Product Name

  • Name

    1,2-Diethoxybenzene

  • EINECS 218-089-1
  • CAS No. 2050-46-6
  • Article Data21
  • CAS DataBase
  • Density 0.975 g/cm3
  • Solubility 646mg/L at 20℃
  • Melting Point 43-45 °C
  • Formula C10H14O2
  • Boiling Point 218.7 °C at 760 mmHg
  • Molecular Weight 166.22
  • Flash Point 73.8 °C
  • Transport Information
  • Appearance light brown crystalline low melting mass or liquid
  • Safety 24/25
  • Risk Codes
  • Molecular Structure Molecular Structure of 2050-46-6 (1,2-Diethoxybenzene)
  • Hazard Symbols
  • Synonyms Benzene,o-diethoxy- (6CI,7CI,8CI);Catechol diethyl ether;NSC6189;o-Diethoxybenzene;
  • PSA 18.46000
  • LogP 2.48400

Synthetic route

benzene-1,2-diol
120-80-9

benzene-1,2-diol

ethyl iodide
75-03-6

ethyl iodide

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

Conditions
ConditionsYield
With potassium carbonate In acetone Heating;88%
With 18-crown-6 ether; potassium carbonate In acetonitrile for 18h; Reflux;76%
With sodium hydroxide
With potassium hydroxide
3,4-diethoxybenzoic acid
5409-31-4

3,4-diethoxybenzoic acid

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

Conditions
ConditionsYield
With methyllithium; calcium carbonate bei der Destillation;
diethyl sulfate
64-67-5

diethyl sulfate

benzene-1,2-diol
120-80-9

benzene-1,2-diol

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

Conditions
ConditionsYield
With potassium carbonate; acetone
2-Ethoxyphenol
94-71-3

2-Ethoxyphenol

ethyl iodide
75-03-6

ethyl iodide

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

Conditions
ConditionsYield
With potassium hydroxide
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 80℃; for 30h;
benzene-1,2-diol
120-80-9

benzene-1,2-diol

ethyl iodide
75-03-6

ethyl iodide

alcoholic potash

alcoholic potash

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

benzene-1,2-diol
120-80-9

benzene-1,2-diol

haloethane

haloethane

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

Conditions
ConditionsYield
With potassium hydroxide In 2-methoxy-ethanol
benzene-1,2-diol
120-80-9

benzene-1,2-diol

C2H5Hal

C2H5Hal

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

Conditions
ConditionsYield
With alkali
ethyl bromide
74-96-4

ethyl bromide

benzene-1,2-diol
120-80-9

benzene-1,2-diol

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

Conditions
ConditionsYield
With potassium hydroxide In ethanol
3,4-diethoxybenzoic acid ethyl ester
75332-44-4

3,4-diethoxybenzoic acid ethyl ester

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diluted NaOH-solution
2: lime/chalk/ / bei der Destillation
View Scheme
benzene-1,2-diol
120-80-9

benzene-1,2-diol

Et-X (X = Br or I)

Et-X (X = Br or I)

A

2-Ethoxyphenol
94-71-3

2-Ethoxyphenol

B

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

Conditions
ConditionsYield
With potassium carbonate In acetone
ethanol
64-17-5

ethanol

2-methoxy-phenol
90-05-1

2-methoxy-phenol

A

3,5-Di-tert-butylcatechol
1020-31-1

3,5-Di-tert-butylcatechol

B

2,6-di-tert-butylphenol
128-39-2

2,6-di-tert-butylphenol

C

2,4-diisopropylphenol
2934-05-6

2,4-diisopropylphenol

D

2,6-diisopropylphenol
2078-54-8

2,6-diisopropylphenol

E

2,4,6-triisopropylphenol
2934-07-8

2,4,6-triisopropylphenol

F

2,6-di-tert-butyl-4-ethylphenol
4130-42-1

2,6-di-tert-butyl-4-ethylphenol

G

2,6-di-tert-butyl-4-hydroxyphenol
2444-28-2

2,6-di-tert-butyl-4-hydroxyphenol

H

2,6-di-tert-butyl-4-methoxymethylene-phenol
87-97-8

2,6-di-tert-butyl-4-methoxymethylene-phenol

I

3,5-Di-tert-butylphenol
1138-52-9

3,5-Di-tert-butylphenol

J

2,4-dimethyl-6-tert-butylphenol
1879-09-0

2,4-dimethyl-6-tert-butylphenol

K

2-(2',5'-dimethoxyphenyl)propionaldehyde
52417-48-8

2-(2',5'-dimethoxyphenyl)propionaldehyde

L

2,6-di-tert-butyl-4-sec-butylphenol
17540-75-9

2,6-di-tert-butyl-4-sec-butylphenol

M

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

N

1,4-dimethoxy-2-tert-butylbenzene
21112-37-8

1,4-dimethoxy-2-tert-butylbenzene

O

1-ethoxy-4-methoxybenzene
5076-72-2

1-ethoxy-4-methoxybenzene

P

2,5-di(tert-amyl)-1,4-hydroquinone
79-74-3

2,5-di(tert-amyl)-1,4-hydroquinone

Q

2,4-di-tert-amylphenol
120-95-6

2,4-di-tert-amylphenol

R

2,5-diethyl phenol
876-20-0

2,5-diethyl phenol

S

4-ethoxy-3-methoxytoluene
33963-27-8

4-ethoxy-3-methoxytoluene

T

1,2-dimethoxy-4-butylbenzene
59056-76-7

1,2-dimethoxy-4-butylbenzene

U

1,2-diethoxy-4-ethyl-benzene
131358-04-8

1,2-diethoxy-4-ethyl-benzene

V

3,5-di-t-butyl-4-hydroxybenzaldehyde
1620-98-0

3,5-di-t-butyl-4-hydroxybenzaldehyde

Conditions
ConditionsYield
With ortho-tungstic acid at 300℃; for 6h; Autoclave;
ethanol
64-17-5

ethanol

2-methoxy-phenol
90-05-1

2-methoxy-phenol

A

2-Ethoxyphenol
94-71-3

2-Ethoxyphenol

B

3,5-Di-tert-butylcatechol
1020-31-1

3,5-Di-tert-butylcatechol

C

2,4-diisopropylphenol
2934-05-6

2,4-diisopropylphenol

D

2,6-diisopropylphenol
2078-54-8

2,6-diisopropylphenol

E

2,4,6-triisopropylphenol
2934-07-8

2,4,6-triisopropylphenol

F

2,6-di-tert-butyl-4-ethylphenol
4130-42-1

2,6-di-tert-butyl-4-ethylphenol

G

2,6-di-tert-butyl-4-hydroxyphenol
2444-28-2

2,6-di-tert-butyl-4-hydroxyphenol

H

2,6-di-tert-butyl-4-methoxymethylene-phenol
87-97-8

2,6-di-tert-butyl-4-methoxymethylene-phenol

I

3,5-Di-tert-butylphenol
1138-52-9

3,5-Di-tert-butylphenol

J

2,4-dimethyl-6-tert-butylphenol
1879-09-0

2,4-dimethyl-6-tert-butylphenol

K

2-(2',5'-dimethoxyphenyl)propionaldehyde
52417-48-8

2-(2',5'-dimethoxyphenyl)propionaldehyde

L

2,6-di-tert-butyl-4-sec-butylphenol
17540-75-9

2,6-di-tert-butyl-4-sec-butylphenol

M

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

N

1,4-dimethoxy-2-tert-butylbenzene
21112-37-8

1,4-dimethoxy-2-tert-butylbenzene

O

1-ethoxy-4-methoxybenzene
5076-72-2

1-ethoxy-4-methoxybenzene

P

2,5-di(tert-amyl)-1,4-hydroquinone
79-74-3

2,5-di(tert-amyl)-1,4-hydroquinone

Q

2,4-di-tert-amylphenol
120-95-6

2,4-di-tert-amylphenol

R

2,5-diethyl phenol
876-20-0

2,5-diethyl phenol

S

4-ethoxy-3-methoxytoluene
33963-27-8

4-ethoxy-3-methoxytoluene

T

1,2-dimethoxy-4-butylbenzene
59056-76-7

1,2-dimethoxy-4-butylbenzene

U

1,2-diethoxy-4-ethyl-benzene
131358-04-8

1,2-diethoxy-4-ethyl-benzene

V

3,5-di-t-butyl-4-hydroxybenzaldehyde
1620-98-0

3,5-di-t-butyl-4-hydroxybenzaldehyde

Conditions
ConditionsYield
With tungsten(VI) oxide at 300℃; for 6h; Reagent/catalyst; Autoclave;
ethanol
64-17-5

ethanol

benzene-1,2-diol
120-80-9

benzene-1,2-diol

A

3,5-Di-tert-butylcatechol
1020-31-1

3,5-Di-tert-butylcatechol

B

2,6-di-tert-butylphenol
128-39-2

2,6-di-tert-butylphenol

C

2,4-diisopropylphenol
2934-05-6

2,4-diisopropylphenol

D

2,6-diisopropylphenol
2078-54-8

2,6-diisopropylphenol

E

2,4,6-triisopropylphenol
2934-07-8

2,4,6-triisopropylphenol

F

2,6-di-tert-butyl-4-ethylphenol
4130-42-1

2,6-di-tert-butyl-4-ethylphenol

G

2,6-di-tert-butyl-4-hydroxyphenol
2444-28-2

2,6-di-tert-butyl-4-hydroxyphenol

H

2,6-di-tert-butyl-4-methoxymethylene-phenol
87-97-8

2,6-di-tert-butyl-4-methoxymethylene-phenol

I

3,5-Di-tert-butylphenol
1138-52-9

3,5-Di-tert-butylphenol

J

2,4-dimethyl-6-tert-butylphenol
1879-09-0

2,4-dimethyl-6-tert-butylphenol

K

2-(2',5'-dimethoxyphenyl)propionaldehyde
52417-48-8

2-(2',5'-dimethoxyphenyl)propionaldehyde

L

2,6-di-tert-butyl-4-sec-butylphenol
17540-75-9

2,6-di-tert-butyl-4-sec-butylphenol

M

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

N

1,4-dimethoxy-2-tert-butylbenzene
21112-37-8

1,4-dimethoxy-2-tert-butylbenzene

O

1-ethoxy-4-methoxybenzene
5076-72-2

1-ethoxy-4-methoxybenzene

P

2,5-di(tert-amyl)-1,4-hydroquinone
79-74-3

2,5-di(tert-amyl)-1,4-hydroquinone

Q

2,4-di-tert-amylphenol
120-95-6

2,4-di-tert-amylphenol

R

2,5-diethyl phenol
876-20-0

2,5-diethyl phenol

S

4-ethoxy-3-methoxytoluene
33963-27-8

4-ethoxy-3-methoxytoluene

T

1,2-dimethoxy-4-butylbenzene
59056-76-7

1,2-dimethoxy-4-butylbenzene

U

1,2-diethoxy-4-ethyl-benzene
131358-04-8

1,2-diethoxy-4-ethyl-benzene

V

3,5-di-t-butyl-4-hydroxybenzaldehyde
1620-98-0

3,5-di-t-butyl-4-hydroxybenzaldehyde

Conditions
ConditionsYield
With ortho-tungstic acid at 300℃; for 6h; Autoclave;
2-Ethoxyphenol
94-71-3

2-Ethoxyphenol

ethanol
64-17-5

ethanol

A

3,5-Di-tert-butylcatechol
1020-31-1

3,5-Di-tert-butylcatechol

B

2,6-di-tert-butylphenol
128-39-2

2,6-di-tert-butylphenol

C

2,4-diisopropylphenol
2934-05-6

2,4-diisopropylphenol

D

2,6-diisopropylphenol
2078-54-8

2,6-diisopropylphenol

E

2,4,6-triisopropylphenol
2934-07-8

2,4,6-triisopropylphenol

F

2,6-di-tert-butyl-4-ethylphenol
4130-42-1

2,6-di-tert-butyl-4-ethylphenol

G

2,6-di-tert-butyl-4-hydroxyphenol
2444-28-2

2,6-di-tert-butyl-4-hydroxyphenol

H

2,6-di-tert-butyl-4-methoxymethylene-phenol
87-97-8

2,6-di-tert-butyl-4-methoxymethylene-phenol

I

3,5-Di-tert-butylphenol
1138-52-9

3,5-Di-tert-butylphenol

J

2,4-dimethyl-6-tert-butylphenol
1879-09-0

2,4-dimethyl-6-tert-butylphenol

K

2-(2',5'-dimethoxyphenyl)propionaldehyde
52417-48-8

2-(2',5'-dimethoxyphenyl)propionaldehyde

L

2,6-di-tert-butyl-4-sec-butylphenol
17540-75-9

2,6-di-tert-butyl-4-sec-butylphenol

M

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

N

1,4-dimethoxy-2-tert-butylbenzene
21112-37-8

1,4-dimethoxy-2-tert-butylbenzene

O

1-ethoxy-4-methoxybenzene
5076-72-2

1-ethoxy-4-methoxybenzene

P

2,5-di(tert-amyl)-1,4-hydroquinone
79-74-3

2,5-di(tert-amyl)-1,4-hydroquinone

Q

2,4-di-tert-amylphenol
120-95-6

2,4-di-tert-amylphenol

R

2,5-diethyl phenol
876-20-0

2,5-diethyl phenol

S

4-ethoxy-3-methoxytoluene
33963-27-8

4-ethoxy-3-methoxytoluene

T

1,2-dimethoxy-4-butylbenzene
59056-76-7

1,2-dimethoxy-4-butylbenzene

U

1,2-diethoxy-4-ethyl-benzene
131358-04-8

1,2-diethoxy-4-ethyl-benzene

V

3,5-di-t-butyl-4-hydroxybenzaldehyde
1620-98-0

3,5-di-t-butyl-4-hydroxybenzaldehyde

Conditions
ConditionsYield
With ortho-tungstic acid at 300℃; for 6h; Autoclave;
ethene
74-85-1

ethene

benzene-1,2-diol
120-80-9

benzene-1,2-diol

A

2-Ethoxyphenol
94-71-3

2-Ethoxyphenol

B

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

Conditions
ConditionsYield
With zinc dibromide In tetralin at 240℃; under 7500.75 Torr; for 8h; Reagent/catalyst; Solvent; Temperature; Pressure; Autoclave; Green chemistry;A 11.2 g
B 0.26 g
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

1,2-diethoxy-4,5-dinitrobenzene
40294-27-7

1,2-diethoxy-4,5-dinitrobenzene

Conditions
ConditionsYield
With nitric acid at 80℃;95%
Multi-step reaction with 2 steps
1: (nitration)
2: NH4NO3, H2SO4 / acetic acid
View Scheme
With nitric acid
Octanoic acid
124-07-2

Octanoic acid

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

1-(3,4-diethoxy-phenyl)-octan-1-one

1-(3,4-diethoxy-phenyl)-octan-1-one

Conditions
ConditionsYield
With aluminium dodecatungsten phosphate; trifluoroacetic anhydride at 20℃; for 1.5h;94%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

acetyl chloride
75-36-5

acetyl chloride

1-(3,4-diethoxyphenyl)ethanone
1137-71-9

1-(3,4-diethoxyphenyl)ethanone

Conditions
ConditionsYield
With zinc(II) chloride In dichloromethane at 0 - 20℃; for 1h;93.8%
With hydrogenchloride; sodium carbonate; aluminium trichloride In dichloromethane80%
With aluminium trichloride; nitrobenzene at 0℃;
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

1,2-Dichloro-4,5-diethoxy-benzene
124391-50-0

1,2-Dichloro-4,5-diethoxy-benzene

Conditions
ConditionsYield
With benzyltrimethylazanium tetrachloro-λ3-iodanuide In acetic acid for 1h; Ambient temperature;93%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

potassium thioacyanate
333-20-0

potassium thioacyanate

3,4-diethoxybenzthioamide
60759-00-4

3,4-diethoxybenzthioamide

Conditions
ConditionsYield
With methanesulfonic acid at 30℃; for 4.3h;93%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

acetic anhydride
108-24-7

acetic anhydride

1-(3,4-diethoxyphenyl)ethanone
1137-71-9

1-(3,4-diethoxyphenyl)ethanone

Conditions
ConditionsYield
With aluminium dodecatungsten phosphate at 60 - 70℃; for 0.6h;93%
With HY zeolite (Si:Al 60) at 120℃; for 1h;91%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

acetic acid
64-19-7

acetic acid

1-(3,4-diethoxyphenyl)ethanone
1137-71-9

1-(3,4-diethoxyphenyl)ethanone

Conditions
ConditionsYield
With aluminium dodecatungsten phosphate; trifluoroacetic anhydride at 20℃; for 0.67h; Friedel-Crafts acylation;93%
With aluminium dodecatungsten phosphate; trifluoroacetic anhydride at 20℃; for 0.65h;93%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

1,2-diethoxy-4-nitrobenzene
4992-63-6

1,2-diethoxy-4-nitrobenzene

Conditions
ConditionsYield
With Montmorillonite KSF; nitric acid; hafnium oxychloride In tetrahydrofuran at 20℃; for 18h;92%
With Yb-Mo-modified montmorillonite HKSF; nitric acid In tetrahydrofuran at 20℃; for 12h;66%
With nitric acid; acetic acid
(nitration);
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

Ethyl oxalyl chloride
4755-77-5

Ethyl oxalyl chloride

ethyl 2-(3,4-diethoxyphenyl)-2-oxoacetate
53017-34-8

ethyl 2-(3,4-diethoxyphenyl)-2-oxoacetate

Conditions
ConditionsYield
Stage #1: Ethyl oxalyl chloride With aluminum (III) chloride In toluene at -10 - -5℃; for 0.25h;
Stage #2: 1,2-diethoxybenzene In toluene at 20℃; for 1h;
91.5%
With aluminium trichloride; nitrobenzene
With aluminum (III) chloride In dichloromethane at 5 - 20℃; for 2h; Friedel-Crafts Acylation; Inert atmosphere;
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

benzoic acid
65-85-0

benzoic acid

(4,5-diethoxy-phenyl)-phenyl-methanone
93652-02-9

(4,5-diethoxy-phenyl)-phenyl-methanone

Conditions
ConditionsYield
With aluminium dodecatungsten phosphate; trifluoroacetic anhydride at 20℃; for 3.5h; Friedel-Crafts acylation;91%
With aluminium dodecatungsten phosphate; trifluoroacetic anhydride at 20℃; for 3.5h;91%
phenylacetic acid
103-82-2

phenylacetic acid

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

3,4-diethoxy-deoxybenzoin
810661-50-8

3,4-diethoxy-deoxybenzoin

Conditions
ConditionsYield
With aluminium dodecatungsten phosphate; trifluoroacetic anhydride at 20℃; for 2.5h;91%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

4-bromo-1,2-diethoxybenzene
53207-08-2

4-bromo-1,2-diethoxybenzene

Conditions
ConditionsYield
With Oxone; ammonium bromide In acetonitrile at 20℃; for 4h;90%
With oxone; ammonium bromide In acetonitrile at 20℃; for 4h;90%
With bromine68%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

benzoyl chloride
98-88-4

benzoyl chloride

(4,5-diethoxy-phenyl)-phenyl-methanone
93652-02-9

(4,5-diethoxy-phenyl)-phenyl-methanone

Conditions
ConditionsYield
With aluminium dodecatungsten phosphate at 60 - 70℃; for 2h;90%
With aluminium trichloride In dichloromethane at 20℃; for 3h;87%
With aluminium trichloride In carbon disulfide
With aluminum (III) chloride In nitrobenzene for 12h; Friedel Crafts acylation; Reflux;
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

diphenyl diselenide
1666-13-3

diphenyl diselenide

1,2-diethoxy-4,5-bis(phenylseleno)benzene

1,2-diethoxy-4,5-bis(phenylseleno)benzene

Conditions
ConditionsYield
With dihydroxyphenylselenonium 4-methylphenyl sulfonate In methanol; dichloromethane at 20℃; for 72h;90%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

4-iodobenzoic acid chloride
1711-02-0

4-iodobenzoic acid chloride

(3,4-diethoxy-phenyl)-(4-iodo-phenyl)-methanone
313535-46-5

(3,4-diethoxy-phenyl)-(4-iodo-phenyl)-methanone

Conditions
ConditionsYield
With tin(IV) chloride In dichloromethane at 0 - 20℃; for 2h; Product distribution / selectivity; Heating / reflux;90%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

potassium selenocyanate
3425-46-5

potassium selenocyanate

C11H13NO2Se

C11H13NO2Se

Conditions
ConditionsYield
Stage #1: potassium selenocyanate With hydrogenchloride; sodium nitrite In water; acetonitrile for 0.333333h; Cooling with ice;
Stage #2: 1,2-diethoxybenzene In water; acetonitrile at 20℃; for 48h;
90%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

1,2,3,4-Tetrachloro-5,6-diethoxy-benzene
124391-51-1

1,2,3,4-Tetrachloro-5,6-diethoxy-benzene

Conditions
ConditionsYield
With benzyltrimethylazanium tetrachloro-λ3-iodanuide In acetic acid at 70℃; for 24h;87%
chloral hydrate
302-17-0

chloral hydrate

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

cis-2,3,6,7-tetraethoxy-9,10-bistrichloromethyl-9,10-dihydroanthracene

cis-2,3,6,7-tetraethoxy-9,10-bistrichloromethyl-9,10-dihydroanthracene

Conditions
ConditionsYield
With sulfuric acid In acetic acid at 0℃; for 24h;80%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

2,3,6,7,10,11-hexaethoxytriphenylene
32829-11-1

2,3,6,7,10,11-hexaethoxytriphenylene

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,2-dichloro-ethane at 20℃; for 10h; Scholl Reaction; Inert atmosphere;79%
With iron(III) chloride at 20℃; for 0.666667h; Neat (no solvent); Grinding;63.9%
With iron(III) chloride In dichloromethane at 20℃;36%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

3,4-diethoxybenzaldehyde
2029-94-9

3,4-diethoxybenzaldehyde

Conditions
ConditionsYield
With trichlorophosphate78%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

1,2-Dibromo-4,5-diethoxy-benzene
118132-02-8

1,2-Dibromo-4,5-diethoxy-benzene

Conditions
ConditionsYield
With bromine In tetrachloromethane at 0 - 20℃;76%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

cinnamoyl chloride
102-92-1

cinnamoyl chloride

(E)-1-(3,4-Diethoxy-phenyl)-3-phenyl-propenone
123769-52-8

(E)-1-(3,4-Diethoxy-phenyl)-3-phenyl-propenone

Conditions
ConditionsYield
With aluminium trichloride In dichloromethane at 20℃; for 3h;75%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

4-Methoxycarbonylbenzoyl chloride
7377-26-6

4-Methoxycarbonylbenzoyl chloride

4-(3,4-diethoxy-benzoyl)-benzoic acid methyl ester
1133428-79-1

4-(3,4-diethoxy-benzoyl)-benzoic acid methyl ester

Conditions
ConditionsYield
With tin(IV) chloride at 0℃; for 3.5h;73%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

ethyl 4-(3,4-diethoxyphenyl)-4-oxobutyrate

ethyl 4-(3,4-diethoxyphenyl)-4-oxobutyrate

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane Friedel Crafts acylation; Cooling with ice;69%
Stage #1: ethyl 3-(chloroformyl)propionate; 1,2-diethoxybenzene With aluminum (III) chloride In dichloromethane at 0℃; for 0.75h;
Stage #2: With hydrogenchloride; water In dichloromethane at 0℃;
3,3-Dimethylacryloyl chloride
3350-78-5

3,3-Dimethylacryloyl chloride

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

5,6-diethoxy-3,3-dimethylindan-1-one
97854-46-1

5,6-diethoxy-3,3-dimethylindan-1-one

Conditions
ConditionsYield
With methanesulfonic acid at 70℃; for 3h;64%
succinic acid anhydride
108-30-5

succinic acid anhydride

1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

4-oxo-4-(3,4-diethoxyphenyl)butyric acid
63213-42-3

4-oxo-4-(3,4-diethoxyphenyl)butyric acid

Conditions
ConditionsYield
With aluminium trichloride In dichloromethane at 20℃; for 3h;63%
With aluminium trichloride
Stage #1: succinic acid anhydride; 1,2-diethoxybenzene With aluminum (III) chloride In dichloromethane at 0℃; for 0.5h;
Stage #2: With hydrogenchloride; water In dichloromethane at 0℃; for 1h;
aluminium trichloride In dichloromethane
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

(S)-N-Phthaloylalanin-trifluormethansulfonsaeure-anhydrid

(S)-N-Phthaloylalanin-trifluormethansulfonsaeure-anhydrid

(S)-(3,4-Diethoxyphenyl)-(1-phthalimidoethyl)-keton
111114-07-9

(S)-(3,4-Diethoxyphenyl)-(1-phthalimidoethyl)-keton

Conditions
ConditionsYield
In 1,2-dichloro-ethane at -35℃; for 16h;62%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

cis-1,2,3,6-tetrahydrophthalic anhydride
935-79-5

cis-1,2,3,6-tetrahydrophthalic anhydride

(+/-)-cis-6-(3,4-diethoxybenzoyl)cyclohex-3-enecarboxylic acid

(+/-)-cis-6-(3,4-diethoxybenzoyl)cyclohex-3-enecarboxylic acid

Conditions
ConditionsYield
With aluminium trichloride In dichloromethane for 4h; Friedel-Crafts acylation; Heating;59%
1,2-diethoxybenzene
2050-46-6

1,2-diethoxybenzene

2,3,8,9-tetraethoxydibenzo(c,g)-1,2,5,6-tetrathiocine

2,3,8,9-tetraethoxydibenzo(c,g)-1,2,5,6-tetrathiocine

Conditions
ConditionsYield
With disulfur dichloride; acetic acid at 20℃; for 60h; Inert atmosphere; Schlenk technique; Glovebox;53%
With disulfur dichloride In acetic acid for 18h;16%

1,2-Diethoxybenzene Chemical Properties

Molecular Formula: C10H14O2
Molar mass: 166.22 g/mol
EINECS: 218-089-1
Density: 0.975 g/cm3
Flash Point: 73.8 °C
Melting point: 43-45 °C
Index of Refraction: 1.485
Boiling Point: 218.7 °C at 760 mmHg
Vapour Pressure: 0.183 mmHg at 25°C
Appearance: Light brown crystalline low melting mass or liquid
Product categories: Aromatic ethers
Structure of 1,2-Diethoxybenzene (2050-46-6):
             
XLogP3-AA: 2.4
H-Bond Donor: 0
H-Bond Acceptor: 2
IUPAC Name: 1,2-Diethoxybenzene
Canonical SMILES: CCOC1=CC=CC=C1OCC
InChI: InChI=1S/C10H14O2/c1-3-11-9-7-5-6-8-10(9)12-4-2/h5-8H,3-4H2,1-2H3 
InChIKey: QZYDOKBVZJLQCK-UHFFFAOYSA-N

1,2-Diethoxybenzene Production

Its preparation method is: adding catechol, 25% sodium hydroxide solution, chloroethane and solvent into autoclave, and then heating to 90 ℃ and then keep 5h, and then have de-solvent, filtering to get the product: 1,2-Diethoxybenzene (2050-46-6).Etherification agent can also be replaced with Dimethyl sulfate , O-p-toluenesulfonate ester , Ethyl iodide , Ethyl bromide and so on, but using of chloroethane as etherification agent, it is better fpr raw materials readily available, inexpensive, low cost, high yield characteristics.

1,2-Diethoxybenzene Toxicity Data With Reference

1.    

eye-rbt 100 mg MLD

    FCTOD7    Food and Chemical Toxicology. 20 (1982),573.
2.    

eye-rbt 100 mg/30S RNS MLD

    FCTOD7    Food and Chemical Toxicology. 20 (1982),573.

Carcinogenicity of 1,2-Diethoxybenzene (2050-46-6) hasn't been listed as a carcinogen by NTP, IARC,ACGIH, or CA Prop 65. And its toxicological properties have not been fully investigated.

1,2-Diethoxybenzene Consensus Reports

Reported in EPA TSCA Inventory.

1,2-Diethoxybenzene Safety Profile

An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

1,2-Diethoxybenzene Specification

 1,2-Diethoxybenzene (2050-46-6) also can be called o-Diethoxy benzene ; Benzene, 1,2-diethoxy- ; Benzene, o-diethoxy- ; Catechol diethyl ether .And it is used as raw materials for pharmaceutical and pesticide.
 1,2-Diethoxybenzene (2050-46-6) is hazardous,so the first aid measures and others should be known.Such as: When on the skin: first,should  flush skin with plenty of water immediatelyfor at least 15 minutes while removing contaminated clothing. Secondly,Get shoesmedical aid . Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.Then get medical aid soon.While ,it's Inhaled: Remove from exposure and move to fresh air immediately.Then you have the ingesting of the product : Wash mouth out with water,and get medical aid immediately.
In addition, 1,2-Diethoxybenzene (2050-46-6) is moisture sensitive. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials.And also prevent it to broken down into hazardous decomposition products: carbon dioxide,carbon monoxide.

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View