Evaluating the proficiency of complex based polymers in order to increase the bioavailability and protection of bioactive compounds through nanoencapsulation has been studied during last years. The present work reports on preparation of saffron extract included-nanocomplexes of chitosan (CS) and...

Among spices, Saffron is among the most extensively interrogated for purity and authenticity. Numerous methods have been recommended for authentication of Saffron samples and for detection of adulterants for codex compliance. However, none of these methods can fulfill both of these important qua...

This work aims to study the effect of the addition of saffron extract on fresh pasta in-vitro digestibility. Fresh pasta was formulated with different concentrations of saffron extracts (0.2 and 0.4 %w/w), cooked at two different times (1.5 and 3 min), and in vitro digested (oral, gastric and in...

:Saffron, the dried red stigmas of Crocus sativus L. is the world's most expensive spice. The expense of Saffron has led to greater incidences of fraudulent practice within this market. The importation and rebranding of cheaper growing regions to be passed off as regions of higher quality i...

BackgroundSaffron is an enriched pool of bioactives including crocins, crocetin, safranal, picrocrocins, essential oils, minerals and trace amounts of B1 and B2 vitamins. Obtaining any valuable ingredients like bioactive compounds which are naturally present in plants is completely depending on ...

Synthesis of 7-O-(3-amino-2,3,6-trideoxy-α-l-lyxo-hexopyranosyl)-ε-(iso)rhodomycinones 16 and 17, and their 3′-morpholino derivatives are described. Glycosylation (trimethylsilyl triflate, 10:1 dichloromethane-acetone, −35°) of 1-O-tert-butyldimethylsilyl-2,3,6-trideoxy-4-O-p-nitrobenzoyl-3-...

Biosynthetically blocked mutants isolated from the β-rhodomycin-producing Streptomyces violaceus A262 strain SC-7 and daunomycin-producing Streptomyces sp. D788 strain G1-1 were found to accumulate maggiemycin in their culture broths. Bioconversion tests using mutants that did not produce these...

In this paper, three Renaissance tapestries depicting scenes painted by Raffaello Sanzio, conserved at the Vatican Museum, were investigated using in-situ UV–Visible fluorimetric measurements. The results show that this technique is suitable for the detection of natural organic colorants used f...

In this paper the potentialities of spectrophotometric and fluorimetric techniques for identifying the materials used in artistic textiles are investigated. A portable non-destructive instrument suitable to record fluorescence spectra on surfaces was set up and successfully experienced. A natura...

A precise, accurate, nonambiguous and high-throughput method is required to assess nuclear maturation of mammalian oocytes. The objectives of this study were to compare the efficiency and ease of use of a simplified fluorescence imaging (anti-lamin A/C and 4′,6-diamidino-2-phenylindole [DAPI]) ...

In this paper, the preliminary results of a study aimed to discriminate between the different species of lichens, from which orchil dyes originate, are presented. A multi-analytical approach has been used to analyze several species of lichens, in particular Roccella tinctoria DC, Lasallia pustul...

An Au/Orcein/p-Si/Al device was fabricated and the current–voltage measurements of the devices showed diode characteristics. Then the current–voltage (I–V), capacitance–voltage (C–V) and capacitance–frequency (C–f) characteristics of the device were investigated at room temperature. Some ...

In this work, a novel method for identification of orcein derivatives from orchil is presented. It was developed, similarly to other methods used to determine natural dyes, with the use of liquid chromatography coupled to tandem mass spectrometry (LC/MS/MS). Apart from presenting a novel method ...

This paper reports for the first time a detailed spectroscopic investigation into the ground- and excited-state properties of α-amino-orcein (α-AO), one of the main components of the orcein dye, in solvents of different proticity and water at different pHs. In order to gain insight into the na...

Purpose of the present research work was to evaluate the effect of carrier composition and nanoparticles surface charge on the physicochemical and antifungal properties of the Nystatin nanoparticles. For preparation of the nanoparticles, a positively charged polymer, Eudragit RS100, and a negati...

The influences of ergosterol and cholesterol on the activity of the nystatin were investigated experimentally in a POPC model membrane as well as theoretically. The behavior of giant unilamellar vesicles (GUVs) under osmotic stress due to the formation of transmembrane pores was observed on sing...

The complex pathophysiology involved in migraine necessitates the drug treatment to act on several receptors simultaneously. The present investigation was an attempt to discover the unidentified anti-migraine activity of the already marketed drugs. Shared featured pharmacophore modeling was empl...

The objective of the present work was the development and evaluation of nystatin (Nys) nanocapsular hydrogel, as an attractive dosage form for treatment of topical candidiasis. The nanocapsular dispersions were prepared using the nanoprecipitation method. The influence of formulation factors, na...

The aim of the presented research was the preparation and in vitro and in vivo evaluation of mucoadhesive oral films containing nystatin. Multivariate data analysis was used to evaluate an innovative approach, in which a combination of different mucoadhesive polymers was employed. The purpose of...

The purpose of this work is to develop a new formulation of nystatin using chewing gum as a drug delivery system to optimize the drug release rate in order to improve the desired efficacy in the site of action for treating patients with oral candidiasis. Medical chewing gum is a pleasant and hig...