Diphosgene supplier | CasNO.503-38-8

Name
Diphosgene
EINECS 207-965-9
CAS No. 503-38-8
Article Data25
CAS DataBase
Density 1.64
Solubility may decompose
Melting Point -57 ºC
Formula C2Cl4 O2
Boiling Point 128 ºC
Molecular Weight 197.833
Flash Point >110°C
Transport Information UN 1076/3277
Appearance clear, colorless liquid
Safety Low toxicity by inhalation. A corrosive liquid. When heated to decomposition it emits toxic vapors of Cl⁻.
Risk Codes R26/27/28;R34
Molecular Structure
Hazard Symbols
Synonyms Formicacid, chloro-, trichloromethyl ester (6CI,7CI,8CI); Methanol, trichloro-,chloroformate (8CI); Diphosgen; Diphosgene; Trichloromethyl chlorocarbonate;Trichloromethyl chloroformate
PSA 26.30000
LogP 2.68950

Synthetic route

: 79-22-1
methyl chloroformate

: 503-38-8
trichloromethyl chloroformate

Conditions

Conditions	Yield
With chlorine at 75 - 85℃; for 35h;	84%
bei Chlorierung im Sonnenlicht;
bei der Chlorierung schliesslich;
bei der Chlorierung im UV-Licht; die Bildungsgeschwindigkeit waechst mit steigender Temperatur bis 110-112grad;
beim Chlorieren im Sonnenlicht;

: 22128-62-7
carbonochloridic acid, chloromethyl ester

A: 22128-63-8
dichloromethoxycarbonyl chloride

B: 503-38-8
trichloromethyl chloroformate

Conditions

Conditions	Yield
With chlorine for 61h;	A 76% B n/a
With chlorine for 61h; Yields of byproduct given;

: 107-31-3
Methyl formate

A: 22128-63-8
dichloromethoxycarbonyl chloride

B: 22128-62-7
carbonochloridic acid, chloromethyl ester

C: 503-38-8
trichloromethyl chloroformate

Conditions

Conditions	Yield
Bei der Chlorierung im Licht;
With oxygen; chlorine at 22.85℃; Kinetics; Further Variations:; Reagents;

...Expand

: 107-31-3
Methyl formate

: 503-38-8
trichloromethyl chloroformate

Conditions

Conditions	Yield
bei der Chlorierung im UV-Licht; die Bildungsgeschwindigkeit waechst mit steigender Temperatur bis 110-112grad;
beim Chlorieren im Sonnenlicht;
With diacetyl peroxide; chlorine at 60℃; unter Ausschluss von Licht;
durch photochemische Chlorierung;
With chlorine im Licht einer Metallfadenlampe;

: 32315-10-9
bis(trichloromethyl) carbonate

: 503-38-8
trichloromethyl chloroformate

: 32315-10-9
bis(trichloromethyl) carbonate

A: 75-44-5
phosgene

B: 503-38-8
trichloromethyl chloroformate

Conditions

Conditions	Yield
beim Destillieren;
beim Destillieren;
With chloride In hexane at 20℃; Kinetics;
distn. or warming at reflux cooling;

: 107-31-3
Methyl formate

: 7782-50-5
chlorine

: 503-38-8
trichloromethyl chloroformate

Conditions

Conditions	Yield
mit ueberschuessigem Chlor;
im Sonnenlicht entsteht zunaechst Chlorameisensaeuremethylester;
mit ueberschuessigem Chlor;

: 20332-16-5
4,5-methylenedioxyanthranilic acid

: 503-38-8
trichloromethyl chloroformate

: 57385-14-5
1,3-dioxolo<4,5-g><3,1>benzoxazine-6,8(5H)dione

Conditions

Conditions	Yield
In 1,4-dioxane for 6h; Heating;	100%

: 64987-77-5
2-(2-nitrophenyl)propanol

: 503-38-8
trichloromethyl chloroformate

: 179691-31-7
2-(2-nitrophenyl)propyl chloroformate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%
With triethylamine In tetrahydrofuran 1.) 0 deg C, 30 min, 2.) room temperature, 2 h;	96%
Yield given;
With triethylamine In tetrahydrofuran at 0 - 20℃; for 3.75h;
With 4-methyl-morpholine In tetrahydrofuran

: 73670-87-8
(E)-hexa-3,5-dien-1-ol

: 503-38-8
trichloromethyl chloroformate

: C7H9ClO2

Conditions

Conditions	Yield
With pyrographite In tetrahydrofuran at 20℃; for 3h;	100%

: 335201-57-5
2-(5-bromo-2-nitrophenyl)propan-1-ol

: 503-38-8
trichloromethyl chloroformate

: 335201-61-1
2-(5-bromo-2-nitrophenyl)propyl carbonochloridate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%
In tetrahydrofuran; triethylamine at 0℃; for 1h;	99%

: 611-71-2, 611-72-3, 17199-29-0, 90-64-2
MANDELIC ACID

: 503-38-8
trichloromethyl chloroformate

: 42783-36-8
(d)-5-phenyl-1,3-dioxolan-2,4-dione

Conditions

Conditions	Yield
With pyrographite In tetrahydrofuran at 20℃; for 8h;	100%

: 7138-34-3, 32189-36-9, 76496-63-4, 492-86-4
p-chloromandelic acid

: 503-38-8
trichloromethyl chloroformate

: 5-(4-chloro-phenyl)-[1,3]dioxolane-2,4-dione

Conditions

Conditions	Yield
With pyrographite In tetrahydrofuran at 20℃; for 8h;	100%

: 6940-50-7
4-bromo-DL-mandelic acid

: 503-38-8
trichloromethyl chloroformate

: 5-(4-bromo-phenyl)-[1,3]dioxolane-2,4-dione

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 8h;	100%

: 6341-54-4
1-naphthylglycolic acid

: 503-38-8
trichloromethyl chloroformate

: 5-naphthalen-1-yl-[1,3]dioxolane-2,4-dione

Conditions

Conditions	Yield
With pyrographite In tetrahydrofuran at 20℃; for 8h;	100%

: 828-01-3
phenyllactic acid

: 503-38-8
trichloromethyl chloroformate

: 421545-77-9
5-benzyl-1,3-dioxolane-2,4-dione

Conditions

Conditions	Yield
With pyrographite In tetrahydrofuran at 20℃; for 8h;	100%

: 32222-45-0, 52923-25-8, 52950-15-9, 395-33-5
4-fluoromandelic acid

: 503-38-8
trichloromethyl chloroformate

: 5-(4-fluorophenyl)-1,3-dioxolane-2,4-dione

Conditions

Conditions	Yield
With pyrographite In tetrahydrofuran at 20℃; for 8h;	100%

: 10421-85-9, 52923-23-6, 52950-18-2, 52950-19-3
2-chloromandelic acid

: 503-38-8
trichloromethyl chloroformate

: 5-(2-chloro-phenyl)-[1,3]dioxolane-2,4-dione

Conditions

Conditions	Yield
With pyrographite In tetrahydrofuran at 20℃; for 8h;	100%

: 4263-93-8
2-hydroxy-4-phenylbutanoic acid

: 503-38-8
trichloromethyl chloroformate

: 5-phenethyl-[1,3]dioxolane-2,4-dione

Conditions

Conditions	Yield
With pyrographite In tetrahydrofuran at 20℃; for 8h;	100%

: 4607-63-0
4-isopropylmandelic acid

: 503-38-8
trichloromethyl chloroformate

: 421545-72-4
5-(4-isopropyl-phenyl)-[1,3]dioxolane-2,4-dione

Conditions

Conditions	Yield
With pyrographite In tetrahydrofuran at 20℃; for 8h;	100%

: 395-35-7
4-(trifluoromethyl)mandelic acid

: 503-38-8
trichloromethyl chloroformate

: 5-(4-trifluoromethyl-phenyl)-[1,3]dioxolane-2,4-dione

Conditions

Conditions	Yield
With pyrographite In tetrahydrofuran at 20℃; for 8h;	100%

: 2-(3,4-difluorophenyl)-2-hydroxyacetic acid

: 503-38-8
trichloromethyl chloroformate

: 5-(3,4-difluoro-phenyl)-[1,3]dioxolane-2,4-dione

Conditions

Conditions	Yield
With pyrographite In tetrahydrofuran at 20℃; for 8h;	100%

: ethyl anti-(+/-)-3-(4-methoxyphenylamino)-2-hydroxy-3-phenylpropanoate

: 503-38-8
trichloromethyl chloroformate

: (4R,5R)-3-(4-Methoxy-phenyl)-2-oxo-4-phenyl-oxazolidine-5-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0℃;	100%

: (2R*,3S*)-ethyl 3-(4-methoxyphenylamino)-2-hydroxy-3-phenylpropanoate

: 503-38-8
trichloromethyl chloroformate

: (4R,5S)-3-(4-Methoxy-phenyl)-2-oxo-4-phenyl-oxazolidine-5-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0℃;	100%

: 157943-97-0
[2-(3-chlorophenoxy)-1-ethyl]ethanol

: 503-38-8
trichloromethyl chloroformate

: 551937-23-6
[2-(3-chlorophenoxy)-1-ethyl]ethyl chloroformate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 25℃; for 3h;	100%

: 56920-93-5
1-(3-nitro-2-thienyl)ethanol

: 503-38-8
trichloromethyl chloroformate

: C7H6ClNO4S

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%

: 20898-87-7
(3-nitro-2-thienyl)methanol

: 503-38-8
trichloromethyl chloroformate

: C6H4ClNO4S

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%

: 16764-13-9
α-phenyl-2-nitrophenethyl alcohol

: 503-38-8
trichloromethyl chloroformate

: C15H12ClNO4

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%

: 19190-46-6
8-nitro-1-hydrohymethylnaphthoic acid

: 503-38-8
trichloromethyl chloroformate

: C12H8ClNO4

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%

: 102781-43-1
4-(hydroxymethyl)-5-nitro-1,2,3,4-tetrahydronaphtalene

: 503-38-8
trichloromethyl chloroformate

: C12H12ClNO4

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%

: 73428-04-3
(3-nitronaphthalen-2-yl)methanol

: 503-38-8
trichloromethyl chloroformate

: C12H8ClNO4

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%

: 244140-70-3
2-(4-bromo-2-nitrophenyl)propan-1-ol

: 503-38-8
trichloromethyl chloroformate

: 244140-73-6
C10H9BrClNO4

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%

: 244140-69-0
2-(4-chloro-2-nitrophenyl)propan-1-ol

: 503-38-8
trichloromethyl chloroformate

: 244140-72-5
C10H9Cl2NO4

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%

: 244140-71-4
2-(4-iodo-2-nitrophenyl)propan-1-ol

: 503-38-8
trichloromethyl chloroformate

: 244140-74-7
C10H9ClINO4

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%

: 702643-69-4
2-(3-nitro-2-thienyl)ethanol

: 503-38-8
trichloromethyl chloroformate

: C7H6ClNO4S

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%

: 2-(3-nitro-2-thienyl)propan-1-ol

: 503-38-8
trichloromethyl chloroformate

: C8H8ClNO4S

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%

: 702643-35-4
3-(2-nitrophenyl)butan-2-ol

: 503-38-8
trichloromethyl chloroformate

: C11H12ClNO4

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%

Diphosgene Chemical Properties

IUPAC Name:Trichloromethyl carbonochloridate (503-38-8)
Synonyms: Carbonochloridic acid, trichloromethyl ester ; Carbonochloridicacid,trichloromethylester ; Carbonochloridicacidtrichloromethylester ; Chloro-formicacitrichloromethylester ; Difosgen ; Diphosgen ; DP ; Formic acid, chloro-, trichloromethyl ester
CAS: 503-38-8
MF: C₂Cl₄O₂

MS:
MW: 197.83
EINECS: 207-965-9
Product Categories: Pharmaceutical Intermediates
Mol File: 503-38-8.mol
Surface Tension: 44.2 dyne/cm
Density: 1.788 g/cm³
Flash Point: 32.2 °C
Melting Point:-57 °C
Enthalpy of Vaporization: 36.57 kJ/mol
Boiling Point: 128 °C at 760 mmHg
Vapour Pressure: 10.8 mmHg at 25°C
Refractive index n20/D 1.458
Storage temp: 2-8°C
Water Solubility: may decompose
Sensitive: Moisture Sensitive
Merck : 14,3334
BRN : 970225

Diphosgene Uses

Trichloromethyl chloroformate (503-38-8) has effects on tearing.

Diphosgene Production

1.Cl-CO-OCH₃ + 3 Cl₂ —(hv)→ Cl-CO-OCCl₃ + 3 HCl

2.H-CO-OCH₃ + 4 Cl₂ —(hv)→ Cl-CO-OCCl₃ + 4 HCl

Diphosgene Safety Profile

Hazard Codes: T+,Xi
Risk Statements: 34-26/27/28-36/37/38
34: Trichloromethyl chloroformate (503-38-8) can causes burns.
26/27/28: Very Toxic by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-28-36/37/39-45
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR: UN 3277 6.1/PG 2
WGK Germany: 3
RTECS: LQ7350000
F : 8-10-19
HazardClass: 6.1
PackingGroup: II

Diphosgene Specification

1.General Description: Trichloromethyl chloroformate (503-38-8) is colorless liquid, odorless to fruity.
2.Air & Water Reactions: Decomposes slowly in water or moist air (or when inhaled) to form very corrosive hydrogen chloride gas (hydrochloric acid) and carbon monoxide.
3.Fire Hazard :Some may burn but none ignite readily. Vapors from liquefied gas are initially heavier than air and spread along ground. Some of these materials may react violently with water. Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket.

Product Name

Diphosgene

Synthetic route

Diphosgene Chemical Properties

Diphosgene Uses

Diphosgene Production

Diphosgene Safety Profile

Diphosgene Specification

Related Products

Hot Products