ObjectiveNystatin and chlorhexidine are extensively used in oral medicine; however, there is some controversy about the possibility of these drugs showing antagonism. To clarify this issue, this study investigated the efficacy and stability of nystatin and chlorhexidine in combination.

We present a case of increased cyclosporine concentration and liver function right after the combinational use of cyclosporine and nystatin, which indicated a drug–drug interaction between them. Both the concentration and liver function were decreased after discontinuation of nystatin and remai...

BackgroundCandida species have an influence in the pathogenesis of denture stomatitis. The current study aimed to investigate the efficacy of indocyanine green (ICG)-mediated photodynamic therapy (PDT) in combination with nystatin mouthwash (PDT + nystatin) for the treatment of denture stomatiti...

Complexes of phenobarbital with quinine, quinidine, or hydroquinidine have been prepared and characterized. By means of infrared spectroscopy, these complexes were differentiated from physical mixtures of their respective components when the drug was examined either alone or in pharmaceutical do...

Quinine and quinidine have been cited as drugs that may cause significant morbidity and mortality in toddlers who ingest one or two pills. The use of both of these drugs has declined in the United States since the 1980s. A review of the literature and Poison Control data reveals that large quini...

IntroductionTo analyse the impact of both epilepsy and pharmacological modulation of P-glycoprotein on brain uptake and kinetics of positron emission tomography (PET) radiotracers [11C]quinidine and [11C]laniquidar.

Quinidine (Chemical s Service Registry Number 56-54-2) is a class I antiarrhythmic agent, which primarily works by blocking the fast inward sodium current. It is used to suppress abnormal rhythms of the heart such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular f...

Quinidine is the d-isomer of quinine. Quinidine is an important class Ia antiarrhythmic drug. It is among the few effective drugs in Brugada Syndrome and in Short QT Syndrome. Recent evidence suggests that it could also be useful in a few non cardiological conditions including pseudobulbar affec...

Quinidine has a very long history as antiarrhythmic medication. The alkaloid has been used in the treatment of almost all cardiac arrhythmias, especially atrial fibrillation, since the early twentieth century. Despite decreases in clinical prescription over the last two decades, mainly due to si...

ABSTRACTEpilepsy of infancy with migrating focal seizures is a devastating pediatric neurologic disorder that often results in treatment-resistant seizure activity and developmental delay. The condition has been associated with mutations in the KCNT1 gene that cause a gain of function in neurona...

Mycobactin J 1 is a commercially available siderophore isolated from Mycobacterium avium subsp. paratuberculosis. There are discrepancies between previous reports of its structure and none have addressed its absolute configuration. We report here the complete structure and stereochemistry of myc...

Mycobactin acylation plays a crucial role in the ability of Mycobacterium tuberculosis to acquire intracellular iron during infection. M. tuberculosis Rv1347c, the lysine Nε-acyltransferase responsible for mycobactin acylation, represents a valid target for the development of novel anti-tubercu...

The inability of Mycobacterium avium subspecies paratuberculosis (MAP) to produce endogenous mycobactin in-vitro is most likely due to the presence of a truncated mbtA gene within the mycobactin cluster of MAP. The main goal of this study was to investigate this unique mbtA truncation as a poten...

Two species of melanopline grasshoppers (Melanoplus bivittatus and M. sanguinipes) tolerated high levels of 3-nitropriopionic acid (NPA) in their diet (LD30 = 3 μg g−1). The NPA was absorbed, conjugated to glycine, l-serine or l-glutamate and excreted in the frass as amides. Karakin was also co...

Gymnemic acids (GA) inhibited rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity. Binding of GA to GAPDH was observed by surface plasmon resonance measurement. Incubation of GAPDH with GA induced a smearing of the GAPDH band in SDS–PAGE. The GA-induced smearing was diminish...

Gymnema sylvestre is an important medicinal plant which bears bioactive compound namely gymnemic acids. The present work deals with optimization of cell suspension culture system of G. sylvestre for the production of biomass and gymnemic acid and we investigated effects of macro elements (NH4NO3...

ObjectivesAccording to a report by the United States National Health and Nutrition Examination Survey, nearly 60% of patients with diabetes have more than one complication caused by chronic diabetes. Type 2 diabetes is a multifactorial metabolic disorder that accounts for more than 95% of people...

The individual chemical components of commercial extract of Gymnema sylvestre, a medicinal plant used in the traditional systems of the Indian medicine for its antidiabetic and hypolipidemic properties, were isolated and evaluated for their capability to act as modulators of nuclear and membrane...

Gymnemic acid is the main phytoconstituents of Gymnema sylvestre (Asclepiadaceae) found in the different parts of world. Gymnemic acid posseses different pharmacological activities including supression of taste sensitivity to sweetness, showed inhibition of intestinal glucose absorption and lowe...

A gymnemic acids lozenge that blocks sweet taste receptors reduced the decision to consume candy in humans even before the candy was tasted after the gymnemic acids dose, suggesting that blocking sweet taste receptors reduces valuation of sweet foods. The present study used functional magnetic r...