Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:162515-68-6
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:162515-68-6
Min.Order:1 Metric Ton
Negotiable
Type:Manufacturers
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:162515-68-6
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryProduct: 1-(Mercaptomethyl) Cyclopropane Acetic Acid[CAS:162515-68-6] Batch No: 110408-1 Manufacturing Date: April 2011 Expiry Date: April 2012 Analysis report number: 20110513 Quantity: 1 Kg Items
Cas:162515-68-6
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
Cas:162515-68-6
Min.Order:1 Kilogram
Negotiable
Type:Manufacturers
inquiryItems Standard Result Appearance White or off-white crystalline powder Off-white crystalline powder Assay
Cas:162515-68-6
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:162515-68-6
Min.Order:1
Negotiable
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:162515-68-6
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Cas:162515-68-6
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryColorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on
Cas:162515-68-6
Min.Order:1 Metric Ton
Negotiable
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:162515-68-6
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryName:2-[1-(Mercaptomethyl)cyclopropyl]acetic acid CAS NO: 162515-68-6 Grade:Montelukast sodium intermediate Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vul
Cas:162515-68-6
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiry2-[1-(Mercaptomethyl)cyclopropyl]acetic acid Basic information Product Name: 2-[1-(Mercaptomethyl)cyclopropyl]acetic acid Synonyms: 2-[1-(MERCAPTOMETHYL)CYCLOPROPYL]ACETIC ACID;1-(MERCAP
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:162515-68-6
Min.Order:1 Gram
FOB Price: $6.0 / 9.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:162515-68-6
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryName: 1-(Mercaptomethyl)-Cyclopropaneaceticacid Molecular Formula:C6H10O2S Molecular Weight:146.2074 CAS No.:162515-68-6 Appearance:Similar White crystal Powder Appearance:Similar White crystal Powder Storage:Store in cool and dry place, away fro
Cas:162515-68-6
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Other
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:162515-68-6
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:162515-68-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
Cas:162515-68-6
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:162515-68-6
Min.Order:1 Kilogram
FOB Price: $120.0 / 160.0
Type:Trading Company
inquiry2-[1-(Mercaptomethyl)cyclopropyl]acetic acid CAS:162515-68-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in
Cas:162515-68-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:162515-68-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:162515-68-6
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryAppearance:Off-white solid Storage:Room temperature Package:25kg/drum Application:Montelukast intermediates Transportation:Express/Sea/Air Port:Any port in china
Cas:162515-68-6
Min.Order:25 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
Cas:162515-68-6
Min.Order:1 Kilogram
FOB Price: $15.0 / 30.0
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:162515-68-6
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:162515-68-6
Min.Order:0
Negotiable
Type:Manufacturers
inquiryWe have one R&D laboratory and two product bases in Hangzhou which are established as per GMP requirements. Our technical force is rich and has a passel of technologists who have engaged in research and production of medication for m
Cas:162515-68-6
Min.Order:1 Kilogram
Negotiable
Type:Other
inquirySpecification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Application:162515-68-6
Cas:162515-68-6
Min.Order:0 Metric Ton
Negotiable
Type:Trading Company
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:162515-68-6
Min.Order:1 Kilogram
FOB Price: $1.0 / 100000.0
Type:Lab/Research institutions
inquiry2-[1-(mercaptomethyl)cyclopropyl]acetic acid methyl ester
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
With water; potassium hydroxide at 0 - 20℃; for 3h; | 93% |
Stage #1: 2-[1-(mercaptomethyl)cyclopropyl]acetic acid methyl ester With methanol; sodium hydroxide; water at 70 - 80℃; for 2h; Stage #2: With hydrogenchloride; water at 40℃; pH=3.0 - ~ 4.0; |
C6H9ClO2
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Stage #1: C6H9ClO2 With thiourea In water for 3h; Reflux; Stage #2: With sodium hydroxide In water for 2h; Reflux; | 91.6% |
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
With sodium hydroxide Reflux; | 91.4% |
Stage #1: 1-(isothiuroniummethyl)cyclopropaneacetonitrile hydrobromide With sodium hydroxide; water for 14h; Heating / reflux; Stage #2: With formic acid In water at -5 - 5℃; pH=3.5 - 4.0; | 76.7% |
C15H19NO2S
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Stage #1: C15H19NO2S With potassium hydroxide; water at 120℃; for 14h; Stage #2: With hydrogenchloride; water In diethyl ether Product distribution / selectivity; | 80% |
With water In tetrahydrofuran at 80℃; Product distribution / selectivity; | 50% |
1-(Acetylthiomethyl)cyclopropaneacetonitrile
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide In toluene | 11.99 g (82%) |
1-bromomethylcyclopropyl acetic acid methyl ester
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: copper(l) iodide / N,N-dimethyl-formamide / 50 - 60 °C 2: potassium carbonate; methanol / 6 h / Reflux 3: phosphorus tribromide / dichloromethane / 0 - 10 °C 4: acetonitrile / Reflux 5: sodium hydroxide / Reflux View Scheme |
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium carbonate; methanol / 6 h / Reflux 2: phosphorus tribromide / dichloromethane / 0 - 10 °C 3: acetonitrile / Reflux 4: sodium hydroxide / Reflux View Scheme |
1-(hydroxymethyl)cyclopropaneacetonitrile
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: phosphorus tribromide / dichloromethane / 0 - 10 °C 2: acetonitrile / Reflux 3: sodium hydroxide / Reflux View Scheme |
[1-(hydroxymethyl)cyclopropyl]methanol
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: sulphate-doped anatase / tetrahydrofuran / 45 - 55 °C 2.1: isobutyric acid sodium salt / tetrahydrofuran / 10 - 20 °C / Inert atmosphere 2.2: 0.5 h 3.1: phosphorus tribromide / dichloromethane / 0 - 20 °C 4.1: copper(l) iodide / N,N-dimethyl-formamide / 50 - 60 °C 5.1: potassium carbonate; methanol / 6 h / Reflux 6.1: phosphorus tribromide / dichloromethane / 0 - 10 °C 7.1: acetonitrile / Reflux 8.1: sodium hydroxide / Reflux View Scheme |
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: isobutyric acid sodium salt / tetrahydrofuran / 10 - 20 °C / Inert atmosphere 1.2: 0.5 h 2.1: phosphorus tribromide / dichloromethane / 0 - 20 °C 3.1: copper(l) iodide / N,N-dimethyl-formamide / 50 - 60 °C 4.1: potassium carbonate; methanol / 6 h / Reflux 5.1: phosphorus tribromide / dichloromethane / 0 - 10 °C 6.1: acetonitrile / Reflux 7.1: sodium hydroxide / Reflux View Scheme |
1-hydroxymethylcyclopropylacetic acid methyl ester
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: phosphorus tribromide / dichloromethane / 0 - 20 °C 2: copper(l) iodide / N,N-dimethyl-formamide / 50 - 60 °C 3: potassium carbonate; methanol / 6 h / Reflux 4: phosphorus tribromide / dichloromethane / 0 - 10 °C 5: acetonitrile / Reflux 6: sodium hydroxide / Reflux View Scheme |
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: potassium borohydride / tetrahydrofuran / 2 h / 20 °C 2.1: pyridine; triphenylphosphine; tetrachloromethane / 18 h / 75 °C 3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 4.1: trifluoroacetic acid; sodium nitrite / 5 h / 20 °C / Cooling with ice 5.1: thiourea / water / 3 h / Reflux 5.2: 2 h / Reflux View Scheme |
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: pyridine; triphenylphosphine; tetrachloromethane / 18 h / 75 °C 2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 3.1: trifluoroacetic acid; sodium nitrite / 5 h / 20 °C / Cooling with ice 4.1: thiourea / water / 3 h / Reflux 4.2: 2 h / Reflux View Scheme |
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 2.1: trifluoroacetic acid; sodium nitrite / 5 h / 20 °C / Cooling with ice 3.1: thiourea / water / 3 h / Reflux 3.2: 2 h / Reflux View Scheme |
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: trifluoroacetic acid; sodium nitrite / 5 h / 20 °C / Cooling with ice 2.1: thiourea / water / 3 h / Reflux 2.2: 2 h / Reflux View Scheme |
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydroxide / 5 h / 20 °C 2.1: trifluoroacetic acid; sodium nitrite / 5 h / 20 °C / Cooling with ice 3.1: thiourea / water / 3 h / Reflux 3.2: 2 h / Reflux View Scheme |
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydroxide / methanol / 2 h / 20 °C 2.1: trifluoroacetic acid; sodium nitrite / 5 h / 20 °C / Cooling with ice 3.1: thiourea / water / 3 h / Reflux 3.2: 2 h / Reflux View Scheme |
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 20 °C / 20686.5 Torr / Autoclave 2.1: trifluoroacetic acid; sodium nitrite / 5 h / 20 °C / Cooling with ice 3.1: thiourea / water / 3 h / Reflux 3.2: 2 h / Reflux View Scheme |
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; water at 90℃; for 8h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; | 7.84 g |
1-(sulfanylmethyl)cyclopropaneacetic acid
cyclopentyl 3-{2-methoxy-4-[(o-tolylsulfonyl)carbamoyl]benzyl}-1-methyl-1H-indol-5-ylcarbamate
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 0 - 20℃; Reagent/catalyst; Solvent; | 98.8% |
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
With di-tert-butyl peroxide; water-d2; ethydiphenylphosphine oxide In dichloromethane at 20℃; for 10h; Irradiation; Green chemistry; | 97% |
C28H20ClNO3
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
With C38H54FeN2O2(1+)*Cl(1-) In 1,2-dichloro-ethane at -5℃; for 39h; | 96% |
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
With C38H54ClFeN2O2 In 1,2-dichloro-ethane at -5℃; for 39h; enantioselective reaction; | 96% |
Conditions | Yield |
---|---|
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With 3-ethyl-1-methyl-1H-imidazol-3-ium bromide In dimethyl sulfoxide at 10℃; for 0.0833333h; Stage #2: With potassium tert-butylate In dimethyl sulfoxide at 10℃; for 0.166667h; Stage #3: 2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-diphenylphosphatoxypropyl)phenyl)-2-propanol In dimethyl sulfoxide at 15 - 17℃; for 1h; Product distribution / selectivity; | 93% |
Conditions | Yield |
---|---|
In methanol; N,N-dimethyl-formamide at 20℃; for 4h; | 93% |
1-(sulfanylmethyl)cyclopropaneacetic acid
3-methylenepentanoic acid
Conditions | Yield |
---|---|
With di-tert-butyl peroxide; triethyl phosphite In N,N-dimethyl-formamide | 92% |
With di-tert-butyl peroxide; triethyl phosphite In acetonitrile at 25℃; for 6h; Irradiation; | 92% |
(S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol
1-(sulfanylmethyl)cyclopropaneacetic acid
(R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid
Conditions | Yield |
---|---|
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium t-butanolate In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: (S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol In N,N-dimethyl-formamide at 20℃; for 48.5h; Stage #3: With tartaric acid In water; ethyl acetate; N,N-dimethyl-formamide pH=7; Product distribution / selectivity; | 87.5% |
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In toluene at 102℃; for 13h; Inert atmosphere; Sealed tube; | 86% |
N-cyclohexyl-cyclohexanamine
2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol
1-(sulfanylmethyl)cyclopropaneacetic acid
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt
Conditions | Yield |
---|---|
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium t-butanolate In toluene at -3 - 10℃; for 1h; Inert atmosphere; Stage #2: 2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol In tetrahydrofuran; toluene at -5 - 15℃; Stage #3: N-cyclohexyl-cyclohexanamine In tetrahydrofuran; ethyl acetate; toluene at 10 - 15℃; for 1h; | 85.45% |
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With n-butyllithium In tetrahydrofuran at -12.5℃; for 0.666667h; Stage #2: 2-[2-[3(S)-[3-[(1E)-2-(7-chloroquinoline-2-yl)ethenyl]phenyl]-3-methanesulfonyloxypropyl]phenyl]-2-propanol In tetrahydrofuran at -2℃; for 3.5h; Stage #3: N-cyclohexyl-cyclohexanamine In isopropyl alcohol; acetonitrile at 29℃; for 15.5h; Product distribution / selectivity; |
Conditions | Yield |
---|---|
In methanol; N,N-dimethyl-formamide at 20℃; for 4h; | 81% |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide; acetonitrile at 20℃; for 4h; | 77% |
(S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol
1-(sulfanylmethyl)cyclopropaneacetic acid
montelukast
Conditions | Yield |
---|---|
Stage #1: (S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -15 - -10℃; Inert atmosphere; Stage #2: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium methylate In tetrahydrofuran; methanol; 4-methyl-2-pentanone at -15 - 20℃; | 68.55% |
Stage #1: (S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -15 - -10℃; Inert atmosphere; Stage #2: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium methylate In tetrahydrofuran; methanol; 4-methyl-2-pentanone at -15 - 20℃; |
(S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol
1-(sulfanylmethyl)cyclopropaneacetic acid
(1-{1-(R)-(3-bromophenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid
Conditions | Yield |
---|---|
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium t-butanolate In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: (S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol In N,N-dimethyl-formamide at 20℃; for 48.5h; Stage #3: With tartaric acid In water; ethyl acetate; N,N-dimethyl-formamide pH=7; Product distribution / selectivity; | 67.8% |
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With n-butyllithium In tetrahydrofuran; hexane at -22 - 0℃; for 0.25h; Metallation; Stage #2: Methanesulfonic acid (S)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)-phenyl]-propyl ester In tetrahydrofuran; hexane at -22 - 0℃; for 2h; Substitution; | 66% |
(S)-methyl 2-(3-(3-bromophenyl)-3-methylsulfonyloxypropyl)benzoate
1-(sulfanylmethyl)cyclopropaneacetic acid
(R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid
Conditions | Yield |
---|---|
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium methylate In tetrahydrofuran for 0.5h; Inert atmosphere; Stage #2: (S)-methyl 2-(3-(3-bromophenyl)-3-methylsulfonyloxypropyl)benzoate In tetrahydrofuran at -15 - 10℃; for 6.5h; Inert atmosphere; | 61.1% |
methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate
N-cyclohexyl-cyclohexanamine
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; for 2h; Stage #2: methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate In N,N-dimethyl-formamide at -5 - 0℃; for 25h; Stage #3: N-cyclohexyl-cyclohexanamine In ethyl acetate at 20 - 25℃; for 37.5h; | 52.8% |
N-cyclohexyl-cyclohexanamine
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
Stage #1: methyl 2-[(3S)-[3-[(2E)-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate; 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; Inert atmosphere; Stage #2: N-cyclohexyl-cyclohexanamine In ethyl acetate at 20 - 45℃; | 52.8% |
2-(2-(3(S)-chloro-3-(3-(2-(7-chloro-2-quinolinyl)-(E)ethenyl)phenyl)propyl)phenyl)-2-propanol
N-cyclohexyl-cyclohexanamine
1-(sulfanylmethyl)cyclopropaneacetic acid
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt
Conditions | Yield |
---|---|
Stage #1: 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium hydride In N,N-dimethyl-formamide at -5℃; for 1h; Stage #2: 2-(2-(3(S)-chloro-3-(3-(2-(7-chloro-2-quinolinyl)-(E)ethenyl)phenyl)propyl)phenyl)-2-propanol In N,N-dimethyl-formamide at -5 - 0℃; for 13h; Stage #3: N-cyclohexyl-cyclohexanamine In ethyl acetate at 20 - 22℃; for 1.75h; | 40.5% |
Stage #1: 2-(2-(3(S)-chloro-3-(3-(2-(7-chloro-2-quinolinyl)-(E)ethenyl)phenyl)propyl)phenyl)-2-propanol; 1-(sulfanylmethyl)cyclopropaneacetic acid With sodium hydride In N,N-dimethyl-formamide at -5 - 0℃; Inert atmosphere; Stage #2: N-cyclohexyl-cyclohexanamine In ethyl acetate at 20 - 45℃; Product distribution / selectivity; | 40.5% |
benzylidene phenylamine
1-(sulfanylmethyl)cyclopropaneacetic acid
Conditions | Yield |
---|---|
With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In 2-methyltetrahydrofuran at 20℃; Inert atmosphere; Cooling; | 24% |
Conditions | Yield |
---|---|
In methanol; N,N-dimethyl-formamide at 20℃; for 15h; | 17% |
[1-[(R)-1-(3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]-phenyl)-3-(2-isopropenylphenyl)propylsulfanylmethyl]cyclopropyl]acetic acid dicyclohexylamine salt
1-(sulfanylmethyl)cyclopropaneacetic acid
C41H44ClNO4S2
Conditions | Yield |
---|---|
With sodium methylate In methanol; N,N-dimethyl-formamide at 25 - 45℃; for 26h; | 12.4% |
1-(sulfanylmethyl)cyclopropaneacetic acid
Methanesulfonic acid (S)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-2-methoxymethoxy-1-methyl-ethyl)-phenyl]-propyl ester
(1-{(R)-1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-2-methoxymethoxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid
Conditions | Yield |
---|---|
With n-butyllithium 1.) THF, 0 deg C, 30 min, 2.) THF, -15 deg C, overnight; Yield given. Multistep reaction; |
1-(sulfanylmethyl)cyclopropaneacetic acid
Butane-1-sulfonic acid (S)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-2-((S)-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-ethyl ester
Conditions | Yield |
---|---|
With n-butyllithium 1.) THF, 0 deg C, 15 min, 2.) THF, 4 deg C, 16 h; Yield given. Multistep reaction; |
1-(sulfanylmethyl)cyclopropaneacetic acid
Butane-1-sulfonic acid (S)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-2-((R)-3-oxo-1,3-dihydro-isobenzofuran-1-yl)-ethyl ester
Conditions | Yield |
---|---|
With n-butyllithium 1.) THF, 0 deg C, 15 min, 2.) THF, 4 deg C, 16 h; Yield given. Multistep reaction; |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View