A selective and sensitive analytical method for the simultaneous determination of cucurbitacin B, E, I and E-glucoside in plant material and body fluids by HPLC–MS was developed. After liquid–liquid extraction with dichlormethane, separation was achieved on a Phenomenex Luna Pentafluorophenyl ...

Cucurbitacin E glucoside (1) is a tetracyclic triterpenoid glucoside, isolated from Cucurbitaceae plants. In the present study the pharmacological and biochemical effects of cucurbitacin-E-glucoside and two of its microbial transformation derivatives (2 and 3) produced by Curvularia lunata NRRL ...

One or two methyl groups have been introduced on the aromatic ring of two chiral clofibric acid analogs, 2-(4-chloro-phenoxy)propanoic and 2-(4-chloro-phenoxy)butanoic acids. The biological activity of the derivatives obtained (3–6) has been evaluated on the skeletal muscle chloride conductance...

Phase transfer catalytic methylation was applied to directly derivatise chlorophenoxy acid herbicides in superheated water extracts from sand and soil samples. The extractions were carried out at 120 °C statically for 5 min and then dynamically for 10 min at 1.0 mL min−1 using water at pH 11.0 ...

Infrared (IR) and vibrational circular dichroism (VCD) spectra of N-Acetyl-l-Cysteine Methyl Ester (NALCME) and N-Acetyl-l-Cysteine (NALC) in D2O under different pHs were measured. We focus on the VCD signatures of the amide I and the CO stretching spectral signatures of the neutral NALCME and N...

A series of 3-(2-aminocarbonylphenyl)propanoic acid analogs possessing the (1R)-1-(3,5-dimethylphenyl)-3-methylbutylamine moiety on the carboxyamide side chain were synthesized and evaluated for their binding affinity for the EP1-4 receptors and their antagonist activity for the EP3 receptor. Ra...

A capillary liquid chromatography (cLC) method with gradient elution has been used to determine chlorophenoxy acid herbicides: 2,4-dichlorophenoxyacetic acid, 4-chloro-2-methylphenoxyacetic acid, 2-(2,4-dichlorophenoxy)propanoic acid, 2-(4-chloro-2-methylphenoxy)propanoic acid, 4-(2,4-dichloroph...

A total of 51 natural and synthetic simple coumarins, furanocoumarins, chromanones, furanochromanones and some structurally related compounds were tested for their antimutagenic potencies with respect to IQ in Salmonella typhimurium TA 98. Antimutagenic potencies were quantified by the inhibitor...

Treatment of chromanone, thiochromanone, tetralone and benzo[b]thiepinone derived allylic alcohols with phosphorous tribromide furnished unexpected products instead of desired bromo derivatives. Reaction of 7-methoxy-2,2-dimethylchromenyl-aryl-methanols and 7-methoxy-2,2-dimethylthiochromenyl-ar...

The present study reports the thermophysical properties such as density and viscosity for aqueous blends of sarcosine (SAR) with 1-(2-aminoethyl) piperazine (APZ) and diethylenetriamine (DETA). The properties have been measured for various mass fractions at atmospheric pressure and temperature r...

The structures of xylo-4,5,6,-trihydroxy-2-oxo-1,3-bis(phenylhydrazono)cyclohexane (1), 2-oxo-1,3-bis(phenylhydrazono)cyclohexane (2), 2-oxo-1,3-bis(phenylhydrazono)cyclopentane (3),3-oxo-2,4-bis(phenylhydrazono)cyclohexane-1-carboxylic acid (4), 2-oxo-1,3-bis(phenylhydrazono)indan (5), and 2-ox...

A novel fluorescence molecule (2‑hydroxy‑4‑methoxyphenyl)(phenyl)‑methanone azine (HMPM) has been explored theoretically in this present work. Based on density functional theory (DFT) and time-dependent density functional theory (TDDFT) methods, we investigate the excited state hydrogen bonding ...

The main synthetic routes to phosphine and arsine macrocycles are described. These include high dilution and template directed routes, and the advantages and disadvantages of these methods are discussed. Syntheses are also described for a selection of mixed donor macrocycles containing P or As d...

Macrocyclic phosphine compounds are sought after as ligands for transition metal complexes because of their strong binding properties. As such, these ligands are particularly useful in applications where robust transition metal–phosphine complexes are employed, as in homogeneous catalysis or in...

Copper(I) complexes with a phenanthroline-phosphine set of ligands were synthesized by refluxing methanolic solutions of CuBr2 with at least a four fold molar excess of the phosphine ligands, followed by the treatment of the formed {CuBr(PR3)3 complexes [R = phenyl (1a), 4-fluorophenyl (1b), cyc...

A series of acetate ester containing diiron ethanedithiolate complexes have been synthesized and structurally characterized. CO substitution of complex [Fe2(CO)6{μ-SCH2CH(CH2O2CCH3)S}] (1) with the phosphine ligands tris(2-furyl)phosphine, tris(2-thienyl)phosphine, tris(4-fluorophenyl)phosphine...

The molecular and crystal structures of tris(3-methylphenyl)phosphine, tris(3-methylphenyl)phosphine oxide, tris(3-methylphenyl)phosphine sulfide and tris(3-methylphenyl)phosphine selenide were determined by X-ray diffraction. It was previously indicated that phosphine oxide should be isostructu...

The structures and spectroscopic properties of two high coordinate gold(I) phosphine complexes with the TFFPP=tri(4-fluorophenyl)phosphine ligand are reported. Synthesis in a 1:3 metal to ligand ratio provided the compound [AuCl(TFFPP)3] (2) that crystallize in the P1¯ space group, where the as...

2-(Diphenylphosphinomethyl)aniline, H2L1, reacts with [RuCl2(PPh3)3] to yield the monomeric complexes [RuCl2(H2L1)(PPh3)(CH3CN)], [RuCl2(H2L1)2] and the chloro-bridged dimer [(H2L1)(PPh3)Ru(μ-Cl)2Ru(PPh3)(H2L1)] depending on the conditions applied. Exclusively the monochelate [RuCl2(H2L1)(dmso)...

A catalyst-free water-mediated N-Boc deprotection of N-Boc-amines is reported. In the absence of any additional reagents, the free amines were formed from a variety of aromatic and aliphatic N-Boc-amines as well as from some N-Boc-amino acid derivatives.