The first total synthesis of the aquatic peptide microcin SF608 isolated from the cyanobacterium Microcystis aeruginosa is outlined in this chapter. The peptide natural product has been reported to possess potent serine protease trypsin inhibitory activity.

Microcins and bacteriocins are ribosomally-synthesized defence peptides produced by Gram-negative and -positive bacteria to target competitors in their niche. Some of them carry posttranslational modifications established by dedicated enzymes. To protect themselves from their own toxic peptides,...

Steady-state and time-resolved spectroscopy experiments with picosecond or subpicosecond resolution are carried out in order to clarify the anomalous fluorescence properties of solutions prepared with triphenylphosphine compounds in various non-deaerated solvents at room temperature. Evidence is...

This article has been retracted by agreement between the journal Chief Editor, Patrik Bavoil, Elsevier and Wiley-Blackwell. The author has been notified. Please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).Reason: The retraction has been agreed due ...

This article has been retracted by agreement between the journal Chief Editor, Patrik Bavoil, Elsevier and Wiley-Blackwell. The author has been notified. Please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).Reason: The retraction has been agreed due ...

Liposomal hamycin was found to elicit enhanced microbicidal activity and reduced toxicity in experimental leishmaniasis in a hamster model under in vivo conditions. Mannose-coated liposomal hamycin was seen to produce increased therapeutic efficacy as judged from the lowering of spleen parasite ...

Hamycin, either alone or in suspension as hamycin-cholesterol complex, was intravenously administered to mice in a single dose. Plasma antifungal activity at different time intervals and LD50 at varying drug: cholesterol proportions were studied. Hamycin alone was eight-fold more toxic than the ...

Hamycin activity (in vitro) against Malassezia ovale was studied and compared with old and newly discovered polyene antifungal antibiotics. Hamycin showed a marked anti-M. ovale activity, which was enhanced in the presence of divalent cations like Cu++ and Zn++. Furthermore, the absorption of ha...

SummaryHamycin, a polyene antibiotic, now in extensive use in the treatment of candidiasis and otomycosis, is found to be remarkably effective in killing Leishmaniadonovani promastigotes in a liquid medium at a concentration of 0.2 μg/ml. The glucose stimulated respiration and the uptake of 2-d...

Hamycin is an antifungal antibiotic produced by Streptomyces pimprina Thirum. In the present study, the effect of hamycin on (a) the phagocytosis of Candida albicans by murine peritoneal macrophages and (b) the cell surface hydrophobicity (CSH) of C. albicans was investigated. Addition of hamyci...

The aim of this study was to develop a biodegradable nanostructured electrospun layer based on collagen (COL), hydroxyapatite nanoparticles (HA), vancomycin hydrochloride (V), gentamicin sulphate (G) and their combination (VG) for the treatment of prosthetic joint infections and the prevention o...

Sustained antibiotic release is important to prevent the infections after surgical treatments such as guided tissue regeneration (GTR). Electrospinning provides a simple way to fabricate nanofibers for drug delivery. In this study, a simple method to achieve sustained antibiotic release by intro...

Sodium alginate (Alg) reacted with antibiotic gentamicin sulfate (GS) in an aqueous-phase condition mediated by carbodiimide chemistry, in the molar ratios Alg: GS of (1:0.5), (1:1) and (1:2). The Alg-GS conjugated derivatives were characterized by elemental analysis for nitrogen content, Fourie...

Due to superior properties, chitosan (CS) has been widely applied in health field. However its acid-solubility and poor antimicrobial activity compromise its safety and applications, respectively. To enhance its water-solubility and antimicrobial activity, gentamicin-grafted-chitosan (GT-CS) is ...

Sustained and controlled drug delivery system has an important application in the field of tissue regeneration. In this study, drug loaded MCM-41 silica was used to fabricate nano-composite fibres for efficient and extended drug carrier in deep wounds dressing. Mesoporous silica nanoparticles we...

Gentamicin B and gentamicin C1a are the direct precursor for Isepamicin and Etimicin synthesis, respectively. Although producing strains have been improved for many years, both gentamicin B titer and gentamicin C1a titer in the fermentation are still low. Because all gentamicin components are bi...

Gentamicin induced renal complications are well known in humans and animals. Medicinal properties of Withania somnifera (L.) Dunal, Solanaceae, are recognized to improve renal functions. However, the pharmacological function of W. somnifera is not completely understood. We sought to unravel medi...

ObjectiveThis study aimed to determine the effectiveness of an intratympanic (IT) injection of a mixture of gentamicin and dexamethasone compared with intratympanic dexamethasone (ITD) for controlling vertigo and protecting the hearing level of Meniere's disease patients who have persistent...

In pharmaceutical industry, isepamicin is mainly manufactured from gentamicin B, which is produced by Micromonospora echinospora as a minor component of the gentamicin complex. Improvement of gentamicin B production through metabolic engineering is therefore important to satisfy the increasing d...

BackgroundRates of patent ductus arteriosus (PDA) and infection are high in preterm infants. Preterm infants with infection are more likely to develop symptomatic PDA, a potentially fatal disease. Clinically, gentamicin is widely used for early-onset infection in neonates including preterm infan...