Product Name

  • Name

    Ethyl glycolate

  • EINECS 210-798-4
  • CAS No. 623-50-7
  • Article Data76
  • CAS DataBase
  • Density 1.089 g/cm3
  • Solubility It is very soluble in water, alcohols, acetone, acetates, slightly soluble in ethyl ether, sparingly soluble in hydrocarbon solvents, polymerization occurs above 50 C.
  • Melting Point >300 °C
  • Formula C4H8O3
  • Boiling Point 156.7 °C at 760 mmHg
  • Molecular Weight 104.106
  • Flash Point 61.7 °C
  • Transport Information
  • Appearance clear colorless liquid
  • Safety 26-37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 623-50-7 (Ethyl glycolate)
  • Hazard Symbols IrritantXi
  • Synonyms Aceticacid, hydroxy-, ethyl ester (9CI);Glycolic acid, ethyl ester (7CI,8CI);2-Hydroxyacetic acid ethyl ester;Ethyl 2-hydroxyacetate;Acetic acid,2-hydroxy-, ethyl ester;Ethyl hydroxyacetate;NSC 8835;
  • PSA 46.53000
  • LogP -0.45820

Synthetic route

formaldehyd
50-00-0

formaldehyd

ethanol
64-17-5

ethanol

carbon monoxide
201230-82-2

carbon monoxide

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
Stage #1: formaldehyd; carbon monoxide With 1,3,5-Trioxan; hydrogenchloride; oxalic acid In 1,4-dioxane; water; 1,2-dichloro-ethane; toluene at 165℃; under 45004.5 Torr;
Stage #2: ethanol In 1,4-dioxane; water; 1,2-dichloro-ethane; toluene at 170℃; under 12001.2 Torr; for 36h;
98.3%
oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
With ethanol; C42H44ClN4P2Ru(1+)*Cl(1-); potassium tert-butylate at 80℃; for 5h; Schlenk technique; Inert atmosphere;94%
With Ag/SiO2; hydrogen In ethanol at 84 - 242℃; under 22502.3 - 23402.3 Torr; Temperature;
With hydrogen; copper at 210 - 220℃;
glycolic Acid
79-14-1

glycolic Acid

ethanol
64-17-5

ethanol

A

glycolide
502-97-6

glycolide

B

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 10h; Reflux;A n/a
B 82.8%
glycolic Acid
79-14-1

glycolic Acid

ethanol
64-17-5

ethanol

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 10h; Reflux;81.8%
With sulfuric acid at 60℃; for 3h;80%
With ion exchanger (Dowex 50WX8) In chloroform for 72h; Heating;74%
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
With water at 25℃; for 24h; Green chemistry;80%
With water; acetic acid In dichloromethane for 72h; Darkness;66%
With copper(II) sulfate at 130℃; for 6h;20%
With hydrogen fluoride
With Pt(II)halide; water
ethanol
64-17-5

ethanol

glycolonitrile
107-16-4

glycolonitrile

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
With hydrogenchloride; water at -10 - -5℃; for 4h; Reflux;78.85%
ethanol
64-17-5

ethanol

Glyoxal
131543-46-9

Glyoxal

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
With zeolite MFI-ATSn for 6h; Reagent/catalyst; Time; Sealed tube; Green chemistry;69%
ethanol
64-17-5

ethanol

betaine
107-43-7

betaine

A

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

B

N-<(ethoxycarbonyl)methyl>trimethylammonium chloride
3032-11-9

N-<(ethoxycarbonyl)methyl>trimethylammonium chloride

Conditions
ConditionsYield
With chloroacetic acid ethyl ester at 40℃; for 192h;A 55%
B 66%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

A

nitroacetic acid ethyl ester
626-35-7

nitroacetic acid ethyl ester

B

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
With Amberlite IRA 900 NO2- form In acetonitrile at -15℃;A 65%
B 28%
ethanol
64-17-5

ethanol

betaine
107-43-7

betaine

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
With ethyl bromoacetate 1) 22 h, 50 deg C, 2) 90 min, reflux, 3) 50 deg C;62%
glycerol
56-81-5

glycerol

A

1,3-dioxolane-4-methanol
5464-28-8

1,3-dioxolane-4-methanol

B

glycerol formal
4740-78-7

glycerol formal

C

glycolic Acid
79-14-1

glycolic Acid

D

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

E

diglycerol
627-82-7

diglycerol

F

oxiranyl-methanol
556-52-5

oxiranyl-methanol

G

hydroxy-2-propanone
116-09-6

hydroxy-2-propanone

H

acrolein
107-02-8

acrolein

Conditions
ConditionsYield
With pretreated aluminium vanadium phosphate In water at 280℃; under 760.051 Torr; Catalytic behavior; Activation energy; Reagent/catalyst; Temperature;A n/a
B n/a
C n/a
D n/a
E n/a
F n/a
G n/a
H 62%
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

A

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

B

(4-phenyl-butoxy)-acetic acid ethyl ester

(4-phenyl-butoxy)-acetic acid ethyl ester

Conditions
ConditionsYield
[Rh(OPiv)2]2 In waterA n/a
B 45%
[Rh(OPiv)2]2 In water for 2.75h;A n/a
B 45%
Trimethylammoniumessigsaeurebetain-acetoxyethyl-ester-bromid

Trimethylammoniumessigsaeurebetain-acetoxyethyl-ester-bromid

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
With sodium hydrogencarbonate In water at 30℃;44%
ethyl N-nitroso-N-(triphenylmethyl)glycinate
75934-52-0

ethyl N-nitroso-N-(triphenylmethyl)glycinate

A

triphenylmethyl alcohol
76-84-6

triphenylmethyl alcohol

B

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

C

triphenylmethane
519-73-3

triphenylmethane

Conditions
ConditionsYield
In neat (no solvent) at 180℃; for 4h; Product distribution; Mechanism;A 43%
B 10%
C 16%
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

A

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

B

ethyl 2-nitrooxyacetate
999-17-7

ethyl 2-nitrooxyacetate

Conditions
ConditionsYield
With sodium nitrate; water; nitric acid
formaldehyd
50-00-0

formaldehyd

hydrogen cyanide
74-90-8

hydrogen cyanide

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
With 1,4-dioxane; sodium hydroxide; water Behandeln des mit Aethanol versetzten Reaktionsgemisches mit Chlorwasserstoff und anschliessenden Erwaermen;
glycolic Acid
79-14-1

glycolic Acid

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
With sulfuric acid
ethanol
64-17-5

ethanol

sodium monochloroacetic acid
3926-62-3

sodium monochloroacetic acid

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
at 120 - 130℃; im geschlossenen Gefaess;
at 120 - 130℃; im geschlossenen Gefaess;
at 120 - 130℃;
ethanol
64-17-5

ethanol

chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
With sodium acetate at 150℃;
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

A

ethyl 2-fluoroacetate
459-72-3

ethyl 2-fluoroacetate

B

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
With potassium fluoride; ethanol
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
With water; formamide at 150℃;
ethanol
64-17-5

ethanol

chloroacetic acid
79-11-8

chloroacetic acid

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
at 120 - 130℃; Reaktion des Natriumsalzes;
chloroacetic acid
79-11-8

chloroacetic acid

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

dimethylacetylene
503-17-3

dimethylacetylene

A

4,5-dimethyl-2(5H)-furanone
10547-85-0

4,5-dimethyl-2(5H)-furanone

B

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

C

2,3-dimethyl-1-ethoxycarbonylcyclopropene
5783-75-5

2,3-dimethyl-1-ethoxycarbonylcyclopropene

D

2-Ethoxy-4,5-dimethyl-furan
66481-30-9

2-Ethoxy-4,5-dimethyl-furan

E

Diethyl maleate
141-05-9

Diethyl maleate

Conditions
ConditionsYield
With copper(II) sulfate at 100℃; for 2h; Product distribution; influence of temperature, other catalyst;A 4 % Chromat.
B 7 % Chromat.
C 2 % Chromat.
D 15 % Chromat.
E 9 % Chromat.
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

prop-1-yne
74-99-7

prop-1-yne

A

4-methyl-2(5H)-furanone
6124-79-4

4-methyl-2(5H)-furanone

B

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

C

ethyl ester of 3-pentynoic acid
52750-56-8

ethyl ester of 3-pentynoic acid

D

ethyl ester of 1-methylcyclopropene-3-carboxylic acid
5809-04-1

ethyl ester of 1-methylcyclopropene-3-carboxylic acid

Conditions
ConditionsYield
With copper(II) sulfate at 100℃; for 2h; Further byproducts given;A 3 % Chromat.
B 2 % Chromat.
C 12 % Chromat.
D 1.4 % Chromat.
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

prop-1-yne
74-99-7

prop-1-yne

A

4-methyl-2(5H)-furanone
6124-79-4

4-methyl-2(5H)-furanone

B

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

C

ethyl ester of 3-pentynoic acid
52750-56-8

ethyl ester of 3-pentynoic acid

D

ethyl ester of 1-methylcyclopropene-3-carboxylic acid
5809-04-1

ethyl ester of 1-methylcyclopropene-3-carboxylic acid

E

Diethyl maleate
141-05-9

Diethyl maleate

Conditions
ConditionsYield
With copper(II) sulfate at 100℃; for 2h; Product distribution; influence of temperature, other catalyst;A 3 % Chromat.
B 2 % Chromat.
C 12 % Chromat.
D 1.4 % Chromat.
E 6 % Chromat.
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

A

diethyl diglycolate
6634-17-9

diethyl diglycolate

B

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

C

ethyl 2-cyclohexylacetate
5452-75-5

ethyl 2-cyclohexylacetate

D

diethyl Fumarate
623-91-6

diethyl Fumarate

E

Diethyl maleate
141-05-9

Diethyl maleate

Conditions
ConditionsYield
NaCuX-79 In cyclohexane at 24.9℃; Product distribution; effect of the type of the catalyst;
glycolic Acid
79-14-1

glycolic Acid

C20H20OP(1+)*ClO4(1-)

C20H20OP(1+)*ClO4(1-)

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
for 5h; Heating;91 % Chromat.
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

water
7732-18-5

water

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

Conditions
ConditionsYield
beim Kochen;
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

aqueous HF

aqueous HF

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

glycolamide
598-42-5

glycolamide

Conditions
ConditionsYield
With ammonia In methanol at 20℃;100%
With ammonia for 24h; Ambient temperature;90%
With ammonia
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

acetyl chloride
75-36-5

acetyl chloride

acetoxy-acetic acid ethyl ester
623-86-9

acetoxy-acetic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 10℃; for 1h; Solvent;100%
With chloroform
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

ethyl 2-(tert-butyldimethylsilyloxy)acetate
67226-78-2

ethyl 2-(tert-butyldimethylsilyloxy)acetate

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide for 1h; Ambient temperature;100%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 1h; Inert atmosphere;100%
With 1H-imidazole In dichloromethane at 0℃; for 1h;100%
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

2-chloro-3-methyl-1,3,2-oxazaphospholidine
22082-71-9

2-chloro-3-methyl-1,3,2-oxazaphospholidine

2-(Ethoxycarbonyl)methoxy-3-methyl-1,3,2-oxazaphosphacyclopentane
129274-36-8

2-(Ethoxycarbonyl)methoxy-3-methyl-1,3,2-oxazaphosphacyclopentane

Conditions
ConditionsYield
With triethylamine In dichloromethane for 1h; -60 deg C to RT;100%
isocyanate de chlorosulfonyle
1189-71-5

isocyanate de chlorosulfonyle

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

C5H8ClNO6S

C5H8ClNO6S

Conditions
ConditionsYield
In dichloromethane for 1h;100%
4-chloro-5-fluoro-nicotinic acid ethyl ester
1009334-54-6

4-chloro-5-fluoro-nicotinic acid ethyl ester

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

7-fluoro-3-hydroxy-furo[3,2-c]pyridine-2-carboxylic acid ethyl ester
1009334-57-9

7-fluoro-3-hydroxy-furo[3,2-c]pyridine-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2h;100%
ethyl 2,4-dichloropyridine-3-carboxylate
62022-04-2

ethyl 2,4-dichloropyridine-3-carboxylate

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

4-chloro-3-hydroxy-furo[3,2-c]pyridine-2-carboxylic acid ethyl ester
1009334-69-3

4-chloro-3-hydroxy-furo[3,2-c]pyridine-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0℃; for 3h;100%
triethylsilyl chloride
994-30-9

triethylsilyl chloride

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

α-(triethylsiloxy)acetic acid ethyl ester
1046153-40-5

α-(triethylsiloxy)acetic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;100%
With dmap In pyridine at 20℃; for 0.666667h; Inert atmosphere;99%
With 1H-imidazole In dichloromethane at 20℃; for 10h; Inert atmosphere;
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

2-((tert-butyl(diphenyl)silyl)oxy)acetic acid ethyl ester
441784-83-4

2-((tert-butyl(diphenyl)silyl)oxy)acetic acid ethyl ester

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 4.5h;100%
With 1H-imidazole In dichloromethane at 20℃; for 16h; Cooling with ice;91%
With 1H-imidazole In dichloromethane at 20℃; for 5.33333h;47.6%
With 1H-imidazole; dmap In dichloromethane at 0 - 15℃; for 2h;
With 1H-imidazole In N,N-dimethyl-formamide at 0℃; for 1.3h; Inert atmosphere;8.3 g
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

(R)-1-phenyl-ethyl-amine
3886-69-9

(R)-1-phenyl-ethyl-amine

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

3-[(1R)-1-phenylethyl]oxazolidine-2,4-dione

3-[(1R)-1-phenylethyl]oxazolidine-2,4-dione

Conditions
ConditionsYield
Stage #1: ethyl 2-hydroxyacetate; (R)-1-phenyl-ethyl-amine With sodium methylate In methanol at 120℃; for 1.5h;
Stage #2: 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide for 1h;
100%
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

1,2,3-trichlorobenzene
87-61-6

1,2,3-trichlorobenzene

(dichloro-2,3 phenoxy)acetate d'ethyle
37536-92-8

(dichloro-2,3 phenoxy)acetate d'ethyle

Conditions
ConditionsYield
Stage #1: ethyl 2-hydroxyacetate With potassium methanolate at 30℃;
Stage #2: 1,2,3-trichlorobenzene at 100℃;
99.1%
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

ethyl (tetrahydropyranyloxy)acetate
61675-94-3

ethyl (tetrahydropyranyloxy)acetate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene at 25℃; for 1h;99%
toluene-4-sulfonic acid In toluene at 20℃; Product distribution / selectivity; Industrial scale;94.7%
With toluene-4-sulfonic acid at 20℃;91.5%
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

3-tert-2-chloro-1,3,2-oxazaphosphacyclopentane
67105-49-1

3-tert-2-chloro-1,3,2-oxazaphosphacyclopentane

3-tert-butyl-2-ethoxycarbonylmethoxy-1,3,2-oxazaphosphacyclopentane
139715-64-3

3-tert-butyl-2-ethoxycarbonylmethoxy-1,3,2-oxazaphosphacyclopentane

Conditions
ConditionsYield
With triethylamine In dichloromethane for 1h; -60 deg C to rt;99%
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

chlorodimethyl(1,1,2-trimethylpropyl)silane
67373-56-2

chlorodimethyl(1,1,2-trimethylpropyl)silane

[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-acetic acid ethyl ester
799804-41-4

[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-acetic acid ethyl ester

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;99%
5-bromo-2-fluoropyridine
766-11-0

5-bromo-2-fluoropyridine

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

ethyl 2-((5-bromopyridin-2-yl)oxy)acetate

ethyl 2-((5-bromopyridin-2-yl)oxy)acetate

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 23℃; for 4h;99%
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 6h; Time;
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

dimethyl amine
124-40-3

dimethyl amine

2-hydroxy-N,N-dimethylacetamide
14658-93-6

2-hydroxy-N,N-dimethylacetamide

Conditions
ConditionsYield
In water at 20℃; for 16h;98%
In water at 20℃; for 18h;58%
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

ethyl 2-(tert-butoxycarbonyloxy)acetate
1609490-80-3

ethyl 2-(tert-butoxycarbonyloxy)acetate

Conditions
ConditionsYield
With dmap In acetonitrile at 20℃; for 18h;98%
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

(R)-1-(4-chlorophenyl)ethylamine
27298-99-3

(R)-1-(4-chlorophenyl)ethylamine

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

3-[(1R)-1-(4-chlorophenyl)ethyl]oxazolidine-2,4-dione

3-[(1R)-1-(4-chlorophenyl)ethyl]oxazolidine-2,4-dione

Conditions
ConditionsYield
Stage #1: ethyl 2-hydroxyacetate; (R)-1-(4-chlorophenyl)ethylamine With sodium methylate In methanol at 120℃; for 2h;
Stage #2: 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃; for 2h;
98%
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

2-bromo-5-(trifluoromethyl)-pyrazine
1196152-38-1

2-bromo-5-(trifluoromethyl)-pyrazine

ethyl 2-((5-(trifluoromethyl)pyrazin-2-yl)oxy)acetate

ethyl 2-((5-(trifluoromethyl)pyrazin-2-yl)oxy)acetate

Conditions
ConditionsYield
Stage #1: ethyl 2-hydroxyacetate With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: 2-bromo-5-(trifluoromethyl)-pyrazine In tetrahydrofuran at 20℃;
98%
Stage #1: ethyl 2-hydroxyacetate With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: 2-bromo-5-(trifluoromethyl)-pyrazine In tetrahydrofuran at 20℃;
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

methylamine
74-89-5

methylamine

2-hydroxy-N-methylacetamide
5415-94-1

2-hydroxy-N-methylacetamide

Conditions
ConditionsYield
In tetrahydrofuran; water at 15 - 20℃; for 1h;97%
In ethanol
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

o-phenylenediamine dihydrochloride
615-28-1

o-phenylenediamine dihydrochloride

2-(Hydroxymethyl)benzimidazole
4856-97-7

2-(Hydroxymethyl)benzimidazole

Conditions
ConditionsYield
In ethylene glycol for 0.025h; microwave irradiation;97%
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

1,2-dichloro-4-fluoro-5-nitrobenzene
2339-78-8

1,2-dichloro-4-fluoro-5-nitrobenzene

ethyl [(4,5-dichloro-2-nitrophenyl)oxy]acetate
1003878-22-5

ethyl [(4,5-dichloro-2-nitrophenyl)oxy]acetate

Conditions
ConditionsYield
With potassium fluoride In 1,4-dioxane at 100℃; for 2h;96%
With potassium fluoride In 1,4-dioxane at 100℃;96%
1,3-bis(dodecylamino)-2-propanol

1,3-bis(dodecylamino)-2-propanol

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

3,7-didodecyl-2,8-dioxo-3,7-diaza-1,5,9-nonanetriol
167160-05-6

3,7-didodecyl-2,8-dioxo-3,7-diaza-1,5,9-nonanetriol

Conditions
ConditionsYield
In toluene96%
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

ethyl α-methanesulfonyloxyacetate
29169-19-5

ethyl α-methanesulfonyloxyacetate

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 0 - 20℃; for 1h;95%
With triethylamine In dichloromethane for 1h;68%
4,5-dibromonicotinic acid ethyl ester
1009333-82-7

4,5-dibromonicotinic acid ethyl ester

ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

ethyl 7-bromo-3-hydroxy-furo[3,2-c]pyridine-2-carboxylate
1009333-80-5

ethyl 7-bromo-3-hydroxy-furo[3,2-c]pyridine-2-carboxylate

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2.25h;95%
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

propynoic acid methyl ester
922-67-8

propynoic acid methyl ester

methyl (E)-3-(2-ethoxy-2-oxoethoxy)acrylate
1572179-22-6

methyl (E)-3-(2-ethoxy-2-oxoethoxy)acrylate

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane In dichloromethane95%
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

3-chloro-4-fluoro-1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid methyl ester

3-chloro-4-fluoro-1-methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid methyl ester

7-fluoro-3-hydroxy-4-methyl-5-oxo-4,5-dihydrofuro[3,2-b]pyridine-2-carboxylic acid ethyl ester

7-fluoro-3-hydroxy-4-methyl-5-oxo-4,5-dihydrofuro[3,2-b]pyridine-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 2h; Cooling with ice;95%
ethyl 2-hydroxyacetate
623-50-7

ethyl 2-hydroxyacetate

hydrocinnamic acid chloride
645-45-4

hydrocinnamic acid chloride

carboethoxymethyl hydrocinnamate
74275-79-9

carboethoxymethyl hydrocinnamate

Conditions
ConditionsYield
With pyridine In 1,2-dimethoxyethane at 20℃; for 2h; Inert atmosphere;95%

Ethyl glycolate Chemical Properties

IUPAC Name: Ethyl 2-hydroxyacetate 
Following is the structure of Ethyl glycolate (CAS NO.623-50-7):

Empirical Formula: C4H8O3
Molecular Weight: 104.1045
EINECS: 210-798-4
Index of Refraction: 1.414
Molar Refractivity: 23.89 cm3
Molar Volume: 95.5 cm3
Density: 1.089 g/cm3
Flash Point: 61.7 °C
Surface Tension: 35.2 dyne/cm
Enthalpy of Vaporization: 45.82 kJ/mol
Boiling Point: 156.7 °C at 760 mmHg
Vapour Pressure: 1.03 mmHg at 25 °C
Appearance of Ethyl glycolate (CAS NO.623-50-7): clear colorless liquid
Product Categories: C2 to C5 ; Carbonyl Compounds ; Esters
Canonical SMILES: CCOC(=O)CO
InChI: InChI=1S/C4H8O3/c1-2-7-4(6)3-5/h5H,2-3H2,1H3
InChIKey: ZANNOFHADGWOLI-UHFFFAOYSA-N

Ethyl glycolate Uses

 Ethyl glycolate (CAS NO.623-50-7) can be  used in organic synthesis . It  also can be used as solvents.

Ethyl glycolate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LDLo intraperitoneal 1500mg/kg (1500mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Journal of Pharmacy and Pharmacology. Vol. 11, Pg. 150, 1959.

Ethyl glycolate Consensus Reports

Reported in EPA TSCA Inventory.

Ethyl glycolate Safety Profile

Moderately toxic by intraperitoneal route. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes of Ethyl glycolate (CAS NO.623-50-7):  symbolXi
Risk Statements:  36/37/38 
 R36/37/38:  Irritating to eyes, respiratory system and skin. 
Safety Statements:  26-37/39
S26:  In case of contact with eyes, rinse immediately with plenty of water and  seek medical advice. 
S37/39:  Wear suitable gloves and eye/face protection 
WGK Germany:  3
RTECS: MC5410000
HazardClass: 3.2
PackingGroup: III

Ethyl glycolate Specification

 Ethyl glycolate , its cas register number 623-50-7. It also can be called Ethyl hydroxyacetate ; Hydroxyacetic acid ethyl ester ; and Acetic acid, 2-hydroxy-, ethyl ester . Ethyl glycolate (CAS NO.623-50-7) should avoid the condition like incompatible materials. It is not compatible with strong oxidizing agents, strong bases. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide. However, its hazardous polymerization has not been reported.

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View