1,3-Diphenylacetone supplier

Name
1,3-Diphenylacetone
EINECS 203-000-0
CAS No. 102-04-5
Article Data214
CAS DataBase
Density 1.069 g/cm³
Solubility Slightly soluble in water.
Melting Point 32-34 °C(lit.)
Formula C₁₅H₁₄O
Boiling Point 331 °C at 760 mmHg
Molecular Weight 210.276
Flash Point 149.4 °C
Transport Information
Appearance light yellow solid
Safety 24/25-22
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 1,3-Diphenyl-2-propanone;2-Propanone,1,3-diphenyl-;1,3-Diphenylpropanone;Benzyl ketone;Dibenzyl ketone;NSC220312;NSC 407392;NSC 4577;a,a'-Diphenylacetone;
PSA 17.07000
LogP 3.04090

Synthetic route

: 76312-47-5
2,2-bis(benzyl)-1,3-dithiolane

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With trichloroisocyanuric acid; silver nitrate In water; acetonitrile Ambient temperature;	99%
With (CH3)3CI; dimethyl sulfoxide for 12h;	95%
With trimethylsilyl iodide; dimethyl sulfoxide In tetrachloromethane at 75 - 80℃; for 6h;	85%
With hydrogenchloride; dihydrogen peroxide In methanol Ambient temperature;	81%

: C27H24S2

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile at 20 - 25℃; for 2h; Irradiation;	98%

: 4362-53-2
1,3-diphenyl-2-propanone ethylene acetal

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With chloral hydrate In hexane at 25℃; for 5h; Inert atmosphere;	98%

: 1788-30-3
phenylhydrazone of dibenzyl ketone

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With copper(II) sulfate In tetrahydrofuran; methanol; water for 4h; Heating;	95%

: 19689-93-1
1,3-Diphenylpropanone oxime O-acetate

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
Stage #1: 1,3-Diphenylpropanone oxime O-acetate With dicobalt octacarbonyl; triethylamine In diethyl ether at 20℃; for 0.25h; deoximation; Stage #2: With water In methanol at 20℃; for 0.5h; Hydrolysis;	93%
With diiron nonacarbonyl In methanol at 60℃; for 1h; Product distribution; Fe(CO)5, UV irradiation;	82%

: 101587-37-5
1,3-diphenylacetone N,N-dimethylhydrazone

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With dihydrogen peroxide; methyltrioxorhenium(VII) In acetic acid; acetonitrile at 0 - 20℃; Product distribution; oxidative cleavage;	93%
With porcin pancreatic lipase In water; acetone at 20℃; for 96h; Hydrolysis;	94 % Chromat.

: 85855-49-8
1,3-diphenyl-1-phenylsulfanylpropan-2-one

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With zinc In acetic acid	92%

: 462-06-6
fluorobenzene

: 67-64-1
acetone

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With n-butyllithium at -78℃; for 8h;	92%

: 1788-31-4
1,3-diphenylpropan-2-one oxime

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With copper(II) sulfate In tetrahydrofuran; methanol; water for 19h; Heating;	90%
With iron pentacarbonyl In methanol for 48h; Product distribution; Irradiation; Fe2(CO)9, 60 deg C;	81%
With water; oxygen In acetonitrile at 60℃; under 760.051 Torr; for 6h; Autoclave; Green chemistry;	32%
With bismuth(lll) trifluoromethanesulfonate; bismuth(III) bromide In water; acetone; acetonitrile for 4h; Heating;
Multi-step reaction with 2 steps 1: acetic acid; chlorine 2: NaN3; aqueous acetic acid; CO2 View Scheme

: 100-39-0
benzyl bromide

: 103-80-0
phenylacetyl chloride

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel(0); 4,4'-di-tert-butyl-2,2'-bipyridine; magnesium chloride; zinc In acetonitrile at 25℃; for 12h; Inert atmosphere;	90%
With bis(1,5-cyclooctadiene)nickel(0); 4,4'-di-tert-butyl-2,2'-bipyridine; magnesium chloride; zinc In acetonitrile at 25℃; for 12h; Schlenk technique; Inert atmosphere;	90%
With tetrabutylammonium tetrafluoroborate; (2,2'-bipyridine)nickel(II) dibromide In acetonitrile Ambient temperature; zinc rod as the anode, vitreous carbon gauze as the cathode, 0.1 A;	80%
With [2,2]bipyridinyl; tetrabutylammonium tetrafluoroborate; tris(2,2'-bipyridine)nickel(II) tetrafluoroborate In acetonitrile at 25℃; Product distribution; Kinetics; Electrochemical reaction;
With bis(1,5-cyclooctadiene)nickel(0); magnesium chloride; zinc In acetonitrile at 20℃; for 12h; Inert atmosphere;	41 mmol

: 100-44-7
benzyl chloride

Fe(CO)5: Fe(CO)5

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With (2,2'-bipyridine)nickel(II) dibromide; tetrabutylammonium tetrafluoroborate In N,N-dimethyl-formamide Ambient temperature; electrolysis;	90%

: 100-39-0
benzyl bromide

K2, K2: K2, K2

A: 140-29-4
phenylacetonitrile

B: 103-29-7
1,1'-(1,2-ethanediyl)bisbenzene

C: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
add of carbon monoxide;	A 1% B 6% C 89%

...Expand

: 541-41-3
chloroformic acid ethyl ester

: 100-44-7
benzyl chloride

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With [2,2]bipyridinyl; chloro-trimethyl-silane; nickel(II) bromide 2-methoxyethyl ether complex; zinc In tetrahydrofuran; N,N-dimethyl acetamide at 40℃; for 2h; Sealed tube; Inert atmosphere;	86%

: 5381-92-0
1,3-diphenylpropan-2-ol

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With silica gel; cobalt(II) nitrate for 0.283333h; microwave irradiation;	85%
With pyridiniumchlorochromate on aluminumoxide at 20℃; for 20h;	84%
With boron trifluoride diethyl etherate; tetrabutylammonium periodite In acetonitrile for 4h; Heating;	60%
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethylsulfoxide-d6 at 23℃; primary kinetic isotope effect by its α-deuterio analog;

: 101-41-7
benzeneacetic acid methyl ester

: (phenylmethylene)bis(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolane)

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With lithium tert-butoxide In tetrahydrofuran at 23℃; for 3h; Glovebox;	81%

: 103-80-0
phenylacetyl chloride

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
In acetonitrile Ambient temperature; Bu4NBF4, nickel rod anode, nickel foam catode, 1.5 A/dm2;	80%
With diethyl ether; triethylamine
Multi-step reaction with 4 steps 1: 98 percent / diethyl ether 2: 93 percent / diethyl ether 3: 89 percent / SnCl4 / Ambient temperature 4: 92 percent / Zn / acetic acid View Scheme
Multi-step reaction with 2 steps 1: dmap / dichloromethane / 96 h / Cooling with ice 2: 3,6-dimethyl-1,2,4,5-tetrazine / chloroform / 1 h / 20 °C View Scheme

: 95110-67-1
2,3-epoxy-1,3-diphenyl-2-phenylsulfinylpropane

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With sodium phenylselenide In ethanol for 3h; Ambient temperature;	80%
With sodium phenylselenide In ethanol for 3h; Ambient temperature;	80%

: 201230-82-2
carbon monoxide

: 100-44-7
benzyl chloride

A: 103-29-7
1,1'-(1,2-ethanediyl)bisbenzene

B: 108-88-3
toluene

C: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With [2,2]bipyridinyl; tetrabutylammonium tetrafluoroborate; iron(II) chloride; Fe64/Ni36 anode In N,N-dimethyl-formamide Ambient temperature; electrolysis;	A 10 % Chromat. B n/a C 80%
With [2,2]bipyridinyl; tetrabutylammonium tetrafluoroborate; iron(II) chloride; Fe64/Ni36 anode In N,N-dimethyl-formamide Product distribution; Mechanism; Ambient temperature; electrolysis, var. of electrode material, ligand, halogen, other aryl and alkyl halogenides;	A 10 % Chromat. B n/a C 90 % Chromat.

...Expand

: 40939-52-4
2.2-Dibenzyl-1.3-dithian

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With antimonypentachloride In dichloromethane at 0℃; for 0.166667h;	78%
With 2,4,6-triphenylpyrilium perchlorate; oxygen In acetonitrile for 5h; Irradiation;	31%

: 71916-06-8
3,3,6,6-tetrabenzyl-1,2,4,5-tetraoxan

A: 103-82-2
phenylacetic acid

B: 102-16-9
benzyl 2-phenylacetate

C: 103-29-7
1,1'-(1,2-ethanediyl)bisbenzene

D: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
In benzene at 150℃; for 72h; Product distribution; Mechanism; thermolysis; var. temp., time and solvent;	A n/a B 12% C 77% D 2%

...Expand

: 201230-82-2
carbon monoxide

: [FeBn2(1-mesityl-3-(pyridin-2-ylmethyl)imidazol-1-ylidene)]

: [Fe(CO)3(1-mesityl-3-(pyridin-2-ylmethyl)imidazol-1-ylidene)]

B: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
In toluene at 20℃; under 760.051 Torr; Inert atmosphere; Schlenk technique;	A 72% B 76%

...Expand

: 201230-82-2
carbon monoxide

: 100-39-0
benzyl bromide

A: 103-82-2
phenylacetic acid

B: 102-16-9
benzyl 2-phenylacetate

C: 103-29-7
1,1'-(1,2-ethanediyl)bisbenzene

D: 108-88-3
toluene

E: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
iron pentacarbonyl; tetrabutylammonium sulfate In sodium hydroxide; benzene at 20℃; under 760 Torr; for 15h; Product distribution; variation of solvent, temperature, catalyst, pressure, reaction time and ratio of catalyst and substrate, examinations with further benzyl halides;	A 75% B 3% C 6% D 2% E 14%

...Expand

: 100-39-0
benzyl bromide

K2, K2: K2, K2

A: 103-29-7
1,1'-(1,2-ethanediyl)bisbenzene

B: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
add of carbon monoxide;	A 9% B 75%

...Expand

: 110-91-8
morpholine

: 40814-69-5
3,3-bis(phenylmethyl)-1,2-dioxetane

A: 141248-85-3
N-<(2-benzyl-2-hydroxy-3-phenylpropyl)oxy>morpholine

B: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
In dichloromethane for 15h;	A 74% B 12%

...Expand

: 101-97-3
Ethyl 2-phenylethanoate

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With lithium; 4,4'-di-tert-butylbiphenyl In tetrahydrofuran for 60h; Ambient temperature; Irradiation; ultrasonic irradiation;	73%

: 100-39-0
benzyl bromide

Fe(CO)5: Fe(CO)5

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With (2,2'-bipyridine)nickel(II) dibromide; tetrabutylammonium tetrafluoroborate In N,N-dimethyl-formamide Ambient temperature; electrolysis;	70%

: 108-88-3
toluene

: 103-80-0
phenylacetyl chloride

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate; nickel(II) chloride hexahydrate; 4-acetoxybenzophenone; 4,4'-di-tert-butyl-2,2'-bipyridine at 35℃; for 48h; Inert atmosphere; Sealed tube; Irradiation; Schlenk technique;	70%

: 201230-82-2
carbon monoxide

: 100-39-0
benzyl bromide

A: 103-82-2
phenylacetic acid

B: 102-16-9
benzyl 2-phenylacetate

C: 103-29-7
1,1'-(1,2-ethanediyl)bisbenzene

D: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
iron pentacarbonyl; tetrabutylammonium sulfate In sodium hydroxide; dichloromethane at 20℃; under 760 Torr; for 20h;	A 69% B 7% C 3% D 20%
iron pentacarbonyl; tetrabutylammonium sulfate In sodium hydroxide; dichloromethane at 25℃; under 45600 Torr; for 27h;	A 66% B 8% C 4% D 11%

...Expand

: 108-90-7
chlorobenzene

: 67-64-1
acetone

: 102-04-5
1,3-Diphenylpropanone

Conditions

Conditions	Yield
With C41H50ClN3Pd; sodium t-butanolate In 1,4-dioxane at 100℃; for 4h; Reagent/catalyst;	69%

: 102-04-5
1,3-Diphenylpropanone

: 5381-92-0
1,3-diphenylpropan-2-ol

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol; water	100%
With sodium tetrahydroborate In methanol at 0℃; for 0.25h; Inert atmosphere;	100%
With C26H33ClN5Ru(1+)*BF4(1-); potassium tert-butylate In isopropyl alcohol for 4h; Inert atmosphere; High pressure; Reflux;	100%

: 102-04-5
1,3-Diphenylpropanone

: 1788-31-4
1,3-diphenylpropan-2-one oxime

Conditions

Conditions	Yield
With acetic acid; acetone oxime at 135℃; for 1.5h;	100%
With hydroxylamine hydrochloride; glycine In N,N-dimethyl-formamide at 25℃; for 6h;	98%
With hydroxylamine hydrochloride; sodium acetate In ethanol; water Reflux;	96%

: 540-63-6
ethane-1,2-dithiol

: 102-04-5
1,3-Diphenylpropanone

: 76312-47-5
2,2-bis(benzyl)-1,3-dithiolane

Conditions

Conditions	Yield
Nafion-H In benzene Heating;	100%
With silica gel; zirconium(IV) chloride In dichloromethane for 0.5h; Ambient temperature;	99%
With silica gel; iron(III) chloride In dichloromethane Ambient temperature;	98%

: 100-63-0
phenylhydrazine

: 102-04-5
1,3-Diphenylpropanone

: 4679-91-8
2-benzyl-3-phenyl-1H-indole

Conditions

Conditions	Yield
With trichloroacetic acid at 100℃; for 0.0833333h; Fischer indole synthesis;	100%
With phosphorus trichloride In benzene	80%
With Amberlite IR 120 In ethanol at 80℃; for 12h; Fischer Indole Synthesis;	80%
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate at 110℃; for 0.25h; Fischer indole synthesis; Microwave irradiation; Sealed vessel;	77%

: 5927-18-4
trimethyl phosphonoacetate

: 102-04-5
1,3-Diphenylpropanone

: 157731-51-6
4-Phenyl-3-(phenylmethyl)-2-butenoic acid methyl ester

Conditions

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium In diethyl ether; hexane 1.) -20 deg C, 20 min, 2.) r.t., 50 h;	100%

: 1068-57-1
acetic acid hydrazide

: 102-04-5
1,3-Diphenylpropanone

: Acetic acid (1-benzyl-2-phenyl-ethylidene)-hydrazide

Conditions

Conditions	Yield
With acetic acid In methanol Heating;	100%

: 637-60-5
p-tolylhydrazine hydrochloride

: 102-04-5
1,3-Diphenylpropanone

: 2-benzyl-5-methyl-3-phenyl-1H-indole

Conditions

Conditions	Yield
at 250℃; for 0.0166667h; Fischer indole synthesis;	100%

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 102-04-5
1,3-Diphenylpropanone

: 2-((1,3-diphenylpropan-2-yl)oxy)pinacolborane

Conditions

Conditions	Yield
With La(Cp)3 In tetrahydrofuran at 20℃; for 2h; Reagent/catalyst; Inert atmosphere;	100%
With [RhCl2(p-cymene)]2 In neat liquid at 60℃; for 15h; Inert atmosphere; Glovebox; chemoselective reaction;
With C23H33MnN3Si2 In diethyl ether at 25℃; for 16h; Glovebox; Inert atmosphere; chemoselective reaction;

: 109-77-3
malononitrile

: 102-04-5
1,3-Diphenylpropanone

: 10394-97-5
2-(1,3-diphenylpropan-2-ylidene)malononitrile

Conditions

Conditions	Yield
With ammonium acetate; acetic acid In benzene at 120℃; Knoevenagel Condensation; Dean-Stark;	99%
With ammonium acetate In acetic acid; benzene for 48h; Heating;	65%

: 4440-01-1
lithium phenylacetylide

: 102-04-5
1,3-Diphenylpropanone

: 1,3-Diphenyl-2-(phenylethynyl)-2-propanol

Conditions

Conditions	Yield
With lithium perchlorate In diethyl ether at 20℃; for 0.25h;	99%

: 7677-24-9
trimethylsilyl cyanide

: 102-04-5
1,3-Diphenylpropanone

: 2-benzyl-3-phenyl-2-((trimethylsilyl)oxy)propanenitrile

Conditions

Conditions	Yield
With C29H46LaN3Si2 at 15℃; for 4h; Inert atmosphere; Glovebox; Schlenk technique;	99%
With tris(2,4,6-trimethoxyphenyl)phosphine In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;	98%
With L-proline potassium salt at 20℃; for 24h;	92%
With iodine In dichloromethane at 0℃; for 0.5h;
With boron trifluoride diethyl etherate In dichloromethane at 20℃; for 0.5h;

: m-bis(p'-thiophenoxyphenylglyoxylyl)benzene

: 102-04-5
1,3-Diphenylpropanone

: 2,5-diphenyl-4-p-thiophenoxyphenylcyclopentadienone

Conditions

Conditions	Yield
With potassium hydroxide In ethanol	98.8%

: 3457-48-5
1,2-di(4-methylphenyl)-1,2-ethanedione

: 102-04-5
1,3-Diphenylpropanone

: 38305-61-2
2,5-diphenyl-3,4-di(p-tolyl)cyclopenta-2,4-dien-1-one

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at -78℃; for 0.5h;	98%
With potassium hydroxide In ethanol for 0.25h; Heating;	90%
With sodium hydroxide In methanol for 2h; Aldol condensation; Reflux;	86%

: 102-04-5
1,3-Diphenylpropanone

: 24767-69-9
benzyl α-chlorobenzyl ketone

Conditions

Conditions	Yield
With chloro-trimethyl-silane; tetrabutylammomium bromide; dimethyl sulfoxide In acetonitrile for 1h;	98%
With [bis(acetoxy)iodo]benzene; iron(III) chloride hexahydrate In acetic acid at 20℃; for 12h; Inert atmosphere;	82%
With tetrachloromethane; sulfuryl dichloride at 40℃; anschliessend Erhitzen auf Siedetemperatur;
With sulfuryl dichloride In tetrachloromethane

: 693-03-8
n-butyl magnesium bromide

: 102-04-5
1,3-Diphenylpropanone

: 84735-51-3
1-phenyl-2-(phenylmethyl)-2-hexanol

Conditions

Conditions	Yield
With cerium(III) chloride In tetrahydrofuran at 0℃; for 0.5h;	98%
With cerium(III) chloride In tetrahydrofuran at 0℃; for 1h;	93%
With cerium(III) chloride In tetrahydrofuran 1.) 0 deg C, 2 h, 2.) 0 deg C, 0.5 h;	82%
In tetrahydrofuran 1.) -78 deg C, 3 h 2.) 0 deg C, 1 h;	20%

: 109-72-8, 29786-93-4
n-butyllithium

: 102-04-5
1,3-Diphenylpropanone

: 84735-51-3
1-phenyl-2-(phenylmethyl)-2-hexanol

Conditions

Conditions	Yield
With cerium(III) triiodide In tetrahydrofuran at -65℃; for 3h; Product distribution; various lanthanoid chlorides;	98%
With cerium(III) triiodide In tetrahydrofuran at -65℃;	98%
With cerium(III) triiodide In tetrahydrofuran; hexane at -65℃; for 3h;	98%
With cerium(III) chloride at -78℃; for 3h; Product distribution; other organometallics;	96%
With cerium(III) chloride In tetrahydrofuran at -78℃; for 1.5h;	96%

: 115348-16-8
Methyllanthanum triflate

: 102-04-5
1,3-Diphenylpropanone

: 42117-23-7
2-methyl-1,3-diphenylpropan-2-ol

Conditions

Conditions	Yield
In tetrahydrofuran at -78℃; for 0.166667h; Product distribution; Mechanism; other carbonyl compounds, other times;	98%

: 4,4'-bis[(3,5-dibromophenyl)glyoxalylphenoxy]benzil

: 102-04-5
1,3-Diphenylpropanone

: 3,3'-(1,3-phenylene)-4,4'-bis[4-phenylethynylphenyl]-2,5-diphenylcyclopentadienone

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydroxide In methanol; isopropyl alcohol; toluene at 80℃; Inert atmosphere;	97.7%

: 107-21-1
ethylene glycol

: 102-04-5
1,3-Diphenylpropanone

: 4362-53-2
1,3-diphenyl-2-propanone ethylene acetal

Conditions

Conditions	Yield
With diphenylamine-terephthalaldehyde resin p-toluenesulfonate with high sulfo group content In toluene for 6h; Dean-Stark; Reflux;	97%
With zeolite HSZ-360 In toluene for 5h; Heating;	95%
With Ti(4+)-exchanged montmorillonite In toluene for 3h; Heating;	94%

: 756-79-6
dimethyl methane phosphonate

: 102-04-5
1,3-Diphenylpropanone

: 88708-58-1
dimethyl (2-benzyl-2-hydroxy-3-phenyl)propylphosphonate

Conditions

Conditions	Yield
Stage #1: dimethyl methane phosphonate With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Metallation; Stage #2: 1,3-Diphenylpropanone In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Addition;	97%

: 1068-55-9
isopropylmagnesium chloride

: 102-04-5
1,3-Diphenylpropanone

: 75245-67-9
2-Benzyl-3-methyl-1-phenyl-2-butanol

Conditions

Conditions	Yield
With neodymium(III) chloride; lithium chloride In tetrahydrofuran at 0℃;	97%
Stage #1: 1,3-Diphenylpropanone With lanthanium (III) chloride bis(lithium chloride) complex In tetrahydrofuran Inert atmosphere; Stage #2: isopropylmagnesium chloride In tetrahydrofuran at 0 - 25℃; Inert atmosphere;	86%

: 67-56-1
methanol

: 102-04-5
1,3-Diphenylpropanone

: 193829-29-7
1,3-diphenylacetone dimethyl acetal

Conditions

Conditions	Yield
With trimethyl orthoformate at 20℃; for 2h;	97%

: 100-59-4
phenylmagnesium chloride

: 102-04-5
1,3-Diphenylpropanone

: 5472-27-5
1,2,3-triphenyl-propan-2-ol

Conditions

Conditions	Yield
Stage #1: 1,3-Diphenylpropanone With lanthanium (III) chloride bis(lithium chloride) complex In tetrahydrofuran Inert atmosphere; Stage #2: phenylmagnesium chloride In tetrahydrofuran at 0 - 25℃; Inert atmosphere;	97%

: 82-86-0
acenaphthene quinone

: 102-04-5
1,3-Diphenylpropanone

: 641-57-6
acecyclone

Conditions

Conditions	Yield
With potassium hydroxide In ethanol; toluene at 78℃; for 1.25h;	96%
With potassium hydroxide In ethanol Reflux;	95%
With potassium hydroxide In ethanol; toluene for 0.0833333h; Heating;	94%

: 50-00-0
formaldehyd

: 102-04-5
1,3-Diphenylpropanone

: 92527-70-3
2-Benzyl-3-phenyl-1,2-propanediol

Conditions

Conditions	Yield
With Vanadium (III) chloride-(tris-tetrahydrofuran); zinc In dichloromethane for 12h;	96%

: 94616-73-6
n-butylcerium dichloride

: 102-04-5
1,3-Diphenylpropanone

: 84735-51-3
1-phenyl-2-(phenylmethyl)-2-hexanol

Conditions

Conditions	Yield
In tetrahydrofuran at -78℃; for 3h;	96%

: 1449-46-3
benzyltriphenylphosphonium bromide

: 102-04-5
1,3-Diphenylpropanone

: 50485-27-3
2-benzyl-1,3-diphenyl-1-propene

Conditions

Conditions	Yield
With sodium hydride In benzene 1.) reflux, 2 h, 2.) reflux, 120 h;	96%

1,3-Diphenylacetone Chemical Properties

Molecule structure of 1,3-Diphenylacetone (CAS NO.102-04-5):

IUPAC Name: 1,3-Diphenylpropan-2-one
Molecular Weight: 210.27106 g/mol
Molecular Formula: C₁₅H₁₄O
Density: 1.069 g/cm³
Melting Point: 32-34 °C(lit.)
Boiling Point: 331 °C at 760 mmHg
Flash Point: 149.4 °C
Index of Refraction: 1.574
Molar Refractivity: 64.95 cm³
Molar Volume: 196.5 cm³
Surface Tension: 42.1 dyne/cm
Enthalpy of Vaporization: 57.36 kJ/mol
Vapour Pressure: 0.00016 mmHg at 25 °C
Storage Temp.: 2-8 °C
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
XLogP3-AA: 3.1
H-Bond Acceptor: 1
Rotatable Bond Count: 4
Tautomer Count: 2
Exact Mass: 210.104465
MonoIsotopic Mass: 210.104465
Topological Polar Surface Area: 17.1
Heavy Atom Count: 16
Canonical SMILES: C1=CC=C(C=C1)CC(=O)CC2=CC=CC=C2
InChI: InChI=1S/C15H14O/c16-15(11-13-7-3-1-4-8-13)12-14-9-5-2-6-10-14/h1-10H,11-12H2
InChIKey: YFKBXYGUSOXJGS-UHFFFAOYSA-N
EINECS: 203-000-0
Product Categories: Aromatic Ketones (substituted)

1,3-Diphenylacetone Uses

1,3-Diphenylacetone (CAS NO.102-04-5) is frequently used in an aldol condensation reaction with benzil (a dicarbonyl) and base to create tetraphenylcyclopentadienone.

1,3-Diphenylacetone Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	oral	> 2gm/kg (2000mg/kg)	BEHAVIORAL: ATAXIA	National Technical Information Service. Vol. OTS0559576,

1,3-Diphenylacetone Safety Profile

Safety Statements: 24/25-22
S24/25:Avoid contact with skin and eyes.
S22:Do not breathe dust.
WGK Germany: 3
RTECS: EC2030000

1,3-Diphenylacetone Specification

1,3-Diphenylacetone (CAS NO.102-04-5) is also named as 1,3-Diphenyl-2-propanone ; 1,3-Diphenylpropanone ; 2-Propanone, 1,3-diphenyl- ; AI3-05001 ; Benzyl ketone ; Dibenzyl ketone ; FEMA No. 2397 ; NSC 220312 ; alpha,alpha'-Diphenylacetone . 1,3-Diphenylacetone (CAS NO.102-04-5) is light yellow solid.

Product Name

1,3-Diphenylacetone

Synthetic route

1,3-Diphenylacetone Chemical Properties

1,3-Diphenylacetone Uses

1,3-Diphenylacetone Toxicity Data With Reference

1,3-Diphenylacetone Safety Profile

1,3-Diphenylacetone Specification

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