1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid supplier

Name
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
EINECS 214-439-2
CAS No. 112811-72-0
Article Data12
CAS DataBase
Density 1.174 g/cm³
Solubility
Melting Point 192-194 ºC
Formula C₁₄H₁₁F₂NO₄
Boiling Point 245.2 ºC at 760 mmHg
Molecular Weight 295.242
Flash Point 102.1 ºC
Transport Information
Appearance off-white to light-yellow powder
Safety 24/25
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms 1-Cyclopropyl-1,4-dihydro-6,7-difluoro-8-methoxy-4-oxoquinoline-3-carboxylicacid;1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylicacid;1-Cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylicacid;1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid;1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinolin-3-carboxylicacid;1-Cyclopropyl-6,7-difluoro-8-methoxy-4-quinolone-3-carboxylic acid;3-Quinolinecarboxylicacid, 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-;
PSA 68.53000
LogP 2.32140

Synthetic route

: 112811-71-9
ethyl 8-methoxy-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water at 65℃; for 15h; Solvent; Temperature;	96.83%
With sulfuric acid; acetic acid In water for 2h; Reflux;	95.92%
With hydrogenchloride for 3h; Heating;	90%

: 154093-72-8
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinoline carboxylic acid

: 77-78-1
dimethyl sulfate

A: 141290-02-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid methyl ester

B: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
With potassium chloride In acetone Product distribution / selectivity; Heating / reflux;

...Expand

: 141290-02-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid methyl ester

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
With water; potassium carbonate for 0.5h; Product distribution / selectivity; Heating / reflux;

: 112811-70-8
ethyl 3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
With sodium fluoride In N,N-dimethyl-formamide
Multi-step reaction with 2 steps 1: sodiumfluoride / N,N-dimethyl-formamide / 5 h 2: sulfuric acid; water / acetic acid / 1 h View Scheme

: 112811-64-0
2,4,5-trifluoro-3-methoxy-benzamide

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1: sulfuric acid / 3.5 h / 100 °C 2: thionyl chloride / 3 h 3: magnesium ethylate / toluene 4: toluene-4-sulfonic acid / water / 9 h 5: acetic anhydride / 11 h 6: ethanol / 2 h / 20 °C 7: sodiumfluoride / N,N-dimethyl-formamide / 5 h 8: sulfuric acid; water / acetic acid / 1 h View Scheme

: 112811-63-9
3-methoxy-2,4,5-trifluorobenzonitrile

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1: sulfuric acid; water / 1 h / 110 °C 2: sulfuric acid / 3.5 h / 100 °C 3: thionyl chloride / 3 h 4: magnesium ethylate / toluene 5: toluene-4-sulfonic acid / water / 9 h 6: acetic anhydride / 11 h 7: ethanol / 2 h / 20 °C 8: sodiumfluoride / N,N-dimethyl-formamide / 5 h 9: sulfuric acid; water / acetic acid / 1 h View Scheme

: 112811-67-3
diethyl 3-methoxy-2,4,5-trifluorobenzoylmalonate

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: toluene-4-sulfonic acid / water / 9 h 2: acetic anhydride / 11 h 3: ethanol / 2 h / 20 °C 4: sodiumfluoride / N,N-dimethyl-formamide / 5 h 5: sulfuric acid; water / acetic acid / 1 h View Scheme

: 13332-24-6
1-bromo-2,4,5-trifluoro-3-methoxybenzene

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 10 steps 1: 1-methyl-pyrrolidin-2-one / 4.5 h / 140 - 150 °C 2: sulfuric acid; water / 1 h / 110 °C 3: sulfuric acid / 3.5 h / 100 °C 4: thionyl chloride / 3 h 5: magnesium ethylate / toluene 6: toluene-4-sulfonic acid / water / 9 h 7: acetic anhydride / 11 h 8: ethanol / 2 h / 20 °C 9: sodiumfluoride / N,N-dimethyl-formamide / 5 h 10: sulfuric acid; water / acetic acid / 1 h View Scheme

Yield

Multi-step reaction with 10 steps
1: 1-methyl-pyrrolidin-2-one / 4.5 h / 140 - 150 °C
2: sulfuric acid; water / 1 h / 110 °C
3: sulfuric acid / 3.5 h / 100 °C
4: thionyl chloride / 3 h
5: magnesium ethylate / toluene
6: toluene-4-sulfonic acid / water / 9 h
7: acetic anhydride / 11 h
8: ethanol / 2 h / 20 °C
9: sodiumfluoride / N,N-dimethyl-formamide / 5 h
10: sulfuric acid; water / acetic acid / 1 h
View Scheme

: 112811-65-1
3-methoxy-2,4,5-trifluorobenzoic acid

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: thionyl chloride / 3 h 2: magnesium ethylate / toluene 3: toluene-4-sulfonic acid / water / 9 h 4: acetic anhydride / 11 h 5: ethanol / 2 h / 20 °C 6: sodiumfluoride / N,N-dimethyl-formamide / 5 h 7: sulfuric acid; water / acetic acid / 1 h View Scheme

: 112811-66-2
2,4,5-trifluoro-3-methoxybenzoyl chloride

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: magnesium ethylate / toluene 2: toluene-4-sulfonic acid / water / 9 h 3: acetic anhydride / 11 h 4: ethanol / 2 h / 20 °C 5: sodiumfluoride / N,N-dimethyl-formamide / 5 h 6: sulfuric acid; water / acetic acid / 1 h View Scheme

: 112811-68-4
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: acetic anhydride / 11 h 2: ethanol / 2 h / 20 °C 3: sodiumfluoride / N,N-dimethyl-formamide / 5 h 4: sulfuric acid; water / acetic acid / 1 h View Scheme

: 122375-85-3
ethyl 3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylate

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: ethanol / 2 h / 20 °C 2: sodiumfluoride / N,N-dimethyl-formamide / 5 h 3: sulfuric acid; water / acetic acid / 1 h View Scheme

: 530-62-1
1,1'-carbonyldiimidazole

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 869310-07-6
1-cyclopropyl-6,7-difluoro-3-(imidazole-1-carbonyl)-8-methoxy-1H-quinolin-4-one

Conditions

Conditions	Yield
In tetrahydrofuran Heating / reflux;	100%
In chloroform Heating / reflux;	100%
In tetrahydrofuran Heating / reflux;	100%
In tetrahydrofuran Heating / reflux;	100%

: 11113-50-1
boric acid

: 108-24-7
acetic anhydride

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 139693-52-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid-O3,O4(bis(acyloxy-O)) borate

Conditions

Conditions	Yield
Stage #1: boric acid; acetic anhydride With potassium hydroxide; zinc(II) chloride at 100℃; for 12h; Stage #2: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid at 50℃; for 1h; Concentration; Temperature; Reagent/catalyst;	97.4%

...Expand

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 847233-56-1
1-cyclopropyl-1,4-dihydro-6,7-difluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid difluoroborate ester

Conditions

Conditions	Yield
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With potassium carbonate In tetrahydrofuran at 20℃; for 0.0833333h; Stage #2: With boron trifluoride diethyl etherate In tetrahydrofuran at 20 - 66℃; for 6.08333h;	97%
With boron trifluoride diethyl etherate; potassium carbonate In tetrahydrofuran at 20 - 66℃; Inert atmosphere;	97%
With BF3OEt In various solvent(s) Cyclization; Heating;	83%
With boron trifluoride diethyl etherate In tetrahydrofuran for 36h; Heating / reflux;
Multi-step reaction with 2 steps 1: acetonitrile / 1 h / 70 - 80 °C / Inert atmosphere; Large scale 2: 1 h / 0 - 15 °C / Large scale View Scheme

: 109-63-7
boron trifluoride diethyl etherate

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: (1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-(oxo-κO)-3-quinoline-carboxylato-κO3)difluoro-Boron

Conditions

Conditions	Yield
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With potassium carbonate In tetrahydrofuran at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: boron trifluoride diethyl etherate In tetrahydrofuran at 60℃; for 6h; Temperature; Reagent/catalyst;	97%

: 124-68-5
2-Amino-2-methyl-1-propanol

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: C18H18F2N2O3

Conditions

Conditions	Yield
In toluene at 105 - 115℃; Temperature; Solvent; Inert atmosphere; Industrial scale;	96.6%

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 151213-40-0
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane

: 151096-09-2
moxifloxacin

Conditions

Conditions	Yield
With [BCl2(4-picoline)][AlCl4]; triethylamine In methanol at 85℃; for 6h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature;	96%
In dimethyl sulfoxide at 65 - 70℃; for 6 - 8h;	89.7%
With triethylamine In N,N-dimethyl-formamide; acetonitrile at 0 - 78℃; for 11h; Reflux;	66%

: 151213-42-2
[R,R]-2,8-diazabicyclo[4.3.0]nonane

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: moxifloxacin

Conditions

Conditions	Yield
With nano iron oxide on ZrO2 coated sulfonic acid In water for 0.416667h; Reflux;	96%
at 150℃; Microwave irradiation;	83%

: 4887-24-5
triacetoxyborane

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid-(O3,O4)-bis-(acetate-O)borate

Conditions

Conditions	Yield
In water at 0 - 90℃; for 4h;	95.3%

: 3-methylaminopiperidine dihydrochloride

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-7-(3-methylaminopiperidin-1-yl)-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
Stage #1: 3-methylaminopiperidine dihydrochloride; 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With boron trifluoride-tetrahydrofuran complex; triethylamine In acetonitrile at 20℃; for 26h; Stage #2: With methanol for 6h; Reflux; Stage #3: With sodium hydroxide In methanol; water at 20℃; for 16h; pH=8;	92%
With triethylamine In acetonitrile

: 13264-88-5, 66918-24-9, 75336-85-5, 75336-89-9, 93334-99-7
(+/-)-2-methylpiperazine bis(hydrochloride)

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 160738-57-8, 112811-59-3
gatifloxacin

Conditions

Conditions	Yield
Stage #1: (+/-)-2-methylpiperazine bis(hydrochloride); 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With boron trifluoride-tetrahydrofuran complex; triethylamine In acetonitrile at 20℃; for 25h; Stage #2: With methanol for 5h; Reflux; Stage #3: With sodium hydroxide In methanol; water at 20℃; for 16h; pH=7;	91%

: 87-69-4
L-Tartaric acid

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 151213-40-0
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane

: 1082245-30-4
L(+)-moxifloxacin tartrate

Conditions

Conditions	Yield
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane In N,N-dimethyl-formamide at 65 - 70℃; for 6 - 8h; Stage #2: L-Tartaric acid In N,N-dimethyl-formamide at 25 - 80℃; for 13 - 16h; Product distribution / selectivity;	90.32%

...Expand

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 154093-72-8
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinoline carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride; calcium chloride In water; dimethyl sulfoxide at -5 - 25℃; for 3.5h; pH=4;	90%
With hydrogen bromide; acetic acid at 100℃; for 24h;
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With hydrogen bromide In acetic acid at 100℃; for 1h; Stage #2: With water In acetic acid at 0℃;
With hydrogen bromide; acetic acid at 100℃; for 24h;

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 151213-40-0
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane

: 186826-86-8
moxifloxacin hydrochloride

Conditions

Conditions	Yield
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane With titanium(IV) isopropylate; triethylamine In isopropyl alcohol at 100℃; Inert atmosphere; Stage #2: With hydrogenchloride In methanol at 20℃; for 1h; pH=1; Solvent; Reagent/catalyst;	90%
Multi-step reaction with 2 steps 1: Alkaline conditions 2: hydrogenchloride View Scheme
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; (1S,6S)-2,8-diazabicyclo[4.3.0]nonane With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20 - 85℃; for 36h; Inert atmosphere; Stage #2: With hydrogenchloride In water at 15℃; for 1h; pH=1.4 - 1.8; Inert atmosphere;	3.3 g

: 21850-12-4
cycloperhydroisoindole

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1-cyclopropyl-6-fluoro-8-methoxy-7-(octahydro-2H-isoindol-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 24h; Reflux;	89%

: 123-75-1
pyrrolidine

: 121-43-7
Trimethyl borate

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(pyrrolidin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Conditions

Conditions	Yield
In ethanol; acetonitrile	88.2%

...Expand

: 660-68-4
diethyl amine hydrochloride

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1028205-74-4
1-cyclopropyl-N,N-diethyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 10 - 35℃; Inert atmosphere;	87.3%

: 882-33-7
diphenyldisulfane

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1-cyclopropyl-6,7-difluoro-8-methoxy-3-(phenylthio)quinolin-4(1H)-one

Conditions

Conditions	Yield
With palladium diacetate; triphenylphosphine; silver carbonate In dimethyl sulfoxide at 130℃; for 12h; Schlenk technique;	87%

: 121-43-7
Trimethyl borate

: 79286-87-6
(RS)-3-(acetyl-methyl-amino)-pyrrolidine

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-7-[3-(N-acetyl-N-methylamino)pyrrolidino]pyrrolidino-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
In ethanol; acetonitrile	83.9%

...Expand

: C14H18N2O2S

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: C28H28FN3O6S

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 80℃; for 3h;	82.3%

: 109-07-9
(RS)-2-methylpiperazine

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 160738-57-8, 112811-59-3
gatifloxacin

Conditions

Conditions	Yield
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With 1,1,1,3,3,3-hexamethyl-disilazane In acetonitrile at 76 - 80℃; for 1h; Heating / reflux; Stage #2: With boron trifluoride diethyl etherate In acetonitrile at 0 - 25℃; for 2h; Stage #3: (RS)-2-methylpiperazine With triethylamine In acetonitrile at 15 - 25℃; for 3h; pH=~ 9;	81.8%
In dimethyl sulfoxide at 55℃; for 24h;	66%
In dimethyl sulfoxide at 60 - 65℃; for 29 - 45h;	53.7%
In dimethyl sulfoxide at 20 - 73℃; for 13.9167 - 14.3333h;	52%
In dimethyl sulfoxide at 70 - 95℃; for 2h;

: C26H26N2

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: C40H36FN3O4

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 80℃; for 3h;	81.8%

: C12H20N2O2

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: C26H30FN3O6

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 80℃; for 3h;	81.5%

: C7H9N3O2

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1018938-14-1
C21H19FN4O6

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation;	79%

: 177-11-7
4,4-ethylenedioxy-piperidine

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 848070-83-7
1-cylopropyl-7-(1,4-dioxa-8-aza-spiro[4,5]dec-8-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation;	73%

: 2744-08-3, 2744-09-4, 6329-61-9
decahydroisoquinoline

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1-cyclopropyl-6-fluoro-8-methoxy-7-(octahydroisoquinolin-2(1H)-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 24h; Reflux;	73%

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 151213-40-0
(1S,6S)-2,8-diazabicyclo[4.3.0]nonane

: 721970-36-1
1-cyclopropyl-6-fluoro-8-hydroxy-7-((4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid With isobutylamine; copper dichloride In methanol; ethylene glycol at 50℃; for 4h; Inert atmosphere; Stage #2: (1S,6S)-2,8-diazabicyclo[4.3.0]nonane In methanol; ethylene glycol for 5h; Reflux; Stage #3: With sodium hydroxide In methanol; water; ethylene glycol for 1h; Reflux;	72.1%

: 123-90-0
Thiomorpholin

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 114213-99-9
1-Cyclopropyl-6-fluoro-8-methoxy-7-thiomorpholino-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation;	70%

: 3367-95-1
N,N-diethylpiperidine-3-carboxamide

: 112811-72-0
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

: 1018937-94-4
C24H30FN3O5

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide for 0.0333333h; microwave irradiation;	70%

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid Chemical Properties

Following is the structure of 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid (CAS NO.112811-72-0):

Empirical Formula: C₁₄H₁₁F₂NO₄
Molecular Weight: 295.2382 g/mol
Melting point: 192-194 °C
Molar Refractivity: 66.37 cm³
Molar Volume: 186.6 cm³
Density: 1.581 g/cm³
Flash Point: 240.7 °C
Index of Refraction: 1.629
Surface Tension: 66 dyne/cm
Enthalpy of Vaporization: 77.71 kJ/mol
Boiling Point: 474.4 °C at 760 mmHg
Vapour Pressure: 8.35E-10 mmHg at 25 °C
Appearance: Off-White to Light-Yellow Powder
Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals; Gatifloxacin Hemihydrate
SMILES: Fc3c(F)c(OC)c1c(C(=O)\C(=C/N1C2CC2)C(=O)O)c3
InChI: InChI=1/C14H11F2NO4/c1-21-13-10(16)9(15)4-7-11(13)17(6-2-3-6)5-8(12(7)18)14(19)20/h4-6H,2-3H2,1H3,(H,19,20)
InChIKey: WQJZXSSAMGZVTM-UHFFFAOYAT

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid Uses

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid (CAS NO.112811-72-0) can be used as Moxifloxacin intermediate.

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid Specification

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid , its cas register number is 112811-72-0. It also can be called 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo- .

Product Name

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Synthetic route

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid Chemical Properties

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid Uses

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid Specification

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