Morpholine supplier | CasNO.110-91-8

Name
Morpholine
EINECS 203-815-1
CAS No. 110-91-8
Article Data311
CAS DataBase
Density 0.931 g/cm³
Solubility miscible with water.
Melting Point -5 °C
Formula C₄H₉NO
Boiling Point 128.9 °C at 760 mmHg
Molecular Weight 87.1216
Flash Point 35.6 °C
Transport Information UN 2054 8/PG 1
Appearance aqueous solution with a fishlike odor
Safety 23-36-45
Risk Codes 10-20/21/22-34
Molecular Structure
Hazard Symbols C
Synonyms Diethylenimide oxide;Drewamine;BASF 238;1-Oxa-4-azacyclohexane;Tetrahydro-2H-1,4-oxazine;Morpholine (4-oxazine);Tetrahydro-p-oxazine;Diethyleneimide oxide;Diethylene oximide;Tetrahydro-1,4-oxazine;2H-1,4-Oxazine, tetrahydro-;Morpholine hydrochloride;p-Isoxazine, tetrahydro-;Diethylene imidoxide;Tetrahydro-1, 4-isoxazine;1-oxa-4-azoniacyclohexane;4H-1,4-Oxazine, tetrahydro-;
PSA 21.26000
LogP -0.06500

Synthetic route

: (1S,2S,5R,6R,7S,8S)-1,6-Dimethyl-8-morpholin-4-yl-3,4-diaza-tricyclo[3.2.1.02,7]oct-3-ene-2,5-dicarboxylic acid dimethyl ester

A: 110-91-8
morpholine

B: 2166-25-8
dimethyl 4-methylpyridazine-3,6-dicarboxylate

Conditions

Conditions	Yield
In xylene for 6h; Heating;	A n/a B 100%
under 0.075006 Torr; Pyrolysis;

: 25070-77-3
allyl morpholine-1-carboxylate

A: 110-91-8
morpholine

B: 696-57-1
N-allylmorpholine

Conditions

Conditions	Yield
With diethylamine; palladium diacetate; trisodium tris(3-sulfophenyl)phosphine In water for 0.166667h; Ambient temperature;	A 98% B 2%
With formic acid; triphenylphosphine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex In tetrahydrofuran at 30℃; for 3h;	A 16 % Chromat. B 84 % Chromat.

: 111-46-6
diethylene glycol

A: 110-91-8
morpholine

B: 109-02-4
4-methyl-morpholine

Conditions

Conditions	Yield
With methylamine	A 98% B n/a

: 4837-31-4
4-Phenylsulfanyl-morpholine

: 691-96-3
diisopropyl phosphite

A: 110-91-8
morpholine

B: 15267-38-6
thiophosphoric acid O,O'-diisopropyl ester S-phenyl ester

Conditions

Conditions	Yield
	A n/a B 96%

...Expand

: 114406-39-2
prop-2-yn-1-yl morpholine-4-carboxylate

: 110-91-8
morpholine

Conditions

Conditions	Yield
With benzyltriethylammonium tetrathiomolybdate In acetonitrile at 20℃; for 2.5h;	95%
With potassium tetrachloroplatinate(II) In d(4)-methanol; water-d2 at 20℃; for 14h; Reagent/catalyst;

: 4394-85-8
4-morpholinecarboxaldehyde

: 110-91-8
morpholine

Conditions

Conditions	Yield
With Ru-MACHO; potassium tert-butylate; hydrogen In tetrahydrofuran at 140℃; under 38002.6 Torr; for 2.5h; Catalytic behavior; Temperature; Glovebox; Autoclave; Cooling with ice;	95%
With [bis({2‐[bis(propan‐2‐yl)phosphanyl]ethyl})amide](carbonyl)(hydride)iron(II); hydrogen In tetrahydrofuran at 100℃; under 22801.5 Torr; for 4h; Catalytic behavior;

: 437-81-0
2,6-difluorobenzaldehyde

: 2365-48-2
Methyl thioglycolate

: 95-15-8
Benzo[b]thiophene

A: 110-91-8
morpholine

B 2-(1-Morpholino)-6-fluorobenzaldehyde: 2-(1-Morpholino)-6-fluorobenzaldehyde

Conditions

Conditions	Yield
With triethylamine In NaH; dimethyl sulfoxide; acetonitrile	A 93% B n/a

...Expand

: 112918-83-9
4-(9-fluorenylmethoxycarbonyl)morpholine

: 110-91-8
morpholine

Conditions

Conditions	Yield
With triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate In neat (no solvent) at 25℃; for 0.0666667h; Green chemistry;	93%

: 7529-22-8
4-methylmorpholine N-oxide

: 110-91-8
morpholine

Conditions

Conditions	Yield
With 1,3,5-trichloro-2,4,6-triazine; potassium carbonate In chloroform at 0 - 20℃;	92%

: 779-53-3
4-morpholinylacetophenone

: 110-91-8
morpholine

Conditions

Conditions	Yield
With magnesium; acetic acid In methanol at 20℃;	92%

: 220199-85-9
morpholine-4-carboxylic acid tert-butyl ester

: 110-91-8
morpholine

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane for 3h; Ambient temperature;	91%

: 25070-77-3
allyl morpholine-1-carboxylate

A: 110-91-8
morpholine

B: 696-57-1
N-allylmorpholine

C: 187737-37-7
propene

Conditions

Conditions	Yield
With formic acid; triphenylphosphine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex In tetrahydrofuran at 30℃; for 3h;	A 16 % Chromat. B 84% C n/a

...Expand

: 4837-31-4
4-Phenylsulfanyl-morpholine

: 762-04-9, 123-22-8
Diethyl phosphonate

A: 110-91-8
morpholine

B: 37097-43-1
Diethyl 4-morpholidophosphate

C: 1889-58-3
O,O-diethyl S-phenyl phosphorothioate

Conditions

Conditions	Yield
	A n/a B 5% C 83%

...Expand

: 59-89-2
N-nitrosomorpholine

: 110-91-8
morpholine

Conditions

Conditions	Yield
With ammonium formate; PdMCM-41 In methanol at 69.84℃; for 2h;	80%
With isocyanate de chlorosulfonyle In diethyl ether for 10h; Ambient temperature;	75%
With perchloric acid; ammonium sulfamate; sodium thiocyanide at 50℃; Rate constant; piperidinium perchlorate, 18h; transnitrosating studies;
With benzophenone In N,N-dimethyl-formamide at 25℃; Rate constant; var. organic electron carriers, object of study - homogeneous electrochemical reduction with the aid of organic electron carriers;

: 14212-87-4
1,1-bis(N-morpholinyl)ethylene

: 109-77-3
malononitrile

A: 110-91-8
morpholine

B: 1696-20-4
4-acetylmorpholine

C: 111505-54-5
2-(1-morpholinoethylidene)malononitrile

Conditions

Conditions	Yield
In diethyl ether for 8h; Heating;	A n/a B n/a C 74%

...Expand

: 5033-21-6
4-benzenesulfonylmorpholine

: 110-91-8
morpholine

Conditions

Conditions	Yield
With chloro-trimethyl-silane; sodium iodide In acetonitrile for 3h; Heating;	70%

: ethyl 2-<(1H-benzimidazol-2-yl)sulfinylmethyl>-4-morpholino-5-pyrimidinecarboxylate

A: 110-91-8
morpholine

B: 40752-96-3
ethyl 4-aminopyrimido<1,2-a>benzimidazole-3-carboxylate

C: 173545-83-0
ethyl 4-<2-(2-hydroxyethyldithio)-1-(2-hydroxyethylthio)ethylideneamino>pyrimido<1,2-a>benzimidazole-3-carboxylate

Conditions

Conditions	Yield
With hydrogenchloride; 2-hydroxyethanethiol In methanol for 4h; Ambient temperature;	A 69% B 5% C 64%

...Expand

: ethyl 2-<(1H-benzimidazol-2-yl)sulfinylmethyl>-4-morpholino-5-pyrimidinecarboxylate

: 60-24-2
2-hydroxyethanethiol

A: 110-91-8
morpholine

B: 40752-96-3
ethyl 4-aminopyrimido<1,2-a>benzimidazole-3-carboxylate

C: 173545-83-0
ethyl 4-<2-(2-hydroxyethyldithio)-1-(2-hydroxyethylthio)ethylideneamino>pyrimido<1,2-a>benzimidazole-3-carboxylate

Conditions

Conditions	Yield
With hydrogenchloride In methanol for 4h; Ambient temperature;	A 69% B 5% C 64%

...Expand

: 4837-31-4
4-Phenylsulfanyl-morpholine

: 96-36-6, 868-85-9
methyl phosphite

A: 110-91-8
morpholine

B: 4237-00-7
thiophosphoric acid O,O'-dimethyl ester S-phenyl ester

Conditions

Conditions	Yield
	A n/a B 67%

...Expand

: 13368-42-8
4-(trimethylsilyl)morpholine

: 110-91-8
morpholine

Conditions

Conditions	Yield
With C8H20BO(1-)*Na(1+) In tetrahydrofuran at 80℃; for 6h; Reagent/catalyst; Inert atmosphere; Schlenk technique; High pressure;	66%
Stage #1: 4-(trimethylsilyl)morpholine With cesium fluoride at 100℃; for 0.5h; Inert atmosphere; Sealed tube; Stage #2: In chloroform-d1 Inert atmosphere; Acidic conditions;	29%
With potassium trimethylsilonate In dimethyl sulfoxide at 70℃; for 6h; Sealed tube; Schlenk technique;	47 %Chromat.
With Na(1+)C6H15BC2H5O(1-) In tetrahydrofuran at 80℃; for 6h; Reagent/catalyst;	66 %Chromat.

: 105787-50-6
4,4'-<3,3'-Oxybis(2-methyl-1-phenyl-2-propenyliden)>dimorpholinium-bis(trifluormethansulfonat)

A: 110-91-8
morpholine

B: 55439-08-2
3-Hydroxy-2-methyl-1-oxo-1-phenylprop-2-ene

Conditions

Conditions	Yield
With water In acetonitrile for 96h; Product distribution; Ambient temperature;	A n/a B 62%

: 141-43-5
ethanolamine

: 74-86-2
acetylene

A: 110-91-8
morpholine

B: 7336-29-0
2-aminoethyl vinyl ether

C: 57796-76-6
2-vinyloxy-1,3-butadiene

D: 93555-19-2
N-Ethylideneethanolamine Vinyl Ether

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 100℃; under 760 Torr; for 2h; Product distribution; reaction under different conditions (temperature, pressure, time, base, solvent);	A n/a B 60% C n/a D n/a
With potassium hydroxide In dimethyl sulfoxide at 100℃; under 760 Torr; for 2h;	A n/a B 60% C n/a D n/a

...Expand

: 670-80-4
4-cyclohexen-1-ylmorpholine

: C10H7BrF3NO3

A: 110-91-8
morpholine

: (7S*,12bS*,12cS*,4aS*)-11-bromo-4a-morpholino-7-(trifluoromethyl)-2,3,4,4a,12b,12c-hexahydro-1H,7H-chromeno[3,4-c][1,2]benzoxazin-6-oxide

C: 108-94-1
cyclohexanone

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 0.5h; Michael Addition; diastereoselective reaction;	A n/a B 59% C n/a

...Expand

: 4542-47-6
3-Morpholin-4-yl-propionitrile

A: 110-91-8
morpholine

B: 123-00-2
4-(3-Aminopropyl)morpholine

Conditions

Conditions	Yield
With sodium tetrahydroborate; hydrogen; nickel dichloride In tert-butyl alcohol at 70℃; under 760.051 Torr; for 8h;	A 22% B 59%

: 110-91-8
morpholine

: 106-92-3
Allyl glycidyl ether

: N-(3-allyloxy-2-hydroxypropyl)morpholine

Conditions

Conditions	Yield
In 2,2,2-trifluoroethanol at 20℃; for 6h; regioselective reaction;	100%
With copper(II) ferrite In dichloromethane at 20℃; regioselective reaction;	95%
With Montmorillonite K10 clay for 0.0166667h; aminolysis, ring cleavage; Irradiation;	74%
at 130 - 140℃; for 3h;	60%

: 110-91-8
morpholine

: 117-80-6
2,3-Dichloro-1,4-naphthoquinone

: 6336-72-7
2-chloro-3-morpholin-4-yl-[1,4]naphthoquinone

Conditions

Conditions	Yield
In water at 50℃; for 0.333333h;	100%
With water at 50℃; for 0.5h;	98%
With triethylamine In diethyl ether at 20℃; for 24h;	64%

: 110-91-8
morpholine

: 123-56-8
Succinimide

: 50-00-0
formaldehyd

: 13314-97-1
N-[{morpholin-1-yl}-methyl]-pyrrolidine-2,5-dione

Conditions

Conditions	Yield
With aluminum oxide In water for 0.2h; Condensation; microwave irradiation;	100%
In ethanol at 60℃; for 2h;	88%

...Expand

: 110-91-8
morpholine

: 67-56-1
methanol

: 109-02-4
4-methyl-morpholine

Conditions

Conditions	Yield
chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II) at 100℃;	100%
With [RhCl2(p-cymene)]2; bis[2-(diphenylphosphino)phenyl] ether In toluene at 250℃; under 37503.8 Torr; Flow reactor;	93%
With Cu1-Mo1/TiO2 In neat liquid at 20℃; for 21h; Catalytic behavior; Inert atmosphere; UV-irradiation;	82%

: 110-91-8
morpholine

: 4548-45-2
2-chloro-5-nitropyridine

: 26820-62-2
4-(5-nitro-pyridin-2-yl)-morpholine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 3h;	100%
With potassium carbonate In tetrahydrofuran at 80℃; for 4h;	99%
With potassium carbonate In tetrahydrofuran at 80℃; for 4h;	99%

: 110-91-8
morpholine

: 50-00-0
formaldehyd

: 109-02-4
4-methyl-morpholine

Conditions

Conditions	Yield
With oxalic acid at 100 - 120℃; Eschweiler-Clarke methylation;	100%
With hydrogen In methanol at 100℃; under 9750.98 Torr; for 3h; Autoclave;	97%
With acetic acid at 30℃; for 2h;	96%

: 110-91-8
morpholine

: 64-18-6
formic acid

: 4394-85-8
4-morpholinecarboxaldehyde

Conditions

Conditions	Yield
With cyano-hydroxyimino-acetic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20℃; for 3h; Reagent/catalyst; Solvent;	100%
In butan-1-ol at 120℃; Solvent; Temperature;	99.35%
In ethanol at 140℃; for 24h; Solvent; Autoclave;	98%

: 110-91-8
morpholine

: 108-86-1
bromobenzene

: 92-53-5
4-Phenylmorpholine

Conditions

Conditions	Yield
With sodium t-butanolate; palladium diacetate; [(μ-PPh2CH2PPh2)Co2(CO)4][μ,η-PhCCP(tBu)2] In toluene at 60℃; for 20h; Product distribution; Further Variations:; Catalysts; Reagents; Solvents; Temperatures;	100%
With C20H45N2OP; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene at 105℃; for 20h; Reagent/catalyst;	100%
With bis(η3-allyl-μ-chloropalladium(II)); [(μ-Ph2PCH2PPh2)Co2(CO)4(μ,η-Me2NCH2CCP(C6H11)2)]; sodium t-butanolate In toluene at 80℃; for 2h; Inert atmosphere;	99%

: 110-91-8
morpholine

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 6601-22-5
2,6-Dichloro-4-morpholino-1,3,5-triazine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at -78℃; for 0.166667h;	100%
With triethylamine In dichloromethane at -78 - -30℃; for 1.5h; Inert atmosphere;	99%
With triethylamine In acetone for 0.5h; Cooling with ice;	98%

: 110-91-8
morpholine

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 7597-22-0
2-chloro-4,6-di-morpholin-4-yl-[1,3,5]triazine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane at 0 - 40℃; for 3h;	100%
In dichloromethane; water at 0 - 5℃; for 3.25h; Large scale;	98%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 1h;	95%

: 110-91-8
morpholine

: 506-68-3
bromocyane

: 1530-89-8
N-cyanomorpholine

Conditions

Conditions	Yield
	100%
With sodium hydrogencarbonate In dichloromethane; water at 0 - 20℃;	86.5%
With triethylamine In diethyl ether at 0℃;	82%

: 110-91-8
morpholine

: 3460-18-2
1,4-dibromo-2-nitrobenzene

: 90841-34-2
4-(4-bromo-2-nitro-phenyl)-morpholine

Conditions

Conditions	Yield
In isopropyl alcohol	100%
With triethylamine In isopropyl alcohol at 70℃; for 24h;	73%

: 110-91-8
morpholine

: 2882-19-1
ethyl 2-phenyl-2-bromoacetate

: 22083-23-4
α-morpholine ethyl phenylacetate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 1.5h;	100%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 1.5h;	100%
With triethylamine at 20℃;	80%
With isopropyl alcohol

: 110-91-8
morpholine

: 286-20-4
cyclohexane-1,2-epoxide

: 14909-79-6
trans-2-morpholinocyclohexanol

Conditions

Conditions	Yield
With zirconium(IV) chloride at 20℃; for 0.25h;	100%
With zinc(II) perchlorate hexahydrate at 80℃; for 1h;	100%
With zinc(II) bis(tetrafluoroborate) hydrate at 20℃; for 2h; Neat (no solvent);	97%

: 110-91-8
morpholine

: 100-52-7
benzaldehyde

: 6425-08-7
4,4'-(phenylmethylene)bismorpholine

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In water at 20℃; for 0.0333333h;	100%
In benzene at 20℃; for 16h; Inert atmosphere;	99%
In benzene Reflux;	95%

: 110-91-8
morpholine

: 90-02-8
salicylaldehyde

: 127704-26-1
2-(dimorpholinomethyl)phenol

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In water at 20℃; for 0.0333333h;	100%
at 50℃; for 0.333333h; Molecular sieve; Microwave irradiation;	98%
at 100℃; for 0.166667h; Microwave irradiation; Neat (no solvent);	95%

: 110-91-8
morpholine

: 103-71-9
phenyl isocyanate

: 4559-92-6
N-phenylmorpholine-4-carboxamide

Conditions

Conditions	Yield
at 0 - 20℃; for 48.3333h;	100%
In diethyl ether at 20℃; for 18h;	99.2%
In diethyl ether at 20℃; for 0.75h; Addition;	97%

: 110-91-8
morpholine

: 105-36-2
ethyl bromoacetate

: 3235-82-3
N-morpholylacetic acid ethyl ester

Conditions

Conditions	Yield
In benzene for 0.5h; Reflux;	100%
In toluene for 8h;	92%
In benzene for 0.5h; Alkylation; Heating;	91%

: 110-91-8
morpholine

: 100-00-5
4-chlorobenzonitrile

: 10389-51-2
1-morpholino-4-nitrobenzene

Conditions

Conditions	Yield
In tetrahydrofuran at 50℃; under 4500360 Torr; for 20h;	100%
With potassium carbonate In dimethyl sulfoxide at 120℃; for 19h;	100%
In tetrahydrofuran at 50℃; under 10000 Torr; for 2h; Product distribution; other pressure;	99.7%

: 110-91-8
morpholine

: 88-73-3
2-Chloronitrobenzene

: 5320-98-9
N-(2-nitrophenyl)morpholine

Conditions

Conditions	Yield
In tetrahydrofuran at 50℃; under 4500360 Torr; for 20h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 6h;	99%
With potassium phosphate; Al2O3#dotCo(2+) In water at 100℃; for 7h;	90%

: 110-91-8
morpholine

: 135-73-9
2-Bromo-4'-phenylacetophenone

: 94164-35-9
1-biphenyl-4-yl-2-morpholin-4-yl-ethanone

Conditions

Conditions	Yield
Stage #1: morpholine; 2-Bromo-4'-phenylacetophenone In diethyl ether; dichloromethane at 0 - 20℃; for 1h; Stage #2: With sodium hydrogencarbonate In dichloromethane; water Product distribution / selectivity;	100%
With triethylamine In diethyl ether at 0 - 20℃; for 2.5h; Product distribution / selectivity;	93%

: 110-91-8
morpholine

: 107-13-1
acrylonitrile

: 4542-47-6
3-Morpholin-4-yl-propionitrile

Conditions

Conditions	Yield
In methanol	100%
With zirconium(IV) chloride In dichloromethane at 20℃; for 1h; Michael addition;	100%
With poly(ethylene glycol) 2000; ruthenium trichloride at 50℃; for 6h; aza-Michael addition;	99%

: 110-91-8
morpholine

: 79-04-9
chloroacetyl chloride

: 1440-61-5
N-chloroacetylmorpholine

Conditions

Conditions	Yield
With potassium carbonate In toluene at 60℃; for 2h;	100%
Stage #1: morpholine; chloroacetyl chloride With triethylamine In dichloromethane at 0 - 27℃; for 2h; Stage #2: With hydrogenchloride In dichloromethane; water	100%
With triethylamine In dichloromethane at 0 - 20℃; for 6h;	99%

: 110-91-8
morpholine

: 105-56-6
ethyl 2-cyanoacetate

: 15029-32-0
4-cyanoacetylmorpholine

Conditions

Conditions	Yield
In neat (no solvent) at 20℃; Inert atmosphere;	100%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In 2-methyltetrahydrofuran at 40℃; for 4h;	87%
at 130℃; for 4h;	75%

: 110-91-8
morpholine

: 89-61-2
2,5-dichloronitrobenzene

: 65976-60-5
4-(4-chloro-2-nitro-phenyl)morpholine

Conditions

Conditions	Yield
In tetrahydrofuran at 50℃; under 4500360 Torr; for 20h;	100%
at 2℃; Heating;	50%

: 110-91-8
morpholine

: 59-89-2
N-nitrosomorpholine

Conditions

Conditions	Yield
With [NO(1+)18-crown-6H(NO3)2(1-)] In dichloromethane at 20℃; for 0.0833333h;	100%
With silica gel; zinc(II) chloride; sodium nitrite In dichloromethane at 20℃; for 0.75h; Nitrosation;	99%
With Iron(III) nitrate nonahydrate; tetrabutylammonium perchlorate In acetonitrile at 70℃; Kinetics; Reagent/catalyst; Inert atmosphere; Electrolysis; Green chemistry;	99%

: 110-91-8
morpholine

: 1828-66-6
morpholine-4-sulfonyl chloride

Conditions

Conditions	Yield
With sulfuryl dichloride In acetonitrile for 24h; Heating / reflux;	100%
With hydrogenchloride; sodium hypochlorite; sulfur dioxide; chlorine In dichloromethane; water	60%
With hydrogenchloride; sodium hypochlorite; sulfur dioxide; chlorine In dichloromethane; water	60%

: 110-91-8
morpholine

: 122-60-1
Phenyl glycidyl ether

: 5296-26-4
4-(2-hydroxy-3-phenoxypropyl)morpholine

Conditions

Conditions	Yield
In 2,2,2-trifluoroethanol at 20℃; for 6h; regioselective reaction;	100%
In water at 0 - 20℃;	97%
With sulfated zirconia In neat (no solvent) at 20℃; for 3h; regioselective reaction;	97%

: 110-91-8
morpholine

: 106-89-8
epichlorohydrin

: 40893-69-4
1-chloro-3-(4-morpholinyl)-2-propanol

Conditions

Conditions	Yield
In ethanol for 24h; Heating;	100%
With zinc(II) chloride In water at 60℃; for 8h; regioselective reaction;	96%
In water at 0 - 5℃; for 4h;	92%

: 110-91-8
morpholine

: 3034-53-5
2-bromo-1,3-thiazole

: 21429-06-1
2-(morpholine-1-yl)thiazole

Conditions

Conditions	Yield
at 120℃; for 9h;	100%
for 72h; Heating;	95%
at 100℃; for 4h; Neat (no solvent);	95%

Morpholine Chemical Properties

Molecular structure of Morpholine (CAS NO.110-91-8) is:

Product Name: Morpholine
CAS Registry Number: 110-91-8
IUPAC Name: morpholine
Molecular Weight: 87.12036 [g/mol]
Molecular Formula: C₄H₉NO
XLogP3: -0.9
H-Bond Donor: 1
H-Bond Acceptor: 2
EINECS: 203-815-1
Melting Point: -5 °C
Refractive index: n20/D 1.454(lit.)
Storage temp.: Store at R.T.
Water Solubility: MISCIBLE
Sensitive: Hygroscopic
Surface Tension: 29.2 dyne/cm
Density: 0.931 g/cm³
Flash Point: 35.6 °C
Enthalpy of Vaporization: 36.66 kJ/mol
Boiling Point: 128.9 °C at 760 mmHg
Vapour Pressure: 10.4 mmHg at 25°C
Product Categories: Organic Chemicals;BasesChemical Synthesis;Organic Bases;Supported Reagents;Supported Synthesis;Synthetic Reagents

Morpholine Uses

Morpholine (CAS NO.110-91-8) is a common additive because its volatility is about the same as water. Morpholine is often used in conjunction with low concentrations of hydrazine or ammonia to provide a comprehensive all-volatile treatment chemistry for corrosion protection for the steam systems of such plants.

Morpholine Production

Morpholine (CAS NO.110-91-8) may be produced by the dehydration of diethanolamine with sulfuric acid.

Morpholine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	oral	100mg/kg (100mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE	Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 236, 1939.
mammal (species unspecified)	LC50	inhalation	12000mg/m³ (12000mg/m³)		Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 90, 1975.
mammal (species unspecified)	LD50	oral	1220mg/kg (1220mg/kg)		Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 90, 1975.
mouse	LC50	inhalation	1320mg/m³/2H (1320mg/m³)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 8, Pg. 60, 1966.
mouse	LD50	intraperitoneal	413mg/kg (413mg/kg)		Cancer Vol. 2, Pg. 1055, 1949.
mouse	LD50	oral	525mg/kg (525mg/kg)	BEHAVIORAL: SLEEP BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Biomedica Biochimica Acta. Vol. 44, Pg. 795, 1985.
mouse	LD50	subcutaneous	458mg/kg (458mg/kg)		United States Patent Document. Vol. #4576951,
rabbit	LD50	skin	500uL/kg (0.5mL/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.
rat	LC50	inhalation	8000ppm/8H (8000ppm)		Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 85, 1974.
rat	LD50	oral	1450mg/kg (1450mg/kg)		Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 25, 1968.
rat	LDLo	unreported	1600mg/kg (1600mg/kg)		"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 662, 1969.

Morpholine Safety Profile

Moderately toxic by ingestion, inhalation, skin contact, and intraperitoneal routes. Mutation data reported. A corrosive irritant to skin, eyes, and mucous membranes. Can cause kidney damage. Questionable carcinogen with experimental neoplastigenic data. Flammable liquid. A very dangerous fire hazard when exposed to flame, heat, or oxidizers; can react with oxidizing materials. To fight fire, use alcohol foam, CO₂, dry chemical. Mixtures with nitromethane are explosive. May ignite spontaneously in contact with cellulose nitrate of high surface area. When heated to decomposition it emits highly toxic fumes of NO_x.
Hazard Codes: Corrosive C
Risk Statements: 10-20/21/22-34
R10:Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R34:Causes burns.
Safety Statements: 23-36-45
S23:Do not breathe vapour.
S36:Wear suitable protective clothing.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2054 8/PG 1
WGK Germany: 3
RTECS: QD6475000
HazardClass: 8
PackingGroup: I

Morpholine Specification

Morpholine , its cas register number is 110-91-8. It also can be called Tetrahydro-1,4-oxazine ; 1-Oxa-4-azacyclohexane ; 2H-1,4-Oxazine, tetrahydro- ; 4H-1,4-Oxazine, tetrahydro- ; Diethylene imidoxide ; Diethylene oximide ; Tetrahydro-1,4-isoxazine ; Tetrahydro-1,4-oxazine ; Tetrahydro-p-oxazine ; p-Isoxazine, tetrahydro- .It is a aqueous solution with a fishlike odor.It is highly flammable and water soluble.It dissolved in water neutralizes acids in exothermic reactions to form salts plus water. It may cause toxic effects if inhaled or ingested/swallowed. Morpholine decomposes reasonably slowly in the absence of oxygen even at the high temperatures and pressures in these steam systems.

Product Name

Morpholine

Synthetic route

Morpholine Chemical Properties

Morpholine Uses

Morpholine Production

Morpholine Toxicity Data With Reference

Morpholine Safety Profile

Morpholine Specification

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