m-Tolualdehyde supplier | CasNO.620-23-5

Name
m-Tolualdehyde
EINECS 210-632-0
CAS No. 620-23-5
Article Data415
CAS DataBase
Density 1.023 g/cm³
Solubility slightly soluble in water
Melting Point <25 °C
Formula C₈H₈O
Boiling Point 199 °C at 760 mmHg
Molecular Weight 120.151
Flash Point 78.3 °C
Transport Information
Appearance clear yellow to brown liquid
Safety 23-24/25-37/39-26
Risk Codes 36/38
Molecular Structure
Hazard Symbols Xi
Synonyms m-Tolualdehyde(8CI);3-Methylbenzaldehyde;3-Methylphenylcarboxaldehyde;3-Tolualdehyde;NSC1244;NSC 89859;m-Formyltoluene;m-Methylbenzaldehyde;
PSA 17.07000
LogP 1.80750

Synthetic route

: 201230-82-2
carbon monoxide

: 625-95-6
3-Iodotoluene

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With triethylsilane; palladium diacetate; sodium hydrogencarbonate; sodium carbonate at 20℃; under 760.051 Torr; for 48h;	90%
With rhodium(III) chloride trihydrate; hydrogen; triethylamine; triphenylphosphine In N,N-dimethyl acetamide at 90℃; under 7500.75 Torr; for 12h; Autoclave;	90%
With sodium formate In N,N-dimethyl-formamide at 110℃; under 760.051 Torr; for 5h;	86%
With sodium formate In N,N-dimethyl-formamide at 100℃; under 760.051 Torr; for 10h;	84%
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene at 110℃; under 66195.7 Torr; for 2h;	68 % Chromat.

: 52707-50-3, 52707-55-8, 41977-54-2
3-methylbenzaldehyde oxime

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With N,N'-dichlorophenobarbital In acetonitrile at 20℃;	95%
With molybdenum(V) chloride; zinc In acetonitrile at 20℃; for 0.0833333h;	94%
With potassium permanganate; 1-n-butyl-3-methylimidazolim bromide at 20℃; for 1h; Ionic liquid; chemoselective reaction;	91%

: 120158-57-8
1,1-diacetoxy-1-(3-methylphenyl)-methane

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With sulphated zirconia In acetonitrile at 60℃; for 0.3h; Microwave irradiation;	100%
With sulfonated rice husk ash In acetonitrile at 60℃; for 0.0333333h;	91%
With saccharin sulfonic acid at 90℃; for 0.05h; Neat (no solvent);	90%

: 621-36-3
m-methylphenylacetic acid

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With dihydrogen peroxide In water; acetonitrile at 25℃; for 10h; UV-irradiation;	92%
With potassium 12-tungstocobaltate(III) In water; acetonitrile for 0.166667h; Microwave irradiation;	90%
With dipotassium peroxodisulfate In water at 90℃; for 12h; Green chemistry;	80%
With oxygen; copper diacetate In dimethyl sulfoxide at 120℃; for 18h; Sealed tube;	71%
With iron(III) chloride; oxygen In N,N-dimethyl-formamide at 110℃;	67%

: 124-38-9
carbon dioxide

: 625-95-6
3-Iodotoluene

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 80℃; under 7500.75 Torr; for 20h; Autoclave; Green chemistry;	86%
With carbon supported Pd nanoparticles; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 80℃; under 7500.75 Torr; for 12h; Sealed tube; Green chemistry;	82%
With rhodium(III) iodide; hydrogen; acetic anhydride; triethylamine; triphenylphosphine In N,N-dimethyl acetamide at 100℃; for 24h; Autoclave;	80%

: 64-18-6
formic acid

: 625-95-6
3-Iodotoluene

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With iodine; triethylamine; triphenylphosphine In toluene at 80℃; Inert atmosphere; Sealed tube;	81%
With iodine; triethylamine; triphenylphosphine In toluene at 80℃; for 2h; Sealed tube;	77%
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; tricyclohexylphosphine In N,N-dimethyl-formamide at 80℃; for 10h; Inert atmosphere; Sealed tube;	67%

: 620-19-9
1-chloromethyl-3-methyl-benzene

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With water; sodium hydroxide at 20℃; for 0.05h; Microwave irradiation;	98%
With 4-methylmorpholine N-oxide; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride; potassium iodide at 100℃; for 0.0333333h; Microwave irradiation; Ionic liquid;	90%
With 4-methylmorpholine N-oxide In tetrahydrofuran at 20℃; for 12h; Reflux;	80%

: 587-03-1
3-methylbenzyl alcohol

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With iodosylbenzene; Cl-CH2-PS supported 5-amino-1,10-phenanthroline-Ru In acetonitrile at 60℃; for 2h;	100%
Stage #1: 3-methylbenzyl alcohol With iron(III) chloride hexahydrate; oxygen; silica gel In toluene for 0.0833333h; Autoclave; Stage #2: With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical In toluene at 80℃; under 3750.38 Torr; for 8h; Autoclave;	99%
With dihydrogen peroxide In water at 100℃; for 6.5h; chemoselective reaction;	99%

: 99-04-7
m-Toluic acid

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate; fac-tris(2-phenylpyridinato-N,C2')iridium(III); tris-(trimethylsilyl)silane; dimethyl dicarbonate In acetonitrile at 20℃; for 6h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;	90%
With potassium phosphate; sodium hypophosphite; 2,2-dimethylpropanoic anhydride; palladium diacetate; tricyclohexylphosphine In tetrahydrofuran at 60℃; for 16h;	73%
ueber <3-Methyl-α-phenylimino-benzyl>-phenyl-carbamidsaeure-aethylester;

: 625-95-6
3-Iodotoluene

: 298-12-4
Glyoxilic acid

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; 2,2'-azobis(isobutyronitrile); oxygen; triethylamine In N,N-dimethyl-formamide at 110℃; under 760.051 Torr; for 4h; Schlenk technique; Sealed tube;	63%

: 620-22-4
3-Methylbenzonitrile

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With formic acid; platinum(IV) oxide In water at 55 - 60℃; for 3h;	92%
With C13H26B(1-)*K(1+) In tetrahydrofuran for 24h; Ambient temperature;	89%
With diisobutylaluminium hydride In diethyl ether at 20℃; for 5h;	76%

: 591-17-3
meta-bromotoluene

: 298-12-4
Glyoxilic acid

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; 2,2'-azobis(isobutyronitrile); oxygen; triethylamine In N,N-dimethyl-formamide at 110℃; under 760.051 Torr; for 5h; Schlenk technique; Sealed tube;	52%

: 1711-06-4
3-Methylbenzoyl chloride

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With quinoline; Pd-BaSO4; xylene Hydrogenation;
With thexyl-s-butoxyborane In tetrahydrofuran at 25℃; for 120h; Yield given;
Multi-step reaction with 2 steps 1: 83 percent / pyridine / 0 °C 2: anhydrous potassium carbonate / methanol / 118 h / Heating View Scheme

: 587-03-1
3-methylbenzyl alcohol

A: 620-23-5
m-tolyl aldehyde

B: 99-04-7
m-Toluic acid

Conditions

Conditions	Yield
With tetra-n-butylammonium peroxomonosulfate In dichloromethane at 20℃; for 0.5h;
With oxygen In water at 80℃; under 760.051 Torr; for 8h;
With Oxone In water at 50℃; for 21h;
With potassium peroxymonosulfate sulfate; tetrabutylammomium bromide In water at 70℃; for 4h; Reagent/catalyst; Green chemistry;

: 620-13-3
1-bromomethyl-3-methyl-benzene

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With bis-{4-methoxy-phenyl}-selenoxyde; sodium hydrogencarbonate In acetonitrile at 75℃; for 5h;	93%
With potassium hydrogencarbonate; dimethyl sulfoxide for 0.05h; Microwave irradiation;	89%
With hexamethylenetetramine durch Behandeln mit Wasser oder verd. Alkohol;
Multi-step reaction with 3 steps 1: 99 percent / Na2CO3 2: 99 percent / permaleic acid 3: 1.) trifluoroacetic anhydride; 2.) NBS / 1.) 10 min, r.t.; 2.) 80percent CH3CN, 20 min, r.t. View Scheme
With hexamethylenetetramine durch Behandeln mit Wasser oder verd. Alkohol;

: 120-33-2
ethyl 3-methylbenzoate

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With sodium tris(diethylamino)aluminum hydride In tetrahydrofuran; dodecane at -78℃; for 24h;	89%
With lithium-tris(diethylamino)hydridoaluminate In tetrahydrofuran at -78℃; for 3h; Reduction;
With Na(1+)*C12H27AlNO5(1-) In tetrahydrofuran; toluene at 0 - 20℃; for 0.5h;	99 %Chromat.

: 201230-82-2
carbon monoxide

: 591-17-3
meta-bromotoluene

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With N,N,N,N,-tetramethylethylenediamine; hydrogen; palladium diacetate; propyl di-tert-butylphosphinite In toluene at 100℃; under 3750.38 Torr; for 20h; Inert atmosphere;	89%
With poly-γ-(p-diphenylphosphinophenyl)propylsiloxane Pd; sodium acetate In N,N-dimethyl-formamide at 110℃; for 12h;	53%

: 100-80-1
3-methylstyrene

A: 704898-29-3, 1195902-12-5
3-methylstyrene oxide

B: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With [Cu(2,2'-bipyridine)(2-hap)(ClO4)]; dihydrogen peroxide In acetonitrile at 60℃; for 8h;	A 85% B n/a
With tert.-butylhydroperoxide In acetonitrile at 65 - 68℃; for 24h;	A 63% B 23%
With tert.-butylhydroperoxide; Gd2(N3)(nic)2(OH)3(Hnic)(H2O) In acetonitrile at 68 - 70℃; for 24h;	A 60% B 35%

: 6935-65-5
3,N,N-trimethylbenzamide

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With lithium diisobutylmorpholinoaluminum hydride In tetrahydrofuran; hexane at 0℃; for 0.5h;	97 %Chromat.
With benzoic acid ethyl ester; copper diisobutyl-t-butoxyaluminum hydride In tetrahydrofuran at 20℃; for 12h; Temperature; Solvent; Inert atmosphere; chemoselective reaction;	95 %Chromat.
With acetophenone In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;	33 %Chromat.

: 35286-92-1
(E)-3,3'-dimethylstilbene

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With iodine; oxygen; trifluoroacetic acid In methanol for 20h; Irradiation;	83%

: 108-38-3
m-xylene

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With carbon tetrabromide; oxygen In acetonitrile at 20℃; for 2.5h; Irradiation; Green chemistry;	90%
With 1,4-bis(triphenylphosphonium)butane cerium nitrate In water; acetic acid for 0.5h; Reflux;	88%
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In fluorobenzene; dimethyl sulfoxide at 85℃; for 16h;	85%

: 587-03-1
3-methylbenzyl alcohol

: 62-53-3
aniline

A: 6906-25-8
N-(3-methylbenzylidene)aniline

B: 75366-13-1
N-(3-methylbenzyl)aniline

C: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With PdAu alloy nanoparticles encapsulated inside MIL-100(Fe) cavities In acetonitrile for 24h; Irradiation; Inert atmosphere; Schlenk technique; Sealed tube;	A 14% B 77% C 36%
With Pd nanoparticles encapsulated inside a MIL100(Fe) cavity In acetonitrile for 24h; Sealed tube; Irradiation; Inert atmosphere;	A 16% B 62% C 24%

...Expand

: 82436-18-8
2-(m-tolyl)-1,3-dithiolane

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With silica gel; ferric nitrate In hexane at 50℃; for 0.166667h;	98%
With indium (III) iodide; dihydrogen peroxide In water; toluene at 20℃; for 15h; Inert atmosphere; Sealed tube;	82 mg

: 124-38-9
carbon dioxide

: 591-17-3
meta-bromotoluene

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With rhodium(III) iodide; dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); hydrogen; acetic anhydride; triethylamine; triphenylphosphine In N,N-dimethyl acetamide at 100℃; for 24h; Autoclave;	90%
With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 100℃; under 7500.75 Torr; for 20h; Autoclave; Green chemistry;	76%

: 108-38-3
m-xylene

A: 587-03-1
3-methylbenzyl alcohol

B: 620-23-5
m-tolyl aldehyde

C: 99-04-7
m-Toluic acid

Conditions

Conditions	Yield
With zinc(II) 1,8,15,22-tetrachlorophthalocyanine; C60H60BrFeN4; oxygen; nickel diacetate at 125℃; under 4500.45 - 7500.75 Torr; for 1.5h; Reagent/catalyst; Pressure; Temperature;
Stage #1: m-xylene at 220℃; under 18001.8 Torr; Stage #2: With water at 182℃; under 12001.2 Torr;
With [(copper(II))3(μ3-1κN3,2κN2O,3κN-N′-(di(pyridin-2-yl)methylene)pyrazine-2-carbohydrazide)(μ-nitrate)(nitrate)3(H2O)3]*(nitrate); dihydrogen peroxide In acetonitrile at 50℃; for 3h; Time; Reagent/catalyst; Microwave irradiation;	A 15.3 %Chromat. B 5.9 %Chromat. C 3.4 %Chromat.

...Expand

: 78649-50-0
1-(3'-methylphenyl)-1,2-dihydroxyethane

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
With oxygen; sodium carbonate In water at 20℃; for 5h; Irradiation; Green chemistry;	79%

: 62381-20-8
2-(3-methylphenyl)-1,3-dithiane

: 620-23-5
m-tolyl aldehyde

Conditions

Conditions	Yield
Stage #1: 2-(3-methylphenyl)-1,3-dithiane With trichloroisocyanuric acid; silica gel at 20℃; for 0.05h; Stage #2: With water at 20℃;	94%
With tetrachlorosilane; dimethyl sulfoxide In dichloromethane at 20℃; for 0.583333h;	93%

: 109-55-7
1-amino-3-(dimethylamino)propane

: 620-23-5
m-tolyl aldehyde

: N-(3-methylbenzylidene)-N',N'-dimethyl-1,3-propanediamine

Conditions

Conditions	Yield
In ethanol Heating;	100%
In benzene Heating;

propylamine: propylamine

: 620-23-5
m-tolyl aldehyde

: N-(3-methylbenzylidene)propan-1-amine

Conditions

Conditions	Yield
at 20℃; for 12h;	100%
In methanol at 25℃; Mechanism; Rate constant; Thermodynamic data; ΔH(excit.), ΔS(excit.), kinetic solvent isotope effect;
With sodium sulfate In dichloromethane for 2h;

: 557-20-0
diethylzinc

: 620-23-5
m-tolyl aldehyde

: 213267-92-6
(S)-1-(3-methylphenyl)propan-1-ol

Conditions

Conditions	Yield
(1S)-1-(9-piperidylfluoren-9-yl)ethanol In hexane; toluene at 0℃; for 4h; Addition;	100%
Stage #1: diethylzinc With 2,2'-(propane-2,2-diyl)bis(6,6-dimethyl-5,6,7,8-tetrahydro-5,7-methanoquinoline-8,2-diyl)bis(diphenylmethanol) In toluene at 20℃; for 0.166667h; Inert atmosphere; Stage #2: m-tolyl aldehyde In toluene at -20℃; for 57h; Inert atmosphere; enantioselective reaction;	95%
Stage #1: m-tolyl aldehyde With (E,4R,5S)-N-allyl-5-cyclohexyl-5-hydroxy-4-morpholinopent-2-enamide In toluene at 20℃; for 0.333333h; Inert atmosphere; Stage #2: diethylzinc In hexane; toluene at 20℃; for 6h; Reagent/catalyst; Inert atmosphere; enantioselective reaction;	95%

: 557-20-0
diethylzinc

: 620-23-5
m-tolyl aldehyde

: 32019-31-1, 112777-68-1
(R)-1-(3-tolyl)-1-propanol

Conditions

Conditions	Yield
Stage #1: diethylzinc; m-tolyl aldehyde With (1S,2R,3S,5S)-6,6-dimethyl-2-morpholinobicyclo[3.1.1]heptan-3-ol; (1R,2S,3R,5R)-6,6-dimethyl-2-morpholinobicyclo[3.1.1]heptan-3-ol In hexane at -15 - 0℃; for 18h; Inert atmosphere; Stage #2: With water; ammonium chloride In hexane at 0℃; optical yield given as %ee; enantioselective reaction;	100%
With 4-methyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide In hexane at 0℃; for 24h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	97%
With titanium(IV) isopropylate In dichloromethane at 0℃;	96%

: 107-11-9
1-amino-2-propene

: 620-23-5
m-tolyl aldehyde

: 246509-62-6
Allyl-[1-m-tolyl-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 20h;	100%
With 3 A molecular sieve In benzene at 65℃;

: 6335-34-8
2-bromo-N,N-diphenylacetamide

: 620-23-5
m-tolyl aldehyde

: C22H19NO2

Conditions

Conditions	Yield
With potassium hydroxide In acetonitrile at 20℃; for 4h; Darzens condensation;	100%
With potassium hydroxide In dichloromethane at 20℃; Darzens condensation;	76%

: 74-89-5
methylamine

: 620-23-5
m-tolyl aldehyde

: 17972-15-5
N-[(3-methylphenyl)methylene]methanamine

Conditions

Conditions	Yield
at 20℃; for 12h;	100%
at 20℃; for 1h;
In benzene for 2h; Reflux;

: 2579-20-6
cis, trans-1,3-dimethylaminocyclohexane

: 620-23-5
m-tolyl aldehyde

: 1217526-70-9
C24H30N2

Conditions

Conditions	Yield
In methanol at 20℃; Molecular sieve;	100%
In methanol at 20℃; Molecular sieve;

: 620-23-5
m-tolyl aldehyde

: 149-73-5
trimethyl orthoformate

: 90470-72-7
1,1-dimethoxy-1-(3-methylphenyl)methane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In methanol at 20℃; for 18h;	100%
With Pd(PhCN)2(OTf)2 at 20℃; for 0.5h; Inert atmosphere;	91%
With toluene-4-sulfonic acid In methanol at 20℃; for 2h; Molecular sieve;

: 132330-44-0
N-prenyl-N-propargyltosylamide

: 620-23-5
m-tolyl aldehyde

: 1174503-11-7
C23H27NO3S

Conditions

Conditions	Yield
Stage #1: N-prenyl-N-propargyltosylamide With ethylmagnesium bromide In tetrahydrofuran at 50℃; for 1h; Stage #2: m-tolyl aldehyde In tetrahydrofuran at 20℃; for 3h;	100%
Stage #1: N-prenyl-N-propargyltosylamide With ethylmagnesium bromide In tetrahydrofuran at 50℃; for 1h; Stage #2: m-tolyl aldehyde In tetrahydrofuran at 20℃; for 3h;

: 1346683-43-9
dimethyl (2-oxo-2-(1H-pyrrol-1-yl)ethyl)phosphonate

: 620-23-5
m-tolyl aldehyde

: 1608108-44-6
(E)-1-(1H-pyrrol-1-yl)-3-(m-tolyl)prop-2-en-1-one

Conditions

Conditions	Yield
Stage #1: dimethyl (2-oxo-2-(1H-pyrrol-1-yl)ethyl)phosphonate With N-ethyl-N,N-diisopropylamine; lithium chloride In acetonitrile at 0℃; for 0.333333h; Stage #2: m-tolyl aldehyde In acetonitrile at 20℃; for 15h;	100%

: 769-42-6
1,3-dimethylbarbituric acid

: 109-89-7
diethylamine

: 620-23-5
m-tolyl aldehyde

: 1621511-05-4
5,5'-(3-tolylmethylene)bis(1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione) diethylaminium salt

Conditions

Conditions	Yield
In water at 20℃; Inert atmosphere;	100%
With water; dimedone at 20℃; Green chemistry;	97%

...Expand

: 126-81-8
dimedone

: 109-89-7
diethylamine

: 620-23-5
m-tolyl aldehyde

: Diethylammonium 2-((2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)(m-tolyl)methyl)-5,5-dimethyl-3-oxocyclohex-1-enolate

Conditions

Conditions	Yield
In water at 20℃; Inert atmosphere;	100%

...Expand

: 40307-11-7
1-ethyl-4-ethynylbenzene

: 620-23-5
m-tolyl aldehyde

: 101273-46-5
1-(4′-methylphenyl)isoquinoline

Conditions

Conditions	Yield
With palladium diacetate; sodium carbonate; triphenylphosphine In toluene at 80℃; for 2h; Inert atmosphere;	100%

: 40307-11-7
1-ethyl-4-ethynylbenzene

: 620-23-5
m-tolyl aldehyde

: 3-(4-ethylphenyl)-1-(m-tolyl)prop-2-yn-1-ol

Conditions

Conditions	Yield
Stage #1: 1-ethyl-4-ethynylbenzene With n-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: m-tolyl aldehyde In tetrahydrofuran at -78℃; for 3h; Inert atmosphere;	100%

: 108-91-8
cyclohexylamine

: 620-23-5
m-tolyl aldehyde

: (E)-N-cyclohexyl-1-(3-tolyl)methanimine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; for 15h; Inert atmosphere;	100%

: 5927-18-4
trimethyl phosphonoacetate

: 620-23-5
m-tolyl aldehyde

: 82444-40-4, 118315-74-5, 95416-56-1
(E)-methyl 3-methylcinnamate

Conditions

Conditions	Yield
Stage #1: trimethyl phosphonoacetate With sodium hydride In tetrahydrofuran; paraffin oil at 0 - 20℃; for 0.5h; Inert atmosphere; Stage #2: m-tolyl aldehyde In tetrahydrofuran; paraffin oil at -78 - 20℃; Inert atmosphere;	100%

: 620-23-5
m-tolyl aldehyde

: 587-03-1
3-methylbenzyl alcohol

Conditions

Conditions	Yield
With alumina; isopropyl alcohol at 180℃; under 11251.1 Torr; for 0.666667h; Microwave irradiation; Sealed tube;	99%
With Candida boidinii formate dehydrogenase; Geobacillus stearothermophilus ε‐deaminating L‐lysine dehydrogenase variant 27; nicotinamide adenine dinucleotide In aq. buffer at 30℃; for 24h; pH=7; Reagent/catalyst; Enzymatic reaction;	99%
With triethylamine; isopropyl alcohol; lithium bromide at 20℃; for 48h; Meerwein-Ponndorf-Verley reaction;	98%

m-Tolualdehyde Chemical Properties

Empirical Formula: C₈H₈O
Molecular Weight: 120.1485 g/mol
Index of Refraction: 1.557
Density: 1.023 g/cm³
Flash Point: 78.3 °C
Enthalpy of Vaporization: 43.52 kJ/mol
Boiling Point: 199 °C at 760 mmHg
Vapour Pressure: 0.349 mmHg at 25 °C
Water solubility: Slightly soluble
Sensitive: Air Sensitive
Appearance: Clear yellow to brownish liquid
Structure of p-Tolualdehyde (CAS NO.620-23-5):

Product Category of p-Tolualdehyde (CAS NO.620-23-5): Benzene derivatives;Aromatic Aldehydes & Derivatives (substituted)

m-Tolualdehyde Toxicity Data With Reference

p-Tolualdehyde (CAS NO.620-23-5) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65. And the toxicological properties have not been fully investigated.

m-Tolualdehyde Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/38
R36/38:Irritating to eyes and skin.
Safety Statements: 23-24/25-37/39-26
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.

m-Tolualdehyde Specification

m-Tolualdehyde , its cas register number is 620-23-5. It also can be called m-Tolualdehyde ; Benzaldehyde, 3-methyl- ; and 3-Methylbenzaldehyde . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, p-Tolualdehyde (CAS NO.620-23-5) is air sensitive. It is not compatible with strong oxidizing agents, strong reducing agents, strong bases, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide.

Product Name

m-Tolualdehyde

Synthetic route

m-Tolualdehyde Chemical Properties

m-Tolualdehyde Toxicity Data With Reference

m-Tolualdehyde Safety Profile

m-Tolualdehyde Specification

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