tungsten(0)

A: 127-18-4
1,1,2,2-tetrachloroethylene

B: 74-87-3
methylene chloride

C: 75-09-2
dichloromethane

D: 67-66-3
chloroform

Conditions

Conditions	Yield
In tetrachloromethane byproducts: HCl, Cl2; further products; N2; stirred; gas-chromy., MAS; elem. anal.;	A 6.8% B 2% C 0.2% D 3.6%

...Expand

: 56-23-5
tetrachloromethane

: 75-09-2
dichloromethane

Conditions

Conditions	Yield
With isopropyl alcohol In acetonitrile at 20℃; Reagent/catalyst;
With sodium hydroxide; iron(II) sulfate

: 288-32-4
1H-imidazole

: 75-09-2
dichloromethane

: 84661-56-3
1,1'-bis(imidazolyl)methane

Conditions

Conditions	Yield
With potassium hydroxide; tetrabutylammomium bromide for 13h; Ambient temperature;	100%
With sodium hydroxide; phase transfer catalysis by tetraethylammonium bromide for 16h; Ambient temperature;	96%
With tetrabutylammomium bromide; sodium hydroxide Inert atmosphere; Reflux;	87%

: 613-91-2
acetophenone oxime

: 75-09-2
dichloromethane

: 71516-53-5
1-Phenyl-ethanone O-[1-phenyl-eth-(E)-ylideneaminooxymethyl]-oxime

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate	100%
With 1-butyl-3-methylimidazolium Tetrafluoroborate; sodium hydroxide at 20℃; for 0.5h;	96%
With sodium hydroxide In water for 17.5h;	95%
With sodium hydroxide; trialkyl-methyl-ammonium chloride

: 7126-41-2
3-benzoylpyrrole

: 75-09-2
dichloromethane

: 98258-78-7
[1-(2-Benzoyl-pyrrol-1-ylmethyl)-1H-pyrrol-2-yl]-phenyl-methanone

Conditions

Conditions	Yield
With sodium hydroxide; tetra-(n-butyl)ammonium iodide In dichloromethane for 4h;	100%

: 75-09-2
dichloromethane

: 106-48-9
4-chloro-phenol

: 555-89-5
bis(p-chlorophenoxy)methane

Conditions

Conditions	Yield
With potassium hydroxide; benzyltrimethylammonium chloride In water at 40℃; for 72h;	100%
With potassium hydroxide; benzyltrimethylammonium chloride In dichloromethane at 40℃; for 72h;	100%
Stage #1: 4-chloro-phenol With sodium hydride In 1-methyl-pyrrolidin-2-one Stage #2: dichloromethane In 1-methyl-pyrrolidin-2-one at 40℃; for 9h;	98%
With 1-methyl-pyrrolidin-2-one; sodium hydride at 40℃; for 9h;	98%
With sodium hydroxide; Amberlite IRA-400 (Cl-) 2.) reflux, 15 h; Yield given. Multistep reaction;

: 75-09-2
dichloromethane

: 108-95-2
phenol

: 4442-41-5
diphenoxymethane

Conditions

Conditions	Yield
With potassium hydroxide; octopus-type calixarene at 40℃; for 24h; Product distribution; also with substituted phenols; effect of catalysts poly(ethylene glycol)diethyl ether, poly(ethylene glycol), benzyltrimethylammonium chloride, none; also with water solvent;	100%
With potassium hydroxide; octopus-type calixarene at 40℃; for 24h;	100%
With potassium hydroxide; 5,11,17,23,29,35-Hexa-p-tert-butyl-37,38,39,40,41,42-hexakis-(3,6,9-trioxadecyloxy)calix<6>arene In dichloromethane at 40℃; for 24h;	100%

: 75-09-2
dichloromethane

: 313640-98-1
(2R,3R)-3-(methylamino)-3-phenyl-1,2-propanediol

: (4R,5R)-3-methyl-4-phenyl-1,3-oxazinan-5-ol

Conditions

Conditions	Yield
at 100℃; for 28h; Cyclization;	100%

: 75-09-2
dichloromethane

: 2592-95-2
benzotriazol-1-ol

: 3912-23-0
1-chloromethoxy-1H-benzotriazole

Conditions

Conditions	Yield
at 55℃;	100%

: 75-09-2
dichloromethane

: 109-89-7
diethylamine

: 185316-64-7
2,2-dimethyl-2H-1-benzopyran-6-sulfonyl chloride

: 186181-08-8
N,N-diethyl-2,2-dimethyl-2H-1-benzopyran-6-sulfonamide

Conditions

Conditions	Yield
In water	100%

...Expand

: 75-09-2
dichloromethane

: 117571-35-4
1-(bromomethyl)-4-methyl-2-(phenylmethoxy)benzene

: 117571-36-5
<4-methyl-2-(phenylmethoxy)phenyl>acetonitrile

Conditions

Conditions	Yield
With NaCN; tetrabutylammomium bromide In water	100%

Nα -Boc-L-ornithine: Nα -Boc-L-ornithine

: 75-09-2
dichloromethane

: 394-47-8
2-fluorobenzonitrile

: 159877-02-8
(2S)-2-amino-5-(2-cyanophenylamino)pentanoic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide; acetic acid In ethanol; water	100%

...Expand

: 75-09-2
dichloromethane

: 1575-61-7
5-Chlorovaleroyl chloride

: 21835-63-2
1,4-dihydro-4-(3-aminophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid,dimethyl ester

: 1,4-Dihydro-4-[3-[[5-chloro-1-oxo-1-pentyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid, dimethyl ester

Conditions

Conditions	Yield
In tetrahydrofuran; water; ethyl acetate	100%
In tetrahydrofuran; water; ethyl acetate	100%
In tetrahydrofuran; water; ethyl acetate	100%

...Expand

(CH3)2 AlNH2: (CH3)2 AlNH2

: 75-09-2
dichloromethane

: 163734-89-2
2-bromo-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetic acid phenylmethyl ester

: 164083-06-1
2-bromo-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetamide

Conditions

Conditions	Yield
With hydrogenchloride; aluminium In benzene	100%

...Expand

CH3 I: CH3 I

: 15733-82-1
2-carboxy-4-chloroquinoline

: 75-09-2
dichloromethane

: 7732-18-5
water

: 114935-92-1
Methyl-4-chloroquinaldate

Conditions

Conditions	Yield
With NaH In N,N-dimethyl-formamide	100%

...Expand

: 75-09-2
dichloromethane

: 75-64-9
tert-butylamine

: 5231-87-8
3,4-diethoxy-3-cyclobuten-1,2-dione

: 186184-26-9
3-(1,1-dimethylethylamino)-4-ethoxy-3-cyclobutene-1,2-dione

Conditions

Conditions	Yield
In tetrahydrofuran; methanol	100%

...Expand

: 75-09-2
dichloromethane

: 24424-99-5
di-tert-butyl dicarbonate

: 6-(tert-butyloxycarbonylamino)-1-diethylamino-2-hydroxyhexane

Conditions

Conditions	Yield
	100%

: 142885-90-3
5-METHOXY-2-((3,5-DIMETHYL-4-NITRO-2-PYRIDINYL-N-OXIDE)-METHYLTHIO)-1H-BENZIMIDAZOLE

: 75-09-2
dichloromethane

: 142885-92-5
5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzimidazole

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; sodium methylate In methanol; water	100%

: 186581-53-3, 908094-01-9
diazomethane

: 174487-79-7
methyl α-tert-butoxycarbonylamino-p-carboxymethylphenylacetate

: 75-09-2
dichloromethane

: 174487-81-1
Methyl α-tert-butoxycarbonylamino-p-methoxycarbonylmethylphenylacetate

Conditions

Conditions	Yield
	100%

...Expand

: chloro(1,5-cyclooctadiene)rhodium(I) dimer

: 75-09-2
dichloromethane

: 603-36-1
triphenylantimony

: Rh(C8H12)(Sb(C6H5)3)2Cl*0.5CH2Cl2

Conditions

Conditions	Yield
In ethanol (under Ar, Schlenk); Rh-complex added to refluxing soln. of Sb(C6H5)3 inEtOH; ppt. filtered, washed with CH2Cl2/hexane, dried in vacuo; elem. anal.;	100%

...Expand

: 75-09-2
dichloromethane

: PdCl((OCH3)2C6H3CHNC6H10NCHC6H2(OCH3)2)

: silver perchlorate

: 100-01-6
4-nitro-aniline

: Pd(NH2C6H4NO2)((OCH3)2C6H3CHNC6H10NCHC6H2(OCH3)2)(1+)*ClO4(1-)*0.6CH2Cl2=C30H35N4O6PdClO4*0.6CH2Cl2

Conditions

Conditions	Yield
In acetone byproducts: AgCl; soln. of palladium complex treated with AgClO4 in absence of light; 30 min stirred at room temp.; added to soln. of p-nitroaniline; soln. stirred at room temp. for 30 min; solvent evapd.; oil treated with Et2O; solid pptd.; elem. anal.;	100%

...Expand

: 75-09-2
dichloromethane

: hh-[(p-tolyl)Pt(μ-2-diphenylphosphinopyridine)2PtMe2](trifluoroacetate)*0.7(methylene chloride)

: ht-[(p-tolyl)Pt(μ-2-diphenylphosphinopyridine)2PtMe2](trifluoroacetate)*0.5(methylene chloride)

Conditions

Conditions	Yield
In dichloromethane soln. of Pt complex in CH2Cl2 stored at room temp. for 10 d; solvent evapd.; washed with hexane; elem. anal.;	100%

: 13755-29-8
sodium tetrafluoroborate

: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer

: 75-09-2
dichloromethane

: 486403-20-7
(C6F5)(C6H5)PC6H4SCH3

: [(η5-C5(CH3)5RhCl(C6F5)PhPC6H4SMe-2]BF4

Conditions

Conditions	Yield
In not given Atherton, M. J.; Fawcett, J.; Holloway, J. H.; Hope, E. G.; Karacar, A.;Russell, D. R.; Saunders, G. C. J. Chem. Soc., Dalton Trans. 1996, 321 5; elem. anal.;	100%

...Expand

: 12080-32-9
dichloro( 1,5-cyclooctadiene)platinum(ll)

: 75-09-2
dichloromethane

: 681435-29-0
(bromodifluoromethyl)diphenylphosphine

: cis-[PtCl2(κ1-Ph2PCF2Br)2]*(dichloromethane)

Conditions

Conditions	Yield
In dichloromethane by a react. of Ph2PCF2Br with Pt-contg. compd. at 20°C for 0.2 h; elem. anal.;	100%

...Expand

: 64443-05-6
tetrakis(actonitrile)copper(I) hexafluorophosphate

: 75-09-2
dichloromethane

: 2769-64-4
n-butyl isonitrile

: 1032544-28-7
3,5-bis[bis-(4,5-diphenyl-1-methylimidazol-2-yl)methoxymethyl]pyrazole

: [(3,5-bis[bis-(4,5-diphenyl-1-methylimidazol-2-yl)methoxymethyl]pyrazole-H)Cu2(n-BuNC)]2(PF6)2*3.8CH2Cl2

Conditions

Conditions	Yield
With KOC(CH3)3 In tetrahydrofuran; acetonitrile (N2, glove box) a soln. of Cu-complex in CH3CN was added to a soln. of pyrazole-compound and KOC(CH3)3 in THF, stirred for 15 min, n-butylisocyanide was added, stirred for 20 min; the solvent was removed in vac., the solid was dissolved in CH2Cl2 and filtered; elem. anal.;	100%

...Expand

: 10170-68-0, 16997-54-9
trichlorotris(tetrahydrofuran)chromium(III)

: 75-09-2
dichloromethane

: 1046479-99-5
2,6-bis(1-methylimidazol-2-ylidene)pyridine

: [2,6-bis(1-methylimidazol-2-ylidene)pyridine chromium trichloride]*CH2Cl2

Conditions

Conditions	Yield
In tetrahydrofuran (N2); std. Schlenk technique; soln. of carbene in THF was slowly added to soln. of Cr complex in THF; stirred for 1 h; filtered; washed (THF, CH2Cl2); dried (vac.); elem. anal.;	100%

...Expand

: 75-09-2
dichloromethane

: 1026988-13-5
C39H41N3O4

: 1026988-19-1
C40H43ClN3O4(1+)*Cl(1-)

Conditions

Conditions	Yield
at 25℃; Kinetics;	100%

: 75-09-2
dichloromethane

: Ti(N(CH3)2)2(NC4H3CH2PO(C6H5)2)2

: Ti(N(CH3)2)Cl(NC4H3CH2PO(C6H5)2)2

Conditions

Conditions	Yield
In dichloromethane (N2, Schlenk) a soln. of complex in CH2Cl2 allowed to stand for 2 h; volatiles were removed under vac.; elem. anal.;	100%

: 52462-29-0
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

: 75-09-2
dichloromethane

: 5-diphenylphosphino-17-p-tolyl-25,26,27,28-tetrapropoxycalix[4]arene

: dichlorido-(η6-cymene)-[5-diphenylphosphino-17-(p-tolyl)-25,26,27,28-tetrapropoxycalix[4]arene]ruthenium(II)*0.5(dichloromethane)

Conditions

Conditions	Yield
In dichloromethane (under N2, Schlenk); soln. of Ru-complex in CH2Cl2 added dropwise to soln. of ligand in CH2Cl2, stirred for 1 h; concd., hexane added; elem. anal.;	100%

...Expand

: 616-47-7
1-methyl-1H-imidazole

: 75-09-2
dichloromethane

: 1,1′-methylenebis(3-methyl-1H-imidazol-3-ium) dichloride

Conditions

Conditions	Yield
In chloroform at 60℃; under 14251400 Torr; for 24h; Kinetics; Pressure; Temperature; Menshutkin Reaction; High pressure; Autoclave;	100%
for 0.25h; Microwave irradiation; Reflux;	48%
at 75℃; for 24h;	42.6%

: 75-09-2
dichloromethane

: 1305346-38-6
C30H24O12

: 107-15-3
ethylenediamine

: CH2Cl2*C66H54N6O18(6-)*6Na(1+)

Conditions

Conditions	Yield
With [D]-sodium hydroxide; sodium acetate In water-d2 for 2h; pD >11;	100%

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: 75-09-2
dichloromethane

: trans-bromo(bis(triphenylphosphine))(3-(-)-menthyloxy-3-oxy-1-propinyl)palladium(II)

: 420-37-1
trimethoxonium tetrafluoroborate

: trans-(acetonitrile)(3-(-)-menthyloxy-3-oxy-1-propinyl)palladium(II) tetrafluoroborate dichloromethane sesquisolvate

Conditions

Conditions	Yield
In acetonitrile inert atmosphere, Schlenk technique; soln. of Pd-complex in CH3CN treated at -40 °C with (H3C)3OBF4, stirred at -40 °C for 60 min,warmed to room temp., solvent removed (vac.), recrystd. from petroleum ether/CH2Cl2; elem. anal.;	100%

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Dichloromethane Specification

Basic Information of Dichloromethane:
Dichloromethane (CAS NO.75-09-2) is a colorless liquid with a sweet, penetrating-like ether. If exposed to high temperatures , it may emit toxic chloride fumes. Vapors are narcotic in high concentrations. Used as a solvent and paint remover. It is somewhat soluble in water, subjected to slow hydrolysis which is accelerated by light. It has some kinds of uses. Solvent is the most important use of methylene chloride. Dichloromethane with the dissolving ability, low boiling point and relatively low toxicity, so it has be made as the highest frequency use in organic synthesis. It can be used as extraction solvent, mainly as the extraction of caffeine in coffee beans, besides it can be used as hops, spices oil-resin extraction solvents, pigment thinner, organic synthesis. As a solvent for resins and plastics industry is widely used in pharmaceutical, plastics and film industries.

Physical properties about Dichloromethane are:
(1)ACD/LogP: 1.405; (2)ACD/LogD (pH 5.5): 1.41; (3)ACD/LogD (pH 7.4): 1.41; (4)ACD/BCF (pH 5.5): 6.88; (5)ACD/BCF (pH 7.4): 6.88; (6)ACD/KOC (pH 5.5): 138.38; (7)ACD/KOC (pH 7.4): 138.38; (8)Index of Refraction: 1.398; (9)Molar Refractivity: 16.38 cm³; (10)Molar Volume: 67.812 cm³; (11)Polarizability: 6.494 10-24cm³; (12)Surface Tension: 23.1989994049072 dyne/cm; (13)Density: 1.252 g/cm³; (14)Flash Point: -14.127 °C; (15)Enthalpy of Vaporization: 28.06 kJ/mol; (16)Boiling Point: 39.639 °C at 760 mmHg; (17)Vapour Pressure: 448.006011962891 mmHg at 25°C

Preparation of Dichloromethane:
Dichloromethane is produced by treating either methyl chloride or methane with chlorine gas at 400–500 °C. At these temperatures, both methane and methyl chloride undergo a series of reactions producing progressively more chlorinated products.
CH₄ + Cl₂→ CH₃Cl + HCl
CH₃Cl + Cl₂ → CH₂Cl₂ + HCl
CH₂Cl₂ + Cl₂ → CHCl₃ + HCl
CHCl₃+ Cl₂ → CCl₄ + HCl
The output of these processes is a mixture of methyl chloride, dichloromethane, chloroform, and carbon tetrachloride. These compounds are separated by distillation.

Uses of Dichloromethane:
DCM's volatility and ability to dissolve a wide range of organic compounds makes it a useful solvent for many chemical processes. Concerns about its health effects have led to a search for alternatives in many of these applications. It is widely used as a paint stripper and a degreaser. In the food industry, it has been used to decaffeinate coffee and tea as well as to prepare extracts of hops and other flavorings.[2] Its volatility has led to its use as an aerosol spray propellant and as a blowing agent for polyurethane foams.

You can still convert the following datas into molecular structure:
(1)InChI=1S/CH2Cl2/c2-1-3/h1H2;
(2)InChIKey=YMWUJEATGCHHMB-UHFFFAOYSA-N;
(3)Smiles=C(Cl)Cl;

The toxicity data of Dichloromethane is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	1329ug/kg/31D (1.329mg/kg)	LIVER: LIVER FUNCTION TESTS IMPAIRED	American Journal of Gastroenterology. Vol. 83, Pg. 576, 1988.
man	TDLo	oral	21mg/kg/26W-I (21mg/kg)	PERIPHERAL NERVE AND SENSATION: FASCICULATIONS	Postgraduate Medical Journal. Vol. 63, Pg. 311, 1987.
mouse	LD50	intraperitoneal	13300mg/kg (13300mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 811, 1980.
mouse	LD50	intravenous	> 18mg/kg (18mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 811, 1980.
mouse	LD50	oral	2gm/kg (2000mg/kg)		Polish Journal of Pharmacology and Pharmacy. Vol. 35, Pg. 77, 1983.
mouse	LD50	subcutaneous	> 10gm/kg (10000mg/kg)		Drugs in Japan Vol. 6, Pg. 235, 1982.
rat	LD50	intraperitoneal	14200mg/kg (14200mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 11, Pg. 811, 1980.
rat	LD50	oral	> 15gm/kg (15000mg/kg)		Drugs in Japan Vol. 6, Pg. 235, 1982.
rat	LD50	subcutaneous	> 10gm/kg (10000mg/kg)		Drugs in Japan Vol. 6, Pg. 235, 1982.

Product Name

Dichloromethane

Synthetic route

Dichloromethane Specification

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