1,2,4-Butanetriol supplier | CasNO.3068-00-6

Name
1,2,4-Butanetriol
EINECS 221-323-5
CAS No. 3068-00-6
Article Data61
CAS DataBase
Density 1.213 g/cm³
Solubility
Melting Point -20 °C
Formula C₄H₁₀O₃
Boiling Point 303.9 °C at 760 mmHg
Molecular Weight 106.122
Flash Point 153.9 °C
Transport Information
Appearance clear yellow to slightly brownish liquid
Safety 26-36
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms 1,2,4-Trihydroxybutane;1,3,4-Butanetriol;2-Deoxyerythritol;Butane-1,2,4-triol;
PSA 60.69000
LogP -1.27800

Synthetic route

: 617-48-1
malic acid

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With hydrogen; 5% activated charcoal-supported ruthenium catalyst In ethanol at 120℃; under 120012 Torr; for 70 - 90h; Product distribution / selectivity;	90%
In water	77%
With hydrogen; 5% activated charcoal-supported ruthenium catalyst In water at 100 - 120℃; under 7500.75 - 90009 Torr; for 6 - 24h; Product distribution / selectivity;	63%

: 928-01-8
maleamide

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With ruthenium on silica; hydrogen In tetrahydrofuran at 200℃; under 75007.5 Torr; for 12h; Temperature; Pressure; Time;	87%

: 38115-87-6
malic acid dimethyl ester

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With hydrogen; CuO/ZnO/Al2O3 In tetrahydrofuran at 180℃; under 7500.75 - 75007.5 Torr; for 4h; Product distribution / selectivity;	80%
With potassium tert-butylate In 1,4-dioxane at 70℃; for 48h; Temperature; Time;	62%
With potassium borohydride In ethanol
With hydrogenchloride; sodium borohydrid In tetrahydrofuran; methanol; isopropyl alcohol; acetone
With hydrogen; [(MeC(CH2PPh2)3)Ru(acetonitrile)3](CF3SO3)2 In methanol at 100℃; under 30003 Torr; for 14h; Product distribution / selectivity; Inert atmosphere; Autoclave;	>= 99.9 %Chromat.

: 617-48-1
malic acid

A: 57-55-6
propylene glycol

B: 110-63-4
Butane-1,4-diol

C: 3068-00-6
D,L-1,2,4-butanetriol

D: 107-21-1
ethylene glycol

Conditions

Conditions	Yield
With hydrogen; Ru-carbon In water at 135℃; under 258574 Torr; for 10h; Further byproducts given;	A 11% B 8% C 74% D 3%

...Expand

: 627-27-0
homoalylic alcohol

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
Stage #1: homoalylic alcohol With formic acid; water; dihydrogen peroxide at 55 - 60℃; for 7h; Stage #2: With methanol; Marlon-AS3 at 55 - 85℃; for 3h;	72%
With sulfuric acid; water; dihydrogen peroxide
Stage #1: homoalylic alcohol With sodium periodate; acetic acid; lithium bromide at 95℃; for 18h; Prevost-Woodward reaction; Stage #2: With potassium carbonate In methanol at 25℃; for 24h;
With potassium permanganate

: 33835-83-5
rac-3,4-dihydroxybutyl bromide

A: 3068-00-6
D,L-1,2,4-butanetriol

B: rac-3,4-dihydroxybutylarsonic acid

Conditions

Conditions	Yield
With 3-Hydroxytetrahydrofuran; trisodium arsenite; hydrogen bromide for 96h; Ambient temperature;	A 5% B 17%

: 7554-12-3
diethylmalate

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With copper chromite; ethanol at 100 - 150℃; under 257428 Torr; Hydrogenation;
With ethanol; nickel at 100 - 150℃; under 257428 Torr; Hydrogenation;

: 140-86-3
1,4-dihydroxy-2-butanone

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With water; nickel at 60 - 100℃; under 147102 Torr; Hydrogenation;
With copper oxide-chromium oxide; water; silica gel at 80 - 100℃; under 147102 Torr; Hydrogenation;

: 50-00-0
formaldehyd

A: 3068-00-6
D,L-1,2,4-butanetriol

B: 2319-57-5, 2418-52-2, 6968-16-7, 7493-90-5, 7541-59-5
1,2,3,4-butanetetrol

C: 107-21-1
ethylene glycol

D: 89615-91-8
2-C-hydroxymethyltetritol

E: 56-81-5
glycerol

F: 50-70-4, 69-65-8, 87-78-5, 133-43-7, 488-44-8, 488-45-9, 608-66-2, 643-01-6, 643-03-8, 5552-13-6, 6706-59-8, 24557-79-7, 25878-23-3, 26566-34-7, 45007-61-2, 60660-56-2, 60660-57-3, 60660-58-4, 132747-27-4
sorbitol

Conditions

Conditions	Yield
With calcium oxide Product distribution; Heating; reduction of formed monosacharides;;

...Expand

: 131076-15-8, 79677-01-3
3-Benzoyloxytetrahydrofuran

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With titanium tetrachloride 1) CH2Cl2, 72h, reflux 2) saponification; Multistep reaction;

: 129956-99-6
4-Methoxy-benzoic acid tetrahydro-furan-3-yl ester

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With titanium tetrachloride; potassium carbonate 1) CH2Cl2, 72h, reflux 2) MeOH, 10h, r.t.; Yield given. Multistep reaction;

: 82644-93-7
2-6'-acetoxy-6'-formyloxy-4'-oxo-2'-hexenamido-3-hydroxy-2-cyclopenten-1-one

A: 3068-00-6
D,L-1,2,4-butanetriol

B: 80548-64-7
2-glycolamido-3-hydroxy-2-cyclopenten-1-one

Conditions

Conditions	Yield
With sodium tetrahydroborate; ozone 1.) dichloromethane, cooled with dry ice-acetone, 40 min.; 2.) ethanol, water, 30 min, cooling; room temperature, 30 min; Yield given. Multistep reaction. Yields of byproduct given;
With sodium tetrahydroborate; ozone 1.) dichloromethane, cooled with dry ice-acetone, 40 min.; 2.) ethanol, water, 30 min. cooling; room temperature, 30 min; Yield given. Multistep reaction. Yields of byproduct given;

: 452-51-7, 13046-70-3, 29780-54-9, 36792-87-7, 36792-88-8, 113890-35-0, 113890-38-3
D-2-deoxyribose

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With 1-methyl-pyrrolidin-2-one; RhCl(PPh3)3 at 130℃; for 0.5h;	90 % Chromat.

: 627-27-0
homoalylic alcohol

A: 453-20-3
3-Hydroxytetrahydrofuran

B: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With titanium silicate; dihydrogen peroxide at 24.9℃; for 6h; Title compound not separated from byproducts;

: 124-04-9
Adipic acid

NaNO3: NaNO3

platinum anode: platinum anode

nitric acid ester: nitric acid ester

A: 4435-50-1
butane-1,2,3-triol

B: 3068-00-6
D,L-1,2,4-butanetriol

C: 909878-64-4
meso-erythritol

D: 107-21-1
ethylene glycol

Conditions

Conditions	Yield
Das Natriumsalz bei der reduzierenden Verseifung mit Ba(SH)2 in Butandiol-(1.2);

...Expand

(+-)-1,2,4-triacetoxy-butane: (+-)-1,2,4-triacetoxy-butane

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With hydrogenchloride; methanol
With methanol; sulfuric acid

salt of/the/ 3-isopentyloxy-propionic acid: salt of/the/ 3-isopentyloxy-propionic acid

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With sodium nitrate Electrolysis.an einer Platinanode und reduzierende Verseifung des Reaktionsgemisches mit Ba(SH)2;

salt of/the/ adipic acid: salt of/the/ adipic acid

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With sodium nitrate Electrolysis.an einer Platinanode und reduzierende Verseifung des Reaktionsgemisches mit Ba(SH)2;

salt of/the/ levulinic acid: salt of/the/ levulinic acid

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With sodium nitrate Electrolysis.an einer Platinanode und reduzierende Verseifung des Reaktionsgemisches mit Ba(SH)2;

: 627-27-0
homoalylic alcohol

KMnO4: KMnO4

: 3068-00-6
D,L-1,2,4-butanetriol

: 140-86-3
1,4-dihydroxy-2-butanone

: 7732-18-5
water

Raney nickel: Raney nickel

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
at 60 - 100℃; under 147102 Torr; Hydrogenation;

...Expand

triacetate of butanetriol-(1.2.4): triacetate of butanetriol-(1.2.4)

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With barytes

: 7124-16-5
1,2-dibromo-4-methoxy-butane

: 7732-18-5
water

A: 453-20-3
3-Hydroxytetrahydrofuran

B: 3068-00-6
D,L-1,2,4-butanetriol

C: 90325-06-7
4-methoxy-1,2-butanediol

...Expand

: 617-55-0
dimethyl (S)-malate

A: 3068-00-6
D,L-1,2,4-butanetriol

B: 52079-23-9
(3S)-3-hydroxydihydrofuran-2(3H)-one

C: 497-23-4
2-buten-4-olide

D: 88246-12-2
methyl 3,4-dihydroxybutanoate

Conditions

Conditions	Yield
With hydrogen In Dimethyl ether at 56 - 110℃; under 120012 Torr; for 0.5 - 2h; Product distribution / selectivity;	A n/a B n/a C n/a D n/a

...Expand

: 4440-87-3
cis-2,3-epoxy-1,4-butanediol

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With hydrogen; Ni(30 wt%)/SiO2 In isopropyl alcohol at 90 - 120℃; under 68404.6 Torr; Product distribution / selectivity;
With hydrogen; nickel In isopropyl alcohol at 120℃; under 68404.6 Torr; for 6h; Product distribution / selectivity;
With hydrogen; 5%-palladium/activated carbon In isopropyl alcohol at 120℃; under 68404.6 Torr; for 5h; Product distribution / selectivity;

: 70681-41-3
(R)-dimethyl malate

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water
With sodium hydroxide In tetrahydrofuran; water

: 96-48-0
4-butanolide

: 3068-00-6
D,L-1,2,4-butanetriol

Conditions

Conditions	Yield
In tetrahydrofuran

: 50-70-4
D-sorbitol

A: 57-55-6
propylene glycol

B: 64-17-5
ethanol

C: 18826-95-4, 107-88-0
1.3-butanediol

D: 3068-00-6
D,L-1,2,4-butanetriol

E: 87-99-0
XYLITOL

F: 107-21-1
ethylene glycol

G: 67-63-0
isopropyl alcohol

H: 56-81-5
glycerol

I: 513-85-9
2.3-butanediol

J: 584-03-2
1,2-dihydroxybutane

Conditions

Conditions	Yield
With potassium hydroxide; hydrogen; nickel-rhenium-on-carbon In water at 220℃; under 31029.7 - 62059.4 Torr; for 4h; Product distribution / selectivity;

...Expand

: 109-87-5
Dimethoxymethane

: 3068-00-6
D,L-1,2,4-butanetriol

: 4728-06-7
(1,3-dioxan-4-yl)methanol

Conditions

Conditions	Yield
	100%

: 3068-00-6
D,L-1,2,4-butanetriol

: 98-88-4
benzoyl chloride

: 129956-98-5
(+/-)-1,2,4-tris(benzoyloxy)butane

Conditions

Conditions	Yield
With dmap; triethylamine In tetrahydrofuran at 25℃;	100%

: 3068-00-6
D,L-1,2,4-butanetriol

: 51936-06-2
2,2-diphenylacetaldehyde dimethyl acetal

: 2-(2-benzhydryl-1,3-dioxolan-4-yl)ethan-1-ol

Conditions

Conditions	Yield
With chloro-trimethyl-silane; cobalt(II) chloride In acetonitrile at 20℃; for 17h;	100%

: 3068-00-6
D,L-1,2,4-butanetriol

: 707-07-3
orthobenzoic acid trimethyl ester

: 131076-15-8, 79677-01-3
3-Benzoyloxytetrahydrofuran

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 0℃; for 2h;	99%

: 3068-00-6
D,L-1,2,4-butanetriol

: 453-20-3
3-Hydroxytetrahydrofuran

Conditions

Conditions	Yield
sulfuric acid at 140℃; under 49.505 Torr; Product distribution / selectivity; Reactive distillation; Intramolecular dehydration;	98%
samarium(III) trifluoromethanesulfonate at 140℃; under 49.505 Torr; Product distribution / selectivity; Reactive distillation; Intramolecular dehydration;	97%
strong acid ion exchange resin (Amberlyst 15, H+ form) In 1,4-dioxane at 100℃; under 760.051 Torr; for 20h; Product distribution / selectivity;	96%

: 3068-00-6
D,L-1,2,4-butanetriol

: 67-64-1
acetone

: 5754-34-7
4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 20℃; for 4h;	98%
With toluene-4-sulfonic acid at 20℃; for 20h;	97%
With toluene-4-sulfonic acid	86%

: 3068-00-6
D,L-1,2,4-butanetriol

: 108-94-1
cyclohexanone

: 616876-76-7
2-(1,4-dioxa-spiro[4.5]dec-2-yl)-ethanol

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In diethyl ether at 0 - 20℃;	97%

: 3068-00-6
D,L-1,2,4-butanetriol

: 77-76-9
2,2-dimethoxy-propane

: 61821-85-0
(2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethanol

Conditions

Conditions	Yield
In dichloromethane	96.7%

: 3068-00-6
D,L-1,2,4-butanetriol

: barium D-butane-1,2,4-triol-1-phosphate barium

Conditions

Conditions	Yield
With water-d2; phospho(enol)pyruvic acid mono potassium salt; adenosine 5'-triphosphate disodium salt; barium(II) chloride; magnesium chloride; glycerol kinase from S. cerevisiae or from E. coli and pyruvate kinase In various solvent(s) for 1h;	95%

: 3068-00-6
D,L-1,2,4-butanetriol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 631899-30-4
1,4-di(tert-butyldimethylsilanyloxy)butan-2-ol

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃;	95%
With 1H-imidazole In dichloromethane Inert atmosphere; chemoselective reaction;
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; Cooling;

: 3068-00-6
D,L-1,2,4-butanetriol

: didocosahexanoyl ketone

: 2,2-didocosahexaenoyl-4-(2-hydroxyethyl)-[1,3]-dioxolane

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In toluene Reflux; Inert atmosphere; Dean-Stark;	95%

: 3068-00-6
D,L-1,2,4-butanetriol

: 1169768-30-2
(6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-one

: 1190203-55-4
2,2-dilinoleyl-4-(2-hydroxyethyl)-[1,3]-dioxolane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid for 3h; Reflux; Molecular sieve;	90%
With toluene-4-sulfonic acid In toluene Reflux; Dean-Stark;	47%
With pyridinium p-toluenesulfonate In toluene Reflux; Inert atmosphere;
With pyridinium p-toluenesulfonate In toluene
With pyridinium p-toluenesulfonate In toluene Inert atmosphere; Reflux; Dean-Stark tube;

: 3068-00-6
D,L-1,2,4-butanetriol

: heptatriaconta-6,9,28,31-tetraen-19-one

: C41H74O3

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 3h; Reflux; Molecular sieve;	90%
With toluene-4-sulfonic acid In toluene for 3h; Reflux; Molecular sieve;	90%

: 3068-00-6
D,L-1,2,4-butanetriol

: 101268-52-4
(benzoyloxy)acetaldehyde diethyl acetal

: cis-[4-(hydroxymethyl)-1,3-dioxan-2-yl]methyl benzoate

Conditions

Conditions	Yield
With chloro-trimethyl-silane; cobalt(II) chloride In acetonitrile at 20℃; for 0.1h; stereoselective reaction;	90%

: 3068-00-6
D,L-1,2,4-butanetriol

: 108-44-1
1-amino-3-methylbenzene

: 5422-64-0
1-m-tolyl-pyrrolidin-3-ol

Conditions

Conditions	Yield
Stage #1: D,L-1,2,4-butanetriol With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In toluene at 20℃; for 0.666667h; Molecular sieve; Inert atmosphere; Schlenk technique; Green chemistry; Stage #2: 1-amino-3-methylbenzene In toluene at 20℃; for 48.33h; Inert atmosphere; Schlenk technique; Sealed tube; Reflux; Green chemistry;	90%

Yield

Stage #1: D,L-1,2,4-butanetriol With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In toluene at 20℃; for 0.666667h; Molecular sieve; Inert atmosphere; Schlenk technique; Green chemistry;
Stage #2: 1-amino-3-methylbenzene In toluene at 20℃; for 48.33h; Inert atmosphere; Schlenk technique; Sealed tube; Reflux; Green chemistry;

90%

: 3068-00-6
D,L-1,2,4-butanetriol

: 2283-11-6
hexaethylphosphoric triamide

: 13232-18-3
2,7,8-trioxa-1-phosphabicyclo<3.2.1>octane

Conditions

Conditions	Yield
at 100℃;	89%

: 35573-93-4
3-chloro-1,1-diethoxy-propane

: 3068-00-6
D,L-1,2,4-butanetriol

: cis-[2-(2-chloroethyl)-1,3-dioxan-4-yl]methanol

Conditions

Conditions	Yield
With chloro-trimethyl-silane; cobalt(II) chloride In acetonitrile at 20℃; Inert atmosphere; stereoselective reaction;	89%

: 3068-00-6
D,L-1,2,4-butanetriol

: 754-05-2
ethenyltrimethylsilane

: 33581-75-8
1,2,4-Tris-trimethylsiloxy-butan

Conditions

Conditions	Yield
Wilkinson's catalyst In toluene at 130℃; for 6h;	88%

: 3068-00-6
D,L-1,2,4-butanetriol

: 100-52-7
benzaldehyde

: 3969-69-5, 72258-22-1, 93351-55-4, 95840-93-0, 103773-79-1
(+/-)-cis-4-(hydroxymethyl)-2-phenyl-1,3-dioxane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 4.5h; Heating;	87%
With toluene-4-sulfonic acid In toluene for 1h; Reflux;	53%
With molecular sieve; toluene-4-sulfonic acid In toluene Heating;

: 156053-80-4
(1,3-bis(diphenylphosphino)propane)Pt(CO3)

: 3068-00-6
D,L-1,2,4-butanetriol

: 156053-65-5
[(1,3-bis(diphenylphosphino)propane)]platinum(II)(1,2,4-butanetriolate)

Conditions

Conditions	Yield
In dichloromethane byproducts: CO2, H2O; under Ar; Pt-complex and 1.05 equiv of the triol dissolved in CH2Cl2, soln. stirred 2 h, soln. purged with Ar 4 times over a period of 3 h; evapn. (vac.), dried (vac., 1 h), dissolved in min. amt. CH2Cl2, layered with ether (crystn.), cryst. isolated, dried (vac.), elem. anal.;	87%

: 3068-00-6
D,L-1,2,4-butanetriol

: 100-44-7
benzyl chloride

: 94426-71-8
(+/-)-4-(2-benzyloxyethyl)-2,2-dimethyl-1,3-dioxolane

Conditions

Conditions	Yield
With sodium hydride; sodium iodide In N,N-dimethyl-formamide for 12h; Ambient temperature;	86%

: 3068-00-6
D,L-1,2,4-butanetriol

: 1260142-20-8
C41H82O

: 1260142-21-9
C45H90O3

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In toluene Inert atmosphere; Reflux;	86%

: 3068-00-6
D,L-1,2,4-butanetriol

: 536-90-3
m-Anisidine

: 536742-58-2
1-(3-methoxy-phenyl)-pyrrolidin-3-ol

Conditions

Conditions	Yield
Stage #1: D,L-1,2,4-butanetriol With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In toluene at 20℃; for 0.666667h; Molecular sieve; Inert atmosphere; Schlenk technique; Green chemistry; Stage #2: m-Anisidine In toluene at 20℃; for 48.33h; Inert atmosphere; Schlenk technique; Sealed tube; Reflux; Green chemistry;	86%

Yield

Stage #1: D,L-1,2,4-butanetriol With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In toluene at 20℃; for 0.666667h; Molecular sieve; Inert atmosphere; Schlenk technique; Green chemistry;
Stage #2: m-Anisidine In toluene at 20℃; for 48.33h; Inert atmosphere; Schlenk technique; Sealed tube; Reflux; Green chemistry;

86%

: 3068-00-6
D,L-1,2,4-butanetriol

: 140-86-3
1,4-dihydroxy-2-butanone

Conditions

Conditions	Yield
With C30H42N4O6Pd2(2+)*2CF3O3S(1-); p-benzoquinone In water; acetonitrile at 55℃; for 24h; Darkness; chemoselective reaction;	85%
With Candida boidinii KK912 In methanol; water at 30℃; for 48h; phosphate buffer (pH=7); other butanols;	78.1%
With phosphate buffer; Candida boidinii KK912 In methanol; water at 30℃; for 48h;	78.1%
With [(neocuproine)Pd(OAc)]2(OTf)2; oxygen In water; acetonitrile at 25℃; for 20h; Reagent/catalyst; Temperature; chemoselective reaction;	71%
With 2-Picolinic acid; manganese(II) perchlorate hexahydrate; butanedial; dihydrogen peroxide; sodium acetate In acetonitrile at 0 - 20℃; for 1h; Solvent;

: 3068-00-6
D,L-1,2,4-butanetriol

: 77-76-9
2,2-dimethoxy-propane

: 5754-34-7
4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane

Conditions

Conditions	Yield
With camphor-10-sulfonic acid	85%
With camphor-10-sulfonic acid In acetonitrile at 20℃;	80%
Stage #1: D,L-1,2,4-butanetriol; 2,2-dimethoxy-propane With pyridinium p-toluenesulfonate In acetone at 20℃; for 4h; Reflux; Stage #2: In methanol at 0℃; for 12h;	74%

: 3068-00-6
D,L-1,2,4-butanetriol

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: cis-[2-(bromomethyl)-1,3-dioxan-4-yl]methanol

Conditions

Conditions	Yield
With chloro-trimethyl-silane; cobalt(II) chloride In acetonitrile at 20℃; Inert atmosphere; stereoselective reaction;	85%

: 3068-00-6
D,L-1,2,4-butanetriol

: 1125-88-8
benzaldehyde dimethyl acetal

: 3969-69-5, 72258-22-1, 93351-55-4, 95840-93-0, 103773-79-1
(+/-)-cis-4-(hydroxymethyl)-2-phenyl-1,3-dioxane

Conditions

Conditions	Yield
With chloro-trimethyl-silane; cobalt(II) chloride In acetonitrile at 20℃; Inert atmosphere; stereoselective reaction;	84%

1,2,4-Butanetriol Chemical Properties

Molecular Structure of Butane-1,2,4-triol (CAS NO.3068-00-6):

IUPAC Name: butane-1,2,4-triol
Empirical Formula: C₄H₁₀O₃
Molecular Weight: 106.1204
H bond acceptors: 3
H bond donors: 3
Freely Rotating Bonds: 6
Polar Surface Area: 27.69 Å²
Index of Refraction: 1.486
Molar Refractivity: 25.14 cm³
Molar Volume: 87.4 cm³
Surface Tension: 55.6 dyne/cm
Density: 1.213 g/cm³
Flash Point: 153.9 °C
Enthalpy of Vaporization: 63.12 kJ/mol
Boiling Point: 303.9 °C at 760 mmHg
Vapour Pressure: 8.63E-05 mmHg at 25°C
Sensitive: Hygroscopic
BRN: 1733456
Melting point: -20°C
InChI
InChI=1/C4H10O3/c5-2-1-4(7)3-6/h4-7H,1-3H2
Smiles
C([C@@H](CO)O)CO
EINECS: 221-323-5
Product Categories: Organic Building Blocks; Oxygen Compounds; Polyols

1,2,4-Butanetriol Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	23gm/kg (23000mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 93, Pg. 152, 1953.

1,2,4-Butanetriol Safety Profile

Hazard Codes: Irritant Xi, Harmful Xn
Risk Statements: 36/37/38-20/21/22
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 1
RTECS: EK7176000

1,2,4-Butanetriol Specification

Butane-1,2,4-triol , with CAS number of 3068-00-6, can be called 1,2,4-Trihydroxybutane ; 1,3,4-Butanetriol ; 2-Deoxyerythritol ; (2R)-Butane-1,2,4-triol . It is a clear yellow to slightly brownish liquid.

Product Name

1,2,4-Butanetriol

Synthetic route

1,2,4-Butanetriol Chemical Properties

1,2,4-Butanetriol Toxicity Data With Reference

1,2,4-Butanetriol Safety Profile

1,2,4-Butanetriol Specification

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