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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid Manufacturer/High quality/Best price/In stock

Cas:162515-68-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 1-(Mercaptomethyl)-Cyclopropaneacetic Acid supplier in China

Cas:162515-68-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid CAS NO.162515-68-6

Cas:162515-68-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

Product: 1-(Mercaptomethyl) Cyclopropane Acetic Acid[CAS:162515-68-6] Batch No: 110408-1 Manufacturing Date: April 2011 Expiry Date: April 2012 Analysis report number: 20110513 Quantity: 1 Kg Items

Manufacture 1-(mercaptomethyl) Cyclopropane Acetic Acid

Cas:162515-68-6

Min.Order:1 Kilogram

Negotiable

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid

Cas:162515-68-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White or off-white crystalline powder Off-white crystalline powder Assay

High purity 1-(MERCAPTOMETHYL)-CYCLOPROPANEACETIC ACID CAS:162515-68-6

Cas:162515-68-6

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 1-(mercaptomethyl)cyclopropylacetic acid

Cas:162515-68-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 2-[1-(Mercaptomethyl)cyclopropyl]acetic acid 162515-68-6 ISO Producer

Cas:162515-68-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid

Cas:162515-68-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid

Cas:162515-68-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

1-(Mercaptomethyl)-cyclopropylacetic acid

Cas:162515-68-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:2-[1-(Mercaptomethyl)cyclopropyl]acetic acid CAS NO: 162515-68-6 Grade:Montelukast sodium intermediate Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vul

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid CAS:162515-68-6 Chinese manufacturers high-quality

Cas:162515-68-6

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid Basic information Product Name: 2-[1-(Mercaptomethyl)cyclopropyl]acetic acid Synonyms: 2-[1-(MERCAPTOMETHYL)CYCLOPROPYL]ACETIC ACID;1-(MERCAP

162515-68-6

Cas:162515-68-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

2-[1- (Mercaptomethyl) Cyclopropyl]Acetic Acid CAS :162515-68-6

Cas:162515-68-6

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 162515-68-6 with best quality

Cas:162515-68-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: 1-(Mercaptomethyl)-Cyclopropaneaceticacid Molecular Formula:C6H10O2S Molecular Weight:146.2074 CAS No.:162515-68-6 Appearance:Similar White crystal Powder Appearance:Similar White crystal Powder Storage:Store in cool and dry place, away fro

1-(Mercaptomethyl)-Cyclopropaneaceticacid

Cas:162515-68-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

Montelukast Intermediate Manufacturer 162515-68-6 API Manufacturer

Cas:162515-68-6

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid 162515-68-6

Cas:162515-68-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid

Cas:162515-68-6

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid with CAS:162515-68-6

Cas:162515-68-6

Min.Order:1 Kilogram

FOB Price: $120.0 / 160.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid CAS:162515-68-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid CAS:162515-68-6

Cas:162515-68-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid

Cas:162515-68-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid/ LIDE PHARMA- Factory supply / Best price

Cas:162515-68-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:Off-white solid Storage:Room temperature Package:25kg/drum Application:Montelukast intermediates Transportation:Express/Sea/Air Port:Any port in china

High Quality 2-[1-(Mercaptomethyl)cyclopropyl]acetic acid

Cas:162515-68-6

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid

Cas:162515-68-6

Min.Order:1 Kilogram

FOB Price: $15.0 / 30.0

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid

Cas:162515-68-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

1-(Mercaptomethyl)-Cyclopropaneacetic Acid

Cas:162515-68-6

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou Maytime Bio-Tech Co.,Ltd.

We have one R&D laboratory and two product bases in Hangzhou which are established as per GMP requirements. Our technical force is rich and has a passel of technologists who have engaged in research and production of medication for m

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Application:162515-68-6

Montelukast sodium intermediate

Cas:162515-68-6

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

2-[1-(Mercaptomethyl)cyclopropyl]acetic acid

Cas:162515-68-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Synthetic route

2-[1-(mercaptomethyl)cyclopropyl]acetic acid methyl ester
152922-73-1

2-[1-(mercaptomethyl)cyclopropyl]acetic acid methyl ester

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
With water; potassium hydroxide at 0 - 20℃; for 3h;93%
Stage #1: 2-[1-(mercaptomethyl)cyclopropyl]acetic acid methyl ester With methanol; sodium hydroxide; water at 70 - 80℃; for 2h;
Stage #2: With hydrogenchloride; water at 40℃; pH=3.0 - ~ 4.0;
C6H9ClO2
1314940-03-8

C6H9ClO2

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
Stage #1: C6H9ClO2 With thiourea In water for 3h; Reflux;
Stage #2: With sodium hydroxide In water for 2h; Reflux;
91.6%
1-(isothiuroniummethyl)cyclopropaneacetonitrile hydrobromide

1-(isothiuroniummethyl)cyclopropaneacetonitrile hydrobromide

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
With sodium hydroxide Reflux;91.4%
Stage #1: 1-(isothiuroniummethyl)cyclopropaneacetonitrile hydrobromide With sodium hydroxide; water for 14h; Heating / reflux;
Stage #2: With formic acid In water at -5 - 5℃; pH=3.5 - 4.0;
76.7%
C15H19NO2S
1015076-74-0

C15H19NO2S

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
Stage #1: C15H19NO2S With potassium hydroxide; water at 120℃; for 14h;
Stage #2: With hydrogenchloride; water In diethyl ether Product distribution / selectivity;
80%
With water In tetrahydrofuran at 80℃; Product distribution / selectivity;50%
1-(Acetylthiomethyl)cyclopropaneacetonitrile
152922-72-0

1-(Acetylthiomethyl)cyclopropaneacetonitrile

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In toluene11.99 g (82%)
1-bromomethylcyclopropyl acetic acid methyl ester
855473-50-6

1-bromomethylcyclopropyl acetic acid methyl ester

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: copper(l) iodide / N,N-dimethyl-formamide / 50 - 60 °C
2: potassium carbonate; methanol / 6 h / Reflux
3: phosphorus tribromide / dichloromethane / 0 - 10 °C
4: acetonitrile / Reflux
5: sodium hydroxide / Reflux
View Scheme
1-cyanomethylcyclopropyl acetic acid methyl ester

1-cyanomethylcyclopropyl acetic acid methyl ester

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate; methanol / 6 h / Reflux
2: phosphorus tribromide / dichloromethane / 0 - 10 °C
3: acetonitrile / Reflux
4: sodium hydroxide / Reflux
View Scheme
1-(hydroxymethyl)cyclopropaneacetonitrile
152922-71-9

1-(hydroxymethyl)cyclopropaneacetonitrile

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus tribromide / dichloromethane / 0 - 10 °C
2: acetonitrile / Reflux
3: sodium hydroxide / Reflux
View Scheme
[1-(hydroxymethyl)cyclopropyl]methanol
39590-81-3

[1-(hydroxymethyl)cyclopropyl]methanol

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sulphate-doped anatase / tetrahydrofuran / 45 - 55 °C
2.1: isobutyric acid sodium salt / tetrahydrofuran / 10 - 20 °C / Inert atmosphere
2.2: 0.5 h
3.1: phosphorus tribromide / dichloromethane / 0 - 20 °C
4.1: copper(l) iodide / N,N-dimethyl-formamide / 50 - 60 °C
5.1: potassium carbonate; methanol / 6 h / Reflux
6.1: phosphorus tribromide / dichloromethane / 0 - 10 °C
7.1: acetonitrile / Reflux
8.1: sodium hydroxide / Reflux
View Scheme
6-bromomethyl-5,7-dioxaspiro[2.5]octane

6-bromomethyl-5,7-dioxaspiro[2.5]octane

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: isobutyric acid sodium salt / tetrahydrofuran / 10 - 20 °C / Inert atmosphere
1.2: 0.5 h
2.1: phosphorus tribromide / dichloromethane / 0 - 20 °C
3.1: copper(l) iodide / N,N-dimethyl-formamide / 50 - 60 °C
4.1: potassium carbonate; methanol / 6 h / Reflux
5.1: phosphorus tribromide / dichloromethane / 0 - 10 °C
6.1: acetonitrile / Reflux
7.1: sodium hydroxide / Reflux
View Scheme
1-hydroxymethylcyclopropylacetic acid methyl ester
142148-13-8

1-hydroxymethylcyclopropylacetic acid methyl ester

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: phosphorus tribromide / dichloromethane / 0 - 20 °C
2: copper(l) iodide / N,N-dimethyl-formamide / 50 - 60 °C
3: potassium carbonate; methanol / 6 h / Reflux
4: phosphorus tribromide / dichloromethane / 0 - 10 °C
5: acetonitrile / Reflux
6: sodium hydroxide / Reflux
View Scheme
C14H18O3

C14H18O3

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium borohydride / tetrahydrofuran / 2 h / 20 °C
2.1: pyridine; triphenylphosphine; tetrachloromethane / 18 h / 75 °C
3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
4.1: trifluoroacetic acid; sodium nitrite / 5 h / 20 °C / Cooling with ice
5.1: thiourea / water / 3 h / Reflux
5.2: 2 h / Reflux
View Scheme
C14H20O3

C14H20O3

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: pyridine; triphenylphosphine; tetrachloromethane / 18 h / 75 °C
2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
3.1: trifluoroacetic acid; sodium nitrite / 5 h / 20 °C / Cooling with ice
4.1: thiourea / water / 3 h / Reflux
4.2: 2 h / Reflux
View Scheme
C14H19ClO2

C14H19ClO2

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
2.1: trifluoroacetic acid; sodium nitrite / 5 h / 20 °C / Cooling with ice
3.1: thiourea / water / 3 h / Reflux
3.2: 2 h / Reflux
View Scheme
C6H11ClO

C6H11ClO

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid; sodium nitrite / 5 h / 20 °C / Cooling with ice
2.1: thiourea / water / 3 h / Reflux
2.2: 2 h / Reflux
View Scheme
C13H15ClO2

C13H15ClO2

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / 5 h / 20 °C
2.1: trifluoroacetic acid; sodium nitrite / 5 h / 20 °C / Cooling with ice
3.1: thiourea / water / 3 h / Reflux
3.2: 2 h / Reflux
View Scheme
C9H19ClOSi

C9H19ClOSi

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / methanol / 2 h / 20 °C
2.1: trifluoroacetic acid; sodium nitrite / 5 h / 20 °C / Cooling with ice
3.1: thiourea / water / 3 h / Reflux
3.2: 2 h / Reflux
View Scheme
C13H17ClO

C13H17ClO

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 20 °C / 20686.5 Torr / Autoclave
2.1: trifluoroacetic acid; sodium nitrite / 5 h / 20 °C / Cooling with ice
3.1: thiourea / water / 3 h / Reflux
3.2: 2 h / Reflux
View Scheme
C12H11NOS

C12H11NOS

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 90℃; for 8h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;7.84 g
2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-diphenylphosphatoxypropyl)phenyl)-2-propanol

2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-diphenylphosphatoxypropyl)phenyl)-2-propanol

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

cyclopentyl 3-{2-methoxy-4-[(o-tolylsulfonyl)carbamoyl]benzyl}-1-methyl-1H-indol-5-ylcarbamate
142522-28-9

cyclopentyl 3-{2-methoxy-4-[(o-tolylsulfonyl)carbamoyl]benzyl}-1-methyl-1H-indol-5-ylcarbamate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0 - 20℃; Reagent/catalyst; Solvent;98.8%
1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

C6H9(2)HO2

C6H9(2)HO2

Conditions
ConditionsYield
With di-tert-butyl peroxide; water-d2; ethydiphenylphosphine oxide In dichloromethane at 20℃; for 10h; Irradiation; Green chemistry;97%
C28H20ClNO3
1402070-72-7

C28H20ClNO3

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

{1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(methoxycarbonyl)phenyl]-3-oxopropyl}sulfanyl)methyl]cyclopropyl}acetic acid

{1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(methoxycarbonyl)phenyl]-3-oxopropyl}sulfanyl)methyl]cyclopropyl}acetic acid

Conditions
ConditionsYield
With C38H54FeN2O2(1+)*Cl(1-) In 1,2-dichloro-ethane at -5℃; for 39h;96%
C28H20ClNO3

C28H20ClNO3

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

{1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(methoxycarbonyl)phenyl]-3-oxopropyl}sulfanyl)methyl]cyclopropyl}acetic acid

{1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}-3-[2-(methoxycarbonyl)phenyl]-3-oxopropyl}sulfanyl)methyl]cyclopropyl}acetic acid

Conditions
ConditionsYield
With C38H54ClFeN2O2 In 1,2-dichloro-ethane at -5℃; for 39h; enantioselective reaction;96%
2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-diphenylphosphatoxypropyl)phenyl)-2-propanol

2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-diphenylphosphatoxypropyl)phenyl)-2-propanol

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

montelukast
158966-92-8

montelukast

Conditions
ConditionsYield
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With 3-ethyl-1-methyl-1H-imidazol-3-ium bromide In dimethyl sulfoxide at 10℃; for 0.0833333h;
Stage #2: With potassium tert-butylate In dimethyl sulfoxide at 10℃; for 0.166667h;
Stage #3: 2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-diphenylphosphatoxypropyl)phenyl)-2-propanol In dimethyl sulfoxide at 15 - 17℃; for 1h; Product distribution / selectivity;
93%
C70H109FN12O15

C70H109FN12O15

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

C76H119FN12O17S

C76H119FN12O17S

Conditions
ConditionsYield
In methanol; N,N-dimethyl-formamide at 20℃; for 4h;93%
1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

3-methylenepentanoic acid
21962-25-4

3-methylenepentanoic acid

Conditions
ConditionsYield
With di-tert-butyl peroxide; triethyl phosphite In N,N-dimethyl-formamide92%
With di-tert-butyl peroxide; triethyl phosphite In acetonitrile at 25℃; for 6h; Irradiation;92%
(S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol
1021952-71-5

(S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

(R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid
1015076-82-0

(R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid

Conditions
ConditionsYield
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium t-butanolate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: (S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol In N,N-dimethyl-formamide at 20℃; for 48.5h;
Stage #3: With tartaric acid In water; ethyl acetate; N,N-dimethyl-formamide pH=7; Product distribution / selectivity;
87.5%
C13H6F4INO

C13H6F4INO

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

2-(1-(((2-fluoro-5-((3,4,5-trifluorophenyl)carbamoyl)phenyl)thio)methyl)cyclopropyl)acetic acid

2-(1-(((2-fluoro-5-((3,4,5-trifluorophenyl)carbamoyl)phenyl)thio)methyl)cyclopropyl)acetic acid

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In toluene at 102℃; for 13h; Inert atmosphere; Sealed tube;86%
N-cyclohexyl-cyclohexanamine
101-83-7

N-cyclohexyl-cyclohexanamine

2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol
807638-71-7

2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt
577953-88-9

1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt

Conditions
ConditionsYield
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium t-butanolate In toluene at -3 - 10℃; for 1h; Inert atmosphere;
Stage #2: 2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol In tetrahydrofuran; toluene at -5 - 15℃;
Stage #3: N-cyclohexyl-cyclohexanamine In tetrahydrofuran; ethyl acetate; toluene at 10 - 15℃; for 1h;
85.45%
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With n-butyllithium In tetrahydrofuran at -12.5℃; for 0.666667h;
Stage #2: 2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol In tetrahydrofuran at -2℃; for 3.5h;
Stage #3: N-cyclohexyl-cyclohexanamine In isopropyl alcohol; acetonitrile at 29℃; for 15.5h; Product distribution / selectivity;
C68H103F2N11O15

C68H103F2N11O15

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

C74H113F2N11O17S

C74H113F2N11O17S

Conditions
ConditionsYield
In methanol; N,N-dimethyl-formamide at 20℃; for 4h;81%
C67H101F2N11O14

C67H101F2N11O14

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

C73H111F2N11O16S

C73H111F2N11O16S

Conditions
ConditionsYield
In N,N-dimethyl-formamide; acetonitrile at 20℃; for 4h;77%
(S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol
287930-77-2

(S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

montelukast
158966-92-8

montelukast

Conditions
ConditionsYield
Stage #1: (S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -15 - -10℃; Inert atmosphere;
Stage #2: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium methylate In tetrahydrofuran; methanol; 4-methyl-2-pentanone at -15 - 20℃;
68.55%
Stage #1: (S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -15 - -10℃; Inert atmosphere;
Stage #2: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium methylate In tetrahydrofuran; methanol; 4-methyl-2-pentanone at -15 - 20℃;
(S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol
1021952-71-5

(S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

(1-{1-(R)-(3-bromophenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid
1015076-80-8

(1-{1-(R)-(3-bromophenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid

Conditions
ConditionsYield
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium t-butanolate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: (S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol In N,N-dimethyl-formamide at 20℃; for 48.5h;
Stage #3: With tartaric acid In water; ethyl acetate; N,N-dimethyl-formamide pH=7; Product distribution / selectivity;
67.8%
1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Methanesulfonic acid (S)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl ester

Methanesulfonic acid (S)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl ester

(1-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid

(1-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid

Conditions
ConditionsYield
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With n-butyllithium In tetrahydrofuran; hexane at -22 - 0℃; for 0.25h; Metallation;
Stage #2: Methanesulfonic acid (S)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl ester In tetrahydrofuran; hexane at -22 - 0℃; for 2h; Substitution;
66%
(S)-methyl 2-(3-(3-bromophenyl)-3-methylsulfonyloxypropyl)benzoate
1015076-81-9

(S)-methyl 2-(3-(3-bromophenyl)-3-methylsulfonyloxypropyl)benzoate

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

(R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid
1015076-82-0

(R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid

Conditions
ConditionsYield
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium methylate In tetrahydrofuran for 0.5h; Inert atmosphere;
Stage #2: (S)-methyl 2-(3-(3-bromophenyl)-3-methylsulfonyloxypropyl)benzoate In tetrahydrofuran at -15 - 10℃; for 6.5h; Inert atmosphere;
61.1%
methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate
880769-25-5

methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate

N-cyclohexyl-cyclohexanamine
101-83-7

N-cyclohexyl-cyclohexanamine

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

2-(3(R)-(1-carboxymethyl-cyclopropylmethylsulfanyl)-3-{3-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-propyl)-benzoic acid methyl ester dicyclohexyl-amine

2-(3(R)-(1-carboxymethyl-cyclopropylmethylsulfanyl)-3-{3-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-propyl)-benzoic acid methyl ester dicyclohexyl-amine

Conditions
ConditionsYield
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 2h;
Stage #2: methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate In N,N-dimethyl-formamide at -5 - 0℃; for 25h;
Stage #3: N-cyclohexyl-cyclohexanamine In ethyl acetate at 20 - 25℃; for 37.5h;
52.8%
methyl 2-[(3S)-[3-[(2E)-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate

methyl 2-[(3S)-[3-[(2E)-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate

N-cyclohexyl-cyclohexanamine
101-83-7

N-cyclohexyl-cyclohexanamine

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

2-(3(R)-(1-carboxymethyl-cyclopropylmethylsulfanyl)-3-{3-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-propyl)-benzoic acid methyl ester dicyclohexyl-amine

2-(3(R)-(1-carboxymethyl-cyclopropylmethylsulfanyl)-3-{3-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-propyl)-benzoic acid methyl ester dicyclohexyl-amine

Conditions
ConditionsYield
Stage #1: methyl 2-[(3S)-[3-[(2E)-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate; 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; Inert atmosphere;
Stage #2: N-cyclohexyl-cyclohexanamine In ethyl acetate at 20 - 45℃;
52.8%
2-(2-(3(S)-chloro-3-(3-(2-(7-chloro-2-quinolinyl)-(E)ethenyl)phenyl)propyl)phenyl)-2-propanol
880769-28-8

2-(2-(3(S)-chloro-3-(3-(2-(7-chloro-2-quinolinyl)-(E)ethenyl)phenyl)propyl)phenyl)-2-propanol

N-cyclohexyl-cyclohexanamine
101-83-7

N-cyclohexyl-cyclohexanamine

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt
577953-88-9

1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt

Conditions
ConditionsYield
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium hydride In N,N-dimethyl-formamide at -5℃; for 1h;
Stage #2: 2-(2-(3(S)-chloro-3-(3-(2-(7-chloro-2-quinolinyl)-(E)ethenyl)phenyl)propyl)phenyl)-2-propanol In N,N-dimethyl-formamide at -5 - 0℃; for 13h;
Stage #3: N-cyclohexyl-cyclohexanamine In ethyl acetate at 20 - 22℃; for 1.75h;
40.5%
Stage #1: 2-(2-(3(S)-chloro-3-(3-(2-(7-chloro-2-quinolinyl)-(E)ethenyl)phenyl)propyl)phenyl)-2-propanol; 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; Inert atmosphere;
Stage #2: N-cyclohexyl-cyclohexanamine In ethyl acetate at 20 - 45℃; Product distribution / selectivity;
40.5%
benzylidene phenylamine
538-51-2

benzylidene phenylamine

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

6,7-diphenyl-5-thia-7-azaspiro[2.6]nonan-8-one

6,7-diphenyl-5-thia-7-azaspiro[2.6]nonan-8-one

Conditions
ConditionsYield
With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In 2-methyltetrahydrofuran at 20℃; Inert atmosphere; Cooling;24%
C73H112FN13O17

C73H112FN13O17

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

C79H122FN13O19S

C79H122FN13O19S

Conditions
ConditionsYield
In methanol; N,N-dimethyl-formamide at 20℃; for 15h;17%
[1-[(R)-1-(3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]-phenyl)-3-(2-isopropenylphenyl)propylsulfanylmethyl]cyclopropyl]acetic acid dicyclohexylamine salt
1197374-12-1

[1-[(R)-1-(3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]-phenyl)-3-(2-isopropenylphenyl)propylsulfanylmethyl]cyclopropyl]acetic acid dicyclohexylamine salt

1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

C41H44ClNO4S2
1351973-24-4

C41H44ClNO4S2

Conditions
ConditionsYield
With sodium methylate In methanol; N,N-dimethyl-formamide at 25 - 45℃; for 26h;12.4%
1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Methanesulfonic acid (S)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-2-methoxymethoxy-1-methyl-ethyl)-phenyl]-propyl ester
186353-01-5

Methanesulfonic acid (S)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-2-methoxymethoxy-1-methyl-ethyl)-phenyl]-propyl ester

(1-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-2-methoxymethoxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid
184764-27-0

(1-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-2-methoxymethoxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid

Conditions
ConditionsYield
With n-butyllithium 1.) THF, 0 deg C, 30 min, 2.) THF, -15 deg C, overnight; Yield given. Multistep reaction;
1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Butane-1-sulfonic acid (S)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-2-((S)-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-ethyl ester
184764-00-9

Butane-1-sulfonic acid (S)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-2-((S)-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-ethyl ester

{1-[(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-2-((S)-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-ethylsulfanylmethyl]-cyclopropyl}-acetic acid

{1-[(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-2-((S)-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-ethylsulfanylmethyl]-cyclopropyl}-acetic acid

Conditions
ConditionsYield
With n-butyllithium 1.) THF, 0 deg C, 15 min, 2.) THF, 4 deg C, 16 h; Yield given. Multistep reaction;
1-(sulfanylmethyl)cyclopropaneacetic acid
162515-68-6

1-(sulfanylmethyl)cyclopropaneacetic acid

Butane-1-sulfonic acid (S)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-2-((R)-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-ethyl ester
184764-64-5

Butane-1-sulfonic acid (S)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-2-((R)-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-ethyl ester

{1-[(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-2-((R)-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-ethylsulfanylmethyl]-cyclopropyl}-acetic acid

{1-[(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-2-((R)-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-ethylsulfanylmethyl]-cyclopropyl}-acetic acid

Conditions
ConditionsYield
With n-butyllithium 1.) THF, 0 deg C, 15 min, 2.) THF, 4 deg C, 16 h; Yield given. Multistep reaction;

Raw Materials

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