A fascinating pillared double-layered three-dimensional lead(II) coordination polymer [Pb2(BTC)(DPPZC)]n·2nH2O (1) has been prepared through hydrothermal reaction of lead(II) nitrate with the mixed ligands 1,3,5-benzenetricarboxylic acid (H3BTC) and dipyrido[3,2-a:2′,3′-c]-phenazine-2-carboxy...

In this study, we report the synthesis and spectral characterization of a novel series of 2-phenazinamine derivatives. In vitro evaluation for their anticancer activity toward cultured K562 (human chronic myelogenous leukemia), HepG2 (human hepatocellular carcinoma), MGC803 (human gastric carcin...

Centella asiatica (L.) Urban is a tropical medicinal plant with a long history of therapeutic uses. Madecassic acid and terminolic acid, a pair of structural isomers, are two constituents of Centella asiatica. A method using reversed-phase high performance liquid chromatography in which β-cyclo...

Madecassic acid (MA) is an abundant triterpenoid in Centella asiatica (L.) Urban. (Apiaceae) that has been used as a wound-healing, anti-inflammatory and anti-cancer agent. Up to now, the effects of MA against oxidative stress remain unclear. In this study, we investigated the effect of MA and i...

To develop a simple and highly sensitive high performance liquid chromatography with electrospray ionization mass spectrometric (LC-ESI-MS) method for the simultaneous determination of madecassoside and its major metabolite madecassic acid in rat plasma, and compare the pharmacokinetics of the t...

The [1,3] shift reaction of 3-methyl-2-butenyl phenyl ether was catalyzed more effectively by Montmorillonite K10 clay than Montmorillonite KSF clay, and proceeded with greatest ortho-selectivity in carbon tetrachloride at room temperature.

Four new phenolic glycosides, named 2-ethylene-3,5,6-trimethyl-4-phenol-1-O-β-d-xylopyranosyl-(1→6)-β-d-glucopyranoside (1), 3-methoxy-4-O-β-d-apiofuranosyl-(1→2)-β-d-glucopyranosylpropiophenone (2), 3-hydroxy-1-(4-O-β-d-glucopyranosyl-3-methoxyphenyl)propan-1-one (3) and 4-hydroxy-3,5-bi...

Wessely oxidation of o-(3-butenyl)phenols with lead tetraacetate gives 2,4-cyclohexadienone derivatives that on heating undergo intramolecular Diels-Alder reactions to give 3-acetoxyisotwist-8-en-2-ones.

The nickel(II), copper(II), and silver(I) complexes of the ligand tris[4-(2-thienyl)-3-aza-3-butenyl]amine (TTME) have been prepared and characterized. The nickel(II) complex, [Ni(TTME)(NO3)](PF6), is six-coordinate, the copper(II) complex, [Cu(TTME)(NO3)](PF6), five-coordinate and the silver(I)...

A CO2-recycling reaction using (E)-4-(benzylamino)-2-butenyl methyl carbonates has been examined and substituted vinyloxazolidinones were obtained via a CO2 fixation–elimination process, carried out in the presence of palladium catalyst with DBU.

We describe our efforts to improve the pharmacokinetic properties of a mechanism-based suicide inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (AdoMetDC), essential for the survival of the eukaryotic parasite Trypanosoma brucei responsible for Human African Tryp...

Species from the genus Mesua, Calophyllaceae, are rich source for phenolic compounds such as coumarin xanthone, and benzophenone derivatives. An investigation on the potential biologically active phenolic compounds 1–5 and crude extracts from the stem bark of Mesua hexapetala (Hook. f.) P.S. As...

Nine undescribed compounds, including five xanthone derivatives, two flavonoids, one 2-pyrone derivative, and one undescribed naturally occurring compound, along with 30 known phenolic compounds, were isolated from Hypericum japonicum. In addition, hyperjaponols A and B were identified as racema...

Exocyclic deprotonation and α alkylation with methyliodide of title compounds have been observed. A clarification of Hagemann ester ethylene ketal reactivity toward strong bases is given.

The multiple-step, one-pot procedure for a series of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates, analogues of the natural, sulfur amino acid metabolite lanthionine ketimine (LK), its 5-ethyl ester (LKE) and 2-substituted LKEs is described. Initiating the synthesis with t...

Publisher SummaryThe chapter reviews the physical chemistry related to dicarboxylic acids. The different theories of the ionization of dicarboxylic acids have are discussed. Past theories are analyzed by taking into account the conformational change accompanying the second ionization. Similar da...

The immunomodulatory effect of cucurbitacin E, extracted from Ecballium elaterium, was tested on peripheral human lymphocytes. These lymphocytes were co-cultured with cancer cells and an interesting lymphocyte-mediated cytotoxicity was observed.

Cucurbitane-type triterpenes, cucurbitacins B and E, were reported to exhibit cytotoxic effects in several cell lines mediated by JAK/STAT3 signaling. However, neither compound inhibited phosphorylation of STAT3 in human leukemia (U937) cells at low concentrations. We therefore synthesized a bio...

The study evaluated the potential protective effect and underlying mechanism of Cucurbitacin E (CuE) in both thioacetamide-induced hepatic fibrosis and activated HSCs. CuE inhibited the proliferation of activated HSC/T-6 cells in a concentration- and time-dependent manner; triggered the activati...

Cucurbitacin E (CuE) is a biochemical compound found in plants that are members of the family CuE has been studied for its roles in anti-inflammation and the inhibition of angiogenesis as well as for its properties as an antioxidant. CuE is a new agent that was identified as a selective inhibito...