Maleic acid supplier | CasNO.110-16-7

Name
Maleic acid
EINECS 203-742-5
CAS No. 110-16-7
Article Data402
CAS DataBase
Density 1.499 g/cm³
Solubility 790 g/L (25 °C) in water
Melting Point 137-140 °C(lit.)
Formula C₄H₄O₄
Boiling Point 355.5 °C at 760 mmHg
Molecular Weight 116.073
Flash Point 183 °C
Transport Information UN 2215
Appearance White solid
Safety 26-28-37
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms cis-1,2-Ethylenedicarboxylic acid;cis-2-Butenedioicacid;cis-Butenedioic acid;cis-Butene dioic acid;2-Butenedioicacid (Z)-;Maleic acid (8CI);(2Z)-Butene-2-dioic acid;(Z)-2-Butenedioic acid;2-Butenedioic acid, (Z)-;Malezid CM;Scotchbond MultipurposeEtchant;Toxilic acid;(2Z)-but-2-enedioic acid;(2Z)-2-Butenedioic acid;
PSA 74.60000
LogP -0.28820

Synthetic route

: 110-00-9
furan

: 110-16-7
maleic acid

Conditions

Conditions	Yield
With formic acid; dihydrogen peroxide at 100℃; for 1h;	99%
With air; vanadia at 320℃;
With air; Bismuth vanadate at 320℃;

: 88-14-2
2-furanoic acid

: 110-16-7
maleic acid

Conditions

Conditions	Yield
With potassium hydrogencarbonate In water at 20℃; for 6h; Electrolysis;	95.2%
With dihydrogen peroxide; potassium bromide; potassium hydroxide In water at 100℃; for 3h; Reagent/catalyst;	87.1%
With formic acid; dihydrogen peroxide In water at 79.84℃; under 760.051 Torr; for 24h;	22.4%

: 142-45-0
Acetylenedicarboxylic acid

: 110-16-7
maleic acid

Conditions

Conditions	Yield
With hydrogen In methanol at 20℃; under 760.051 Torr; for 5.5h; Green chemistry;	94%
With hydrogen In methanol under 760.051 Torr; for 6h;	92%
With water; palladium Hydrogenation;

: 3238-40-2
furan-2,5-dicarboxylic acid

: 110-16-7
maleic acid

Conditions

Conditions	Yield
With potassium hydrogencarbonate In water at 20℃; for 6h; Electrolysis;	90.7%
With formic acid; dihydrogen peroxide at 100℃; for 1h;	6%
With dihydrogen peroxide In water at 80℃; for 5h;	40 %Chromat.

: 98-01-1
furfural

: 110-16-7
maleic acid

Conditions

Conditions	Yield
With formic acid; dihydrogen peroxide at 100℃; for 0.666667h; Mechanism; Kinetics; Reagent/catalyst; Temperature; Time; Sealed tube; Green chemistry;	90%
With hierarchical cobalt substituted aluminophosphate molecular sieves synthesized using 0.45 % CTAB as template at 60℃; for 3h; Reagent/catalyst;	86.9%
With dihydrogen peroxide; acetic acid; methyltrioxorhenium(VII) In water at 20℃;	81%

: 98-01-1
furfural

A: 110-15-6
succinic acid

B: 110-16-7
maleic acid

Conditions

Conditions	Yield
With tetrafluoroboric acid; dihydrogen peroxide; 5 weight percent methyltrioxorhenium on polystyrene In water at 20℃; for 24h; Product distribution / selectivity;	A 10% B 90%
With dihydrogen peroxide In water at 79.84℃; under 760.051 Torr; for 24h;	A 72.1% B 13.8%
With dihydrogen peroxide In water at 79.84℃; under 760.051 Torr; for 24h; Reagent/catalyst; Schlenk technique; Green chemistry;	A 74 %Chromat. B 11 %Chromat.
With hydrogenchloride In water at 80℃; for 5h; Reagent/catalyst;	A 22 %Chromat. B 34 %Chromat.
With zinc(II) nitrate hexahydrate; dihydrogen peroxide In water at 80℃; for 5h; Reagent/catalyst;	A 18 %Chromat. B 13 %Chromat.

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

: 110-16-7
maleic acid

Conditions

Conditions	Yield
With formic acid; dihydrogen peroxide at 100℃; for 1h;	89%
With potassium hydrogencarbonate In water at 20℃; for 6h; Electrolysis;	49.3%
With sulfuric acid In water at 60℃; pH=1; Electrochemical reaction;	35.5%
With dihydrogen peroxide In water at 80℃; for 5h;	28 %Chromat.

: 98-01-1
furfural

A: 88-14-2
2-furanoic acid

B: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; 5 weight percent methyltrioxorhenium on polystyrene In water at 20℃; Product distribution / selectivity;	A 87% B 1%
With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide In water; acetonitrile at 10℃; for 1h;	A 82% B 15%
With dihydrogen peroxide; 5 weight percent methyltrioxorhenium on polystyrene In water at 20℃; for 24h; Product distribution / selectivity;	A 18% B 82%
With water; dihydrogen peroxide at 60℃; for 4h; pH=7.5;	A 45 %Spectr. B n/a

: 98-01-1
furfural

A: 617-48-1
malic acid

B: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; acetic acid; 5 weight percent methyltrioxorhenium on polystyrene In water at 20℃; Product distribution / selectivity;	A 9% B 84%

: 6118-51-0
exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride

A: 108-31-6
maleic anhydride

B: 110-16-7
maleic acid

Conditions

Conditions	Yield
With formic acid In water; acetonitrile at 90℃; for 5h; Reagent/catalyst;	A 82% B 7%

: 98-01-1
furfural

A: 88-14-2
2-furanoic acid

B: 110-15-6
succinic acid

C: 110-16-7
maleic acid

Conditions

Conditions	Yield
With tetrafluoroboric acid; dihydrogen peroxide; 5 weight percent methyltrioxorhenium on polystyrene In water at 20℃; for 24h; Product distribution / selectivity;	A 9% B 10% C 81%
With dihydrogen peroxide; acetic acid; 5 weight percent methyltrioxorhenium on poly(4-vinylpyridine) In water at 20℃;	A 41% B 6% C 40%
With water; dihydrogen peroxide at 60℃; for 4h; pH=6; pH-value;	A 50 %Spectr. B n/a C n/a

...Expand

: 823-82-5
2,5-diformylfurane

A: 85-44-9
phthalic anhydride

B: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; water In acetonitrile at 90℃; for 5h;	A 77.2% B 14.4%

: 823-82-5
2,5-diformylfurane

: 110-16-7
maleic acid

Conditions

Conditions	Yield
With formic acid; dihydrogen peroxide at 100℃; for 1h;	77%
With potassium hydrogencarbonate In water at 20℃; for 6h; Electrolysis;	42.1%

: 14032-66-7
5-hydroxy-2-(5H)-furanone

: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 49.84℃; for 24h;	76%
With laccase; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen In acetone at 25℃; for 24h; pH=4.5; Solvent; Reagent/catalyst; pH-value; Temperature; Enzymatic reaction;

: 98-01-1
furfural

A: 497-23-4
2-buten-4-olide

B: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; acetic acid In water at 60℃; for 24h; Green chemistry;	A 71% B 11%
With dihydrogen peroxide; potassium bromide; potassium hydroxide In water at 100℃; for 3h; Concentration;	A 7.1% B 51.9%

: 6338-41-6
5-hydroxymethyl-furan-2-carboxylic acid

: 110-16-7
maleic acid

Conditions

Conditions	Yield
With potassium hydrogencarbonate In water at 20℃; for 6h; Electrolysis;	67.8%

: 110-17-8
(2E)-but-2-enedioic acid

: 110-16-7
maleic acid

Conditions

Conditions	Yield
With triethanolamine; C33H21IrN3O9S3(3-) In water for 20h; Alkaline conditions; Inert atmosphere; Irradiation;	66%
With ethanol Irradiation.UV-Licht;
entsteht das Anhydrid;

: 98-01-1
furfural

A: 88-14-2
2-furanoic acid

B: 110-15-6
succinic acid

C: 110-16-7
maleic acid

D: 110-17-8
(2E)-but-2-enedioic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; 1-butyl-3-methylimidazolium Tetrafluoroborate; methyltrioxorhenium(VII) In water at 20℃;	A 7% B 12% C 66% D 13%

...Expand

: 98-01-1
furfural

A: 88-14-2
2-furanoic acid

B: 617-48-1
malic acid

C: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; methyltrioxorhenium(VII) In dichloromethane; water; acetonitrile at 20℃;	A 10% B 8% C 66%

...Expand

: 98-01-1
furfural

A: 110-15-6
succinic acid

B: 497-23-4
2-buten-4-olide

C: 110-16-7
maleic acid

Conditions

Conditions	Yield
With formic acid; dihydrogen peroxide; sodium sulfate In water; ethyl acetate at 59.84℃; for 3h; Kinetics; Solvent; Reagent/catalyst; Temperature; Concentration;	A 8.5% B 61.5% C 6.7%
With potassium chloride; dihydrogen peroxide; potassium hydroxide In water at 100℃; for 3h; Reagent/catalyst;	A 24.2% B 10.4% C 41.2%
With formic acid; dihydrogen peroxide; sodium sulfate In water at 59.84℃; for 3h; Kinetics; Solvent; Reagent/catalyst;	A 38.3% B 12.8% C 17.3%

...Expand

: 98-01-1
furfural

A: 110-16-7
maleic acid

B: 110-17-8
(2E)-but-2-enedioic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; acidine In water at 100℃; for 0.5h; Temperature;	A 61% B 31%
With dihydrogen peroxide; acidine In water at 100℃; for 2h; Time;	A 10% B 48%
With sodium chlorate; vanadium pentoxide In water at 85 - 95℃; for 19h;	A n/a B 47%
With sodium chlorate; vanadia In water at 80 - 90℃; for 13h; Overall yield = 58 %; Overall yield = 42.3 g;	A n/a B n/a
With choline chloride; dihydrogen peroxide; oxalic acid In water at 50℃; for 24h; Reagent/catalyst; Green chemistry; Overall yield = 95.7 %Chromat.;

: 617-48-1
malic acid

A: 110-16-7
maleic acid

B: 110-17-8
(2E)-but-2-enedioic acid

C: 79-10-7
acrylic acid

Conditions

Conditions	Yield
sodium hydroxide In water at 340℃; under 129290 Torr; pH=3.17; Product distribution / selectivity;	A 10.52% B 6.88% C 59.23%

...Expand

: 98-01-1
furfural

A: 14032-66-7
5-hydroxy-2-(5H)-furanone

B: 64-18-6
formic acid

C: 617-48-1
malic acid

D: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 49.84℃; for 24h; Catalytic behavior; Temperature; Concentration;	A n/a B n/a C n/a D 57%

...Expand

: 13529-17-4
5-Formyl-2-furancarboxylic acid

: 110-16-7
maleic acid

Conditions

Conditions	Yield
With potassium hydrogencarbonate In water at 20℃; for 6h; Electrolysis;	56.9%
With formic acid; dihydrogen peroxide at 100℃; for 1h;	33%

: 617-48-1
malic acid

A: 110-16-7
maleic acid

B: 79-10-7
acrylic acid

Conditions

Conditions	Yield
sodium hydroxide In water at 345℃; under 181007 Torr; pH=3.31; Product distribution / selectivity;	A 5.22% B 56.18%

: 87-72-9, 608-45-7, 608-46-8, 608-47-9, 2460-44-8, 6748-95-4, 6763-34-4, 7261-26-9, 7283-06-9, 7283-07-0, 7296-55-1, 7296-56-2, 7296-58-4, 7296-59-5, 7296-60-8, 7296-61-9, 7296-62-0, 7322-30-7, 10257-31-5, 10257-32-6, 10257-33-7, 10257-34-8, 10257-35-9, 19982-83-3, 20242-88-0, 28697-53-2, 36562-42-2, 41546-41-2, 89299-64-9, 107655-34-5, 115794-06-4, 115794-07-5, 130550-15-1, 130606-21-2
D-lyxose

A: 64-18-6
formic acid

B: 79-14-1
glycolic Acid

C: 526-92-1
D-lyxonic acid

D: 110-16-7
maleic acid

Conditions

Conditions	Yield
With silver nitrate at 100℃; Product distribution; Rate constant; Thermodynamic data; study of the oxidation reaction of D-lyxose by silver ion, kinetic mesurements, ΔS(excit.),;	A 10% B 8% C 55% D 6%

...Expand

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 79-14-1
glycolic Acid

B: 617-48-1
malic acid

C: 110-16-7
maleic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; methyltrioxorhenium(VII) In water; acetic acid at 20℃;	A 55% B 29% C 14%

...Expand

: 67-47-0
5-hydroxymethyl-2-furfuraldehyde

A: 3238-40-2
furan-2,5-dicarboxylic acid

B: 110-16-7
maleic acid

Conditions

Conditions	Yield
With sulfuric acid In water at 60℃; pH=1; Electrochemical reaction;	A 54% B n/a

: 87-72-9, 608-45-7, 608-46-8, 608-47-9, 2460-44-8, 6748-95-4, 6763-34-4, 7261-26-9, 7283-06-9, 7283-07-0, 7296-55-1, 7296-56-2, 7296-58-4, 7296-59-5, 7296-60-8, 7296-61-9, 7296-62-0, 7322-30-7, 10257-31-5, 10257-32-6, 10257-33-7, 10257-34-8, 10257-35-9, 19982-83-3, 20242-88-0, 28697-53-2, 36562-42-2, 41546-41-2, 89299-64-9, 107655-34-5, 115794-06-4, 115794-07-5, 130550-15-1, 130606-21-2
D-lyxose

A: 526-92-1
D-lyxonic acid

B: 124-38-9
carbon dioxide

C: 110-16-7
maleic acid

Conditions

Conditions	Yield
With mercury(II) nitrate at 100℃; Product distribution; Rate constant; Thermodynamic data; study of the oxidation reaction of D-lyxose by mercuric ion, kinetic mesurements, ΔS(excit.);	A 52% B 10% C 12%

...Expand

: 67-56-1
methanol

: 110-16-7
maleic acid

: 624-48-6
dimethyl cis-but-2-ene-1,4-dioate

Conditions

Conditions	Yield
With boron trifluoride at 65℃; for 0.333333h;	100%
With sulfuric acid at 75℃; for 16h;	97%
With sulfuric acid at 75℃; for 16h; Reflux;	97%

: 110-16-7
maleic acid

: 110-15-6
succinic acid

Conditions

Conditions	Yield
With palladium/alumina; hydrogen In water at 80℃; for 6.5h;	100%
With samarium diiodide In tetrahydrofuran for 0.0833333h; Ambient temperature;	99%
With hydrogen; NPF-1 (palladium 0.2 wt percent, nickel 0.2 wt percent, iron 0.07 wt percent on carbon) modified with maleic acid In water at 90 - 100℃; under 15201 Torr; Product distribution / selectivity; Autoclave; Inert atmosphere;	99.5%

: 110-16-7
maleic acid

: 110-17-8
(2E)-but-2-enedioic acid

Conditions

Conditions	Yield
With (E)-4-(2-chlorostyryl)pyridine In methanol at 20℃; for 720h;	100%
With maleic anhydride In water at 190℃; for 6h; Reagent/catalyst; Inert atmosphere; Autoclave; Green chemistry;	99.5%
With N-Bromosuccinimide; dibenzoyl peroxide; acetic acid for 6h; Heating;	90%

: 10596-56-2
S,S-Di(n-propyl) dithiocarbonate

: 110-16-7
maleic acid

: 45015-91-6
(+/-)-propylsulfanyl-succinic acid

Conditions

Conditions	Yield
With potassium hydroxide In methanol; water for 8h; Heating;	100%

: 59565-09-2
2-(vinyloxy)ethyl isothiocyanate

: 110-16-7
maleic acid

: (Z)-But-2-enedioic acid bis-[1-(2-isothiocyanato-ethoxy)-ethyl] ester

Conditions

Conditions	Yield
at 90 - 100℃; for 1h;	100%

: 2095-14-9
3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propan-1-amine

: 110-16-7
maleic acid

: 10-(3-aminopropyl)-2-trifluoromethyl-10H-phenothiazine maleate

Conditions

Conditions	Yield
In ethanol	100%

: 110-16-7
maleic acid

: 38841-00-8
1,2-cis-2,3-trans-3,4-cis-cyclobutane-1,2,3,4-tetracarboxylic acid

Conditions

Conditions	Yield
at 20℃; for 100h; Photolysis;	100%

: 110-16-7
maleic acid

: dihydro-2(3H)furanone-[3,4,5,5-D4]

Conditions

Conditions	Yield
With deuterium; Ru4H4(CO)8(PBu3)4 In tetrahydrofuran at 180℃; for 48h;	100%

: 110-16-7
maleic acid

: disodium cis-epoxysuccinate

Conditions

Conditions	Yield
With sodium hydroxide; dihydrogen peroxide; sodium tungstate In water at 65 - 70℃; for 1.75h; pH=2 - 5.5;	100%

: 110-16-7
maleic acid

: 110-63-4
Butane-1,4-diol

Conditions

Conditions	Yield
With hydrogen In water	100%
With hydrogen In water	100%
With hydrogen In water	100%

: 6-((1SR,3RS)-3-{2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethylamino}cyclopentylmethylamino)nicotinonitrile

: 110-16-7
maleic acid

: 6-((1SR,3RS)-3-{2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethylamino}cyclopentylmethylamino)nicotinonitrile maleate

Conditions

Conditions	Yield
In acetone at 20℃; for 0.333333h;	100%

: (+/-)-4-(3-chloro-1H-indol-6-yl)-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 110-16-7
maleic acid

: (+/-)-4-(3-chloro-1H-indol-6-yl)-2-methyl-1,2,3,4-tetrahydroisoquinoline maleate

Conditions

Conditions	Yield
In methanol; dichloromethane for 1h;	100%

: endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-2-(2-morpholinophenyl)benzoxazole-4-carboxamide

: 110-16-7
maleic acid

: endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-2-(2-morpholinophenyl)benzoxazole-4-carboxamide maleate

Conditions

Conditions	Yield
In methanol; acetonitrile	100%

: endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-2-[2-(4-methylpiperazin-1-yl)phenyl]benzoxazole-4-carboxamide

: 110-16-7
maleic acid

: endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-2-[2-(4-methylpiperazin-1-yl)phenyl]benzoxazole-4-carboxamide maleate

Conditions

Conditions	Yield
In methanol; acetonitrile	100%

: sodium tungstate

concentrated sodium hydroxide: concentrated sodium hydroxide

: 110-16-7
maleic acid

: disodium cis-oxirane-1,2-dicarboxylate

Conditions

Conditions	Yield
With sodium hydroxide; dihydrogen peroxide In water; acetone	100%

...Expand

: 863613-79-0
2-[((2S)-1'-{2-[(2R)-4-[3,5-bis(trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)morpholin-2-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl)oxy]-N-(4-hydroxybutyl)-N-methylacetamide

: 110-16-7
maleic acid

: 2-[((2S)-1'-{2-[(2R)-4-[3,5-bis(Trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)morpholin-2-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl)oxy]-N-(4-hydroxybutyl)-N-methylacetamide maleate

Conditions

Conditions	Yield
In ethanol	100%

: 6-(5-(4-chlorophenyl)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-yl)pyridazin-3-amine

: 110-16-7
maleic acid

: (+/-)-6-(5-(4-chlorophenyl)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-yl)pyridazin-3-amine maleate

Conditions

Conditions	Yield
In methanol; water	100%

: 71125-38-7
meloxicam

: 110-16-7
maleic acid

: 1174325-93-9
4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide maleic acid (1:1)

Conditions

Conditions	Yield
In tetrahydrofuran for 0.5h;	100%
In tetrahydrofuran Product distribution / selectivity;
In ethyl acetate for 19h; Solvent;
In tetrahydrofuran at 20℃; for 24h;

: 109-73-9
N-butylamine

: 110-16-7
maleic acid

: 94267-98-8
N1, N4-dibutylmaleamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 0 - 20℃; for 18h;	100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran for 18h; Cooling with ice;

: 138112-76-2
agomelatine

: 110-16-7
maleic acid

: 1403960-82-6
agomelatine maleic acid

Conditions

Conditions	Yield
In ethanol for 0.75h;	100%
In methanol; ethyl acetate at 20℃; for 168h; Product distribution / selectivity;
for 1h;

: 110-16-7
maleic acid

: 148553-50-8
pregabilin

: 1414928-41-8
(S)-3-(aminomethyl)-5-methylhexanoic acid maleate

Conditions

Conditions	Yield
In 2-methylpropyl acetate for 0.75h; Product distribution / selectivity;	100%

: 1269662-73-8
(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine

: 110-16-7
maleic acid

: (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide maleate

Conditions

Conditions	Yield
In dichloromethane at 20 - 30℃; for 1h; Inert atmosphere;	100%
In dichloromethane at 20 - 30℃; for 1h;	100%

: 1577003-07-6
N,N-bis-(phenylcarbamoylmethyl)dimethylammonium hydroxide

: 110-16-7
maleic acid

: 1577003-12-3
N,N-bis-(phenylcarbamoylmethyl)dimethylammonium maleate

Conditions

Conditions	Yield
In isopropyl alcohol at 25 - 40℃; for 6h;	100%

: 2424-01-3
methyldiallylamine

: 110-16-7
maleic acid

: C7H13N*C4H4O4

Conditions

Conditions	Yield
In water at 25℃; for 0.5h;	100%

: 87760-53-0
tandospirone

: 110-16-7
maleic acid

: tandospirone maleic acid

Conditions

Conditions	Yield
In ethanol; water at 70℃; Temperature; Solvent; Large scale;	99.9%

: 5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(6,7-dihydro-5H-pyrrolo-[2,1-c][1,2,4 ]triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide

: 110-16-7
maleic acid

: C24H22FN7O*C4H4O4

Conditions

Conditions	Yield
In tetrahydrofuran for 8h; Solvent;	99.7%

: 1039743-15-1
4-methyl-6-[1'-(5-methylpyrazin-2-yl)-4,4'-bipiperidin-1-yl]pyrimidine-2-carbonitrile

: 110-16-7
maleic acid

: C4H4O4*C21H27N7

Conditions

Conditions	Yield
In tetrahydrofuran at 35℃;	99.4%

: 110-16-7
maleic acid

: 1,2-dimethyl-5-vinylpyridinium methyl sulfate

polymer, 98.6 mol percent of 1,2-dimethyl-5-vinylpyridinium methyl sulfate, [η] = 2.05 dl/g; monomer(s): 1,2-dimethyl-5-vinylpyridinium methyl sulfate; maleic acid: polymer, 98.6 mol percent of 1,2-dimethyl-5-vinylpyridinium methyl sulfate, [η] = 2.05 dl/g; monomer(s): 1,2-dimethyl-5-vinylpyridinium methyl sulfate; maleic acid

Conditions

Conditions	Yield
With 1-tert-butylperoxy-propan-2-ol In water at 20℃;	99%

: 110-16-7
maleic acid

: 1,2-dimethyl-5-vinylpyridinium methyl sulfate

polymer, 97.0 mol percent of 1,2-dimethyl-5-vinylpyridinium methyl sulfate, [η] = 1.71 dl/g; monomer(s): 1,2-dimethyl-5-vinylpyridinium methyl sulfate; maleic acid: polymer, 97.0 mol percent of 1,2-dimethyl-5-vinylpyridinium methyl sulfate, [η] = 1.71 dl/g; monomer(s): 1,2-dimethyl-5-vinylpyridinium methyl sulfate; maleic acid

Conditions

Conditions	Yield
With 1-tert-butylperoxy-propan-2-ol In water at 20℃;	99%

Maleic acid Consensus Reports

Reported in EPA TSCA Inventory.

Maleic acid Standards and Recommendations

DOT Classification: 8; Label: Corrosive

Maleic acid Specification

The Maleic acid, with the CAS registry number 110-16-7 and EINECS registry number 203-742-5, has the IUPAC name of (Z)-but-2-enedioic acid. And the molecular formula of this chemical is C₄H₄O₄. It is a kind of white solid, and belongs to the product category of Miscellaneous. This dicarboxylic acid is the cis isomer of butenedioic acid, whereas fumaric acid is the trans isomer.

The physical properties of Maleic acid are as following: (1)ACD/LogP: -0.01; (2)# of Rule of 5 Violations: 0; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 4; (8)#H bond donors: 2; (9)#Freely Rotating Bonds: 2; (10)Polar Surface Area: 52.6 Å²; (11)Index of Refraction: 1.526; (12)Molar Refractivity: 23.76 cm³; (13)Molar Volume: 77.4 cm³; (14)Polarizability: 9.42×10^-24cm³; (15)Surface Tension: 67.6 dyne/cm; (16)Density: 1.499 g/cm³; (17)Flash Point: 183 °C; (18)Enthalpy of Vaporization: 65.99 kJ/mol; (19)Boiling Point: 355.5 °C at 760 mmHg; (20)Vapour Pressure: 5.19E-06 mmHg at 25°C.

Preparation of Maleic acid: In industry, it is derived by hydrolysis of maleic anhydride, the latter being produced by oxidation of benzene or butane. It can also be prepared by the hydrolyzation of maleic anhydride, and the maleic anhydride can be obtained from malic acid in the presence of acetyl chloride.

Maleic acid can also be prepared by the hydrolyzation of maleic anhydride, and the maleic anhydride can be obtained from malic acid in the presence of acetyl chloride

Uses of Maleic acid: It is mainly used as a precursor to fumaric acid, and relative to its parent maleic anhydride, maleic acid has few applications. It is also used in pesticide marathon, fumaric acid, unsaturated polyester and dyeing auxiliary.

You should be cautious while dealing with this chemical. It irritates eyes, respiratory system and skin, and it is also harmful if swallowed. Therefore, you had better take the following instructions: Wear suitable gloves, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer).

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O)\C=C/C(=O)O
(2)InChI: InChI=1/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1-
(3)InChIKey: VZCYOOQTPOCHFL-UPHRSURJBG

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	2400mg/kg (2400mg/kg)		Biochemical Journal. Vol. 34, Pg. 1196, 1940.
rabbit	LD50	skin	1560mg/kg (1560mg/kg)	BEHAVIORAL: TREMOR	BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 7-4/1970,
rat	LC50	inhalation	> 720mg/m³/1H (720mg/m³)		BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 7-4/1970,
rat	LD50	oral	708mg/kg (708mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 7-4/1970,

Product Name

Maleic acid

Synthetic route

Maleic acid Consensus Reports

Maleic acid Standards and Recommendations

Maleic acid Specification

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