The antibiotic administration is critical for treating open fracture, especially for tainted bone caused by contamination and the implant. Localized delivery of antibiotics is preferred since it provides elevated antibiotic concentrations at the aiming infection site without systemic toxicity. I...

A life cycle analysis on the cradle-to-gate production of vancomycin hydrochloride, which begins at natural resource extraction and spans through factory (gate) production, not only shows all inputs, outputs, and energy usage to manufacture the product and all related supply chain chemicals, but...

We macroscopically observed vials of vancomycin hydrochloride (VCM) for injection (0.5 g/vial) dissolved in various solvents, and determined the presence or absence of residual VCM crystals. In addition, the residual VCM in vials after use was measured using a bioassay. In vials evaluated after ...

Vancomycin hydrochloride （VANH）, the first glycopeptide antibiotic, is a water-soluble drug for the treatment of acute osteomyelitis. Liposomal formulations of VANH have already been manipulated and characterized, which was a mean of increasing their therapeutic index, reducing their toxicity ...

The present work evaluated the feasibility of chitosan coated liposomes (c-Lips) for the intravenous delivery of vancomycin hydrochloride (VANH), a water-soluble antibiotic for the treatment of gram-positive bacterial infections like osteomyelitis, arthritis, endocarditis, pneumonia, etc. The ob...

Based on investigating the relative fluorescence intensity of vancomycin hydrochloride (VCM) in methanol, a simple, highly sensitive, time-saving and specific spectrofluorimetric method was developed and validated. VCM fluorescence was measured at 335 nm when excited at 268 nm. Excellent lineari...

Controlled release of vancomycin hydrochloride (vanco HCl) in order to enhance therapeutic effects and to reduce toxic effects of systemic administration has received a lot of interest in recent years. In the present study, a hydrogel scaffold of silk fibroin/oxidized pectin (SF/OP) based on Sch...

BackgroundAugmented renal clearance (ARC) refers to enhanced renal elimination of circulating solute has attracted attention widely and in recent years increasing attention has been paid to patients with ARC. A population pharmacokinetic (PPK) analysis was performed to provide a reference for cl...

BACKGROUND CONTEXTSurgical site infection (SSI) is a serious and costly complication of spine surgery. Many surgeons apply vancomycin powder to the surgical wound to prevent SSIs. While multiple studies have reported reduced rates of SSI, others have suggested that widespread use of intrawound v...

ABSTRACTWe have evaluated the literature to review optimal dosing and monitoring of intravenous vancomycin in adults, in response to evolving understanding of targets associated with efficacy and toxicity. The area under the total concentration–time curve (0–24 h) divided by the minimum inhibi...

SummaryThe optimal duration of contact precautions for vancomycin-resistant enterococcus (VRE)-colonized patients is uncertain and individual patient characteristics alone may not predict risk of prolonged colonization. Using a cohort of adult patients who underwent testing for VRE at intensive ...

High energy attrition milled biodegradable βTCP-30(FeAg) (vol%) nanocomposite powders loaded with 1–10 wt% vancomycin (VH) were high pressure consolidated at room temperature/cold sintered to densities ≥90% of theoretical. Specimens exhibit high strength in bending being considerably higher t...

BackgroundAlthough hypersensitivity reactions are well characterized for certain medications, vancomycin-associated drug-induced hypersensitivity syndrome (DIHS), or drug reaction with eosinophilia and systemic symptoms (DRESS), has yet to be defined.

Vancomycin is a glycopeptide antibiotic widely used against Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus and coagulase-negative Staphylococcus. Several studies have found that in adults, continuous infusions of vancomycin showed earlier attainment of desired target ...

ObjectiveStaphylococcus aureus is involved in around 20% of nosocomial pneumonia cases. Vancomycin used to be the reference antibiotic in this indication, but new molecules have been commercialized, such as linezolid. Previous studies comparing vancomycin and linezolid were based on models. Comp...

The practice of ‘vancomycin wrapping’ of harvested hamstring autografts during Anterior Cruciate Ligament Reconstruction (ACLR) surgery has gathered recent interest.This practice involves the wrapping of harvested grafts in a vancomycin-soaked swab during the preparatory phase. Different techn...

Kounis Syndrome is a rare allergic reaction that results in coronary vasospasm and may occur in patients with and without coronary artery disease. A 57-year-old man receiving pre-operative vancomycin for osteomyelitis and gangrene of the foot experienced an episode of anginal symptoms associated...

Several methods are described for the extraction of tyrothricin from products containing oil and ointment bases. A simple decimal dilution type of assay of alcohol and propylene glycol solutions is presented. A supplementary method suitable for use as a check for the routine procedure is also in...

1.1. Within the limits of the described experiments, it can be said that sensitivity to tyrothricin could not be demonstrated.2.2. Tyrothricin would appear, therefore, to be a poor sensitizing agent.

The tyrothricin peptide complex, isolated from the fermentation broth of Bacillus brevis, is comprised of a basic fraction of cyclic decapeptides (the tyrocidines) and a neutral fraction composed of linear peptides (the gramicidins). Previously, five cyclic compounds (tyrocidines A–E) had been ...