Lilolidine supplier | CasNO.5840-01-7

Name
Lilolidine
EINECS 691-285-6
CAS No. 5840-01-7
Article Data14
CAS DataBase
Density 1.16 g/cm³
Solubility
Melting Point 80-81°C
Formula C11H11 N
Boiling Point 318.377 °C at 760 mmHg
Molecular Weight 157.215
Flash Point 146.349 °C
Transport Information
Appearance
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 1,7-Trimethyleneindol;1,8-Trimethyleneindole; 5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinoline; Indole,1,7-(1,3-propanediyl)-; Lilolidene
PSA 4.93000
LogP 2.58750

Synthetic route

: 124730-56-9
5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1-carboxylic acid

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
With quinoline; copper chromite at 185℃; for 3h;	93%
With quinoline; copper chromite at 185℃; for 2h;	72%
With copper chromite In quinoline at 185℃; for 2h;	72%
With quinoline; copper chromite at 185℃; for 4h;	58%
copper(II) chromite In quinoline at 185℃; for 4h;	58%

: 16078-37-8
5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
Stage #1: 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one With diisobutylaluminium hydride In tetrahydrofuran; toluene at -20 - -10℃; Stage #2: With hydrogenchloride In tetrahydrofuran; water; toluene at 40℃; for 0.5h; Temperature; Concentration; Reagent/catalyst;	88.9%

: 1220339-77-4
5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline 1,2-dicarboxylic acid

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
Stage #1: 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline 1,2-dicarboxylic acid With quinoline; copper at 238℃; for 3h; Stage #2: With hydrogenchloride In water Stage #3: With sodium hydroxide In water	72%

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 107-21-1
ethylene glycol

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
With Pt/Al2O3; zinc(II) oxide In neat (no solvent) at 175℃; for 24h; Sealed tube;	50%

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 107-21-1
ethylene glycol

A: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

B: 52704-48-0
2-[1,2,3,4-tetrahydroquinolin-1-yl]ethan-1-ol

Conditions

Conditions	Yield
With palladium on activated charcoal; zinc(II) oxide In water at 150℃; for 24h; Sealed tube;	A 45% B 45%
With palladium on activated charcoal; zinc(II) oxide In water at 150℃; for 24h; Sealed tube;

...Expand

: 91-22-5
quinoline

: 107-21-1
ethylene glycol

A: 635-46-1
1,2,3,4-tetrahydroisoquinoline

B: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
With palladium 10% on activated carbon; zinc In water at 150℃; for 24h; Autoclave;	A 37% B 16%
With palladium 10% on activated carbon; zinc In water at 150℃; for 40h; Autoclave;	A 33 %Spectr. B 33 %Spectr.
With palladium 10% on activated carbon; zinc In water at 150℃; for 70h; Autoclave;	A 45 %Spectr. B 50 %Spectr.

...Expand

: 117273-45-7
5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
With quinoline; copper oxide-chromium oxide; hydrogen at 190℃;

: 1026530-18-6
[(E)-8-Allyl-3,4-dihydro-2H-quinolin-1-ylimino]-acetic acid

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
With potassium hydroxide; sulfuric acid 1.) ethanol, 120 deg C, 4 h, 2.) ethanol, reflux, 4 h; Yield given. Multistep reaction;

: 2-[(E)-8-Allyl-3,4-dihydro-2H-quinolin-1-ylimino]-propionic acid ethyl ester

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
With pyridine; sulfuric acid; acetic anhydride 1.) ethanol, 3.5 h; Yield given. Multistep reaction;

: 194231-71-5
1-allyl-7-bromo-1H-indole

A: 16886-08-1
1-allylindole

B: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In toluene for 12h; Heating; Yield given. Yields of byproduct given;
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In toluene for 12h; Product distribution; Heating; different N-substituted-7-bromoindoles;

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: tetrahydrofuran / 24 h / Ambient temperature 2: MgCl2 / 2-methoxy-ethanol; tetrahydrofuran / 6 h / 125 °C 3: 94 percent / aq. NaOH / ethanol / 2 h / Heating 4: 93 percent / copper chromite, quinoline / 3 h / 185 °C View Scheme
Multi-step reaction with 2 steps 1: palladium 10% on activated carbon / 24 h / 150 °C / Autoclave 2: palladium 10% on activated carbon; zinc / water / 24 h / 150 °C / Autoclave View Scheme
Multi-step reaction with 2 steps 1: palladium 10% on activated carbon / 24 h / 150 °C / Autoclave 2: palladium 10% on activated carbon; zinc / water / 70 h / 150 °C / Autoclave View Scheme

: 124730-53-6
5,6-dihydro-4H-pyrrolo [3,2,1-ij]quinoline-1-carboxylic acid ethyl ester

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 94 percent / aq. NaOH / ethanol / 2 h / Heating 2: 93 percent / copper chromite, quinoline / 3 h / 185 °C View Scheme
Multi-step reaction with 2 steps 1: sodium hydroxide; water / ethanol / 2 h / Reflux 2: copper chromite / quinoline / 2 h / 185 °C View Scheme

: 152712-44-2
3-(3,4-dihydro-2H-quinolin-1-yl)-2-oxopropionic acid ethyl ester

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: MgCl2 / 2-methoxy-ethanol; tetrahydrofuran / 6 h / 125 °C 2: 94 percent / aq. NaOH / ethanol / 2 h / Heating 3: 93 percent / copper chromite, quinoline / 3 h / 185 °C View Scheme
Multi-step reaction with 3 steps 1: magnesium chloride / 2-methoxy-ethanol / 6 h / 125 °C / Reflux 2: sodium hydroxide; water / ethanol / 2 h / Reflux 3: copper chromite / quinoline / 2 h / 185 °C View Scheme

: 92679-18-0
8-allyl-1,2,3,4-tetrahydroquinoline hydrochloride

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 94.8 percent / CF3COOH / acetonitrile / 4 h 2: 88.6 percent / 1.8 N aq. sodium hypochlorite, 2.6 N aq. NaOH / ethanol / 1 h / 70 °C 3: 93 percent / 66percent aq. AcOH / 1 h / Ambient temperature 4: 1.) 10percent aq. H2SO4, 2.) Ac2O, pyridine / 1.) ethanol, 3.5 h View Scheme
Multi-step reaction with 4 steps 1: 94.8 percent / CF3COOH / acetonitrile / 4 h 2: 88.6 percent / 1.8 N aq. sodium hypochlorite, 2.6 N aq. NaOH / ethanol / 1 h / 70 °C 3: 0.2percent aq. H2SO4 / ethanol / 2 h / Ambient temperature 4: 1.) aq. H2SO4, 2.) 30percent aq. KOH / 1.) ethanol, 120 deg C, 4 h, 2.) ethanol, reflux, 4 h View Scheme

: 152771-24-9
8-allyl-1-carbamoyl-1,2,3,4-tetrahydroquinoline

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 88.6 percent / 1.8 N aq. sodium hypochlorite, 2.6 N aq. NaOH / ethanol / 1 h / 70 °C 2: 93 percent / 66percent aq. AcOH / 1 h / Ambient temperature 3: 1.) 10percent aq. H2SO4, 2.) Ac2O, pyridine / 1.) ethanol, 3.5 h View Scheme
Multi-step reaction with 3 steps 1: 88.6 percent / 1.8 N aq. sodium hypochlorite, 2.6 N aq. NaOH / ethanol / 1 h / 70 °C 2: 0.2percent aq. H2SO4 / ethanol / 2 h / Ambient temperature 3: 1.) aq. H2SO4, 2.) 30percent aq. KOH / 1.) ethanol, 120 deg C, 4 h, 2.) ethanol, reflux, 4 h View Scheme

: 152771-25-0
8-allyl-1-amino-1,2,3,4-tetrahydroquinoline

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 93 percent / 66percent aq. AcOH / 1 h / Ambient temperature 2: 1.) 10percent aq. H2SO4, 2.) Ac2O, pyridine / 1.) ethanol, 3.5 h View Scheme
Multi-step reaction with 2 steps 1: 0.2percent aq. H2SO4 / ethanol / 2 h / Ambient temperature 2: 1.) aq. H2SO4, 2.) 30percent aq. KOH / 1.) ethanol, 120 deg C, 4 h, 2.) ethanol, reflux, 4 h View Scheme

: 91-22-5
quinoline

: 107-21-1
ethylene glycol

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

Conditions

Conditions	Yield
With palladium 10% on activated carbon; zinc In water at 150℃; for 24h; Autoclave;	30 %Spectr.

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: C17H22BNO2

Conditions

Conditions	Yield
With benzylidene dichloride; C14H14N3P; N-ethyl-N,N-diisopropylamine In acetonitrile for 16h; regioselective reaction;	98%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 2-((trifluoromethyl)thio)benzo[d]isothiazol-3(2H)-one 1,1-dioxide

: 1-((trifluoromethyl)thio)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline

Conditions

Conditions	Yield
In 2,2,2-trifluoroethanol at 40℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube;	97%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: C11H10(2)HN

Conditions

Conditions	Yield
With water-d2; silver trifluoromethanesulfonate In chloroform-d1 at 90℃; for 18h; regioselective reaction;	96%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 2-((trifluoromethyl)sulfonyl)benzo[d]thiazole

: 1-((trifluoromethyl)sulfinyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline

Conditions

Conditions	Yield
With Diphenylphosphinic chloride In acetonitrile at 60℃; for 1h; Schlenk technique; Inert atmosphere;	95%

: 67-56-1
methanol

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 79-37-8
oxalyl dichloride

: 124-41-4
sodium methylate

: 345264-02-0
(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester

Conditions

Conditions	Yield
Stage #1: 5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline; oxalyl dichloride In tetrahydrofuran at 0℃; for 2.5h; Stage #2: methanol; sodium methylate In tetrahydrofuran at -78℃;	94%
Stage #1: 5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline; oxalyl dichloride In tetrahydrofuran; dichloromethane at 0℃; for 0.5h; Stage #2: methanol; sodium methylate In tetrahydrofuran; dichloromethane at -78 - 20℃; for 2h;	87%

...Expand

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 4290-72-6
5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-dione

Conditions

Conditions	Yield
With oxygen; Rose Bengal lactone In water; N,N-dimethyl-formamide for 48h; Inert atmosphere; Irradiation;	93%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 920-66-1
1,1,1,3',3',3'-hexafluoro-propanol

: 2-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol

Conditions

Conditions	Yield
With copper diacetate; 4,4'-di-tert-butyl-2,2'-bipyridine at 90℃; for 24h; Schlenk technique; regioselective reaction;	92%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 28272-96-0
2-vinylbenzaldehyde

: 8-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-13-methyl-5,6-dihydro-4H-benzo[b]pyrido[3,2,1-jk]carbazole

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; tetrakis(acetonitrile)palladium bistriflate In acetonitrile at 60℃; for 18h; Inert atmosphere; Schlenk technique; Sealed tube; regioselective reaction;	91%

: 3934-20-1
2,6-Dichloropyrimidine

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 1-(2-chloropyrimidin-4-yl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline

Conditions

Conditions	Yield
Stage #1: 2,6-Dichloropyrimidine With aluminum (III) chloride In 1,2-dimethoxyethane at 20℃; for 0.333333h; Stage #2: 5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline In 1,2-dimethoxyethane at 80℃; for 6h;	90.1%
With iron(III) chloride In 1,2-dichloro-ethane at 60℃;
Stage #1: 2,6-Dichloropyrimidine With aluminum (III) chloride In 1,2-dimethoxyethane at 20℃; for 0.333333h; Stage #2: 5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline In 1,2-dimethoxyethane at 80℃; for 6h;
Stage #1: 2,6-Dichloropyrimidine With aluminum (III) chloride In 1,2-dimethoxyethane at 20℃; for 0.333333h; Stage #2: 5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline In 1,2-dimethoxyethane at 80℃; for 6h;

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 137-26-8
Thiram

: 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl N,N-dimethylaminodithioformate

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; potassium iodide at 60℃; for 12h;	89%
With dipotassium peroxodisulfate; potassium iodide In water; N,N-dimethyl-formamide at 60℃; for 12h; Green chemistry;	89%

: 637-69-4
4-Methoxystyrene

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 118334-83-1
1,3-dioxoisoindolin-2-yl (3r,5r,7r)-adamantane-1- carboxylate

: 1-(2-(-adamantan-1-yl)-1-(4-methoxyphenyl)ethyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline

Conditions

Conditions	Yield
With indium(III) triflate; tris[2-phenylpyridinato-C2,N]iridium(III) at 30℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation;	88%

...Expand

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 1,1,1-trifluoro-2-phenylbut-3-yn-2-yl 2,3,4,5,6-pentafluorobenzoate

: C21H16F3N

Conditions

Conditions	Yield
With 4-methyl-morpholine; copper(I) triflate benzene complex; 2,6-bis[(4S,5R)-4,5-diphenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine In methanol at 0℃; for 24h; Schlenk technique; Inert atmosphere; enantioselective reaction;	86%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 124-41-4
sodium methylate

: 345264-02-0
(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester

Conditions

Conditions	Yield
Stage #1: 5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline; oxalyl dichloride In diethyl ether at 0℃; for 0.5 - 0.75h; Stage #2: sodium methylate In methanol; diethyl ether at -78 - 20℃;	85%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 79-37-8
oxalyl dichloride

: 124-41-4
sodium methylate

: 345264-02-0
(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester

Conditions

Conditions	Yield
Stage #1: 5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline; oxalyl dichloride In diethyl ether at 0℃; Stage #2: sodium methylate In methanol at -78 - 20℃;	85%
Stage #1: 5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline; oxalyl dichloride In diethyl ether at 0℃; for 0.666667h; Stage #2: sodium methylate In methanol; diethyl ether at -78 - 24℃; for 2h;	84%

...Expand

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: sodium trifluoroethylsulfinate

: 1-((2,2,2-trifluoroethyl)thio)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]-quinoline

Conditions

Conditions	Yield
With chloro-trimethyl-silane; phosphonic acid diethyl ester In acetonitrile at 85℃; for 3h; Sealed tube;	85%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 2009-97-4
ethyl 2-diazo-3-oxobutanoate

: ethyl 2,2-bis(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-3-oxobutanoate

Conditions

Conditions	Yield
With air In 2,2,2-trifluoroethanol; water at 120℃; for 12h; Sealed tube;	85%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 65094-22-6
diethyl (bromodifluoromethyl)phosphonate

: 1-((difluoromethyl)thio)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline

Conditions

Conditions	Yield
Stage #1: 5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline With water; iodine; thiourea; potassium iodide In 1,4-dioxane at 50℃; Stage #2: With sodium hydroxide In 1,4-dioxane at 50℃; for 1h; Stage #3: diethyl (bromodifluoromethyl)phosphonate In 1,4-dioxane at 20℃; for 4h;	80%

: 288-88-0
1,2,4-Triazole

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: C13H12N4

Conditions

Conditions	Yield
With 5-ethyl-1,3,7,8-tetramethylalloxazinium triflate; iodine; oxygen In acetonitrile at 50℃; under 760.051 Torr; for 36h; Green chemistry;	79%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: C22H20N2

Conditions

Conditions	Yield
With oxygen; palladium diacetate; acetic acid In dimethyl sulfoxide at 40℃; under 760.051 Torr; for 24h; regioselective reaction;	76%

: 637-69-4
4-Methoxystyrene

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 75-05-8
acetonitrile

: 4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(4-methoxyphenyl)butanenitrile

Conditions

Conditions	Yield
With indium(III) triflate; silver carbonate at 120℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;	75%

...Expand

: 288-13-1
NH-pyrazole

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: C14H13N3

Conditions

Conditions	Yield
With 5-ethyl-1,3,7,8-tetramethylalloxazinium triflate; iodine; oxygen In acetonitrile at 50℃; under 760.051 Torr; for 36h; Green chemistry;	75%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: difluoromethylsulfinyl chloride

: 1-((difluoromethyl)thio)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline

Conditions

Conditions	Yield
In acetonitrile at 90℃; for 6h; Inert atmosphere;	73%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 75-89-8
2,2,2-trifluoroethanol

: 1-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2,2,2-trifluoroethan-1-ol

Conditions

Conditions	Yield
With copper diacetate; 4,4'-di-tert-butyl-2,2'-bipyridine at 90℃; for 24h; Schlenk technique; regioselective reaction;	73%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: C19H17NO4

: 1-((2R,4R,4aR,10aS)-4-(nitromethyl)-2-phenyl-3,4,4a,10a-tetrahydro-2H,5H-pyrano[2,3-b]chromen-2-yl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In dichloromethane at 0℃; Inert atmosphere; Molecular sieve; chemoselective reaction;	72%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 2236-52-4
2,2'-diiodobiphenyl

: C23H17N

Conditions

Conditions	Yield
With palladium(II) trimethylacetate; silver carbonate In dimethyl sulfoxide; N,N-dimethyl-formamide at 80℃; for 19h;	72%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 183322-18-1
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

: 1-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline

Conditions

Conditions	Yield
With 1,1,1,3',3',3'-hexafluoro-propanol; bis(trifluoromethanesulfonyl)amide at 100℃; for 6h; Sealed tube;	72%

: 5840-01-7
5,6-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline

: 24415-66-5
7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine

: 1-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolinone

Conditions

Conditions	Yield
With 1,1,1,3',3',3'-hexafluoro-propanol; bis(trifluoromethanesulfonyl)amide at 100℃; for 6h; Sealed tube;	72%
With 1,1,1,3',3',3'-hexafluoro-propanol; bis(trifluoromethanesulfonyl)amide at 100℃; for 6h; Microwave irradiation; Sealed tube;	72%

Lilolidine Chemical Properties

Molecule structure of Lilolidine (CAS NO.5840-01-7):

Molecular Weight: 157.2117 g/mol
Molecular Formula: C₁₁H₁₁N
Density: 1.166 g/cm³
Melting Point: 80-81°C
Boiling Point: 318.377 °C at 760 mmHg
Flash Point: 146.349 °C
Index of Refraction: 1.656
Molar Refractivity: 49.546 cm³
Molar Volume: 134.785 cm³
Polarizability: 19.641×10^-24 cm³
Surface Tension: 44.838 dyne/cm
Enthalpy of Vaporization: 53.758 kJ/mol
Vapour Pressure: 0.001 mmHg at 25 °C
InChI: InChI=1/C11H11N/c1-3-9-5-2-7-12-8-6-10(4-1)11(9)12/h1,3-4,6,8H,2,5,7H2 Copy
InChIKey: QCCKSFHMARIKSK-UHFFFAOYAA
Product Categories of Lilolidine (CAS NO.5840-01-7): Pale White Powder

Lilolidine Specification

Lilolidine (CAS NO.5840-01-7) is also named as 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinoline ; 5,6-dihydro-4h-pyrrolo[3,2,1-ij]quinoline ; 1,7-Trimethyleneindole .

Product Name

Lilolidine

Synthetic route

Lilolidine Chemical Properties

Lilolidine Specification

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