difluoro-nitro-methane
sodium ethanolate
B
sodium nitrite
C
Diethyl carbonate
Conditions | Yield |
---|---|
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile=1:4), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.; | A 81% B 78% C 7% |
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile 1:2, reacting (-10°C for 10-15 min), stirring(0°C for 1 h), reaction mixt. leaving overnight at -20°C; salts. ppt. sepn. (CH2Cl2 addn., cooling), ppt. treatment with boiling ethanol, NaNO2 pptn. from filtrate, aq. H2SO4 addn. to filtrate, org. layer sepn., aq. layer extn. (CH2Cl2), ext. drying (MgSO4), distn. lead to(EtO)2CO; chem. and GLC anal.; | A 48% B 62% C 12% |
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile=1:1), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.; | A 18% B 26% C 9% |
In ethanol; N,N-dimethyl-formamide alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (DMF) (molar ratio F2C(NO2)2:nucleophile=1:2), reacting (-10°C for 10-15 min), stirring (0°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.; |
calcium(II) nitrate
sodium sulfite
B
sodium sulfate
C
sodium nitrite
Conditions | Yield |
---|---|
In neat (no solvent) formation at heating under glowing;; | A n/a B n/a C 60% |
difluoro-nitro-methane
sodium ethanolate
A
carbonate(2-)
C
sodium nitrite
D
Diethyl carbonate
Conditions | Yield |
---|---|
In ethanol byproducts: NO3(1-); alkoxide soln. addn. to F2C(NO2)2 soln. (molar ratio F2C(NO2)2:nucleophile=1:2), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.; | A 8% B 43% C n/a D 14% |
fluorotrinitromethane
sodium ethanolate
A
ethoxyfluorodinitromethane
C
sodium nitrite
D
Diethyl carbonate
Conditions | Yield |
---|---|
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. (dropwise) to FC(NO2)3 soln. (CH2Cl2) (molar ratio FC(NO2)3:nucleophile=1:2), stirring (0-5°C for 1.5 h), 5%H2SO4 soln. addn., extn. (CH2Cl2), drying (MgSO4); residue distn. (vac.), ppt. sepn.; chem. and GLC anal., IR spectroscopy; | A 42% B n/a C n/a D 6.8% |
N,N-bis(methylsulfonyl)hydroxylamine
A
sodium methansulfinate
B
sodium nitrite
Conditions | Yield |
---|---|
With sodium hydroxide In water Product distribution; Mechanism; hydrolysis with basic, neutral and acidic aqu. solutions, also in addition of NaN3 (other products); |
Conditions | Yield |
---|---|
In neat (no solvent) at 150°C;; |
Conditions | Yield |
---|---|
oxidation; | |
oxidation; |
Conditions | Yield |
---|---|
With sodium In neat (no solvent) byproducts: N2; oxydation when heating in presence of Na;; | |
With Na In neat (no solvent) byproducts: N2; oxydation when heating in presence of Na;; |
Conditions | Yield |
---|---|
With sodium In neat (no solvent) byproducts: N2; oxydation when heating in presence of Na;; | |
With Na In neat (no solvent) byproducts: N2; oxydation when heating in presence of Na;; |
Conditions | Yield |
---|---|
In neat (no solvent) | |
In neat (no solvent) |
Conditions | Yield |
---|---|
In melt byproducts: Na2SO4, Na2SO3; in melt at 330°C; |
Conditions | Yield |
---|---|
In water byproducts: H2O; Electrolysis; electrolysis (1.25V vs. SCE), (Bu4N)4(MoFe3S4(SC6H5)3(O2C6Cl4))2 modified glassy carbon electrode, pH 10; |
Conditions | Yield |
---|---|
In acetic acid Kinetics; other Radiation; γ-ray radiation of (60)Co; at 23°C; dose rate of 1.2 Gy s**(-1); |
Conditions | Yield |
---|---|
In ammonia | |
In ammonia NH3 (liquid); |
sodium
A
hydrogen
B
iron
D
sodium hydroxide
E
sodium nitrite
Conditions | Yield |
---|---|
In ammonia -33°C; | |
In ammonia NH3 (liquid); -33°C; |
Conditions | Yield |
---|---|
above 190°C; | |
above 190°C; |
nitrogen(II) oxide
sodium
A
sodium nitrate
B
sodium nitrite
Conditions | Yield |
---|---|
heating with dry NO; |
Conditions | Yield |
---|---|
In ammonia slow O2 flow; | |
In ammonia NH3 (liquid); slow O2 flow; |
Conditions | Yield |
---|---|
In ammonia molar ratio of Na:NaNO3 = 2:1; | |
In ammonia NH3 (liquid); molar ratio of Na:NaNO3 = 2:1; |
Conditions | Yield |
---|---|
at 22-105°C; pressure of NO2 less then 600 torr; | |
at 22-105°C; pressure of NO2 less then 600 torr; |
Conditions | Yield |
---|---|
burning of Na in NO2 atmosphere; | |
slow oxidation of Na at the surface, above the melting point; | |
slow oxidation of Na at the surface, above the melting point; | |
burning of Na in NO2 atmosphere; |
Conditions | Yield |
---|---|
In neat (no solvent) 2 volumeparts NH3 are combusted with 3 volumeparts O2; formed N2O3 (NO and NO2) is absorped by Na2CO3;; | |
In neat (no solvent) 2 volumeparts NH3 are combusted with 3 volumeparts O2; formed N2O3 (NO and NO2) is absorped by Na2CO3;; |
dinitrogen trioxide
sodium nitrite
Conditions | Yield |
---|---|
With sodium hydroxide In water byproducts: H2O; absorption of nitrosic gases in alkaline soln.; | |
With NaOH In water byproducts: H2O; absorption of nitrosic gases in alkaline soln.; |
Conditions | Yield |
---|---|
With cast iron In melt melting of 500 kg KNO3 and 500 kg NaOH together; reaction of the melt with finely powdered cast iron for 5-6 h;; |
sodium nitrite
nitrogen(II) oxide
Conditions | Yield |
---|---|
With acetic acid; potassium iodide In water Product distribution / selectivity; | 100% |
With sulfuric acid; water at 10℃; under 375.038 Torr; for 1.38889E-05h; Reagent/catalyst; Temperature; Pressure; Time; | 99.99% |
With maleic acid; ascorbic acid In water Product distribution / selectivity; |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide byproducts: N2O; at about 80°C, under N2 or CO2, cooling, separation of Na2S2O3;; washing with acetone, analytically pure;; | 100% |
In further solvent(s) byproducts: N2O; solvent: dimethyl acetamide, at about 80°C, under N2 or CO2, cooling, separation of Na2S2O3;; washing with acetone, analytically pure;; | 100% |
sodium nitrite
Conditions | Yield |
---|---|
In not given 100°C, 1 h; | 100% |
sodium nitrite
αβ-s-{Co(2-methyl-3,6,9-triazaundec-2-ene-1,11-diamine)NO2}(ZnCl4)
Conditions | Yield |
---|---|
With ZnCl2 In hydrogenchloride soln. of Co-complex in HCl added NaNO2, heated for 20 min; soln. poured into 2-propanol/acetone (contained ZnCl2), cooled, powder collected, washed (acetone, Et2O), elem. anal.; | 100% |
αβ-i-{Co(3,6,9-triazaundec-2-ene-1,11-diamine)Cl}(ClO4)2
sodium nitrite
αβ-i-{Co(3,6,9-triazaundec-2-ene-1,11-diamine)NO2}(ZnCl4)
Conditions | Yield |
---|---|
With ZnCl2 In perchloric acid soln. of Co-complex in HClO4 added NaNO2, heated for 20 min, poured into a acetone/2-propanol mixture with ZnCl2; cooled to 0°C, washed (acetone Et2O), elem. anal.; | 100% |
Conditions | Yield |
---|---|
In ethanol; sulfuric acid; water aq. H2SO4; B(CNCH3)4(CF3SO3)3 dissolved in H2O and cooled to 0°C, addn. of aq. mixt. of NO and NO2 prepd. from NaNO2, H2SO4, and H2O over 4 h, stirred for 16 h at room temp., addn. of Na2CO3 and ethanol; pptn., filtered, dissolved (H2O), soln. saturated with CO2, addn. of ethanol, pptn., filtered, washed (ethanol, diethyl ether); | 100% |
[N,N'-bis(2-methyl-2-amino-κN-propyl)oxamidato-κ(2)N,N']copper(II)
sodium nitrite
catena-poly[copper(II)-μ-[N,N'-bis(2-methyl-2-aminopropyl)oxamido(2-)-N,N',O':N'',N''',O]copper(II)-di-μ-nitrito(-)-O]
Conditions | Yield |
---|---|
In methanol; water addn. of aq. Cu(NO3)2 and then aq. NaNO2 to Cu-complex (in MeOH) with stirring (pptn.); collection (filtration), washing (MeOH, Et2O), drying in air; elem. anal.; | 98% |
Conditions | Yield |
---|---|
In water at 0℃; for 0.75h; | 98% |
3,4,5-Trimethoxyaniline
sodium nitrite
Conditions | Yield |
---|---|
In water at 0℃; for 0.5h; | 98% |
Stage #1: tetrafluoroboric acid; 3,4,5-Trimethoxyaniline In water at 0℃; for 0.25h; Stage #2: sodium nitrite In water at 0℃; for 0.5h; |
3,3'-Diamino-N-methyldipropylamine
sodium nitrite
[Cu(3,3'-diamino-N-methyldipropylamine)(ONO)(H2O)]ClO4
Conditions | Yield |
---|---|
In methanol soln. of Cu salt added to soln. of org. compd., hot soln. of NaNO2 addeddropwise, heated for 10 min; hot filtered, allowed to crystallize at room temp., filtered, washed with ether, air-dried; elem. anal.; | 97% |
Conditions | Yield |
---|---|
1 equiv of NaNO2 under inert atm. at ambient temp.; silica gel column chromy. in a room atm.; | 97% |
6,16,2,5-tribenzena(1,4)-1,4,8,11,14,18,23,27-octaazabicyclo[9.9.9]nonacosaphane
sodium nitrite
Conditions | Yield |
---|---|
Stage #1: zinc perchlorate; 6,16,2,5-tribenzena(1,4)-1,4,8,11,14,18,23,27-octaazabicyclo[9.9.9]nonacosaphane In methanol at 20℃; for 0.5h; Stage #2: sodium nitrite In methanol for 12h; | 97% |
sodium nitrite
Conditions | Yield |
---|---|
In water; acetone for 12h; Reflux; Inert atmosphere; | 96.89% |
[Ru(η2-C6HCPhCH-1-O-2-CHNHEt-3-NO2-4-Me-5)(PPh3)2(CO)Cl]
sodium nitrite
Conditions | Yield |
---|---|
In dichloromethane; water; acetone aq. soln. of NaNO2 added dropwise to Ru complex soln. in CH2Cl2/acetone,stirred for 5 h; solvent removed (vac.), filtered, washed (H2O), dried (vac.); elem. anal.; | 96% |
Conditions | Yield |
---|---|
In water at 0℃; for 0.75h; Inert atmosphere; | 96% |
Conditions | Yield |
---|---|
In water for 4h; Heating / reflux; | 95% |
Conditions | Yield |
---|---|
In water; acetone prepn. from C6F5Ni(CH3)2C6H5)2Br and excess of NaNO2 in aq. acetone under reflux;; | 95% |
In water; acetone prepn. from C6F5Ni(CH3)2C6H5)2Br and excess of NaNO2 in aq. acetone under reflux;; | 95% |
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
DOT Classification: 5.1; Label: Oxidizer
Sodium Nitrite, its cas register number is 7632-00-0. It also can be called Anti-rust; Azotyn sodowy; Diazotizing salts;Dusitan sodny; Erinitrit; Filmerine; Natrium nitrit; Nitrite de sodium; Nitrito sodico. Sodium nitrite is the inorganic compound with the chemical formula NaNO2. It is a white to slight yellowish crystalline powder that is very soluble in water and is hygroscopic.It is a Nitrous acid sodium salt. And it is used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in analytical chemistry techniques. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.
Preparation of Sodium Nitrite:
Sodium Nitrite is prepared by treating sodium hydroxide with mixtures of nitrogen dioxide and nitric oxide:
2 NaOH + NO2 + NO → 2 NaNO2 + H2O
The conversion is sensitive to the presence of oxygen, which can lead to varying amounts of sodium nitrate.
In former times, sodium nitrite was prepared by reduction of sodium nitrate with various metals.
Uses of Sodium Nitrite:
Sodium nitrite (NaNO2) is a chemical compound commonly used in fertilizers, food preservatives, smoke bombs, as a color fixative, dyes and pyrotechnics.The main use of sodium nitrite is for the industrial production of organonitrogen compounds. It is a reagent for conversion of amines into diazo compounds.Sodium nitrite can be used as part of an intravenous mixture to treat cyanide poisoning.It is well known for its role in inhibiting the growth of Clostridium botulinum spores in refrigerated meats.
Safety information of Sodium Nitrite:
When you are using Sodium Nitrite, please be cautious about it as the following:(1)In case of accident or if you feel unwell, seek medical advice immediately (show label where possible); (2)Avoid release to the environment. Refer to special instructions safety data sheet; (3)Wear suitable protective clothing; (4)In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
You can still convert the following datas into molecular structure:
(1)InChI=1S/HNO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1;
(2)InChIKey=LPXPTNMVRIOKMN-UHFFFAOYSA-M;
(3)SmilesN(=O)[O-].[Na+];
The toxicity data of Sodium Nitrite is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | oral | 1500mg/kg (1500mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1372, 1935. | |
cat | LDLo | subcutaneous | 35mg/kg (35mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 126, Pg. 209, 1927. |
chicken | LD50 | oral | 28944ug/kg (28.944mg/kg) | American Journal of Veterinary Research. Vol. 30, Pg. 2185, 1969. | |
child | LDLo | oral | 22mg/kg (22mg/kg) | VASCULAR: OTHER CHANGES | Lancet. Vol. 2, Pg. 162, 1917. |
dog | LDLo | intravenous | 15mg/kg (15mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 245, 1973. | |
dog | LDLo | oral | 330mg/kg (330mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 245, 1973. | |
dog | LDLo | subcutaneous | 60mg/kg (60mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) GASTROINTESTINAL: NAUSEA OR VOMITING | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 21, Pg. 425, 1911. |
frog | LDLo | subcutaneous | 1gm/kg (1000mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1372, 1935. | |
human | LDLo | oral | 71mg/kg (71mg/kg) | BEHAVIORAL: COMA BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN GASTROINTESTINAL: NAUSEA OR VOMITING | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 543, 1969. |
human | TDLo | oral | 14mg/kg (14mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION | Deutsche Medizinische Wochenschrift. Vol. 74, Pg. 961, 1949. |
man | LDLo | oral | 321mg/kg (321mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: CYANOSIS BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN | Israel Journal of Medical Sciences. Vol. 28, Pg. 289, 1992. |
man | TDLo | oral | 1714ug/kg/70M (1.714mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Journal of Clinical Investigation. Vol. 16, Pg. 73, 1937. |
mouse | LD50 | intraperitoneal | 158mg/kg (158mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 165, Pg. 30, 1969. | |
mouse | LD50 | oral | 175mg/kg (175mg/kg) | VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 97, 1974. |
mouse | LDLo | subcutaneous | 150mg/kg (150mg/kg) | BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 35, Pg. 480, 1929. |
rabbit | LD50 | oral | 186mg/kg (186mg/kg) | Southwestern Veterinarian. Vol. 27, Pg. 246, 1974. | |
rabbit | LDLo | intravenous | 80mg/kg (80mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: COMA KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 121, 1931. |
rabbit | LDLo | subcutaneous | 60mg/kg (60mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1372, 1935. | |
rat | LC50 | inhalation | 5500ug/m3/4H (5.5mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 16(10), Pg. 36, 1972. | |
rat | LD50 | intravenous | 65mg/kg (65mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 320, 1963. | |
rat | LD50 | oral | 180mg/kg (180mg/kg) | American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969. | |
rat | LD50 | subcutaneous | 96600ug/kg (96.6mg/kg) | Archives of Toxicology, Supplement. Vol. 14, Pg. 231, 1991. |
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