Propargyl alcohol supplier

Name
Propargyl alcohol
EINECS 203-471-2
CAS No. 107-19-7
Article Data114
CAS DataBase
Density 0.944 g/cm³
Solubility miscible with water
Melting Point -53 °C
Formula C₃H₄O
Boiling Point 113.6 °C at 760 mmHg
Molecular Weight 56.0642
Flash Point 36.1 °C
Transport Information UN 2929 6.1/PG 1
Appearance clear colourless to slightly yellow liquid
Safety 26-28-36-45-61-28A
Risk Codes 10-23/24/25-34-51/53-43
Molecular Structure
Hazard Symbols T,N
Synonyms 3-Propynol;Propargyl alcohol [NA1986] [Flammable liquid];NA1986;RCRA waste number P102;Propiolic alcohol;NSC 8804;Methanol, ethynyl-;HSDB 6054;Ethynylcarbinol;Ethynyl carbinol;CCRIS 6781;BRN 0506003;Agrisynth PA;1-Hydroxy-2-propyne;1-Propyn-3-ol;2-Propynyl alcohol;3-Hydroxy-1-propyne;2-Propyn-1-ol;4-01-00-02214 (Beilstein Handbook Reference);AI3-24359;Acetylene carbinol;Acetylenylcarbinol;RCRA waste no. P102;
PSA 20.23000
LogP -0.38810

Synthetic route

: 201230-82-2
carbon monoxide

: 74-86-2
acetylene

: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at 0℃;	100%

: 76782-82-6
tert-Butyldimethyl(prop-2-ynyloxy)silane

: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
sulfated SnO2 In methanol at 20℃; for 0.166667h;	97%
With sodium hydrogen sulfate; silica gel In dichloromethane at 20℃; for 0.5h;	93%
With zinc tetrafluoroborate In water for 3h; Ambient temperature;	82%

: 6089-04-9
3-(tetrahydropyran-2'-yloxy)propyne

: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With methanol at 20℃; for 0.5h;	95%
With lithium bromide In methanol for 6h; Substitution; Heating;	89%
With water; β‐cyclodextrin In methanol at 50℃; for 8h;	85%
With pyridinium p-toluenesulfonate In ethanol at 25℃; for 3h;
With iron(III) phosphate In methanol at 20℃; for 2h;	84 %Chromat.

: 29560-84-7
γ-Chlorallylalkohol

: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With hydroquinone; potassium hydroxide In dimethyl sulfoxide at 75℃; for 3h; Temperature; Reagent/catalyst;	71.07%

: 6089-04-9
3-(tetrahydropyran-2'-yloxy)propyne

A: 110922-31-1
5-propargyloxy-pentan-1-ol

B: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With benzo[1,3,2]dioxaborole In benzene at 50℃;	A 22% B 68%
With RhCl(PPh3)3; benzo[1,3,2]dioxaborole In benzene for 5h; Ambient temperature;	A 58% B 26%

: 29680-62-4
Tris(phenylseleno)borane

: 110966-13-7, 109930-21-4
(E)-(3-(prop-2-yn-1-yloxy)prop-1-en-1-yl)benzene

A: 873-66-5
1-propenylbenzene

B: 107-19-7
propargyl alcohol

C: 4-Benzyl-3-phenylselenomethylenetetrahydrofuran

D: 4407-36-7
(2E)-3-phenyl-2-propen-1-ol

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile) In benzene Heating; Further byproducts given;	A 13% B n/a C 65% D 9%

...Expand

: 5272-36-6
3-trimethylsilyl-2-propyn-1-ol

: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; Inert atmosphere; Schlenk technique;	37%
With silver(I) hexafluorophosphate; water In d7-N,N-dimethylformamide at 40℃; for 18h;

: 50-00-0
formaldehyd

: 74-86-2
acetylene

: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 30 - 35℃; for 1h;	35%
in Gegenwart von Katalysatoren;
With potassium hydroxide In dimethyl sulfoxide at 20℃; for 1h; Condensation;
Stage #1: acetylene With n-butyllithium Inert atmosphere; Stage #2: formaldehyd Inert atmosphere;
Stage #1: formaldehyd; acetylene With ammonia In water at 100℃; under 15001.5 Torr; Stage #2: With ammonia In methanol; water at 60℃;

: 110-65-6
1,4-dihydroxybut-2-yne

: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With potassium carbonate at 140 - 150℃;

: 50-00-0
formaldehyd

: 1066-26-8
sodium acetylide

: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With ammonia
With ammonia

: 5976-47-6
2-chloroallyl alcohol

: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With sodium hydroxide

: 69298-56-2
(E)-2,3-dibromoprop-2-en-1-ol

A: 2060-25-5
3-bromoprop-2-yn-1-ol

B: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With ammonia; potassium amide

: 4643-05-4
(2Z)-3-chloroprop-2-en-1-ol

: furan-2,3,5(4H)-trione pyridine (1:1)

: 107-19-7
propargyl alcohol

: 598-19-6
2-bromoallyl alcohol

: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With potassium hydroxide man Saettigt hierauf das Kali mit CO2,destilliert mit Wasser, scheidet aus dem Destillat den Alkohol durch K2CO3 ab und entwaessert ihn ueber K2CO3;
With sodium hydroxide

: 598-19-6
2-bromoallyl alcohol

A: 74886-05-8
bis-(2-bromo-allyl)-ether

B: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With potassium carbonate

: 63915-88-8
1-acetoxy-2-bromo-2-propene

: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With potassium hydroxide

: 2450-71-7
Propargylamine

: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With cis-nitrous acid

: 106-89-8
epichlorohydrin

: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With ammonia; sodium amide

: 67-56-1
methanol

: 50-00-0
formaldehyd

: 1117-94-8
copper(I) acetylide

: 74-86-2
acetylene

A: 110-65-6
1,4-dihydroxybut-2-yne

B: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
at 90 - 130℃; under 7355.08 - 29420.3 Torr; Kinetics;

...Expand

: 50-00-0
formaldehyd

: 1117-94-8
copper(I) acetylide

: 74-86-2
acetylene

: 107-19-7
propargyl alcohol

...Expand

: 50-00-0
formaldehyd

: 74-86-2
acetylene

A: 110-65-6
1,4-dihydroxybut-2-yne

B: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With copper acetylenide upon Fuller's earth; nitrogen; water
With tetrahydrofuran; copper acetylenide upon Fuller's earth; water at 100℃; unter Druck;
bismuth - copper In water at 90℃; Product distribution; Kinetics; pH 4-4.5, different temperature, concentration of catalyst, initial formaldehyde concentration, influence of 1,4-butanediole was studied;

...Expand

: 75-89-8
2,2,2-trifluoroethanol

: 94670-13-0
Dimethyl-[4-(1-prop-2-ynyloxy-ethyl)-phenyl]-amine; compound with perchloric acid

A: 107-19-7
propargyl alcohol

B: Dimethyl-{4-[1-(2,2,2-trifluoro-ethoxy)-ethyl]-phenyl}-amine; compound with perchloric acid

Conditions

Conditions	Yield
With sodium perchlorate In water at 25℃; Equilibrium constant;

...Expand

: 75-89-8
2,2,2-trifluoroethanol

: 94670-23-2
1-(4-methoxyphenyl)-1-(propargyloxy)ethane

A: 94670-31-2
1-(4-methoxyphenyl)ethyl trifluoroethyl ether

B: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With sodium perchlorate In water at 25℃; Equilibrium constant;

...Expand

: 75-89-8
2,2,2-trifluoroethanol

: 94670-00-5
1-(4-methoxy-3-nitrophenyl)ethyl prop-2-yn-1-yl ether

A: 107-19-7
propargyl alcohol

B: 94670-28-7
1-(4-methoxy-3-nitrophenyl)ethyl 2,2,2-trifluoroethyl ether

Conditions

Conditions	Yield
With sodium perchlorate In water at 25℃; Equilibrium constant;

...Expand

: 75-89-8
2,2,2-trifluoroethanol

: 89813-13-8
Dimethyl-phenyl-prop-2-ynyloxy-silane

A: 109629-96-1
(2,2,2-trifluoroethoxy)dimethylphenylsilane

B: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With potassium 2,2,2-trifluoroethoxide at 30℃; Rate constant; μ = 0.05 M with potassium trifluoroacetate;

...Expand

: 32042-39-0
prop-2-ynyl formate

A: 64-18-6
formic acid

B: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With acetate buffer; potassium chloride; water at 25℃; Rate constant; var. anions as catalysts;

: 2187-89-5
1-Prop-2-ynyloxy-ethanol

A: 75-07-0
acetaldehyde

B: 107-19-7
propargyl alcohol

Conditions

Conditions	Yield
With methoxyacetic acid buffer In water Rate constant; other acids; other solvent;

: 110-87-2
3,4-dihydro-2H-pyran

: 107-19-7
propargyl alcohol

: 6089-04-9
3-(tetrahydropyran-2'-yloxy)propyne

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 20℃; for 24h;	100%
With aluminium(III) triflate In dichloromethane at 20 - 25℃; for 2h; Inert atmosphere;	100%
With toluene-4-sulfonic acid for 0.75h;	99%

: 108-24-7
acetic anhydride

: 107-19-7
propargyl alcohol

: 627-09-8
Propargyl acetate

Conditions

Conditions	Yield
zeolite HSZ-360 In neat (no solvent) at 60℃; for 1h;	100%
tetrafluoroboric acid; silica gel at 20℃; for 2h;	100%
indium(III) chloride at 20℃; for 0.5h;	100%

: 76-83-5
trityl chloride

: 107-19-7
propargyl alcohol

: 82816-38-4
1-trityloxy-2-propyne

Conditions

Conditions	Yield
With pyridine; dmap In dichloromethane at 20℃; for 16h;	100%
With pyridine; dmap In dichloromethane at 20℃; for 18h;	95%
With triethylamine In dichloromethane Ambient temperature;	94%

: 103-71-9
phenyl isocyanate

: 107-19-7
propargyl alcohol

: 5416-67-1
2-propynyl phenylcarbamate

Conditions

Conditions	Yield
With dmap; triethylamine In tetrahydrofuran at 20℃; for 90h;	100%
With MoCl2O2(dmf)2 In dichloromethane at 20℃; for 0.333333h;	100%
With MoCl2O2(dmf)2 In dichloromethane at 20℃; for 0.333333h; Inert atmosphere; Sealed tube;	100%

: 111-34-2
-butyl vinyl ether

: 107-19-7
propargyl alcohol

: 871-12-5
3-(1-butoxy-ethoxy)-propyne

Conditions

Conditions	Yield
With trifluoroacetic acid at 20 - 60℃; for 0.5h;	100%
With hydrogenchloride	78%
With hydrogenchloride	50%

: 107-19-7
propargyl alcohol

: 622-79-7
benzyl azide

: 28798-81-4
(1-benzyl-[1,2,3]triazol-4-yl)methanol

Conditions

Conditions	Yield
With bis[1-(4-sodiumsulfonatepropyl)-3-(2,4,6-trimethylphenyl)-4,5-dihydroimidazolyl-3-ylidine]copper(I) hexafluorophosphate In neat (no solvent) at 20℃; for 2.5h;	100%
With copper; triethylamine In benzene-d6 at 40℃; for 66h; Huisgen Cycloaddition; Inert atmosphere; regioselective reaction;	99%
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In water; tert-butyl alcohol	99%

: 107-19-7
propargyl alcohol

: 109-92-2
ethyl vinyl ether

: 18669-04-0
acetaldehyde ethyl propargyl acetal

Conditions

Conditions	Yield
With trifluoroacetic acid Inert atmosphere;	100%
With trifluoroacetic acid at 20 - 60℃; for 0.333333h;	100%
With toluene-4-sulfonic acid at 0 - 15℃;	92%

: 107-19-7
propargyl alcohol

: 98-59-9
p-toluenesulfonyl chloride

: 6165-76-0
propargyl p-toluenesulfonate

Conditions

Conditions	Yield
With sodium hydroxide In diethyl ether; water at 0 - 20℃; for 17h;	100%
With potassium hydroxide In diethyl ether at -5 - 20℃;	96%
With potassium hydroxide In diethyl ether at -5 - 0℃; for 0.5h;	95%

: 591-50-4
iodobenzene

: 107-19-7
propargyl alcohol

: 1504-58-1
3-Phenyl-2-propyn-1-ol

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 5h; Sonogashira coupling; Inert atmosphere;	100%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 12h; Inert atmosphere;	100%
Stage #1: iodobenzene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 0.166667h; Inert atmosphere; Stage #2: propargyl alcohol Inert atmosphere;	99%

: 107-19-7
propargyl alcohol

: 123-72-8
butyraldehyde

: 18864-39-6
(R/S)-hept-2-yne-1,4-diol

Conditions

Conditions	Yield
Stage #1: propargyl alcohol With n-butyllithium In tetrahydrofuran; hexane at -40℃; for 0.333333h; Inert atmosphere; Stage #2: butyraldehyde With cerium(III) chloride In tetrahydrofuran; hexane Reagent/catalyst;	100%
Stage #1: propargyl alcohol With n-butyllithium In tetrahydrofuran; hexane at -40℃; for 0.5h; Inert atmosphere; Stage #2: butyraldehyde In tetrahydrofuran; hexane Inert atmosphere;	70%
In tetrahydrofuran

: 107-19-7
propargyl alcohol

: 124-63-0
methanesulfonyl chloride

: 16156-58-4
prop-2-yn-1-ol methanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at -15℃; for 1h; Green chemistry;	100%
With triethylamine In dichloromethane at 0℃; for 2h;	98%
With triethylamine In dichloromethane at -40℃; for 1h; Inert atmosphere; Sealed tube;	97%

: 107-19-7
propargyl alcohol

: 106-95-6
allyl bromide

: 2749-86-2
hex-5-en-2-yn-1-ol

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate; sodium sulfite In water at 30℃; for 4h;	100%
With copper(I) bromide dimethylsulfide complex; ethylmagnesium bromide In tetrahydrofuran 1.) 50 deg C, 40 min, 2.) r.t., 13 h;	95%
With copper(l) iodide; potassium carbonate; sodium iodide In decane; acetone at 20℃; for 2.5h;	92%

2-methyl-but-2-ene: 2-methyl-but-2-ene

: 107-19-7
propargyl alcohol

: 118616-27-6
2-Bromo-3-methyl-3-(2-propyn-1-yloxy)butane

Conditions

Conditions	Yield
With N-Bromosuccinimide at 0℃; for 1h;	100%
With N-Bromosuccinimide In dichloromethane 1.) -20 deg C, 2 h, 2.) r.t., 15 h;	73%

: 563-79-1
2,3-Dimethyl-2-butene

: 107-19-7
propargyl alcohol

: 118652-82-7
2-Bromo-2,3-dimethyl-3-(2-propyn-1-yloxy)butane

Conditions

Conditions	Yield
With N-Bromosuccinimide at 0℃; for 1h;	100%
With N-Bromosuccinimide In dichloromethane 1.) -20 deg C, 2 h, 2.) r.t., 15 h;	80%

Propargyl alcohol Chemical Properties

Molecular structure of Propargyl alcohol (CAS NO.107-19-7) is:

Product Name: Propargyl alcohol
CAS Registry Number: 107-19-7
IUPAC Name: Prop-2-yn-1-ol
Molecular Weight: 56.06326 [g/mol]
Molecular Formula: C₃H₄O
XLogP3: -0.4
H-Bond Donor: 1
H-Bond Acceptor: 1
EINECS: 203-471-2
Melting Point: -53 °C
Refractive index: n20/D 1.432(lit.)
Storage temp.: 2-8°C
Water Solubility: miscible
Surface Tension: 37.9 dyne/cm
Density: 0.944 g/cm³
Flash Point: 36.1 °C
Enthalpy of Vaporization: 41.04 kJ/mol
Boiling Point: 113.6 °C at 760 mmHg
Vapour Pressure: 10.6 mmHg at 25°C
Product Categories: Acetylenes; Acetylenic Alcohols & Their Derivatives; Pharmaceutical Intermediate

Propargyl alcohol Uses

Propargyl alcohol (CAS NO.107-19-7) is a component of oil-well acidizing compositions, inhibiting the attack of mineral acids on steel, and is also employed in the pickling and plating of metals. It is used as an intermediate in preparation of the miticide Omite 2-(4'-tert-butylphenoxy)cyclohexyl 2-propynyl sulfite, of sulfadiazine, and of halogenated propargyl carbonate fungicides.

Propargyl alcohol Production

Propargyl alcohol(107-19-7) is a by-product of butynediol manufacture. The original high-pressure butynediol processes gave about 5 percent of the by-product; lower-pressure processes give much less. Processes have beendescribed that give much higher proportions of propargyl alcohol.

Propargyl alcohol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	60mg/kg (60mg/kg)		The Threshold Limit Values Vol. 4, Pg. 346, 1980.
mammal (species unspecified)	LC50	inhalation	3gm/m3 (3000mg/m3)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988.
mammal (species unspecified)	LD50	oral	50mg/kg (50mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988.
mammal (species unspecified)	LD50	unreported	53mg/kg (53mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(5), Pg. 61, 1986.
mouse	LC50	inhalation	2000mg/m3/2H (2000mg/m3)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 8, Pg. 97, 1966.
mouse	LD50	oral	50mg/kg (50mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BLOOD: HEMORRHAGE	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 8, Pg. 97, 1966.
rabbit	LD50	skin	16mg/kg (16mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4672, 1982.
rabbit	LDLo	subcutaneous	25mg/kg (25mg/kg)		"Zur Pharmakologie Ungesattigter Alkohole, Dissertation," Bock, H., Pharmakologischen Institu der Universitat Breslau, Poland, 1930Vol. -, Pg. -, 1930.
rat	LC50	inhalation	873ppm/2H (873ppm)		GAF Material Safety Data Sheet.
rat	LD50	oral	20mg/kg (20mg/kg)		"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4672, 1982.

Propargyl alcohol Safety Profile

Hazard Codes: Toxic T, Dangerous N
Risk Statements: 10-23/24/25-34-51/53-43
10: Flammable
23/24/25: Toxic by inhalation, in contact with skin and if swallowed
34: Causes burns
51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
43: May cause sensitization by skin contact
Safety Statements: 26-28-36-45-61-28A
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
61: Avoid release to the environment. Refer to special instructions safety data sheet
RIDADR : UN 2929 6.1/PG 1
WGK Germany : 2
RTECS : UK5075000
HazardClass : 3
Propargyl alcohol is irritating to skin and mucous membranes.

Propargyl alcohol Specification

Propargyl alcohol , its cas register number is 107-19-7. It also can be called 1-Hydroxy-2-propyne ; 1-Propyn-3-ol ; 2-Propyn-1-ol ; 2-Propynyl alcohol ; 3-Hydroxy-1-propyne ; 3-Propynol ; 4-01-00-02214 (Beilstein Handbook Reference) ; AI3-24359 ; Acetylene carbinol ; Acetylenylcarbinol ; Agrisynth PA ; BRN 0506003 ; CCRIS 6781 ; Ethynyl carbinol ; Ethynylcarbinol ; HSDB 6054 ; Methanol, ethynyl- ; NSC 8804 ; Propiolic alcohol ; Propynyl alcohol ; RCRA waste number P102 ; NA1986 ; Propargyl alcohol [NA1986] [Flammable liquid] ; RCRA waste no. P102 . Although it is stable, it has a low flash point, and vapor ignition and violent reactions can occur in the presence of contaminants, particularly at elevated temperatures. Heating in undiluted form with bases or strong acids should be avoided. Weak acids have been used to stabilize propargyl alcohol prior to distillation. Propargyl alcohol is a primary skin irritant and a severe eye irritant and is toxic by all means of ingestion; all necessary precautions must be taken to avoid contact with liquid or vapors.

Product Name

Propargyl alcohol

Synthetic route

Propargyl alcohol Chemical Properties

Propargyl alcohol Uses

Propargyl alcohol Production

Propargyl alcohol Toxicity Data With Reference

Propargyl alcohol Safety Profile

Propargyl alcohol Specification

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