SummaryTwo methods for the preparation of crystalline fradicin base from Streptomyces fradiae fermentation liquors are presented.One method employs chromatography of mycelial extracts on Superfiltrol-Celite 545 columns. The other method, better adapted to largerscale operations, involves a pH-co...

Three basidiomycetes, Lentinus squarrosulus, Cerrena meyenii and Gloeophyllum striatum were studied as potential antagonists against Rigidoporus lignosus, the cause of white rot of Hevea brasiliensis. During direct confrontation between colonies of R. lignosus and the three antagonists on malt a...

An attempt to establish a systematic chromatographic analysis of antibiotics has been made. Sixty-two known antibiotics were distributed into five classes and into fourteen subclasses, according to their RF values in four principal solvent systems. Principles of the classification of antibiotics...

Asperugin B, C23H30O5, a metabolite of a mutant strain of Aspergillus rugulosus which carries the genetic marker “fluffy”, has been identified as 4-O-(trans,trans-farnesyl)-3,5-dihydroxyphthalaldehyde (II)

Calculations of the neutralisation cross-section and relative population of atomic states were performed for ions beams (1 ≤ Z ≤ 89) at 5 and 40 keV incident on free sodium and potassium atoms. To test the validity of the calculations, the population distribution of indium ions incident on a v...

The 5S,12S-dihydroxy-6,8,10,14-(E,Z,E,Z)-eicosatetraenoic acid, a product of double dioxygenation of arachidonic acid by lipoxygenases, undergoes severe decomposition during gas chromatography-mass spectrometric (GC-MS) analysis of the trimethylsilyl ether methyl ester derivative. The decomposit...

Incubation of peripheral blood leukocytes with arachidonic acid (and ionophore A23187) led to the formation of leukotriene B4, Δ6-trans-leukotriene B4, Δ6-trans-12-epi-leukotriene B4, 5-hydroxy-icosatetraenoic acid, 12-hydroxy-icosatetraenoic acid and of 5S,12S-dihydroxy-6,8,10,14-(E,Z,E,Z)-ic...

The wavelengths, electric dipole transition probabilities, and oscillator strengths are calculated for transitions between low-lying states (5s–5p, 5p–5d, 4f–5d, and 5d–5f) in the silver isoelectronic sequence (50 ⩽ Z ⩽ 86) using relativistic perturbation theory with a zero-approximation mod...

Phenolic compounds occur in a variety of plants and can be used as model compounds for investigating the fate of organic wastewater, lignin, or soil organic matter in the environment. The aim of this study was to better understand and differentiate mechanisms associated with photo- and biodegrad...

Use of the Saccharomyces cerevisiae as a biosorbent material has proven versatile in innovative applications like the biosorption of bioactive compounds from plant extracts. The bioactive compounds have different biological activities such antioxidant, antimicrobial and anticancer properties. Th...

Background and purposeSerious educational gaming success has not been replicated in a nonsterile compounding practical skill-based course. The objective of this study was to create a nonsterile compounding escape room to evaluate third-year professional pharmacy students' (1) knowledge of n...

A high-sulfur (4.69 wt%) crude oil was discovered in the China Bohai Bay Basin which is known to contain low sulfur crude oil. The composition of this high sulfur crude oil and its geological origin are unknown. In this study, thiophenic and sulfidic sulfur compounds were isolated from the crude...

Although Membrane Distillation (MD) is envisaged as a cost-effective alternative desalination technology, it remains severely affected by membrane fouling. In Direct Contact MD mode, membrane fouling is exacerbated by the presence of compounds bearing hydrophobic functional groups, e.g., phenols...

Globally, breast cancer is one of the primary reasons of death noticed in women. Despite continuous efforts to formulate effective treatments, search to identify promising therapeutics is underway. Consequently, a drug with low toxicity, high efficacy, and which can escape resistance mechanism i...

Inorganic Te(IV) compounds are important cysteine protease inhibitors and antimicrobial agents; AS-101 [ammonium trichloro (dioxoethylene-O,O′)tellurate] is the first compound of a family with formula NH4[C2H4Cl3O2Te], where a Te(IV) centre is bound to a chelate ethylene glycol, and showed seve...

The binding of ten quinoxaline compounds (1–10) to a site adjacent to S2 (AS2) of cruzain (CRZ) was evaluated by a protocol that include a first analysis through docking experiments followed by a second analysis using the Molecular Mechanics-Poisson-Boltzmann Surface Area method (MM-PBSA). Thro...

In this study, we have performed density functional theory based calculations to investigate the effect of alkali substituents M on the structure and electronic properties of (Bi0.5M0.5)TiO3 compounds with M = Li, Na and K. When the ionic radius of the substituting M cation increases, the corres...

We analyze the classical model of compound interest with a constant per-period payment and interest rate. We examine the outstanding balance function as well as the periodic payment function and show that the outstanding balance function is not generally concave in the interest rate, but instead...

The title synthesis was achieved by featuring i) condensation of the 2-methylthio-Δ1-pyrroline (C8–C13 moiety) with the Δ2-oxazolin-5-one (C6,C7,N16, and C17 moiety), ii) activation of the Δ2-oxazolin-5-one system toward nucleophilic reaction by introducing an allyloxycarbonyl group into the...

A synthetic route to compound 2, the optically active C.1-C.18 segment of carzinophilin A, is described.