Many international researchers have strived to understand the mechanism of action or improve the efficacy of inorganic coordination compounds that have been identified to exhibit anticancer activity. The inherent challenges of chemotherapy demand that new strategies be developed utilising differ...

A new photocatalyst, dichloro (1,10-phenanthroline-5,6-dione) palladium (II) complex supported on SBA-15 silica was synthesized by ship-in-a-bottle method. The products obtained were characterized by X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electr...

The room temperature addition of an aqueous solution of chloroplatinic acid hydrate or cadmium nitrate tetrahydrate to a mixture of an aqueous acetonitrile solution of 1,10-phenanthroline ligand (phen) and sodium azide affords new complexes of [Pt(N3)6Na2(phen)6], (1) and [Cd(phen)2(NO3)2], (2)....

Human interferon alpha 2b (IFN α2b) is a type I interferon exhibiting antiviral, anti-proliferative and immunomodulatory activities. The clinical outcome of the approved recombinant human IFN α2b drugs in the market suffers from short plasma half-life, rapid clearance and other side effects. H...

The first organo/metal cooperatively catalyzed α-sulfenylation of isocyanoacetates with N-(sulfanyl)succinimides has been developed. The reaction condition was suitable to α-aryl and alkyl-substituted isocyanoactates as well as N-(arylthio)succinimides, affording the corresponding products wit...

A cascade cyclization/nucleophilic aromatic substitution (SNAr) reaction of α,β-unsaturated N-tosylhydrazones with N-heteroaryl chlorides was developed for the synthesis of N-heteroaryl pyrazole derivatives. This one-pot reaction provided bi(heteroaryl) derivatives in good to excellent yields ...

The fight against tuberculosis (TB) is a time immemorial one and the emergence of new drug resistant strains of Mycobacterium tuberculosis keeps throwing new challenges to the scientific community immersed in finding mechanisms to control this dreaded disease. Computer aided drug designing (CADD...

Analyses of serotonin and other 5-hydroxyindoles, such as its precursor 5-hydroxytryptophan and major metabolite 5-hydroxyindoleacetic acid (5-HIAA), are indispensable for the elucidation of their (patho)physiological roles. In clinical chemistry attention is mainly focused on the diagnosis and ...

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a mutagen/carcinogen belonging to the class of heterocyclic amines (HCAs) found in cooked meats, is a known rat mammary gland carcinogen. To gain insight into the genomic alterations associated with PhIP-induced carcinogenesis, we used comp...

Humans are exposed to 2-amino-1-methyl-6-phenylimidazo[4,5–b]pyridine (PhIP) and 1-nitropyrene (1-NP) via several environmental sources and both are known mammary carcinogens in rodents, with the former being more potent (K. El-Bayoumy, Y.-H. Chae, P. Upadhyaya, A. Rivenson, K. Kurtzke, B. Redd...

A simple and cost effective unsymmetrical azine based Schiff base, 5-diethylamino-2-[(2-hydroxy-benzylidene)hydrazonomethyl]-phenol (1) was synthesized which selectively detect Cu2 + ions in the presence of other competitive ions through “naked eye” in physiological conditions (EtOH–buffer (1...

The reaction of [Cp*MCl2]2 (M = Rh/Ir) with N–N′ azine Schiff-base ligands (L1–L4) leads to the formation of mononuclear cationic half-sandwich complexes having the general formula [Cp*M(L)Cl]+ (1–8), (M = Rh/Ir and L = (2-hydroxy-4-methoxybenzylidene)2-pyridylamidrazone (L1), (2-hydroxybenz...

[1-(4-(n-alkoxy))-2-(4′-dodecyloxy)benzylidene]hydrazine, (where, n-alkoxy: O(CH2)nH, n = 1,2,3,4,5,6,7,8,9,10,16 or 18) compounds (Asymmetrical azine series-II) were prepared as a part of our continuous works in the designing of hydrophobic azine compounds as photo-luminescent liquid crystalli...

There is an immense push for the development of innovative, convenient and high-performance organic electronics. In this study, we present the synthesis of two azines and the exploration of their photophysical, surface morphological, electrochemical and electroluminescence properties for applica...

There are exhaustive reports on the chemistry of organic compounds that exhibits liquid crystalline phases. The present review is first of its kind that emphasizes on an evidence based survey on the mesogenic properties of 2,3-diaza-1,3-butadienes or azines. The article opens with a brief introd...

Luminogenic materials which feature the unique photophysical phenomenon of aggregation-induced emission (AIE) has attracted growing attention. Research on AIEgens have immensely expanded since 2001. Salicylaldehyde azine derivatives connected through NN single bond have strong AIE fluorescence p...

The main structural, chemical and adsorption features concerning minerals and clays, halide compounds, sulfides, carbides, nitrides, phosphates, oxosalts, heteropolyacids and polyoxometallates, supported acids, organoinorganic materials, carbon materials and ion exchange resins are reviewed and ...

The stability constants of the proton and some metal complexes formed by pyro- and triphosphoric acids at 25° have been evaluated from potentiometric titration measurements.

A series of ternary complexes between adenosine 5′-triphosphoric acid (ATP), 2, 2′-bipyridyl, and the transition metal ions manganese(II), cobalt(II), copper(II), and zinc(II) in the ratio 1:1:1 have been prepared. The solid compounds are crystalline and can be formulated as [M(II)-H2ATP-2, 2′...

The aim of the present work was to develop a medication allowing for the combined delivery of platelet lysate (PL) and an anti-infective model drug, vancomycin hydrochloride (VCM), to chronic skin ulcers. A simple method was set up for the preparation of hyaluronic acid (HA) core-shell particles...