1,1,1,2-Tetrafluoroethane supplier

Name
1,1,1,2-Tetrafluoroethane
EINECS 212-377-0
CAS No. 811-97-2
Article Data86
CAS DataBase
Density 1.223 g/cm³
Solubility 1g/L at 25℃
Melting Point -101 °C
Formula C₂H₂F₄
Boiling Point -26.2 °C
Molecular Weight 102.031
Flash Point
Transport Information UN 3159
Appearance colourless gas or cryogenic liquid
Safety 23-38
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms HC 134a;HCFC 134a;HFA 134;HFA 134a;HFA P134a;HFC 134a;Halon 134A;KLEA 134a;Khladon 134a;Meforex 134a;Norflurane;P 134A;R 134a;RF 134a;Refrigerant R 134a;SUVA134a;Solkane 134a;TG 134a;1,2,2,2-Tetrafluoroethane;AK 134a;Arcton 134a;Ecolo Ace 134a;F 134A;FC134a;Forane 134a;Freon 134a;Fron 134a;Genetron 134a;
PSA 0.00000
LogP 1.51820

Synthetic route

: 2837-89-0
1,1,1,2-tetrafluoro-2-chloroethane

: 811-97-2
1,1,1,2-tetrafluoroethane

Conditions

Conditions	Yield
With hydrogen
With lithium aluminium tetrahydride In tetrahydrofuran Ambient temperature;
Irradiation; electroreduction, solid polymer electrolyte, Ag/AgCl reference electrode;
With hydrogen at 350 - 750℃; under 300.03 Torr; for 0.000277778h; Autoclave;

: 75-88-7
1,1,1-trifluoro-2-chloroethane

: 811-97-2
1,1,1,2-tetrafluoroethane

Conditions

Conditions	Yield
With hydrogen fluoride; chromium; magnesium
With hydrogen fluoride Heating;
With hydrogen fluoride; aluminum oxide; chromium(III) oxide; magnesium oxide; zinc(II) oxide at 350℃; Fluorination;

: 2837-89-0
1,1,1,2-tetrafluoro-2-chloroethane

A: 811-97-2
1,1,1,2-tetrafluoroethane

B: 359-11-5
1,1,2-trifluoroethylene

Conditions

Conditions	Yield
With methylene chloride; oxygen; nickel at 650 - 725℃; under 1277.21 Torr; Product distribution / selectivity;	A 28% B n/a
With methane; oxygen; nickel at 675℃; under 1277.21 Torr; Product distribution / selectivity;
With methane; oxygen; palladium on activated charcoal at 675℃; under 1277.21 Torr; Product distribution / selectivity;

(aqua)(perfluoroethane)iridium complex: (aqua)(perfluoroethane)iridium complex

A: 420-46-2
2,2,2-trifluoroethanol

B: 811-97-2
1,1,1,2-tetrafluoroethane

Conditions

Conditions	Yield
With hydrogen In dichloromethane at 20℃; under 760 Torr;

: 2837-89-0
1,1,1,2-tetrafluoro-2-chloroethane

A: 34557-54-5
methane

B: 811-97-2
1,1,1,2-tetrafluoroethane

Conditions

Conditions	Yield
With hydrogen at 350 - 750℃; under 300.03 Torr; for 0.000277778h; Autoclave;

: 74-86-2
acetylene

: 811-97-2
1,1,1,2-tetrafluoroethane

Conditions

Conditions	Yield
With cobalt (III) fluoride at 10℃; for 0.166667h; Inert atmosphere;	34%

: 374-07-2
1,1-dichlorotetrafluoroethane

A: 75-72-9
chlorotrifluoromethane

B: 811-97-2
1,1,1,2-tetrafluoroethane

Conditions

Conditions	Yield
With methane; oxygen; Ba(NO3)2, γ-alumina, dried at 180-450C, heated to 550C, calcined at 600C, oxidized at 450C at 600℃; under 873.827 - 904.856 Torr; Product distribution / selectivity;
With methane; oxygen; Ba(NO3)2, CsNO3, γ-alumina, dried at 180-450C, heated to 550C, calcined at 600C, oxidized at 450C at 550 - 678℃; under 873.827 - 904.856 Torr; Product distribution / selectivity;
With methane; oxygen; Ba(NO3)2, CsNO3, Co(NO3)2, γ-alumina, dried at 180-400C, heated to 550C, calcined at 575C, oxidized at 400-475C at 600℃; under 873.827 - 904.856 Torr; Product distribution / selectivity;

: 2837-89-0
1,1,1,2-tetrafluoro-2-chloroethane

A: 811-97-2
1,1,1,2-tetrafluoroethane

B: 75-38-7
Vinylidene fluoride

C: 359-11-5
1,1,2-trifluoroethylene

Conditions

Conditions	Yield
In water at 350 - 820℃; under 300.03 Torr; for 8.33333E-05h; Autoclave;

...Expand

: 433-06-7
2,2,2-Trifluoroethyl p-toluenesulfonate

: 811-97-2
1,1,1,2-tetrafluoroethane

Conditions

Conditions	Yield
With potassium fluoride; diethylene glycol at 210 - 240℃; under 500 Torr;
With potassium fluoride; potassium carbonate; [2.2.2]cryptande In acetonitrile at 115℃; under 1050.08 Torr; for 0.416667h; Yield given;

: 2837-89-0
1,1,1,2-tetrafluoro-2-chloroethane

A: 811-97-2
1,1,1,2-tetrafluoroethane

B: 75-38-7
Vinylidene fluoride

C: 359-10-4
1-Chloro-2,2-difluoroethene

D: 359-11-5
1,1,2-trifluoroethylene

Conditions

Conditions	Yield
In water at 350 - 950℃; under 300.03 Torr; for 8.33333E-05h; Autoclave;

...Expand

: 75-38-7
Vinylidene fluoride

: 811-97-2
1,1,1,2-tetrafluoroethane

Conditions

Conditions	Yield
With xenon difluoride; silicon tetrafluoride at 20℃; for 6h; Fluorination;	94%
With sulfur tetrafluoride; lead dioxide at 100℃; for 2h;
With cobalt (III) fluoride at 125℃;

: 27336-23-8
1,1-dibromo-1,2,2,2-tetrafluoroethane

: 811-97-2
1,1,1,2-tetrafluoroethane

Conditions

Conditions	Yield
With ammonium persulfate; ammonium formate In N,N-dimethyl-formamide at 30 - 40℃;	87%

: 374-07-2
1,1-dichlorotetrafluoroethane

A: 811-97-2
1,1,1,2-tetrafluoroethane

B: 2837-89-0
1,1,1,2-tetrafluoro-2-chloroethane

Conditions

Conditions	Yield
With triethylsilane; Perbenzoic acid 1) 25 deg C, 1 h, 2) 80 deg C, 10 h; Yield given; Yields of byproduct given;
With methylene chloride; oxygen; Ba(NO3)2, CsNO3, γ-alumina, dried at 180-450C, heated to 550C, calcined at 600C, oxidized at 450C at 600℃; under 873.827 - 904.856 Torr; Product distribution / selectivity;

: 75-88-7
1,1,1-trifluoro-2-chloroethane

A: 811-97-2
1,1,1,2-tetrafluoroethane

B: 1649-08-7
1,2-dichloro-1,1-difluoroethane

C: 306-83-2
1,1,1-trifluoro-2,2-dichloroethane

D: 430-58-0
1,2-dichloro-2-fluoroethene

E: 79-01-6
Trichloroethylene

F: 2837-89-0
1,1,1,2-tetrafluoro-2-chloroethane

Conditions

Conditions	Yield
Stage #1: 1,1,1-trifluoro-2-chloroethane With hydrogen fluoride; oxygen at 380℃; under 760.051 Torr; Inert atmosphere; Stage #2: With hydrogenchloride at 380℃; under 760.051 Torr;

...Expand

: 374-07-2
1,1-dichlorotetrafluoroethane

A: 420-46-2
2,2,2-trifluoroethanol

B: 811-97-2
1,1,1,2-tetrafluoroethane

C: 2837-89-0
1,1,1,2-tetrafluoro-2-chloroethane

Conditions

Conditions	Yield
With hydrogen; palladium/alumina at 140℃; Product distribution; Mechanism; var. temp.; other catalysts;	A 5.5% B 84.3% C 10.2%
With hydrogen; palladium at 149.85℃; under 770 Torr; Rate constant; Product distribution; Thermodynamic data; E(a); other Pd catalysts; effect of HCl and sulfur;
With hydrogen; palladium/alumina at 199.85℃; for 15h; Product distribution; also fluorinated aluminas catalysts; other substrate;
With hydrogenchloride; hydrogen; 5percent Pd/C-H Kinetics; Activation energy; Further Variations:; Catalysts; Dehydrochlorination;

...Expand

: 75-10-5
Difluoromethane

A: 75-46-7
trifluoromethan

B: 811-97-2
1,1,1,2-tetrafluoroethane

Conditions

Conditions	Yield
With ammonia at 900℃; for 10h;

: 75-10-5
Difluoromethane

A: 811-97-2
1,1,1,2-tetrafluoroethane

B: 359-11-5
1,1,2-trifluoroethylene

Conditions

Conditions	Yield
With ammonia at 1000℃; for 10h;

: 79-01-6
Trichloroethylene

: 811-97-2
1,1,1,2-tetrafluoroethane

Conditions

Conditions	Yield
With hydrogen fluoride at 300 - 514℃; under 760.051 Torr; Catalytic behavior; Reagent/catalyst; Temperature;	10%
With hydrogen fluoride Heating;

: 75-10-5
Difluoromethane

A: 75-46-7
trifluoromethan

B: 811-97-2
1,1,1,2-tetrafluoroethane

C: 359-11-5
1,1,2-trifluoroethylene

Conditions

Conditions	Yield
With ammonia at 950℃; for 10h;

...Expand

: 106-44-5
p-cresol

: 75-88-7
1,1,1-trifluoro-2-chloroethane

A: 811-97-2
1,1,1,2-tetrafluoroethane

B: 359-10-4
1-Chloro-2,2-difluoroethene

C: 369-65-3
(2-chloro-1,1-difluoro-ethyl)-p-tolyl ether

Conditions

Conditions	Yield
With potassium hydroxide at 250℃; under 28880 Torr; for 11h;	A n/a B n/a C 73%

...Expand

: 64-17-5
ethanol

: 75-88-7
1,1,1-trifluoro-2-chloroethane

A: 811-97-2
1,1,1,2-tetrafluoroethane

B: 461-24-5
1,1,1-trifluoroethyl ethyl ether

C: 359-10-4
1-Chloro-2,2-difluoroethene

Conditions

Conditions	Yield
With potassium hydroxide at 280℃; under 45600 Torr; for 11h;	A n/a B 67% C n/a

...Expand

: 75-88-7
1,1,1-trifluoro-2-chloroethane

: 75-89-8
2,2,2-trifluoroethanol

A: 811-97-2
1,1,1,2-tetrafluoroethane

B: 359-10-4
1-Chloro-2,2-difluoroethene

C: 333-36-8
1,1,1-trifluoro-2-(2,2,2-trifluoroethoxy)ethane

Conditions

Conditions	Yield
With potassium hydroxide at 250℃; under 77520 Torr; for 13h;	A n/a B n/a C 70%

...Expand

: 75-88-7
1,1,1-trifluoro-2-chloroethane

: 98-54-4
para-tert-butylphenol

A: 811-97-2
1,1,1,2-tetrafluoroethane

B: 359-10-4
1-Chloro-2,2-difluoroethene

C: 1-tert-butyl-4-(2-chloro-1,1-difluoro-ethoxy)-benzene

Conditions

Conditions	Yield
With potassium hydroxide at 250℃; under 36480 Torr; for 11h;	A n/a B n/a C 67%

...Expand

: 75-88-7
1,1,1-trifluoro-2-chloroethane

: 95-48-7
ortho-cresol

A: 811-97-2
1,1,1,2-tetrafluoroethane

B: 359-10-4
1-Chloro-2,2-difluoroethene

C: 366-41-6
(2-chloro-1,1-difluoro-ethyl)-o-tolyl ether

Conditions

Conditions	Yield
With potassium hydroxide at 250℃; under 34960 Torr; for 11h;	A n/a B n/a C 71%

...Expand

: 75-88-7
1,1,1-trifluoro-2-chloroethane

: 108-95-2
phenol

A: 811-97-2
1,1,1,2-tetrafluoroethane

B: 359-10-4
1-Chloro-2,2-difluoroethene

C: 500-31-2
1-chloro-2,2-difluoroethyl phenyl ether

D: C14H12F2O2

Conditions

Conditions	Yield
With potassium hydroxide at 250℃; under 35720 Torr; for 11h;	A n/a B n/a C 76% D n/a

...Expand

: 75-88-7
1,1,1-trifluoro-2-chloroethane

: 108-95-2
phenol

A: 811-97-2
1,1,1,2-tetrafluoroethane

B: 359-10-4
1-Chloro-2,2-difluoroethene

C: C14H12F2O2

Conditions

Conditions	Yield
With potassium hydroxide at 250℃; under 34200 Torr; for 11h;	A n/a B n/a C 72%

...Expand

: 79-14-1
glycolic Acid

: 811-97-2
1,1,1,2-tetrafluoroethane

Conditions

Conditions	Yield
With sulfur tetrafluoride at 160℃; for 5h;

: 67-56-1
methanol

: 75-88-7
1,1,1-trifluoro-2-chloroethane

A: 811-97-2
1,1,1,2-tetrafluoroethane

B: 460-43-5
2,2,2-trifluoroethyl methyl ether

C: 359-10-4
1-Chloro-2,2-difluoroethene

Conditions

Conditions	Yield
With potassium hydroxide at 260℃; under 57760 Torr; for 10h;	A n/a B 55% C n/a

...Expand

: 75-88-7
1,1,1-trifluoro-2-chloroethane

: 78-92-2, 15892-23-6
iso-butanol

A: 811-97-2
1,1,1,2-tetrafluoroethane

B: 359-10-4
1-Chloro-2,2-difluoroethene

C: 2-(2,2,2-Trifluoro-ethoxy)-butane

Conditions

Conditions	Yield
With potassium hydroxide at 280℃; under 87400 Torr; for 11h;	A n/a B n/a C 64%

...Expand

: 75-10-5
Difluoromethane

: 811-97-2
1,1,1,2-tetrafluoroethane

Conditions

Conditions	Yield
at 900℃; for 10h; Temperature;

: 811-97-2
1,1,1,2-tetrafluoroethane

A: 354-33-6
1,1,1,2,2-pentafluoroethane

B: 75-10-5
Difluoromethane

C: 75-46-7
trifluoromethan

D: 76-16-4
Hexafluoroethane

Conditions

Conditions	Yield
With fluorine at 200 - 250℃; Product distribution; Further Variations:; Reagents;	A 1.1% B 0.9% C 0.4% D 97.6%

...Expand

: 1-(chloromercuri)ferrocene

: 811-97-2
1,1,1,2-tetrafluoroethane

: (C5H5)Fe(C5H4)Hg(CFCF2)

Conditions

Conditions	Yield
With n-BuLi In diethyl ether; hexane under N2, shielded from light; ethereal soln. of CF3CH2F treated under stirring with n-BuLi in hexane at -78°C for 2 h; Fe-Hg complex in ether added at -78°C; stirred at -60°C overnight; warmed to room temp.; hexane added; filtered through Celite; filtrate concd. in vac.; elem. anal.;	93%

: 811-97-2
1,1,1,2-tetrafluoroethane

: mercury dichloride

: 687-61-6
bis(perfluorovinyl)mercury

Conditions

Conditions	Yield
With n-butyllithium In diethyl ether byproducts: LiCl; generation of Li salt witn BuLi at -78°C, addn. of 0.5 equiv. HgCl2; extn., drying, evapn.;	90%
With n-butyllithium In tetrahydrofuran; diethyl ether byproducts: LiCl; generation of Li salt witn BuLi at -78°C in Et2O, addn. of 0.5 equiv. HgCl2 in thf; extn., drying, evapn.;	90%
With BuLi In tetrahydrofuran; diethyl ether N2-atmosphere; slow addn. of BuLi to fluorocarbon (in Et2O, -78°C), stirring for 2 h, addn. of 0.5 equiv. HgCl2 (in THF), stirring overnight; warming to room temp., addn. of satd. aq. NH4Cl, drying of org. layer (MgSO4), solvent removal (reduced pressure), distn. (60-61°C/20 Torr); elem. anal.;	85%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 2708-94-3
Tris(trifluorvinyl)arsan

Conditions

Conditions	Yield
Stage #1: 1,1,1,2-tetrafluoroethane With n-butyllithium In diethyl ether; hexane at -78 - -70℃; for 6h; Inert atmosphere; Stage #2: With arsenic trichloride In diethyl ether; hexane at -85 - 20℃; Inert atmosphere;	90%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 105224-90-6
dimethylaminobis(trifluoromethyl)borane

: dimethylamine-trifluoroethenylbis(trifluoromethyl)borane

Conditions

Conditions	Yield
With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 0.333333h; deprotonation, trifluorovinylation;	89%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 105224-90-6
dimethylaminobis(trifluoromethyl)borane

: 300655-75-8
dimethylamine-trifluoroethenylbis(trifluoromethyl)borane

Conditions

Conditions	Yield
With t-butyl lithium In diethyl ether stirred at -78 °C for 20 min; aq. HCl added, pH 4, ther phase dried over Na2SO4, evapn., sublimation in vac., elem. anal.;	89%

: 309-89-7
titanocene difluoride

: 811-97-2
1,1,1,2-tetrafluoroethane

: 235747-18-9
fluoro(perfluorovinyl)(η(5)-cyclopentadienyl)titanium(IV)

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; diethyl ether; hexane N2-atmosphere; slow addn. of 2 equiv. BuLi (in hexane) to CF3CH2F (in Et2O) at -80°C, standing at -80 to -55°C for 2 h, cooling to -110°C, addn. of 1 equiv. Ti-complex (in THF, cooled to -80°C), slow warming to room temp.; vol. reduction (vac.), hexane addn., filtration, evapn. of filtrate (vac.), washing (hexane), drying (vac.); elem. anal.;	88%

Yield

With n-butyllithium In tetrahydrofuran; diethyl ether; hexane N2-atmosphere; slow addn. of 2 equiv. BuLi (in hexane) to CF3CH2F (in Et2O) at -80°C, standing at -80 to -55°C for 2 h, cooling to -110°C, addn. of 1 equiv. Ti-complex (in THF, cooled to -80°C), slow warming to room temp.; vol. reduction (vac.), hexane addn., filtration, evapn. of filtrate (vac.), washing (hexane), drying (vac.); elem. anal.;

88%

: 1271-19-8
bis(cyclopentadienyl)titanium dichloride

: 811-97-2
1,1,1,2-tetrafluoroethane

: 235747-22-5
bis(perfluorovinyl)(η(5)-cyclopentadienyl)titanium(IV)

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; diethyl ether; hexane N2-atmosphere; slow addn. of 2 equiv. BuLi (in hexane) to CF3CH2F (in Et2O) at -80°C, standing at -80 to -55°C for 2 h, cooling to -110°C, addn. of 0.5 equiv. Ti-complex (in THF, cooled to -80°C), slow warming to room temp.; vol. reduction (vac.), hexane addn., filtration, evapn. of filtrate (vac.), washing (hexane), drying (vac., 30 min); elem. anal.;	88%

Yield

With n-butyllithium In tetrahydrofuran; diethyl ether; hexane N2-atmosphere; slow addn. of 2 equiv. BuLi (in hexane) to CF3CH2F (in Et2O) at -80°C, standing at -80 to -55°C for 2 h, cooling to -110°C, addn. of 0.5 equiv. Ti-complex (in THF, cooled to -80°C), slow warming to room temp.; vol. reduction (vac.), hexane addn., filtration, evapn. of filtrate (vac.), washing (hexane), drying (vac., 30 min); elem. anal.;

88%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 40244-90-4
Chlorodiisopropylphosphane

: 750648-23-8
i-Pr2P(CF=CF2)

Conditions

Conditions	Yield
With n-butyllithium In diethyl ether at -80 - 20℃;	87%

: 1271-19-8
bis(cyclopentadienyl)titanium dichloride

: 811-97-2
1,1,1,2-tetrafluoroethane

: 235747-20-3
chloro(perfluorovinyl)(η(5)-cyclopentadienyl)titanium(IV)

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; diethyl ether; hexane N2-atmosphere; slow addn. of 2 equiv. BuLi (in hexane) to CF3CH2F (in Et2O) at -80°C, standing at -80 to -55°C for 2 h, cooling to -110°C, addn. of 1 equiv. Ti-complex (in THF, cooled to -80°C), slow warming to room temp.; vol. reduction (vac.), hexane addn., filtration, evapn. of filtrate (vac.), washing (hexane), drying (vac.);	87%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 19099-54-8
2-isopropyliodobenzene

: 105436-18-8
1-isopropyl-2-(1,2,2-trifluorovinyl)benzene

Conditions

Conditions	Yield
Stage #1: 1,1,1,2-tetrafluoroethane With zinc(II) chloride; lithium diisopropyl amide In tetrahydrofuran at 15 - 20℃; Stage #2: 2-isopropyliodobenzene With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 65℃; for 2h;	86%
Stage #1: 1,1,1,2-tetrafluoroethane With zinc(II) chloride; lithium diisopropyl amide In tetrahydrofuran at 15 - 20℃; Stage #2: 2-isopropyliodobenzene; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 65℃; for 2h;	86%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 25131-60-6
2-phenacylisoquinolinium bromide

: (2-fluoro-pyrrolo[2,1-a]isoquinolin-3-yl)phenyl-methanone

Conditions

Conditions	Yield
With potassium carbonate; triethylamine In N,N-dimethyl-formamide at 80℃; for 24h;	85%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 766-85-8
3-methoxy-1-iodobenzene

: 1-methoxy-3-(1,2,2-trifluorovinyl)benzene

Conditions

Conditions	Yield
Stage #1: 1,1,1,2-tetrafluoroethane With zinc(II) chloride; lithium diisopropyl amide In tetrahydrofuran at 15 - 20℃; Stage #2: 3-methoxy-1-iodobenzene; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 65℃; for 1h;	85%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 66-98-8
4,4'-diformylbiphenyl

: 4,4'-bis(2-trifluoromethyl-2-fluorovinyl)biphenyl

Conditions

Conditions	Yield
Stage #1: 1,1,1,2-tetrafluoroethane; 4,4'-diformylbiphenyl With n-butyllithium In tetrahydrofuran; hexane at -78℃; Inert atmosphere; Stage #2: With pyridine hydrofluoride In chloroform at 0 - 20℃; for 3h;	84%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 90-14-2
1-Iodonaphthalene

: 33240-13-0
1-(1,2,2-trifluoroethenyl)naphthalene

Conditions

Conditions	Yield
Stage #1: 1,1,1,2-tetrafluoroethane With zinc(II) chloride; lithium diisopropyl amide In tetrahydrofuran at 15 - 20℃; Stage #2: 1-Iodonaphthalene; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 60℃; for 2h;	83%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 696-62-8
para-iodoanisole

: 82907-00-4
para-methoxy phenyl-2 trifluoro-1,1,2 ethylene

Conditions

Conditions	Yield
Stage #1: 1,1,1,2-tetrafluoroethane With zinc(II) chloride; lithium diisopropyl amide In tetrahydrofuran at 15 - 20℃; for 1h; Stage #2: para-iodoanisole With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 60℃; for 1h;	82%
Stage #1: 1,1,1,2-tetrafluoroethane With zinc(II) chloride; lithium diisopropyl amide In tetrahydrofuran at 15 - 20℃; Stage #2: para-iodoanisole; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 60℃; for 1h;	82%

: 637-87-6
1-Chloro-4-iodobenzene

: 811-97-2
1,1,1,2-tetrafluoroethane

: 82907-01-5
1-chloro-4-(1,2,2-trifluoroethenyl)benzene

Conditions

Conditions	Yield
Stage #1: 1,1,1,2-tetrafluoroethane With zinc(II) chloride; lithium diisopropyl amide In tetrahydrofuran at 15 - 20℃; Stage #2: 1-Chloro-4-iodobenzene; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 60℃; for 2h;	82%

: 109-72-8, 29786-93-4
n-butyllithium

: 75-77-4
chloro-trimethyl-silane

: 811-97-2
1,1,1,2-tetrafluoroethane

: 89263-94-5
(Z)-1,2-difluoro-1-(trimethylsilyl)-1-hexene

Conditions

Conditions	Yield
Stage #1: 1,1,1,2-tetrafluoroethane With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Dehydrofluorination; metallation; Stage #2: chloro-trimethyl-silane In tetrahydrofuran; hexane at -78℃; for 1h; Substitution; Stage #3: n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Substitution;	81%

...Expand

: 811-97-2
1,1,1,2-tetrafluoroethane

: 106-45-6
para-thiocresol

: 5324-62-9
tris-p-tolylsulfanyl-ethene

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 60℃; for 24h;	81%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 100-56-1
phenylmercury(II) chloride

: (C6H5)Hg(CFCF2)

Conditions

Conditions	Yield
With n-BuLi In diethyl ether; hexane under N2, shielded from light; ethereal soln. of CF3CH2F treated under stirring with n-BuLi in hexane at -78°C for 2 h; PhHgCl in ether added at -78°C; stirred at -60°C overnight; warmed to room temp.; hexane added; filtered through Celite; filtrate concd. in vac.; elem. anal.;	79%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 625-99-0
3-iodochlorobenzene

: 58174-56-4
3'-chloro-1,2,2-trifluorostyrene

Conditions

Conditions	Yield
Stage #1: 1,1,1,2-tetrafluoroethane With zinc(II) chloride; lithium diisopropyl amide In tetrahydrofuran at 15 - 20℃; Stage #2: 3-iodochlorobenzene; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 65℃; for 2h;	78%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 2674-34-2
1,4-dibromo-2,5-dimethoxybenzene

: 1,4-bis(trifluorovinyl)-2,5-dimethoxybenzene

Conditions

Conditions	Yield
Stage #1: 1,1,1,2-tetrafluoroethane With zinc(II) chloride; lithium diisopropyl amide In tetrahydrofuran; hexane at -20 - 20℃; for 0.5h; Inert atmosphere; Stage #2: 1,4-dibromo-2,5-dimethoxybenzene With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; hexane at 50 - 55℃; for 17h; Inert atmosphere;	77%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 286-20-4
cyclohexane-1,2-epoxide

: trans-2-(1',2',2'-trifluoroethenyl)-cyclohexan-1-ol

Conditions

Conditions	Yield
Stage #1: 1,1,1,2-tetrafluoroethane With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.75h; Stage #2: cyclohexane-1,2-epoxide In tetrahydrofuran; hexane Further stages.;	76%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 589-87-7
1,4-bromoiodobenzene

: 134959-20-9
1-bromo-4-(1,2,2-trifluorovinyl)benzene

Conditions

Conditions	Yield
Stage #1: 1,1,1,2-tetrafluoroethane With zinc(II) chloride; lithium diisopropyl amide In tetrahydrofuran at 15 - 20℃; Stage #2: 1,4-bromoiodobenzene With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 20℃; for 12h;	75%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 4102-50-5
4,6-diiodo-1,3-xylene

: 1,3-bis(trifluorovinyl)-4,6-dimethylbenzene

Conditions

Conditions	Yield
Stage #1: 1,1,1,2-tetrafluoroethane With zinc(II) chloride; lithium diisopropyl amide In tetrahydrofuran; hexane at -20 - 20℃; for 0.5h; Inert atmosphere; Stage #2: 4,6-diiodo-1,3-xylene With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; hexane at 50℃; for 16h; Inert atmosphere;	75%

: 811-97-2
1,1,1,2-tetrafluoroethane

: 100-52-7
benzaldehyde

: 2338-85-4
1-phenyl 1-hydroxy 2.3.3-trifluoro propene (2)

Conditions

Conditions	Yield
With methanol; n-butyllithium In diethyl ether; hexane 1.) -78 deg C;	74%

1,1,1,2-Tetrafluoroethane Chemical Properties

Empirical Formula: C₂H₂F₄
Molecular Weight: 102.0309 g/mol
EINECS: 212-377-0
Index of Refraction: 1.225
Density: 1.223 g/cm³
Vapour Pressure: 6630 mmHg at 25 °C
Melting point: -101 °C
Boiling Point: -26.5 °C(lit.)
Appearance: A colorless gas with a slight ethereal odor
Structure of 1,1,1,2-Tetrafluoroethane (CAS NO.811-97-2):

IUPAC Name: 1,1,1,2-Tetrafluoroethane
Product Category of 1,1,1,2-Tetrafluoroethane (CAS NO.811-97-2): refrigerants;Organics;Gas Cylinders;Halides (Low Boiling point);Synthetic Organic Chemistry;pharmaceutical raw material;veterinary medicine

1,1,1,2-Tetrafluoroethane Uses

1,1,1,2-Tetrafluoroethane (CAS NO.811-97-2) can be used as refrigerant instead of R12.

1,1,1,2-Tetrafluoroethane Toxicity Data With Reference

1.	ihl-rat TCLo:50,000 ppm/6H/2Y-I:NEO	FAATDF Fundamental and Applied Toxicology. 25 (1995),271.
2.	ihl-rat LC :>81 pph/1H	HETOEA Human & Experimental Toxicology. 14 (1995),715.
3.	ihl-mus LC :>81 pph/1H	HETOEA Human & Experimental Toxicology. 14 (1995),715.
4.	ihl-dog LC :>32 pph/1H	HETOEA Human & Experimental Toxicology. 14 (1995),715.

1,1,1,2-Tetrafluoroethane Safety Profile

An asphyxiation hazard. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits toxic vapors of F⁻.
Hazard Codes: Irritant Xi
Safety Statements: 23-38
S23:Do not breathe vapour.
S38:In case of insufficient ventilation, wear suitable respiratory equipment.

1,1,1,2-Tetrafluoroethane Standards and Recommendations

DFG MAK: 1000 ppm

1,1,1,2-Tetrafluoroethane Specification

1,1,1,2-Tetrafluoroethane , its cas register number is 811-97-2. It also can be called Norflurane ; and Ethane, 1,1,1,2-tetrafluoro- .

Product Name

1,1,1,2-Tetrafluoroethane

Synthetic route

1,1,1,2-Tetrafluoroethane Chemical Properties

1,1,1,2-Tetrafluoroethane Uses

1,1,1,2-Tetrafluoroethane Toxicity Data With Reference

1,1,1,2-Tetrafluoroethane Safety Profile

1,1,1,2-Tetrafluoroethane Standards and Recommendations

1,1,1,2-Tetrafluoroethane Specification

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