Tris(hydroxymethyl)aminomethanehydrochloride supplier

Name
2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride
EINECS 214-684-5
CAS No. 1185-53-1
Article Data5
CAS DataBase
Density 1.05g/mLat 20°C
Solubility soluble in water
Melting Point 150-152 ºC
Formula C₄H₁₂ClNO₃
Boiling Point 357 ºC at 760 mmHg
Molecular Weight 157.597
Flash Point 169.7 ºC
Transport Information
Appearance White crystalline powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Tris(Hydroxymethyl)aminomethane hydrochloride [TRIS·HCL];Tris HCl;Tris-HCL;1,3-Propanediol,2-amino-2-(hydroxymethyl)-, hydrochloride (8CI,9CI);2-Amino-2-(hydroxymethyl)-1,3-propanediolhydrochloride;T 6666;Tri(hydroxymethyl)aminomethane hydrochloride;Trischloride;Tris(hydroxymethyl)aminomethane hydrochloride;Trizma hydrochloride;
PSA 86.71000
LogP -0.83690

Synthetic route

: cis-2,8-diphenyl-5-hydroxymethyl-1-aza-3,7-dioxabicyclo[3.3.0]octane

: 1185-53-1
tris hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In methanol for 1h; Heating;	80%

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 1185-53-1
tris hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water at 20℃; for 3h;

: 40018-26-6
1,4-dithiane-2,5-diol

: 1185-53-1
tris hydrochloride

: 2-(2,5-dithia-7-azabicyclo[2.2.1]heptan-7-yl)-2-(hydroxymethyl)propane-1,3-diol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 3h; Reflux;	97%

: 933-40-4
cycloxexanone dimethyl ketal

: 1185-53-1
tris hydrochloride

: C10H19NO3

Conditions

Conditions	Yield
Stage #1: cycloxexanone dimethyl ketal; tris hydrochloride With toluene-4-sulfonic acid In N,N-dimethyl-formamide for 17h; Stage #2: With triethylamine In ethyl acetate	94%

: 1125-88-8
benzaldehyde dimethyl acetal

: 1185-53-1
tris hydrochloride

: 51430-74-1
5-amino-5-hydroxymethyl-2-phenyl-1,3-dioxane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; triethylamine for 12h; Ambient temperature;	90%

: 3H3N*3H(1+)*[CrMo6O18(OH)6](3-)

: 1185-53-1
tris hydrochloride

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 2C4H11NO3*2H(1+)*[H3NC(CH2O)3]CrMo6O18(OH)3(2-)

Conditions

Conditions	Yield
Stage #1: 3H3N3H(1+)[CrMo6O18(OH)6](3-); 2-amino-2-hydroxymethyl-1,3-propanediol In water at 130℃; for 13h; Stage #2: tris hydrochloride In water at 20℃; for 0.166667h;	90%

...Expand

: 1185-53-1
tris hydrochloride

: 77-76-9
2,2-dimethoxy-propane

: 53104-32-8
(5-amino-2,2-dimethyl-1,3-dioxan-5-yl)methanol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; N,N-dimethyl-formamide for 12h; Ambient temperature;	86%
Stage #1: tris hydrochloride; 2,2-dimethoxy-propane With toluene-4-sulfonic acid In N,N-dimethyl-formamide at 20℃; for 60h; Stage #2: With triethylamine In methanol; N,N-dimethyl-formamide Sonication; Stage #3: With triethylamine In methanol; ethyl acetate; N,N-dimethyl-formamide at 20℃; for 0.166667h;	86%
Stage #1: tris hydrochloride; 2,2-dimethoxy-propane; toluene-4-sulfonic acid In N,N-dimethyl-formamide at 20℃; for 18h; Stage #2: With triethylamine In ethyl acetate for 0.5h;	85%

: 1185-53-1
tris hydrochloride

: 66-99-9
β-naphthaldehyde

: 253437-24-0
5-amino-5-hydroxymethyl-2-(2-naphthyl)-1,3-dioxane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 12h; Condensation; Heating;	85%

: 1185-53-1
tris hydrochloride

: 66-77-3
1-naphthaldehyde

: 253437-27-3
5-amino-5-hydroxymethyl-2-(1-naphthyl)-1,3-dioxane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 12h; Condensation; Heating;	82%

: 35718-08-2
propargyl chloroformate

: 1185-53-1
tris hydrochloride

: C8H13NO5

Conditions

Conditions	Yield
With sodium hydrogencarbonate In 1,4-dioxane; water at 20℃; for 19h;	80%

: 1185-53-1
tris hydrochloride

: 104-88-1
4-chlorobenzaldehyde

: 2,8-di-(p-chlorophenyl)-5-hydroxymethyl-1-aza-3,7-dioxabicyclo[3.3.0]octane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 12h; Reflux; optical yield given as %de;	77%

: 933-40-4
cycloxexanone dimethyl ketal

: 1185-53-1
tris hydrochloride

: 5452-79-9
3-amino-3-(hydroxymethyl)-1,5-dioxaspiro[5.5]undecane

Conditions

Conditions	Yield
Stage #1: cycloxexanone dimethyl ketal; tris hydrochloride With toluene-4-sulfonic acid In N,N-dimethyl-formamide at 21 - 23℃; for 18h; Inert atmosphere; Sealed tube; Stage #2: With triethylamine In ethyl acetate for 12h;	74%

: 7732-18-5
water

: CrH6Mo6O24(3-)*3H(1+)*3H3N

: 1185-53-1
tris hydrochloride

: C4H11CrMo6NO24(3-)*3H(1+)*2H3N*5H2O

Conditions

Conditions	Yield
at 140℃; for 30h;	70%

...Expand

: 1185-53-1
tris hydrochloride

: 131118-61-1
3'-tert-butyldimethylsilylthymidine 5'-carboxaldehyde

: 1-[(2R,4S,5S)-5-((R)-4,4-Bis-hydroxymethyl-oxazolidin-2-yl)-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
With triethylammonium bicarbonate buffer In acetonitrile at 20℃; pH=8;	67%

: 1-(3-(4-(diethylamino)-2-(4-(3-(trifluoromethyl)benzylcarbamoyl)pyridin-2-yl)phenylcarbamoyl)phenyl)-5,8,11,14-tetraoxa-2-thiaheptadecan-17-oic acid bis(trifluoroacetate)

: 1185-53-1
tris hydrochloride

: 2-(5-(diethylamino)-2-(3-(20-hydroxy-19,19-bis(hydroxymethyl)-17-oxo-5,8,11,14-tetraoxa-2-thia-18-azaicosyl)benzamido)phenyl)-N-(3-(trifluoromethyl)benzyl)isonicotinamide bis(trifluoroacetate)

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide for 2h;	67%

: 1185-53-1
tris hydrochloride

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: C7H12Cl3NO5

Conditions

Conditions	Yield
In methanol; water at 60℃; for 1h;	58%

: 75-15-0
carbon disulfide

: 1185-53-1
tris hydrochloride

A: 81731-80-8
4,4-bis(hydroxymethyl)thiazolidine-2-thione

B: 89417-47-0
4,4-bis(hydroxymethyl)oxazolidine-2-thione

C: 1311029-71-6
4-hydroxymethyl-4-thiomethyl-thiazolidine-2-thione

Conditions

Conditions	Yield
With sodium hydroxide In water at 60℃; for 24h;	A 45% B 18% C 11%

...Expand

: 1185-53-1
tris hydrochloride

: 6287-38-3
3,4-dichlorobenzaldehyde

: 2,8-di-(3,4-dichlorophenyl)-5-hydroxymethyl-1-aza-3,7-dioxabicyclo[3.3.0]octane

B: 1311029-73-8
2,8-di-(3,4-dichlorophenyl)-5-hydroxymethyl-1-aza-3,7-dioxabicyclo[3.3.0]octane

: {bis-(2,8-di-(m,p-dichlorophenyl)-1-aza-3,7-dioxabicyclo[3.3.0]-octane 5-methoxy)methyl}-3,4-dichlorobenzene

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 12h; Reflux; optical yield given as %de;	A n/a B n/a C 35%

...Expand

: 1185-53-1
tris hydrochloride

: 459-57-4
4-fluorobenzaldehyde

: (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 12h; Reflux; optical yield given as %de;	34%

: 1571096-82-6
N1,N7-bis(2-(2-(2-(3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylsulfonamido)ethoxy)ethoxy)ethyl)-4-(3-(2-(2-(2-(3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylsulfonamido)ethoxy)ethoxy)ethylamino)-3-oxopropyl)-4-isocyanatoheptanediamide

: 1185-53-1
tris hydrochloride

: 76-05-1
trifluoroacetic acid

: N1,N7-bis(2-(2-(2-(3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylsulfonamido)ethoxy)ethoxy)ethyl)-4-(3-(2-(2-(2-(3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylsulfonamido)ethoxy)ethoxy)ethylamino)-3-oxopropyl)-4-(3-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)ureido)heptanediamide

Conditions

Conditions	Yield
Stage #1: N1,N7-bis(2-(2-(2-(3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylsulfonamido)ethoxy)ethoxy)ethyl)-4-(3-(2-(2-(2-(3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylsulfonamido)ethoxy)ethoxy)ethylamino)-3-oxopropyl)-4-isocyanatoheptanediamide; tris hydrochloride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: trifluoroacetic acid In water; N,N-dimethyl-formamide	26%

Yield

Stage #1: N1,N7-bis(2-(2-(2-(3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylsulfonamido)ethoxy)ethoxy)ethyl)-4-(3-(2-(2-(2-(3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylsulfonamido)ethoxy)ethoxy)ethylamino)-3-oxopropyl)-4-isocyanatoheptanediamide; tris hydrochloride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: trifluoroacetic acid In water; N,N-dimethyl-formamide

26%

...Expand

: 1185-53-1
tris hydrochloride

: 1122-91-4
4-bromo-benzaldehyde

: 2,8-di-(m-bromophenyl)-5-hydroxymethyl-1-aza-3,7-dioxabicyclo[3.3.0]octane

B: 1311029-72-7
2,8-di-(m-bromophenyl)-5-hydroxymethyl-1-aza-3,7-dioxabicyclo[3.3.0]octane

C: 1311029-92-1
{bis-(2,8-di-(m-bromophenyl)-1-aza-3,7-dioxabicyclo[3.3.0]-octane 5-methoxy)methyl}-3-bromobenzene

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 12h; Reflux; optical yield given as %de;	A n/a B n/a C 25%

...Expand

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1185-53-1
tris hydrochloride

A: 2,8-di-(p-trifluoromethylphenyl)-5-hydroxymethyl-1-aza-3,7-dioxabicyclo[3.3.0]octane

: 2,8-di-(p-trifluoromethylphenyl)-5-hydroxymethyl-1-aza-3,7-dioxabicyclo[3.3.0]octane

C: 1311029-91-0
{bis(2,8-di-(p-trifluoromethylphenyl)-1-aza-3,7-dioxabicyclo-[3.3.0]octane 5-methoxy)methyl}-4-trifluoromethylbenzene

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 12h; Reflux; optical yield given as %de;	A n/a B n/a C 13%

...Expand

: 1185-53-1
tris hydrochloride

: 108-24-7
acetic anhydride

: 2353-29-9
1,3-diacetoxy-2-acetoxymethyl-2-amino-propane

: 54150-57-1
2-benzoyloxyacetyl chloride

: 1185-53-1
tris hydrochloride

: 115193-31-2
Benzoic acid (2-hydroxy-1,1-bis-hydroxymethyl-ethylcarbamoyl)-methyl ester

Conditions

Conditions	Yield
In benzene Ambient temperature;

: 1185-53-1
tris hydrochloride

: 72586-69-7
N,N'-dimethyl-N'-(p-nitrophenyl)-N-nitrosourea

A: 3-(2-Hydroxy-1,1-bis-hydroxymethyl-ethyl)-1-methyl-1-(4-nitro-phenyl)-urea

B: 100-15-2
N-methyl(p-nitroaniline)

Conditions

Conditions	Yield
With water; sodium chloride; cetyltrimethylammonim bromide at 24.8℃; Rate constant; micellar effect investigated at pH 8.05;

...Expand

: 41158-67-2
myo-inositol-1,2-cyclic phosphate

: 1185-53-1
tris hydrochloride

: Phosphoric acid 2-amino-3-hydroxy-2-hydroxymethyl-propyl ester (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxy-cyclohexyl ester

Conditions

Conditions	Yield
With glycerol In water bacterial phosphatidylinositol-specific phospholipase C presence;

: 1185-53-1
tris hydrochloride

duplex of: 5\-CAAAGCG-3\ (ODN I) and 3\-GTTTCGC-5\ (ODN II): duplex of: 5\-CAAAGCG-3\ (ODN I) and 3\-GTTTCGC-5\ (ODN II)

A: C29H35N13O19P2

B: C33H44N14O21P2

C: C39H50N18O26P4

D 3\-GTTTCGC-5\: 3\-GTTTCGC-5\

Conditions

Conditions	Yield
With mesotetrakis(4-N-methylpiridiniumyl)porphyrinatomanganeseIII; oxygen; tris hydrochloride; sodium sulfite at 4℃; for 5h; pH=9; Product distribution; Enzymatic reaction;

...Expand

: 1185-53-1
tris hydrochloride

: 645-88-5
aminooxyacetic acid

duplex of: 5\-CAAAGCG-3\ (ODN I) and 3\-GTTTCGC-5\ (ODN II): duplex of: 5\-CAAAGCG-3\ (ODN I) and 3\-GTTTCGC-5\ (ODN II)

A: C29H35N13O19P2

B: C31H38N14O21P2

C: C33H44N14O21P2

D: C39H50N18O26P4

Conditions

Conditions	Yield
With mesotetrakis(4-N-methylpiridiniumyl)porphyrinatomanganeseIII; oxygen; tris hydrochloride; sodium sulfite at 20℃; for 1h; pH=9; Product distribution; Enzymatic reaction;

...Expand

: 39837-09-7
DL-N-benzoylhomocysteine thiolactone

: 1185-53-1
tris hydrochloride

: C15H21NO5S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 16h;

Tris(hydroxymethyl)aminomethanehydrochloride Chemical Properties

Molecular Structure:

Molecular Formula: C₄H₁₂ClNO₃
Molecular Weight: 157.596
IUPAC Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride
Synonyms of Tris hydrochloride (CAS NO.1185-53-1): 2-Amino-2-hydroxymethyl-1,3-propanediol hydrochloride ; EINECS 214-684-5 ; Tris chloride ; Tris hydrochloride buffer ; Tris(hydroxymethyl)aminomethane hydrochloride ; Trizma hydrochloride ; Tromethamine HCl ; Tris(hydroxymethyl)aminomethanehydrochloride ; UNII-383V75M34E ; 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride ; 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1)
CAS NO: 1185-53-1
Product Categories: Buffer
Melting Point: 150-152 °C
H bond acceptors: 4
H bond donors: 5
Freely Rotating Bonds: 7
Polar Surface Area: 30.93 Å²
Flash Point: 169.7 °C
Enthalpy of Vaporization: 69.73 kJ/mol
Boiling Point: 357 °C at 760 mmHg
Vapour Pressure: 1.57E-06 mmHg at 25°C

Tris(hydroxymethyl)aminomethanehydrochloride Uses

Tris hydrochloride (CAS NO.1185-53-1) is used as a organic intermediate.

Tris(hydroxymethyl)aminomethanehydrochloride Safety Profile

Safety Information of Tris hydrochloride (CAS NO.1185-53-1):
Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
WGK Germany:3
F:3
HS Code:29221980

Product Name

2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride

Synthetic route

Tris(hydroxymethyl)aminomethanehydrochloride Chemical Properties

Tris(hydroxymethyl)aminomethanehydrochloride Uses

Tris(hydroxymethyl)aminomethanehydrochloride Safety Profile

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