Ether, isopropyl methyl supplier

Name
2-Methoxypropane
EINECS 209-937-1
CAS No. 598-53-8
Article Data32
CAS DataBase
Density 0.731 g/cm³
Solubility
Melting Point
Formula C₄H₁₀O
Boiling Point 50.6 °C at 760 mmHg
Molecular Weight 74.1228
Flash Point
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-Methoxypropane;2-Propylmethyl ether;Isopropyl methyl ether;Isopryl;Methyl iso-propyl ether;Methyl isopropylether;Ether,isopropyl methyl (6CI,7CI,8CI);
PSA 9.23000
LogP 1.04120

Synthetic route

: 38222-83-2
2,6-di-tert-butyl-4-methylpyridine

: 278172-59-1
methyltriphenylbismuthonium tetrafluoroborate

: 67-63-0
isopropyl alcohol

A: 598-53-8
isopropyl methyl ether

B: 160142-36-9
2,6-di-tert-butyl-4-methylpyridinium tetrafluoroborate

C: 603-33-8
triphenylbismuthane

Conditions

Conditions	Yield
In chloroform-d1 alcohol was added to mixt. (Ph3BiMe)(BF4) and 2,6-di-tert-butyl-4-methylpyridine in CDCl3 and allowed to react at 23°C for 4-7 h; detn. by NMR;	A 82% B 100% C 100%

...Expand

: 67-56-1
methanol

: 143885-03-4
isopropyloxy(diphenyl)-λ6-sulfanenitrile

A: 598-53-8
isopropyl methyl ether

B: 22731-83-5
S,S-diphenylsulphoximine

Conditions

Conditions	Yield
at 45℃; for 114h;	A 99% B n/a

...Expand

: 555-31-7
aluminum isopropoxide

: 74-88-4
methyl iodide

: 598-53-8
isopropyl methyl ether

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 48h; Heating;	66%

: 540-67-0
ethyl methyl ether

: 14621-84-2
diazomethane-d2

A: 60-29-7
diethyl ether

B: 598-53-8
isopropyl methyl ether

C: 74-85-1
ethene

D: 115-10-6
Dimethyl ether

E: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
Product distribution; Mechanism; Ambient temperature; Irradiation; deuterium distribution;	A 29.7% B 17.9% C n/a D 37.2% E 15.2%

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 540-67-0
ethyl methyl ether

A: 60-29-7
diethyl ether

B: 598-53-8
isopropyl methyl ether

C: 74-85-1
ethene

D: 557-17-5
methyl propyl ether

Conditions

Conditions	Yield
Product distribution; Mechanism; Ambient temperature; Irradiation;	A 34% B 33.2% C n/a D 32.8%

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 555-31-7
aluminum isopropoxide

: 598-53-8
isopropyl methyl ether

Conditions

Conditions	Yield
With isopropyl alcohol

: 186581-53-3, 908094-01-9
diazomethane

: 555-31-7
aluminum isopropoxide

: 67-63-0
isopropyl alcohol

: 598-53-8
isopropyl methyl ether

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 67-63-0
isopropyl alcohol

A: 598-53-8
isopropyl methyl ether

B: 74-85-1
ethene

C: 78-92-2, 15892-23-6
iso-butanol

D: 75-65-0
tert-butyl alcohol

Conditions

Conditions	Yield
bei der Einw. von Sonnenlicht;

...Expand

: 67-63-0
isopropyl alcohol

: 598-53-8
isopropyl methyl ether

Conditions

Conditions	Yield
With 1,2-dimethoxyethane; naphthalene; sodium Behandlung der Loesung mit Dimethylsulfat unterhalb 20grad;

: 683-60-3
sodium isopropylate

: 74-88-4
methyl iodide

: 598-53-8
isopropyl methyl ether

: 67-63-0
isopropyl alcohol

: 74-88-4
methyl iodide

: 598-53-8
isopropyl methyl ether

Conditions

Conditions	Yield
With sodium hydride
With sodium hydride 1.) ether, 4 h, reflux, 2.) 0.5 h at 20 deg C, reflux, 1 h; Multistep reaction;
With diethylene glycol dimethyl ether; sodium hydride
Stage #1: isopropyl alcohol With sodium hydride In dimethyl sulfoxide Stage #2: methyl iodide In dimethyl sulfoxide at 20℃; for 5h; Further stages.;

: 67-56-1
methanol

: 93000-48-7
Methyltriisopropoxyphosphonium tetrafluoroborate

: 598-53-8
isopropyl methyl ether

Conditions

Conditions	Yield
at 25℃; for 12h;	90 % Spectr.

: 2143-68-2
methoxyl radical

: 74-98-6
propane

: 598-53-8
isopropyl methyl ether

Conditions

Conditions	Yield
Thermodynamic data; Mechanism; calculated (BEBO and equibonding method) activation energies for hydrogen atom transfer reaction, anodic methoxylation;

: 67-63-0
isopropyl alcohol

: 77-78-1
dimethyl sulfate

: 598-53-8
isopropyl methyl ether

Conditions

Conditions	Yield
With sodium hydroxide; tetra-(n-butyl)ammonium iodide In chlorobenzene 1.) ice bath, 1h, 2.) water bath, 2h;

: 1073-91-2
Tetramethyl-[1,2,4,5]tetroxan

A: 67-56-1
methanol

B: 92-52-4
biphenyl

C: 598-53-8
isopropyl methyl ether

D: 79-20-9
acetic acid methyl ester

E: 67-64-1
acetone

F: 108-88-3
toluene

G methane, ethane, oxygen, CO2: methane, ethane, oxygen, CO2

Conditions

Conditions	Yield
In benzene at 135.5 - 165℃; Rate constant; Product distribution; Mechanism; ΔH(excit.), ΔS(excit.); dependence of kexp from ACDP initial conc. at different temperatures;

...Expand

: 187737-37-7
propene

BF3+2CH3OH: BF3+2CH3OH

: 598-53-8
isopropyl methyl ether

Conditions

Conditions	Yield
beim Zersetzen des bildenden Anlagerungsprodukts mit Natronlage;

: 54283-75-9
1-(4-ethoxycarbonylphenyl)-3-methyltriazene

: 67-63-0
isopropyl alcohol

A: 598-53-8
isopropyl methyl ether

B: 94-09-7
p-aminoethylbenzoate

C N2: N2

Conditions

Conditions	Yield
copper(II) ion at 35℃; Rate constant; Mechanism;

...Expand

: 79-20-9
acetic acid methyl ester

: 67-63-0
isopropyl alcohol

A: 187737-37-7
propene

B: 598-53-8
isopropyl methyl ether

C: 108-20-3
di-isopropyl ether

D: 108-21-4
Isopropyl acetate

Conditions

Conditions	Yield
With sodium oxide; aluminum oxide at 280℃; Product distribution; Further Variations:; different persentage compositions of reactans;

...Expand

: 187737-37-7
propene

: 74-98-6
propane

: 115-10-6
Dimethyl ether

: 463-49-0
1,2-propanediene

: 74-99-7
prop-1-yne

A: 67-56-1
methanol

B: 598-53-8
isopropyl methyl ether

C: 108-20-3
di-isopropyl ether

D: 67-63-0
isopropyl alcohol

E: 67-64-1
acetone

Conditions

Conditions	Yield
With hydrogen; hydrogenation catalyst from SCI of Louisville, Ky., USA at 209℃; under 16801.7 Torr;

...Expand

: 67-56-1
methanol

: 463-49-0
1,2-propanediene

: 77-76-9
2,2-dimethoxy-propane

: 74-99-7
prop-1-yne

A: 187737-37-7
propene

B: 598-53-8
isopropyl methyl ether

C: 74-98-6
propane

D: 557-17-5
methyl propyl ether

E: 67-64-1
acetone

Conditions

Conditions	Yield
Zn-Si catalyst prepared from silicagel and zinc acetate, content of zinc amounts to 20percent converting to ZnO Product distribution / selectivity;

...Expand

: 77-76-9
2,2-dimethoxy-propane

: 598-53-8
isopropyl methyl ether

Conditions

Conditions	Yield
With hydrogen In methanol at 210℃; under 37503.8 - 180018 Torr; for 12h;	98 %Chromat.

: 67-56-1
methanol

: 187737-37-7
propene

: 74-98-6
propane

: 463-49-0
1,2-propanediene

: 74-99-7
prop-1-yne

A: 598-53-8
isopropyl methyl ether

B: 557-17-5
methyl propyl ether

C: 67-64-1
acetone

Conditions

Conditions	Yield
Stage #1: methanol at 170℃; under 5250.53 Torr; for 0.25h; Stage #2: propene; propane; 1,2-propanediene; prop-1-yne; Zn-Si catalyst prepared from silicagel and zinc acetate, content of zinc amounts to 20percent converting to ZnO at 175 - 220℃; under 5250.53 Torr; for 506h; Product distribution / selectivity;

...Expand

: 74-87-3
methylene chloride

: 67-63-0
isopropyl alcohol

: 598-53-8
isopropyl methyl ether

Conditions

Conditions	Yield
Stage #1: isopropyl alcohol With methane; dinitrogen monoxide Stage #2: methylene chloride Kinetics; Thermodynamic data; Gas phase;

: 598-53-8
isopropyl methyl ether

: 1431636-22-4
(1R,3R,4S,9R)-6-bromo-5,8-dimethoxy-9-methyl-2,3-dihydro-1,4-(epoxymethano)naphthalene-3,4(1H)-diol

: 1431636-23-5
(3aR,5S,9bR,10R)-8-bromo-6,9-dimethoxy-2,2,10-trimethyl-4,5-dihydro-3aH-5,9b-(epoxymethano)naphtho[1,2-d][1,3]dioxole

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In tetrahydrofuran at 0 - 20℃; for 12h;	91%

: 598-53-8
isopropyl methyl ether

: (2S,3S,4E)-2,5,9-trimethyldeca-4,8-diene-1,3-diol

: (4S,5S)-4-[(1E)-2,6-dimethylhepta-1,5-dienyl]-2,2,5-trimethyl-1,3-dioxane

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In acetone at 20℃; for 3h; Inert atmosphere; Combinatorial reaction / High throughput screening (HTS);	90%

: 598-53-8
isopropyl methyl ether

: (2S,3S,4Z)-2,5,9-trimethyldeca-4,8-diene-1,3-diol

: (4S,5S)-4-[(1Z)-2,6-dimethylhepta-1,5-dienyl]-2,2,5-trimethyl-1,3-dioxane

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In acetone at 20℃; for 3h; Inert atmosphere; Combinatorial reaction / High throughput screening (HTS);	88%

: 598-53-8
isopropyl methyl ether

: 111789-76-5, 111789-79-8
2-<(R)-3-benzyloxytetradecanamido>-2-deoxy-D-glucopyranose

: 135561-40-9, 135583-79-8
2-<(R)-3-(benzyloxy)tetradecanamido>-2-deoxy-4,6-O-isopropylidene-D-glucopyranose

Conditions

Conditions	Yield
With 4 A molecular sieve; toluene-4-sulfonic acid In N,N-dimethyl-formamide for 1h; Ambient temperature;	60%

: 31469-15-5
1-methoxy-2-methyl-1-trimethylsiloxy-1-propene

: 598-53-8
isopropyl methyl ether

: 1727-59-9
methyl 2,2,3-trimethylbut-3-enoate

Conditions

Conditions	Yield
With gallium(III) bromide In 1,2-dichloro-ethane at 80℃; for 2h;	58%

: 598-53-8
isopropyl methyl ether

: 615-36-1
2-bromoaniline

: 2-isopropylamino-1-bromobenzene

Conditions

Conditions	Yield
With sodium tetrahydroborate; acetic acid In 1,2-dichloro-ethane at 20℃; for 16h; Inert atmosphere;	53%

: 598-53-8
isopropyl methyl ether

: 53329-35-4
isopropyl methyl ether hydrotrioxide

Conditions

Conditions	Yield
With ozone In acetone at -78℃; Oxidation;	40%

: 598-53-8
isopropyl methyl ether

: 156556-46-6
2-O-benzoyl-myo-inositol

: 208714-30-1
2-O-benzoyl-1,6:3,4-di-O-isopropylidene-myo-inositol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In N,N-dimethyl-formamide at 50℃; for 1.5h; Inert atmosphere;	35%

: 942-01-8
1,2,3,4-tetrahydrocarbazole

: 598-53-8
isopropyl methyl ether

A: 1140-49-4
1-propyl-1,2,3,4-tetrahydrocarbazole

B: 10257-86-0
1-ethyl-1,2,3,4-tetrahydrocarbazole

C: 1-butyl-1,2,3,4-tetrahydrocarbazole

D: 1-pentyl-1,2,3,4-tetrahydrocarbazole

Conditions

Conditions	Yield
With n-butyllithium; potassium tert-butylate In hexane Ambient temperature;	A n/a B 27% C n/a D n/a

...Expand

: 598-53-8
isopropyl methyl ether

: 32347-02-7, 5877-49-6
2-chlorobenzalaniline

: 41203-41-2
(2-Methoxy-2-methyl-1-phenyl-propyl)-phenyl-amine

Conditions

Conditions	Yield
With sodium

: 598-53-8
isopropyl methyl ether

: 32347-02-7, 5877-49-6
2-chlorobenzalaniline

: 41203-42-3
[1-(2-Chloro-phenyl)-2-methoxy-2-methyl-propyl]-phenyl-amine

Conditions

Conditions	Yield
With sodium

: 598-53-8
isopropyl methyl ether

: 3294-58-4
phenyl(bromodichloromethyl)mercury

: 918-43-4
1,1-dichloro-2-methoxy-2-methyl-propane

Conditions

Conditions	Yield
In benzene

: 598-53-8
isopropyl methyl ether

: 29099-06-7
2-methoxy-propane-2-sulfinic acid

Conditions

Conditions	Yield
With sulfur dioxide Irradiation;

: 598-53-8
isopropyl methyl ether

: 69105-60-8
5-phenyl-3,4-dihydro-2H-pyrrole perchlorate

A: 92490-42-1
2-(1-Methoxy-1-methyl-ethyl)-2-phenyl-pyrrolidine

B: 2-Isopropoxymethyl-2-phenyl-pyrrolidine

Conditions

Conditions	Yield
In acetonitrile Irradiation;

...Expand

: 598-53-8
isopropyl methyl ether

: 146547-11-7
(2S,5S)-1,6-bis[(tert-butyldiphenylsilyl)oxy]hexane-2,5-diol

: 146547-12-8
1,6-di-O-(tert-butyldiphenyl)silyl-2,5-di-O-isopropylidene-3,4-dideoxy-D-threo-hexitol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In tetrahydrofuran at 0℃; for 2h;	4.11 g

: 598-53-8
isopropyl methyl ether

: 32233-42-4
(3aR,4R,5R,6aS)-4-((1E,5Z)-(S)-3-Hydroxy-octa-1,5-dienyl)-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-2-one

: 75351-52-9
(3aR,4R,5R,6aS)-4-[(1E,5Z)-(S)-3-(1-Methoxy-1-methyl-ethoxy)-octa-1,5-dienyl]-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-2-one

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In dichloromethane for 0.166667h; Ambient temperature;

Ether, isopropyl methyl Specification

This chemical is called Ether, isopropyl methyl, and its CAS registry number is 598-53-8. With the molecular formula of C₄H₁₀O, its molecular weight is 74.12. It's often used as pharmaceutical intermediates.

Other characteristics of the Ether, isopropyl methyl can be summarised as followings: (1)ACD/LogP: 0.80; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.8; (4)ACD/LogD (pH 7.4): 0.8; (5)ACD/BCF (pH 5.5): 2.38; (6)ACD/BCF (pH 7.4): 2.38; (7)ACD/KOC (pH 5.5): 64.68; (8)ACD/KOC (pH 7.4): 64.68; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 9.23 Å²; (13)Index of Refraction: 1.358; (14)Molar Refractivity: 22.28 cm³; (15)Molar Volume: 101.3 cm³; (16)Polarizability: 8.83×10^-24cm³; (17)Surface Tension: 17.8 dyne/cm; (18)Density: 0.731 g/cm³; (19)Flash Point: °C; (20)Enthalpy of Vaporization: 26.05 kJ/mol; (21)Boiling Point: 50.6 °C at 760 mmHg; (22)Vapour Pressure: 299 mmHg at 25°C.

Production method of this chemical: The Ether, isopropyl methyl could be obtained by the reactants of iodomethane and propan-2-ol; aluminium salt. This reaction needs the solvent of dimethylformamide. The yield is 66 %. In addition, this reaction should be taken for 2 days. The other condition is heating.

Uses of this chemical: The Ether, isopropyl methyl could react with 2-[(R)-3-(benzyloxy)tetradecanamido]-2-deoxy-D-glucose, and obtain the 2-[(R)-3-(benzyloxy)tetradecanamido]-2-deoxy-4,6-O-isopropylidene-D-glucopyranose. This reaction needs the reagent of p-toluenesulfonic acid, molecular sieves 4A, and the solvent of dimethylformamide. The yield is 60 %. In addition, this reaction should be taken for 1 hour at the ambient temperature.

You can still convert the following datas into molecular structure:
1.SMILES: O(C(C)C)C
2.InChI: InChI=1/C4H10O/c1-4(2)5-3/h4H,1-3H3
3.InChIKey: RMGHERXMTMUMMV-UHFFFAOYAB

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LC50	inhalation	407gm/m³/15M (407000mg/m³)	BEHAVIORAL: GENERAL ANESTHETIC	Anesthesiology. Vol. 11, Pg. 455, 1950. Link to PubMed

Product Name

2-Methoxypropane

Synthetic route

Ether, isopropyl methyl Specification

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