Diethyl oxalacetate supplier

Name
Diethyl oxalacetate
EINECS 203-594-1
CAS No. 108-56-5
Article Data47
CAS DataBase
Density 1.143 g/cm³
Solubility Insoluble in water
Melting Point <25 °C
Formula C₈H₁₂O₅
Boiling Point 254.223 °C at 760 mmHg
Molecular Weight 188.18
Flash Point 106.406 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Butanedioicacid, oxo-, diethyl ester (9CI);Oxalacetic acid, diethyl ester (6CI,7CI,8CI);2-Oxobutanedioic acid diethyl ester;Diethyl 2-oxosuccinate;Diethyl oxobutanedioate;Diethyloxosuccinate;NSC 68476;Oxalacetic ester;
PSA 72.83000
LogP 0.55450

Synthetic route

: 40876-98-0, 88330-76-1, 125898-38-6
sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate

: 108-56-5
diethyl oxaloacetate

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether; water	83%

: 141-78-6
ethyl acetate

: 95-92-1
oxalic acid diethyl ester

: 108-56-5
diethyl oxaloacetate

Conditions

Conditions	Yield
Stage #1: oxalic acid diethyl ester With sodium ethanolate In benzene at 0℃; Inert atmosphere; Stage #2: ethyl acetate In benzene at 0 - 20℃; for 14.5h; Inert atmosphere;	74%
With diethyl ether; sodium ethanolate Behandeln in Wasser mit verduennter Schwefelsaeure in Gegenwart von Aether;
With diethyl ether; sodium Behandeln in Wasser mit verduennter Schwefelsaeure in Gegenwart von Aether;

: 762-21-0
acetylenedicarboxylic acid diethyl ester

: 108-56-5
diethyl oxaloacetate

Conditions

Conditions	Yield
With water; platinum(II) chloride In methanol at 60℃;	42%

: 463-51-4
Ketene

: 79-37-8
oxalyl dichloride

: 108-56-5
diethyl oxaloacetate

Conditions

Conditions	Yield
With chloroform at 65℃; Behandeln des Reaktionsprodukts mit Aethanol.;

: 19064-79-0
Acetoxymaleinsaeureanhydrid

: 64-17-5
ethanol

A: 141-78-6
ethyl acetate

B: 108-56-5
diethyl oxaloacetate

...Expand

: 19064-79-0
Acetoxymaleinsaeureanhydrid

: 64-17-5
ethanol

: 108-56-5
diethyl oxaloacetate

: 2409-52-1
diethylitaconate

: 108-56-5
diethyl oxaloacetate

Conditions

Conditions	Yield
bei der Ozonspaltung;

: 60-29-7
diethyl ether

: 141-52-6
sodium ethanolate

: 141-78-6
ethyl acetate

: 95-92-1
oxalic acid diethyl ester

: 108-56-5
diethyl oxaloacetate

...Expand

: 64-17-5
ethanol

: 141-52-6
sodium ethanolate

: 141-78-6
ethyl acetate

: 95-92-1
oxalic acid diethyl ester

: 108-56-5
diethyl oxaloacetate

...Expand

: 463-51-4
Ketene

: 67-66-3
chloroform

: 4755-77-5
Ethyl oxalyl chloride

A: 108153-39-5
4,6-dioxo-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester

B: 95-92-1
oxalic acid diethyl ester

C: 108-56-5
diethyl oxaloacetate

Conditions

Conditions	Yield
anschliessenden Erwaermen mit Aethanol;

...Expand

: 463-51-4
Ketene

: 4755-77-5
Ethyl oxalyl chloride

: 108-56-5
diethyl oxaloacetate

Conditions

Conditions	Yield
With sulfur dioxide at 65℃; Behandeln des Reaktionsprodukts mit Aethanol.;

: 141-52-6
sodium ethanolate

: 95-92-1
oxalic acid diethyl ester

: 15301-37-8, 67556-07-4, 67556-08-5
3-ethoxycarbonyl-3-penten-2-one

A: 74744-72-2
hydroxy-terephthalic acid diethyl ester

B: 108-56-5
diethyl oxaloacetate

...Expand

: 95-92-1
oxalic acid diethyl ester

: 15301-37-8, 67556-07-4, 67556-08-5
3-ethoxycarbonyl-3-penten-2-one

A: 74744-72-2
hydroxy-terephthalic acid diethyl ester

B: 108-56-5
diethyl oxaloacetate

Conditions

Conditions	Yield
With ethanol; sodium ethanolate

...Expand

: 16493-86-0
Dichlormethylenbrenztraubensaeureaethylester; Dichlorvinylglyoxylsaeureaethylester

: 141-52-6
sodium ethanolate

: 108-56-5
diethyl oxaloacetate

Conditions

Conditions	Yield
In ethanol

: 87670-07-3
2-[(E)-1-Methyl-2-phenyl-ethylimino]-succinic acid diethyl ester

A: 51-64-9
dexamfetamine

B: 156-34-3
l-amphetamine

C: 108-56-5
diethyl oxaloacetate

Conditions

Conditions	Yield
With sulfuric acid In water for 2h; Ambient temperature; Yield given;

...Expand

: 87670-11-9
2-[(E)-1-Phenyl-ethylimino]-succinic acid diethyl ester

A: 2627-86-3
(S)-1-phenyl-ethylamine

B: 3886-69-9
(R)-1-phenyl-ethyl-amine

C: 108-56-5
diethyl oxaloacetate

Conditions

Conditions	Yield
With sulfuric acid In water for 2h; Ambient temperature; Yield given;

...Expand

itaconic acid ethyl ester: itaconic acid ethyl ester

: 108-56-5
diethyl oxaloacetate

Conditions

Conditions	Yield
Ozonolyse;

: 463-51-4
Ketene

: 4755-77-5
Ethyl oxalyl chloride

liquid sulfur dioxide: liquid sulfur dioxide

: 108-56-5
diethyl oxaloacetate

Conditions

Conditions	Yield
anschliessenden Behandeln mit Aethanol;

...Expand

: 60-29-7
diethyl ether

: 141-78-6
ethyl acetate

: 95-92-1
oxalic acid diethyl ester

sodium: sodium

: 108-56-5
diethyl oxaloacetate

...Expand

: 64-17-5
ethanol

: 141-52-6
sodium ethanolate

: 141-78-6
ethyl acetate

: 95-92-1
oxalic acid diethyl ester

A: 108-56-5
diethyl oxaloacetate

B oxalcitric acid lactonetriethyl ester: oxalcitric acid lactonetriethyl ester

C α-pyrone-tricarboxylic acid-(4.5.6)-triethyl ester: α-pyrone-tricarboxylic acid-(4.5.6)-triethyl ester

...Expand

: 60-29-7
diethyl ether

: 141-78-6
ethyl acetate

: 95-92-1
oxalic acid diethyl ester

sodium: sodium

A: 108-56-5
diethyl oxaloacetate

B oxalcitric acid lactonetriethyl ester: oxalcitric acid lactonetriethyl ester

C α-pyrone-tricarboxylic acid-(4.5.6)-triethyl ester: α-pyrone-tricarboxylic acid-(4.5.6)-triethyl ester

...Expand

: 463-51-4
Ketene

: 79-37-8
oxalyl dichloride

liquid sulfur dioxide: liquid sulfur dioxide

A: 3249-69-2
3,4-dioxo-hexanedicarboxylic acid diethyl ester

B: 108-56-5
diethyl oxaloacetate

Conditions

Conditions	Yield
Behandeln des Reaktionsprodukts mit Aethanol;

...Expand

: 64-17-5
ethanol

: 52604-04-3
imino-succinic acid diethyl ester

: 142-71-2
copper diacetate

: 64-19-7
acetic acid

A: 7664-41-7
ammonia

B: 108-56-5
diethyl oxaloacetate

...Expand

: 114352-39-5
acetoxy-hydroxy-fumaric acid diethyl ester

air: air

aqueous solutions of pH > 11: aqueous solutions of pH > 11

A: 144-62-7
oxalic acid

B: 108-56-5
diethyl oxaloacetate

...Expand

: 7647-01-0
hydrogenchloride

: bis-(1,2-bis-ethoxycarbonyl-ethylidene)-guanidine

A: 113-00-8
guanidine nitrate

B: 108-56-5
diethyl oxaloacetate

...Expand

: bis-(1,2-bis-ethoxycarbonyl-ethylidene)-guanidine

: 7664-41-7
ammonia

A: 113-00-8
guanidine nitrate

B: 108-56-5
diethyl oxaloacetate

...Expand

: 3-cyano-propene-1,2,3-tricarboxylic acid triethyl ester

: 10028-15-6
ozone

: 141-78-6
ethyl acetate

A: 924-44-7
glyoxylic acid ethyl ester

B: 108-56-5
diethyl oxaloacetate

C oxalcyanoacetic acid diethyl ester: oxalcyanoacetic acid diethyl ester

Conditions

Conditions	Yield
man erhaelt der Oxalessigester infolge des α-Cyan-aconitsaeure-triaethylester-Gehalts;

...Expand

: 13552-87-9
L-aspartic acid diethyl ester

A: 108-56-5
diethyl oxaloacetate

B bromoethoxycarbonylmethylene-4-nitro-phenylhydrazine: bromoethoxycarbonylmethylene-4-nitro-phenylhydrazine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: benzene / 72 h / Heating 2: H2 / 5percent palladium on charcoal / ethanol / 16 h / Ambient temperature 3: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C 4: sodium ethoxide / ethanol / 1 h / 40 °C 5: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme
Multi-step reaction with 5 steps 1: benzene / 48 h / Heating 2: H2 / 5percent palladium on charcoal / ethanol / 16 h / Ambient temperature 3: tert-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C 4: sodium ethoxide / ethanol / 1 h / 40 °C 5: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme

: 87669-86-1, 87669-99-6
C16H22ClNO4

A: 108-56-5
diethyl oxaloacetate

B bromoethoxycarbonylmethylene-4-nitro-phenylhydrazine: bromoethoxycarbonylmethylene-4-nitro-phenylhydrazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium ethoxide / ethanol / 1 h / 40 °C 2: 5percent sulfuric acid / H2O / 2 h / Ambient temperature View Scheme

: 55243-15-7
aminopyridin-2-ylacetic acid ethyl ester

: 108-56-5
diethyl oxaloacetate

: ethyl 3-(1'-ethoxycarbonylimidazo<1,5-a>pyrid-3'-yl)-2-oxopropionate

Conditions

Conditions	Yield
for 7h; Heating;	8%

: 143-37-3
acetamidine

: 108-56-5
diethyl oxaloacetate

: ethyl 2-methyl-6-oxo-1H-pyrimidine-4-carboxylate

Conditions

Conditions	Yield
In ethanol for 16h; Heating;	10%

: 63149-33-7
9-formyl-8-hydroxyjulolidine

: 108-56-5
diethyl oxaloacetate

: 118043-79-1
Oxo-(10-oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracen-9-yl)-acetic acid ethyl ester

Conditions

Conditions	Yield
With piperidine In acetonitrile for 120h; Heating;	12%

: 3373-59-9
L-threonine methyl ester

: 108-56-5
diethyl oxaloacetate

: 139370-60-8
diethyl 2-N-(2-hydroxy-1-methoxycarbonylpropylamino)but-2-enedioate

Conditions

Conditions	Yield
With sodium sulfate In dichloromethane for 65h; Ambient temperature;	13%

: 5-amino-1,2,3,6-tetramethylindole

: 108-56-5
diethyl oxaloacetate

: diethyl (5-amino-1,2,3,6-tetramethyl-1H-indolyl)fumarate

Conditions

Conditions	Yield
With acetic acid In benzene for 64h; Heating;	16%

: 100568-22-7
5,5-dimethyl-6-hydrazino-4,5-dihydro-2H-pyridazin-3-one

: 108-56-5
diethyl oxaloacetate

: diethyl 2-[(1,4,5,6-tetrahydro-4,4-dimethyl-6-oxo-3-pyridazinyl)hydrazono]butanedioate

Conditions

Conditions	Yield
In ethanol at 20℃; for 120h;	17%

: 1027104-24-0
[2,4,5,6-2H4]3-chloroaniline

: 108-56-5
diethyl oxaloacetate

: 1,4-diethyl (2E)-2-[[3-chloro(2H4)phenyl]imino]butanedioate

Conditions

Conditions	Yield
In acetic acid at 45℃;	17%

: 7570-49-2
5-amino-2-methylindole

: 108-56-5
diethyl oxaloacetate

: diethyl (5-amino-2-methyl-1H-indolyl)fumarate

Conditions

Conditions	Yield
With acetic acid In benzene for 50h; Heating;	19%

: 78-95-5
chloroacetone

: 108-56-5
diethyl oxaloacetate

: 267876-32-4
ethyl 3-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate

Conditions

Conditions	Yield
Stage #1: chloroacetone; diethyl oxaloacetate With ammonia In tetrahydrofuran for 0.666667h; Stage #2: With aluminum (III) chloride In tetrahydrofuran at 23℃; for 96h;	19%

: 13750-16-8
Dimethylaminoguanidin*HBr

: 108-56-5
diethyl oxaloacetate

: 112080-99-6
3-Dimethylamino-5-oxo-dihydro-1,2,4-triazin-6-yl-essigsaeureethylester

Conditions

Conditions	Yield
With sodium acetate In ethanol for 12h; Heating;	20%

: 5-amino-1,6-dimethyl-2-phenylindole

: 108-56-5
diethyl oxaloacetate

: diethyl (5-amino-1,6-dimethyl-2-phenyl-1H-indolyl)fumarate

Conditions

Conditions	Yield
With acetic acid In benzene for 40h; Heating;	20%

: 108-56-5
diethyl oxaloacetate

: 748799-33-9
5-amino-1-methyl-2-phenylindole

: diethyl (5-amino-1-methyl-2-phenyl-1H-indolyl)fumarate

Conditions

Conditions	Yield
With acetic acid In benzene for 61h; Heating;	21%

: 5350-93-6
6-Chloro-pyridin-3-ylamine

: 108-56-5
diethyl oxaloacetate

: 53241-89-7
(6-chloro-pyridin-3-ylamino)-butenedioic acid diethyl ester

Conditions

Conditions	Yield
at 90℃; for 7h;	21%

: 1121-60-4
pyridine-2-carbaldehyde

: 108-56-5
diethyl oxaloacetate

: 109694-41-9
diethyl 2,5-di(pyridin-2-yl)-1H-pyrrole-3,4-dicarboxylate

Conditions

Conditions	Yield
With ammonium acetate In ethanol Reflux;	22%

: 6-methyl-2-phenyl-1H-indol-5-ylamine

: 108-56-5
diethyl oxaloacetate

: 2-(6-methyl-2-phenyl-1H-indol-5-ylamino)-but-2-enedioic acid diethyl ester

Conditions

Conditions	Yield
With acetic acid In benzene for 33h; Heating;	23%

: 70254-43-2, 70254-44-3
4-Hydroxy-2-quinolone

: 108-56-5
diethyl oxaloacetate

: 94192-47-9
2,5-Dioxo-5,6-dihydro-2H-pyrano<3,2-c>quinolinyl-4-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With ammonium acetate In nitrobenzene at 220℃; for 0.5h;	25%

: 3-chloro(2,4,6-2H3)aniline

: 108-56-5
diethyl oxaloacetate

: 1,4-diethyl (2E)-2-[[3-chloro(2,4,6-2H3)phenyl]imino]butanedioate

Conditions

Conditions	Yield
In toluene at 45℃; for 6h;	26%

: 106-49-0
p-toluidine

: 2043-61-0
cyclohexanecarbaldehyde

: 108-56-5
diethyl oxaloacetate

: 512178-20-0
ethyl 2-cyclohexyl-4-hydroxy-5-oxo-1-(4-methylphenyl)-2,5-dihydro-1H-pyrrole-3-carboxylate

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	26%

...Expand

: 135855-58-2
2,3-dimethyl-5-amino-6-methoxyindole

: 108-56-5
diethyl oxaloacetate

: diethyl (5-amino-6-methoxy-2,3-dimethyl-1H-indolyl)fumarate

Conditions

Conditions	Yield
With acetic acid In benzene for 29h; Heating;	27%

: 135855-64-0
2,3-dimethyl-4-aminoindole

: 108-56-5
diethyl oxaloacetate

: [(2,3-dimethyl-1H-indol-4-yl)amino]fumaric acid diethyl ester

Conditions

Conditions	Yield
With acetic acid In benzene for 44h; Heating;	27%

: 555-16-8
4-nitrobenzaldehdye

: 62-53-3
aniline

: 108-56-5
diethyl oxaloacetate

: 131189-27-0
ethyl 4‑hydroxy‑2‑(4‑nitrophenyl)‑5‑oxo‑1‑phenyl‑2,5‑dihydro‑1H‑pyrrole‑3‑carboxylate

Conditions

Conditions	Yield
In methanol; ethanol for 24h; Ambient temperature;	28%

...Expand

: 100-52-7
benzaldehyde

: 106-49-0
p-toluidine

: 108-56-5
diethyl oxaloacetate

: 147298-51-9
ethyl 4-hydroxy-5-oxo-2-phenyl-1-(p-tolyl)-2,5-dihydro-1H-pyrrole-3-carboxylate

Conditions

Conditions	Yield
In ethanol at 20℃; for 24h;	28%

...Expand

: 100-52-7
benzaldehyde

: 100-01-6
4-nitro-aniline

: 108-56-5
diethyl oxaloacetate

: 131189-28-1
ethyl 4-hydroxy-1-(4-nitrophenyl)-5-oxo-2-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylate

Conditions

Conditions	Yield
In methanol; ethanol for 240h; Ambient temperature;	30%

...Expand

: 100-52-7
benzaldehyde

: 106-40-1
4-bromo-aniline

: 108-56-5
diethyl oxaloacetate

: 139325-41-0
ethyl 1-(4-bromophenyl)-2,5-dihydro-4-hydroxy-5-oxo-2-phenyl-1H-pyrrole-3-carboxylate

Conditions

Conditions	Yield
In ethanol at 20℃; for 24h;	30%

...Expand

: 1867-38-5
4-chlorobenzylidenemalonodinitrile

: 108-56-5
diethyl oxaloacetate

: 77151-43-0
6-Amino-4-(4-chloro-phenyl)-5-cyano-4H-pyran-2,3-dicarboxylic acid diethyl ester

Conditions

Conditions	Yield
With morpholine In ethanol for 0.5h; Ambient temperature;	30%

: 123-11-5
4-methoxy-benzaldehyde

: 62-53-3
aniline

: 108-56-5
diethyl oxaloacetate

: 131189-26-9
ethyl 4‑hydroxy‑2‑(4‑methoxyphenyl)‑5‑oxo‑1‑phenyl‑2,5‑dihydro‑1H‑pyrrole‑3‑carboxylate

Conditions

Conditions	Yield
In methanol; ethanol for 72h; Ambient temperature;	33%

...Expand

: 138842-45-2
2-methyl-4-nitro-3-isoxazolin-5(2H)-one

: 108-56-5
diethyl oxaloacetate

: 2,3-bis(ethoxycarbonyl)-1-methyl-4-nitropyrrole

Conditions

Conditions	Yield
Stage #1: diethyl oxaloacetate With sodium In ethanol Stage #2: 2-methyl-4-nitro-3-isoxazolin-5(2H)-one In pyridine at 0 - 20℃; for 5h; Stage #3: With ammonium chloride In ethanol at 80℃; for 10h; Further stages.;	33%

: 1904-31-0
methyl-1 amino-3 pyrazole

: 108-56-5
diethyl oxaloacetate

A: 4-ethoxycarbonyl-2-methyl-2H-pyrazolo<3,4-b>pyridin-6(7H)-one

B: 3-amino-4-(1,2-bis-ethoxycarbonylvinyl)-1-methylpyrazole

C: 3-(1,2-bis-ethoxycarbonylvinylamino)-1-methylpyrazole

D: ethyl α-(3-amino-1-methyl-4-pyrazolyl)-β-acrylate

Conditions

Conditions	Yield
Ambient temperature;	A 33.1% B 5.9% C 32.9% D 20.5%

...Expand

: 16712-58-6
5-amino-2,3-dimethylindole

: 108-56-5
diethyl oxaloacetate

: diethyl (5-amino-2,3-dimethyl-1H-indolyl)fumarate

Conditions

Conditions	Yield
With acetic acid In benzene for 30h; Heating;	34%

: N,N,N-(ferrocenylmethyl)trimethylammonium iodide

: 108-56-5
diethyl oxaloacetate

: (C10H9FeCH2)2C(COOC2H5)COCOOC2H5

Conditions

Conditions	Yield
In N,N-dimethyl-formamide boiling;	35%
In N,N-dimethyl-formamide boiling;	35%

Diethyl oxalacetate Specification

The Diethyl oxalacetate with cas registry number of 108-56-5, has the systematic name of diethyl 2-oxobutanedioate. And its IUPAC name is the same one. Besides this, it is also named Butanedioic acid, oxo-, diethyl ester.

Physical properties about this chemical are: (1)ACD/LogP: 0.68; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.68; (4)ACD/LogD (pH 7.4): 0.59; (5)ACD/BCF (pH 5.5): 1.93; (6)ACD/BCF (pH 7.4): 1.56; (7)ACD/KOC (pH 5.5): 55.65; (8)ACD/KOC (pH 7.4): 44.95; (9)#H bond acceptors: 5; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 69.67 Å²; (13)Index of Refraction: 1.431; (14)Molar Refractivity: 42.69 cm³; (15)Molar Volume: 164.6 cm³; (16)Polarizability: 16.92×10^-24cm³; (17)Surface Tension: 36.5 dyne/cm; (18)Enthalpy of Vaporization: 49.16 kJ/mol; (19)Vapour Pressure: 0.0175 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(C(=O)OCC)CC(=O)OCC;
(2)InChI: InChI=1/C8H12O5/c1-3-12-7(10)5-6(9)8(11)13-4-2/h3-5H2,1-2H3;
(3)InChIKey: JDXYSCUOABNLIR-UHFFFAOYAC;
(4)Std. InChI: InChI=1S/C8H12O5/c1-3-12-7(10)5-6(9)8(11)13-4-2/h3-5H2,1-2H3;
(5)Std. InChIKey: JDXYSCUOABNLIR-UHFFFAOYSA-N

Product Name

Diethyl oxalacetate

Synthetic route

Diethyl oxalacetate Specification

Related Products

Hot Products