Product Name

  • Name

    1-Naphthyl acetonitrile

  • EINECS 205-078-1
  • CAS No. 132-75-2
  • Article Data65
  • CAS DataBase
  • Density 1.116 g/cm3
  • Solubility
  • Melting Point 33-35 °C(lit.)
  • Formula C12H9N
  • Boiling Point 323.9 °C at 760 mmHg
  • Molecular Weight 167.21
  • Flash Point 180.3 °C
  • Transport Information
  • Appearance White crystalline powder
  • Safety 26-37/39-24/25-37-36
  • Risk Codes 20/21/22-36/37/38-22
  • Molecular Structure Molecular Structure of 132-75-2 (1-Naphthyl acetonitrile)
  • Hazard Symbols HarmfulXn
  • Synonyms 1-Cyanomethylnaphthalene;1-Naphthylacetonitrile;2-(1-Naphthyl)acetonitrile;NSC 9844;a-Naphthylacetonitrile;1-Naphthaleneacetonitrile;
  • PSA 23.79000
  • LogP 2.90588

Synthetic route

C25H18N2O4

C25H18N2O4

A

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

B

biphenyl-4-carboxylic acid
92-92-2

biphenyl-4-carboxylic acid

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene Heating;A 98%
B 95%
2-[(Z)-Hydroxyimino]-3-naphthalen-1-yl-propionic acid
139109-57-2

2-[(Z)-Hydroxyimino]-3-naphthalen-1-yl-propionic acid

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With 1,1'-carbonyldiimidazole In benzene 1.) r.t., 15 min, 2.) 68-70 deg C, 1 h;97%
1-Naphthylacetamide
86-86-2

1-Naphthylacetamide

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With trichloromethyl chloroformate In various solvent(s) 0-5 deg C then heated to 60 deg C, 5 min;96%
With (dimethoxy)methylsilane; copper diacetate; 1,2-bis-(dicyclohexylphosphino)ethane In tetrahydrofuran at 20℃; for 12h; Sealed tube;96%
With phosgene In tetrahydrofuran; toluene at 25℃; for 4h; Inert atmosphere;91%
potassium cyanide
151-50-8

potassium cyanide

1-Chloromethylnaphthalene
86-52-2

1-Chloromethylnaphthalene

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
In acetonitrile at 60℃; for 3h; 18-crown-6 polyether;96%
β-(1-naphthyl)nitroethylene
37630-26-5, 4735-49-3

β-(1-naphthyl)nitroethylene

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With titanium tetrachloride; tetraethylammonium tosylate In N,N-dimethyl-formamide electroreduction - 4 mA/cm2;95%
1-Bromonaphthalene
90-11-9

1-Bromonaphthalene

sodium cyanoacetate
1071-36-9

sodium cyanoacetate

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis(η3-allyl-μ-chloropalladium(II)) In 1,3,5-trimethyl-benzene at 20 - 140℃; for 5.16667h; Inert atmosphere; Sealed tube; chemoselective reaction;95%
1-Naphthylboronic acid
13922-41-3

1-Naphthylboronic acid

chloroacetonitrile
107-14-2

chloroacetonitrile

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; sodium carbonate In 1,4-dioxane; water at 60℃; for 12h; Inert atmosphere; Sealed tube;93%
2-[(Z)-Hydroxyimino]-3-naphthalen-1-yl-propionic acid
133712-83-1

2-[(Z)-Hydroxyimino]-3-naphthalen-1-yl-propionic acid

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With 1,1'-oxalyldiimidazole In benzene 1.) r.t., 15 min, 2.) 68-70 deg C, 1 h;90%
2-(3,4-dihydronaphthalen-1-yl)acetonitrile

2-(3,4-dihydronaphthalen-1-yl)acetonitrile

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,2-dichloro-ethane at 100℃; for 24h;90%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,2-dichloro-ethane at 100℃; for 24h;90%
Methylsulfanyl-naphthalen-1-yl-acetonitrile
74607-42-4

Methylsulfanyl-naphthalen-1-yl-acetonitrile

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With acetic acid; zinc at 100℃; for 1h;89%
1-naphthylacetaldehyde
43017-75-0

1-naphthylacetaldehyde

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With HCl·DMPU; hydroxylamine hydrochloride In acetonitrile at 60℃;88%
With ammonia; iodine at 0℃; for 1h;74%
zinc(II) cyanide
557-21-1

zinc(II) cyanide

1-naphthylmethyl 2,2-dimethylpropanoate
72681-59-5

1-naphthylmethyl 2,2-dimethylpropanoate

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
Stage #1: zinc(II) cyanide; 1-naphthylmethyl 2,2-dimethylpropanoate With potassium phosphate; [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride In N,N-dimethyl-formamide for 0.0166667h; Inert atmosphere; Sealed tube;
Stage #2: With diethylzinc In hexane; N,N-dimethyl-formamide at 110℃; for 16h; Inert atmosphere; Sealed tube;
77%
bromocyane
506-68-3

bromocyane

1-naphthalene methanol
4780-79-4

1-naphthalene methanol

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
Stage #1: bromocyane; 1-naphthalene methanol With triphenylphosphine In dichloromethane at 20℃; Inert atmosphere;
Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; Cooling with ice; Inert atmosphere;
69%
1-naphthyl triflate
99747-74-7

1-naphthyl triflate

sodium cyanoacetate
1071-36-9

sodium cyanoacetate

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis(η3-allyl-μ-chloropalladium(II)) In 1,3,5-trimethyl-benzene at 20 - 140℃; for 10.1667h; Inert atmosphere; Sealed tube; chemoselective reaction;68%
sodium cyanide
773837-37-9

sodium cyanide

2-(bromomethyl)naphthalene
3163-27-7

2-(bromomethyl)naphthalene

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide In acetonitrile Inert atmosphere; Reflux;67%
1-Naphthylboronic acid
13922-41-3

1-Naphthylboronic acid

2-aminoacetonitrile hydrochloride
6011-14-9

2-aminoacetonitrile hydrochloride

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With sodium nitrite In water; toluene at 50℃; for 24h; Schlenk technique;65%
[(p-methylphenyl)sulfonylmethyl]isonitrile
38622-91-2, 36635-61-7

[(p-methylphenyl)sulfonylmethyl]isonitrile

1-naphthaldehyde
66-77-3

1-naphthaldehyde

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With potassium tert-butylate In 1,2-dimethoxyethane at -55℃; for 1h;62%
1-Fluoronaphthalene
321-38-0

1-Fluoronaphthalene

acetonitrile
75-05-8

acetonitrile

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With potassium hexamethylsilazane In tetrahydrofuran at 20 - 80℃; for 1.5h; Inert atmosphere; Schlenk technique; Sealed tube;53%
ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

1-Chloronaphthalene
90-13-1

1-Chloronaphthalene

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
Stage #1: ethyl 2-cyanoacetate; 1-Chloronaphthalene With N-(2-methylnaphthalen-1-yl)-N’-(pyridin-2-ylmethyl)oxalamide; copper(I) bromide; sodium t-butanolate In isopropyl alcohol at 105℃; for 24h; Schlenk technique; Inert atmosphere;
Stage #2: With water In isopropyl alcohol at 105℃; for 12h; Schlenk technique; Inert atmosphere; Cooling;
51%
1-Iodonaphthalene
90-14-2

1-Iodonaphthalene

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

A

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

B

ethyl 2-cyano-2-(naphthalen-1-yl)acetate
13234-71-4

ethyl 2-cyano-2-(naphthalen-1-yl)acetate

Conditions
ConditionsYield
With potassium carbonate; copper(l) iodide In dimethyl sulfoxide at 120℃; for 9h;A 27%
B 47%
With potassium carbonate; copper(l) iodide In dimethyl sulfoxide at 120℃; for 9h;A 27%
B 27%
methyl thiocyanate
556-64-9

methyl thiocyanate

1-naphthaldehyde
66-77-3

1-naphthaldehyde

A

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

B

[1]thionaphthoic acid S-methyl ester
4906-34-7

[1]thionaphthoic acid S-methyl ester

Conditions
ConditionsYield
With tributylphosphine 1.) 1h, 0 deg C, 2.) 2h, ambient temperature;A 32%
B 15%
With tributylphosphine 1.) 0 deg C, 1 h, 2.) room temperature, 2 h;A 32%
B 15%
(+)-(1R)-1-exo-Cyano-1a,7b-dihydro-1H-cyclopropanaphthalene
97550-35-1

(+)-(1R)-1-exo-Cyano-1a,7b-dihydro-1H-cyclopropanaphthalene

A

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

B

6-Cyano-2,3-benzonorcaradien
54276-84-5

6-Cyano-2,3-benzonorcaradien

C

(1S)-1-endo-Cyano-1a,7b-dihydro-1H-cyclopropanaphthalene
84518-19-4

(1S)-1-endo-Cyano-1a,7b-dihydro-1H-cyclopropanaphthalene

D

(1R)-1-endo-Cyano-1a,7b-dihydro-1H-cyclopropanaphthalene
84424-58-8, 84518-19-4, 97550-33-9, 97550-34-0, 97550-35-1

(1R)-1-endo-Cyano-1a,7b-dihydro-1H-cyclopropanaphthalene

E

(1S)-1-exo-Cyano-1a,7b-dihydro-1H-cyclopropanaphthalene
84424-58-8

(1S)-1-exo-Cyano-1a,7b-dihydro-1H-cyclopropanaphthalene

Conditions
ConditionsYield
In benzene for 0.5h; Product distribution; Irradiation;A 19%
B 14%
C n/a
D n/a
E n/a
naphthalene
91-20-3

naphthalene

chloroacetonitrile
107-14-2

chloroacetonitrile

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With iron(III) chloride at 175℃;
With iron(III) oxide; potassium bromide
1-Methylnaphthalene
90-12-0

1-Methylnaphthalene

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With cyanogen chloride at 650℃;
Multi-step reaction with 2 steps
1: N-bromosuccinimide / CCl4 / 4 h / 80 °C / Irradiation
2: 18-crown-6 / dimethylsulfoxide / 20 h
View Scheme
Multi-step reaction with 2 steps
1: bromine / 190 - 230 °C / UV-Licht
2: sodium cyanide; potassium cyanide; aqueous methanol
View Scheme
Multi-step reaction with 2 steps
1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Inert atmosphere; Reflux
2: tetra-(n-butyl)ammonium iodide / acetonitrile / Inert atmosphere; Reflux
View Scheme
With cyanogen chloride at 650℃;
1-Chloromethylnaphthalene
86-52-2

1-Chloromethylnaphthalene

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With methanol; potassium cyanide; sodium cyanide
With potassium cyanide; sodium cyanide; ethanol
With sodium cyanide; water
sodium cyanide
143-33-9

sodium cyanide

2-(bromomethyl)naphthalene
3163-27-7

2-(bromomethyl)naphthalene

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With ethanol
2-(bromomethyl)naphthalene
3163-27-7

2-(bromomethyl)naphthalene

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
With potassium cyanide; sodium cyanide; ethanol
With methanol; potassium cyanide; sodium cyanide
sodium cyanide
143-33-9

sodium cyanide

1-Chloromethylnaphthalene
86-52-2

1-Chloromethylnaphthalene

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
In ethanol
naphthalene
91-20-3

naphthalene

chloroacetonitrile
107-14-2

chloroacetonitrile

A

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

B

2-naphthaleneacetonitrile
7498-57-9

2-naphthaleneacetonitrile

Conditions
ConditionsYield
In acetonitrile for 22h; Kinetics; Irradiation;
potassium cyanide
151-50-8

potassium cyanide

2-(bromomethyl)naphthalene
3163-27-7

2-(bromomethyl)naphthalene

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Conditions
ConditionsYield
18-crown-6 ether In dimethyl sulfoxide for 20h;
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

2-naphthalen-1-yl-ethylamine
4735-50-6

2-naphthalen-1-yl-ethylamine

Conditions
ConditionsYield
With lithium aluminium tetrahydride; aluminium trichloride100%
With nickel dichloride; diborane In tetrahydrofuran; methanol for 1h; Ambient temperature;80%
With hydrogenchloride; hydrogen; palladium on activated charcoal In methanol at 20℃; under 1810.02 Torr; for 2.5h;60%
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

2-chlorobenzylthiocyanate
2082-66-8

2-chlorobenzylthiocyanate

2-(naphthalen-1-yl)malononitrile
5518-09-2

2-(naphthalen-1-yl)malononitrile

Conditions
ConditionsYield
With lithium diisopropyl amide In benzene at 5℃; for 1h;100%
With hydrogenchloride; lithium diisopropyl amide In benzene32%
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

5-(1-Naphthylmethyl)-1H-tetrazole
117070-77-6

5-(1-Naphthylmethyl)-1H-tetrazole

Conditions
ConditionsYield
With sodium azide; triethylamine hydrochloride In toluene at 110℃; for 16h; Inert atmosphere;97%
With sodium azide; cerium(III) chloride heptahydrate In water; isopropyl alcohol at 160℃; for 4h; Microwave irradiation;94%
With sodium azide; acetic acid; isopropyl alcohol
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

methyl iodide
74-88-4

methyl iodide

2-methyl-2-(naphthalen-1-yl)propanenitrile
55615-31-1

2-methyl-2-(naphthalen-1-yl)propanenitrile

Conditions
ConditionsYield
Stage #1: naphthalen-1-ylacetonitrile With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.666667h;
Stage #2: methyl iodide In tetrahydrofuran at -78 - 20℃; for 10h;
96%
With lithium diisopropyl amide In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide at -78℃;83%
Stage #1: naphthalen-1-ylacetonitrile With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Metallation;
Stage #2: methyl iodide In N,N-dimethyl-formamide for 1h; Methylation;
78%
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Cysteamine
60-23-1

Cysteamine

2-(1-naphthylmethyl)-4,5-dihydrothiazole
18732-66-6

2-(1-naphthylmethyl)-4,5-dihydrothiazole

Conditions
ConditionsYield
In ethanol Heating;95%
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

allyl bromide
106-95-6

allyl bromide

2-allyl-2-(1-naphthyl)pent-4-enenitrile
56477-54-4

2-allyl-2-(1-naphthyl)pent-4-enenitrile

Conditions
ConditionsYield
Stage #1: naphthalen-1-ylacetonitrile With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.666667h;
Stage #2: allyl bromide In tetrahydrofuran at -78 - 20℃; for 10h;
95%
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

C-phenyl-N-methylnitrone
3376-23-6, 7372-59-0, 59862-60-1

C-phenyl-N-methylnitrone

Triethylsilyl trifluoromethanesulfonate
79271-56-0

Triethylsilyl trifluoromethanesulfonate

3-(methyl((triethylsilyl)oxy)amino)-2-(naphthalen-1-yl)-3-phenylpropanenitrile

3-(methyl((triethylsilyl)oxy)amino)-2-(naphthalen-1-yl)-3-phenylpropanenitrile

Conditions
ConditionsYield
With triethylamine In 1,2-dichloro-ethane at -30℃; for 0.5h; Inert atmosphere;95%
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

1-methyl-3,4,dihydroisoquinoline
2412-58-0

1-methyl-3,4,dihydroisoquinoline

1-(1-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-2-(naphth-1-yl)ethanone

1-(1-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-2-(naphth-1-yl)ethanone

Conditions
ConditionsYield
Stage #1: naphthalen-1-ylacetonitrile; 1-methyl-3,4,dihydroisoquinoline With manganese; chloro-trimethyl-silane; bis(cyclopentadienyl)titanium(IV) diphenoxide; triethylamine hydrochloride In tetrahydrofuran at 60℃; for 24h; Schlenk technique; Inert atmosphere;
Stage #2: With hydrogenchloride; water In tetrahydrofuran; diethyl ether; dichloromethane Cooling; regioselective reaction;
95%
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

1-methyl-1H-indole-2,3-dione
2058-74-4

1-methyl-1H-indole-2,3-dione

2-(3-hydroxy-1-methyl-2-oxoindolin-3-yl)-2-(naphthalen-1-yl)-acetonitrile

2-(3-hydroxy-1-methyl-2-oxoindolin-3-yl)-2-(naphthalen-1-yl)-acetonitrile

Conditions
ConditionsYield
With water; 1,8-diazabicyclo[5.4.0]undec-7-ene at 20℃; for 40h; Green chemistry; diastereoselective reaction;95%
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

1-Naphthylacetamide
86-86-2

1-Naphthylacetamide

Conditions
ConditionsYield
With water; potassium carbonate In isopropyl alcohol at 150℃; for 0.25h; Microwave irradiation;94%
With hydrogenchloride
With sulfuric acid; water at 120 - 125℃;
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

phenylmethanethiol
100-53-8

phenylmethanethiol

(Z)-2-(naphthalen-1-yl)-3-phenylacrylonitrile
27869-65-4

(Z)-2-(naphthalen-1-yl)-3-phenylacrylonitrile

Conditions
ConditionsYield
With 1,10-Phenanthroline; potassium tert-butylate In toluene at 120℃; for 24h;94%
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

2-furoyl-1H-1,2,3-benzotriazole
144223-33-6

2-furoyl-1H-1,2,3-benzotriazole

3-(2-furyl)-2-(1-naphthyl)-3-oxopropanenitrile
63753-52-6

3-(2-furyl)-2-(1-naphthyl)-3-oxopropanenitrile

Conditions
ConditionsYield
Stage #1: naphthalen-1-ylacetonitrile With potassium tert-butylate In dimethyl sulfoxide at 10℃; for 0.166667h;
Stage #2: 2-furoyl-1H-1,2,3-benzotriazole In dimethyl sulfoxide at 25℃; for 12h;
92%
1-bromo-butane
109-65-9

1-bromo-butane

naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

α,α-Dibutyl-(1-naphthyl)-acetonitril
94910-78-8

α,α-Dibutyl-(1-naphthyl)-acetonitril

Conditions
ConditionsYield
Stage #1: naphthalen-1-ylacetonitrile With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.666667h;
Stage #2: 1-bromo-butane In tetrahydrofuran at -78 - 20℃; for 10h;
92%
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

naphth-1-yl acetic acid
86-87-3

naphth-1-yl acetic acid

Conditions
ConditionsYield
With potassium phosphate buffer at 30℃; for 96h; Rhodococcus sp. AJ270 cells;91.3%
Stage #1: naphthalen-1-ylacetonitrile With sodium hydroxide In water for 3h; Reflux;
Stage #2: With hydrogenchloride In water pH=2; Time;
74.8%
With sulfuric acid; acetic acid
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

2-(bromomethyl)naphthalene
3163-27-7

2-(bromomethyl)naphthalene

2,3-di(naphthalen-1-yl)propanenitrile

2,3-di(naphthalen-1-yl)propanenitrile

Conditions
ConditionsYield
With sodium hydroxide; 5,11,17,23,29,35-hexakis-37,38,39,40,41,42-hexamethoxycalix<6>arene In di-isopropyl ether at 70℃; for 5h; Product distribution; Further Variations:; Catalysts;91%
With sodium hydroxide; calix[8]arene with trimethylammoniomethyl groups In various solvent(s) at 70℃; for 2h; Alkylation;78%
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

acetyl chloride
75-36-5

acetyl chloride

methyl-2-(1-naphthalenyl)acetimidate hydrochloride
39739-56-5

methyl-2-(1-naphthalenyl)acetimidate hydrochloride

Conditions
ConditionsYield
In methanol91%
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

diisopropyl-carbodiimide
693-13-0

diisopropyl-carbodiimide

C19H23N3

C19H23N3

Conditions
ConditionsYield
With lithium hexamethyldisilazane In tetrahydrofuran at 60℃; under 760.051 Torr; for 6h; Inert atmosphere; Sealed tube;90%
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

ethanol
64-17-5

ethanol

2-(naphth-1-yl) butyronitrile
56477-48-6

2-(naphth-1-yl) butyronitrile

Conditions
ConditionsYield
With ruthenium-grafted hydrotalcite at 180℃; for 20h;89%
ruthenium-grafted hydrotalcite at 180℃; for 20h;89%
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

3-methyl-4,4-bis(methylthio)but-3-en-2-one
17649-87-5

3-methyl-4,4-bis(methylthio)but-3-en-2-one

(Z)-4-Methyl-3-methylsulfanyl-2-naphthalen-1-yl-5-oxo-hex-2-enenitrile

(Z)-4-Methyl-3-methylsulfanyl-2-naphthalen-1-yl-5-oxo-hex-2-enenitrile

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃;89%
naphthalen-1-ylacetonitrile
132-75-2

naphthalen-1-ylacetonitrile

Pentafluorobenzene
363-72-4

Pentafluorobenzene

2-(naphthalen-1-yl)-2-(2,3,5,6-tetrafluorophenyl)acetonitrile

2-(naphthalen-1-yl)-2-(2,3,5,6-tetrafluorophenyl)acetonitrile

Conditions
ConditionsYield
With lithium tert-butoxide In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere; regioselective reaction;89%

1-Naphthyl acetonitrile Chemical Properties

Product Name: 1-Naphthyl acetonitrile (CAS NO.132-75-2)

Molecular Formula: C12H9N
Molecular Weight: 167.21g/mol
Mol File: 132-75-2.mol
EINECS: 205-078-1
Appearance: White to yellow solid or melt
Melting Point: 33-35 °C(lit.)
Boiling point: 323.9 °C at 760 mmHg
Flash Point: 180.3 °C
Density: 1.116 g/cm3
Refractive index: n20/D 1.6192(lit.)
Index of Refraction: 1.634 
Molar Refractivity: 53.55 cm3 
Molar Volume: 149.7 cm3 
Surface Tension: 48.8 dyne/cm
Enthalpy of Vaporization: 58 kJ/mol
Vapour Pressure: 0.000255 mmHg at 25°C
XLogP3-AA: 2.9
H-Bond Donor: 0
H-Bond Acceptor: 1
Structure Descriptors of 1-Naphthyl acetonitrile (CAS NO.132-75-2):
  IUPAC Name: 2-naphthalen-1-ylacetonitrile
  Canonical SMILES: C1=CC=C2C(=C1)C=CC=C2CC#N
  InChI: InChI=1S/C12H9N/c13-9-8-11-6-3-5-10-4-1-2-7-12(10)11/h1-7H,8H2
  InChIKey: OQRMWUNUKVUHQO-UHFFFAOYSA-N
Product Categories: Intermediates of Dyes and Pigments; Aromatic Nitriles

1-Naphthyl acetonitrile Uses

 1-Naphthyl acetonitrile (CAS NO.132-75-2) is used in organic synthesis.

1-Naphthyl acetonitrile Toxicity Data With Reference

1.    

ivn-mus LD50:180 mg/kg

    CSLNX*    U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#03835 .

1-Naphthyl acetonitrile Consensus Reports

Cyanide and its compounds are on the Community Right-To-Know List. Reported in EPA TSCA Inventory.

1-Naphthyl acetonitrile Safety Profile

Poison by intravenous route. When heated to decomposition it emits toxic fumes of NOx and CN. See also NITRILES.
Safety Information of 1-Naphthyl acetonitrile (CAS NO.132-75-2):
Hazard Codes: XnHarmful
Risk Statements: 20/21/22-36/37/38-22   
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R22:Harmful if swallowed.
Safety Statements: 26-37/39-24/25-37-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S37/39:Wear suitable gloves and eye/face protection. 
S24/25:Avoid contact with skin and eyes. 
S37:Wear suitable gloves. 
S36:Wear suitable protective clothing.
RIDADR: 3276
WGK Germany: 3
RTECS: AM1240000
HazardClass: 6.1
PackingGroup: III

1-Naphthyl acetonitrile Specification

 1-Naphthyl acetonitrile , its CAS NO. is 132-75-2, the synonyms are  Acetonitrile, (1-naphthyl)- ; alpha-(1-Naphthyl)acetonitrile ; alpha-Naphthyl acetonitrile ; alpha-Naphthylacetonitrile ;  1-Naphthaleneacetonitrile ; 1-Naphthylacetonitrile .

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View