Product Name

  • Name

    2,3-Lutidine

  • EINECS 209-514-1
  • CAS No. 583-61-9
  • Article Data32
  • CAS DataBase
  • Density 0.93 g/cm3
  • Solubility 95 g/L (26 ºC)
  • Melting Point -15 °C(lit.)
  • Formula C7H9N
  • Boiling Point 160.7 °C at 760 mmHg
  • Molecular Weight 107.155
  • Flash Point 45.4 °C
  • Transport Information UN 1993 3/PG 3
  • Appearance clear colorless to slightly yellow liquid
  • Safety 16-26-39-36/37-36/37/39
  • Risk Codes 10-22-37/38-41-20/21/22-36/37/38
  • Molecular Structure Molecular Structure of 583-61-9 (2,3-Lutidine)
  • Hazard Symbols HarmfulXn, FlammableF, IrritantXi
  • Synonyms 2,3-Lutidine(8CI);2,3-Dimethylpyridine;NSC 2157;
  • PSA 12.89000
  • LogP 1.69840

Synthetic route

2-Methyl-3-acetoxymethylpyridin
87851-05-6

2-Methyl-3-acetoxymethylpyridin

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
With hydrogen; Pd-BaSO4 In ethanol for 0.5h; Ambient temperature;99.2%
N-(3-methyl-2-methyl-2H-pyridin-1-yl)-N-methyl-benzamidine

N-(3-methyl-2-methyl-2H-pyridin-1-yl)-N-methyl-benzamidine

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
Stage #1: N-(3-methyl-2-methyl-2H-pyridin-1-yl)-N-methyl-benzamidine With manganese triacetate; acetic acid at 60℃; for 2h;
Stage #2: With water; acetic acid at 80℃;
81%
5-chloro-5,6-dimethyl-2,3,4,5-tetrahydropyridine
326893-28-1

5-chloro-5,6-dimethyl-2,3,4,5-tetrahydropyridine

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran Heating;80%
butanone
78-93-3

butanone

A

2,3-Lutidine
583-61-9

2,3-Lutidine

B

2,3,6-trimethylpyridine
1462-84-6

2,3,6-trimethylpyridine

C

2,3,4-lutidine
2233-29-6

2,3,4-lutidine

Conditions
ConditionsYield
With ammonia; chromium(III) oxide; aluminium at 350℃;A 30.7%
B 46.2%
C 23%
butanone
78-93-3

butanone

A

2,6-dimethylpyridine
108-48-5

2,6-dimethylpyridine

B

2,3-Lutidine
583-61-9

2,3-Lutidine

C

2,3,6-trimethylpyridine
1462-84-6

2,3,6-trimethylpyridine

D

2,3,4-lutidine
2233-29-6

2,3,4-lutidine

Conditions
ConditionsYield
With ammonia; chromium(III) oxide; aluminium at 375℃;A 6.8%
B 24.6%
C 45.4%
D 25.7%
With ammonia; chromium(III) oxide; aluminium at 425℃;A 25.3%
B 34.5%
C 13.8%
D 13.8%
With ammonia; chromium(III) oxide; aluminium at 450℃;A 21.8%
B 22.4%
C 29.4%
D 11.7%
With ammonia; chromium(III) oxide; aluminium at 300 - 450℃; Product distribution;
3-Methylpyridine
108-99-6

3-Methylpyridine

A

pyridine
110-86-1

pyridine

B

α-picoline
109-06-8

α-picoline

C

2,3-Lutidine
583-61-9

2,3-Lutidine

D

2,4-lutidine
108-47-4

2,4-lutidine

E

2,5-dimethylpyridine
589-93-5

2,5-dimethylpyridine

Conditions
ConditionsYield
With hydrogen; aluminum oxide; nickel at 330℃; under 750.06 Torr; Product distribution;A 0.3%
B 0.5%
C 5.3%
D 8%
E 30.9%
formaldehyd
50-00-0

formaldehyd

acetaldehyde
75-07-0

acetaldehyde

acetone
67-64-1

acetone

A

2,3-Lutidine
583-61-9

2,3-Lutidine

B

3-ethylpyridine
536-78-7

3-ethylpyridine

C

2,3,4-lutidine
2233-29-6

2,3,4-lutidine

D

3-Methylpyridine
108-99-6

3-Methylpyridine

Conditions
ConditionsYield
With diammonium phosphate In ethanol; water at 234℃; for 1h;A 25%
B 8%
C 13%
D 22%
α-picoline
109-06-8

α-picoline

A

pyridine
110-86-1

pyridine

B

2,6-dimethylpyridine
108-48-5

2,6-dimethylpyridine

C

2,3-Lutidine
583-61-9

2,3-Lutidine

D

2,5-dimethylpyridine
589-93-5

2,5-dimethylpyridine

Conditions
ConditionsYield
With hydrogen; aluminum oxide; nickel at 330℃; under 750.06 Torr; Product distribution;A 14.9%
B 11.4%
C 3%
D 1.6%
5,6-dimethyl-1,2,3,4-tetrahydro-pyridine
412320-62-8

5,6-dimethyl-1,2,3,4-tetrahydro-pyridine

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
With magnesium hydrosilicate; hydrogen; palladium at 280℃;
6-chloro-2,3-dimethylpyridine
72093-13-1

6-chloro-2,3-dimethylpyridine

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
With ethanol; palladium Hydrogenation;
1-Methyl-3-acetylpiperidine
91324-25-3

1-Methyl-3-acetylpiperidine

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
With selenium at 300℃;
4,6-dichloro-2,3-dimethyl-pyridine
101252-84-0

4,6-dichloro-2,3-dimethyl-pyridine

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
With methanol; potassium acetate; palladium Hydrogenation;
2,3-bis(chloromethyl)-pyridine
45754-12-9

2,3-bis(chloromethyl)-pyridine

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
With methanol; palladium on activated charcoal; Lindlar's catalyst Hydrogenation;
methanol
67-56-1

methanol

3-Methylpyridine
108-99-6

3-Methylpyridine

lead(IV) tetraacetate
546-67-8

lead(IV) tetraacetate

acetic acid
64-19-7

acetic acid

A

2,3-Lutidine
583-61-9

2,3-Lutidine

B

2,5-dimethylpyridine
589-93-5

2,5-dimethylpyridine

Conditions
ConditionsYield
at 110℃;
4-methyl-5-oxohexanal
68208-68-4

4-methyl-5-oxohexanal

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
With ethanol; water; hydroxylamine anschliessend Erwaermen mit wss. Salzsaeure;
5,6-dimethyl-1,2,3,4-tetrahydro-pyridine; hydrochloride

5,6-dimethyl-1,2,3,4-tetrahydro-pyridine; hydrochloride

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
bei der Zinstaub-Destillation;
allyl alcohol
107-18-6

allyl alcohol

butanone
78-93-3

butanone

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
With ammonia at 400℃; Leiten ueber mit Cadmiumphosphat impraegnierte Fullererde;
2.3-dimethyl-pyridine-carboxylic acid-(5)

2.3-dimethyl-pyridine-carboxylic acid-(5)

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
With methyllithium; calcium carbonate bei der Destillation;
hydrochloride of 2.3-dimethyl-1.4.5.6-tetrahydro-pyridine

hydrochloride of 2.3-dimethyl-1.4.5.6-tetrahydro-pyridine

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
With zinc durch Destillation;
5,6-dimethylpyridine-3-carboxylic acid
757903-81-4

5,6-dimethylpyridine-3-carboxylic acid

lime/chalk/

lime/chalk/

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
bei der Destillation;
5,6-dimethyl-1,2,3,4-tetrahydro-pyridine
412320-62-8

5,6-dimethyl-1,2,3,4-tetrahydro-pyridine

hydrogen

hydrogen

palladium/ asbestos

palladium/ asbestos

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
at 290℃;
1-Methyl-3-acetylpiperidine
91324-25-3

1-Methyl-3-acetylpiperidine

selenium

selenium

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
at 300℃; unter Druck;
3-methyl-cyclohexanone oxime
4701-95-5

3-methyl-cyclohexanone oxime

P2O5

P2O5

A

2,3-Lutidine
583-61-9

2,3-Lutidine

B

methyl cyclohexane
82166-21-0

methyl cyclohexane

C

toluene
108-88-3

toluene

D

nitrile C6H11+CN

nitrile C6H11+CN

Conditions
ConditionsYield
levorotatory 1-methyl-cyclohexane oxime-(3);
ethyl 2-methyl nicotinate
1721-26-2

ethyl 2-methyl nicotinate

methylphenylsilane
766-08-5

methylphenylsilane

A

2,3-Lutidine
583-61-9

2,3-Lutidine

B

3-(ethoxy-methyl-phenyl-silanyloxymethyl)-2-methyl-pyridine

3-(ethoxy-methyl-phenyl-silanyloxymethyl)-2-methyl-pyridine

Conditions
ConditionsYield
With dimethyltitanocene at 20℃; Title compound not separated from byproducts;
3-Methylpyridine
108-99-6

3-Methylpyridine

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: Tf2O / CH2Cl2 / -40 - 20 °C
1.2: 80 percent / CH2Cl2 / -70 °C
2.1: Mn(OAc)3*2H2O; AcOH / 2 h / 60 °C
2.2: 81 percent / H2IO6; AcOH; H2O / 80 °C
View Scheme
[2,5-Dichloro-1,2-dimethyl-pent-(E)-ylidene]-isopropyl-amine
121076-19-5

[2,5-Dichloro-1,2-dimethyl-pent-(E)-ylidene]-isopropyl-amine

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 28 percent / NaN3 / dimethylsulfoxide / 20 h / 55 °C
2: 48 percent / SnCl2 / methanol / 5 h / 20 °C
3: 80 percent / KOBu-t / tetrahydrofuran / Heating
View Scheme
N-(6-azido-3-chloro-3-methyl-2-hexylidene)isopropylamine

N-(6-azido-3-chloro-3-methyl-2-hexylidene)isopropylamine

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 48 percent / SnCl2 / methanol / 5 h / 20 °C
2: 80 percent / KOBu-t / tetrahydrofuran / Heating
View Scheme
(2-methylpyridin-3-yl)methanol
56826-61-0

(2-methylpyridin-3-yl)methanol

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91 percent / 1.) room temp., 15 h, 2.) reflux, 2 h
2: 99.2 percent / H2 / Pd/BaSO4 / ethanol / 0.5 h / Ambient temperature
View Scheme
ethyl 2-methyl nicotinate
1721-26-2

ethyl 2-methyl nicotinate

2,3-Lutidine
583-61-9

2,3-Lutidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 0.5 h / 40 °C
2: 91 percent / 1.) room temp., 15 h, 2.) reflux, 2 h
3: 99.2 percent / H2 / Pd/BaSO4 / ethanol / 0.5 h / Ambient temperature
View Scheme
2,3-Lutidine
583-61-9

2,3-Lutidine

2,3-dimethylpyridine 1-oxide
22710-07-2

2,3-dimethylpyridine 1-oxide

Conditions
ConditionsYield
With sodium tungstate; dihydrogen peroxide In water at 55℃; for 3h; Temperature;99%
With 3-chloro-benzenecarboperoxoic acid In Isopropyl acetate at 10 - 35℃; for 5.83333h; Green chemistry;98.9%
With △-Na8H[PW9O34]·19H2O; dihydrogen peroxide In water at 20℃; for 24h; Green chemistry;94%
2,3-Lutidine
583-61-9

2,3-Lutidine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl 2,3-dimethylpiperidine-1-carboxylate

tert-butyl 2,3-dimethylpiperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 2,3-Lutidine With chloro(1,5-cyclooctadiene)rhodium(I) dimer; borane-ammonia complex In 2,2,2-trifluoroethanol at 20℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube;
Stage #2: di-tert-butyl dicarbonate With triethylamine In 2,2,2-trifluoroethanol at 20℃; Inert atmosphere; Schlenk technique; Sealed tube;
99%
2,3-Lutidine
583-61-9

2,3-Lutidine

cobalt pivalate

cobalt pivalate

bis(2,3-dimethylpyridino)tetra(μ2-O,O'-trimethylacetato)dicobalt(II)
1006049-96-2

bis(2,3-dimethylpyridino)tetra(μ2-O,O'-trimethylacetato)dicobalt(II)

Conditions
ConditionsYield
In acetonitrile under Ar atm. soln. 2,3-Me2C5H3N in MeCN was added to (Co(Me3CCOO)2)n and strirred at 80°C for 15 min; soln. was concd. at 0.1 Torr and 20°C and allowed to crystallize at 20°C for 12 h, ppt. was washed with cold benzene and dried under Ar stream; elem. anal.;98%
2,3-Lutidine
583-61-9

2,3-Lutidine

Ni2(μ-H2O)(μ-OOC-tert-Bu)2(OOC-tert-Bu)2(tert-BuCOOH)4
515845-82-6

Ni2(μ-H2O)(μ-OOC-tert-Bu)2(OOC-tert-Bu)2(tert-BuCOOH)4

bis(2,3-dimethylpyridino)tetra(μ2-O,O'-trimethylacetato)dinickel(II)
239471-96-6

bis(2,3-dimethylpyridino)tetra(μ2-O,O'-trimethylacetato)dinickel(II)

Conditions
ConditionsYield
In benzene under Ar atm. soln. 2,3-Me2C5H3N in benzene was added to Ni6(Me3CCOO)2)12 and strirred at 70°C for 15 min; soln. was concd. at 0.1 Torr and 20°C and allowed to crystallize at 20°C for 12 h, ppt. was washed with cold benzene and dried under Ar stream; elem. anal.;98%
2,3-Lutidine
583-61-9

2,3-Lutidine

benzoyl chloride
98-88-4

benzoyl chloride

2,3-dimethyl-N-benzoyliminopyridinium ylide
860802-84-2

2,3-dimethyl-N-benzoyliminopyridinium ylide

Conditions
ConditionsYield
Stage #1: 2,3-Lutidine With O-(2,4-dinitrophenyl)hydroxylamine In tetrahydrofuran; water at 40℃; for 12h;
Stage #2: benzoyl chloride With sodium hydroxide In tetrahydrofuran at 20℃; for 4h;
96%
2,3-Lutidine
583-61-9

2,3-Lutidine

methyl 2-((tosylimino)methyl)benzoate

methyl 2-((tosylimino)methyl)benzoate

3-((3-methylpyridin-2-yl)methyl)-2-tosylisoindolin-1-one
1218989-13-9

3-((3-methylpyridin-2-yl)methyl)-2-tosylisoindolin-1-one

Conditions
ConditionsYield
With scandium tris(trifluoromethanesulfonate) In α,α,α-trifluorotoluene at 120℃; for 24h; Inert atmosphere; screw-cap vial;95%
2,3-Lutidine
583-61-9

2,3-Lutidine

1-hexene
592-41-6

1-hexene

C13H21N

C13H21N

Conditions
ConditionsYield
With triphenylcarbenium tetra(pentafluorophenyl)borate; C63H83N2O2ScSi2 In toluene at 40℃; for 48h; Schlenk technique; Inert atmosphere; enantioselective reaction;95%
2,3-Lutidine
583-61-9

2,3-Lutidine

tert-butyl (E)-cinnamyl carbonate
95932-32-4

tert-butyl (E)-cinnamyl carbonate

C16H17N

C16H17N

Conditions
ConditionsYield
Stage #1: 2,3-Lutidine With boron trifluoride diethyl etherate In tetrahydrofuran for 0.5h; Inert atmosphere; Schlenk technique;
Stage #2: tert-butyl (E)-cinnamyl carbonate With C49H50IrNO4P(1+)*CF3O3S(1-); lithium hexamethyldisilazane In tetrahydrofuran at 30℃; for 8h; Inert atmosphere; Schlenk technique; enantioselective reaction;
94%
2,3-Lutidine
583-61-9

2,3-Lutidine

1,5-Hexadien
592-42-7

1,5-Hexadien

C13H19N

C13H19N

Conditions
ConditionsYield
With tris(pentafluorophenyl)borate; C42H51N3PSc In chlorobenzene at 100℃; for 8h; diastereoselective reaction;94%
2,3-Lutidine
583-61-9

2,3-Lutidine

mesitylenesulfonylhydroxylamine
36016-40-7

mesitylenesulfonylhydroxylamine

2,3-dimethylpyridin-1-ium-1-amine 2,4,6-trimethylbenzenesulfonate
81450-86-4

2,3-dimethylpyridin-1-ium-1-amine 2,4,6-trimethylbenzenesulfonate

Conditions
ConditionsYield
In dichloromethane for 0.5h; cooling;93%
2,3-Lutidine
583-61-9

2,3-Lutidine

trimethylamine-iodoborane

trimethylamine-iodoborane

bis(2.3-lutidine)boronium iodide

bis(2.3-lutidine)boronium iodide

Conditions
ConditionsYield
In not given93%
2,3-Lutidine
583-61-9

2,3-Lutidine

Bis(acetonitrile-κN)hexakis(μ-O,O'-trimethylacetato)(nitrato-κ2O,O')dizinc(II)europium(III)

Bis(acetonitrile-κN)hexakis(μ-O,O'-trimethylacetato)(nitrato-κ2O,O')dizinc(II)europium(III)

acetonitrile
75-05-8

acetonitrile

Bis(2,3-dimethylpyridine-κN)hexakis(μ-O,O'-trimethylacetato)(nitrato-κ2O,O')dizinc(II)europium(III) acetonitrile monosolvate

Bis(2,3-dimethylpyridine-κN)hexakis(μ-O,O'-trimethylacetato)(nitrato-κ2O,O')dizinc(II)europium(III) acetonitrile monosolvate

Conditions
ConditionsYield
at 80℃; for 0.333333h;93%
2,3-Lutidine
583-61-9

2,3-Lutidine

meta-bromotoluene
591-17-3

meta-bromotoluene

3-methyl-2-(3-methylbenzyl)pyridine
1334723-74-8

3-methyl-2-(3-methylbenzyl)pyridine

Conditions
ConditionsYield
Stage #1: 2,3-Lutidine With zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex In tetrahydrofuran at 25℃; for 0.25h; Inert atmosphere;
Stage #2: meta-bromotoluene With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 1-ethyl-2-pyrrolidinone; palladium diacetate In tetrahydrofuran at 50℃; for 2h; Inert atmosphere;
91%
2,3-Lutidine
583-61-9

2,3-Lutidine

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

ethyl 3,3,3-trifluoro-2-hydroxy-2-(3-methylpyridin-2-ylmethyl)propanoate
1419293-09-6

ethyl 3,3,3-trifluoro-2-hydroxy-2-(3-methylpyridin-2-ylmethyl)propanoate

Conditions
ConditionsYield
With ytterbium(III) triflate In 1,4-dioxane at 90℃; for 12h;91%
With iron(II) acetate In 1,4-dioxane at 120℃; for 24h; Schlenk technique; Inert atmosphere;24%
2,3-Lutidine
583-61-9

2,3-Lutidine

cyclohexylallene
5664-17-5

cyclohexylallene

C16H23N

C16H23N

Conditions
ConditionsYield
With (C5Me4SiMe3)Sc(CH2C6H4NMe2-o)2; trityl tetrakis(pentafluorophenyl)borate In toluene at 70℃; for 36h; Glovebox; Schlenk technique; Sealed tube; stereoselective reaction;91%
2,3-Lutidine
583-61-9

2,3-Lutidine

5-methyl-indole-2,3-dione
608-05-9

5-methyl-indole-2,3-dione

3-hydroxy-3-((3-methylpyridin-2-yl)methyl)indolin-2-one
1395322-34-5

3-hydroxy-3-((3-methylpyridin-2-yl)methyl)indolin-2-one

Conditions
ConditionsYield
In water for 1h; Reagent/catalyst; Reflux;91%
2,3-Lutidine
583-61-9

2,3-Lutidine

benzoic acid methyl ester
93-58-3

benzoic acid methyl ester

C14H13NO

C14H13NO

Conditions
ConditionsYield
Stage #1: 2,3-Lutidine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere;
Stage #2: benzoic acid methyl ester In tetrahydrofuran; hexane at 0℃; for 3h; Inert atmosphere;
91%
2,3-Lutidine
583-61-9

2,3-Lutidine

styrene
292638-84-7

styrene

C15H17N

C15H17N

Conditions
ConditionsYield
With tris(pentafluorophenyl)borate; C42H51N3PSc In chlorobenzene at 100℃; for 9h; Inert atmosphere; Schlenk technique; Glovebox;91%
2,3-Lutidine
583-61-9

2,3-Lutidine

zinc trimethylacetate

zinc trimethylacetate

[zinc(II)(μ2-κ1O:κ1O'-O2C(t-Bu))2(2,3-lutidine)]2
1307949-66-1

[zinc(II)(μ2-κ1O:κ1O'-O2C(t-Bu))2(2,3-lutidine)]2

Conditions
ConditionsYield
In methanol soln. of C5H3NMe2 in MeOH added to soln. of Zn salt in MeOH, stirred at room temp. for 12 h; volatiles removed under vac., crystd. by diffusing CHCl3 over MeOH soln.at room temp. for 4 d; elem. anal.;90%
2,3-Lutidine
583-61-9

2,3-Lutidine

1-bromo-4-methoxy-benzene
104-92-7

1-bromo-4-methoxy-benzene

2-(4-methoxybenzyl)-3-methylpyridine
33399-83-6

2-(4-methoxybenzyl)-3-methylpyridine

Conditions
ConditionsYield
Stage #1: 2,3-Lutidine With zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex In tetrahydrofuran at 25℃; for 0.25h; Inert atmosphere;
Stage #2: 1-bromo-4-methoxy-benzene With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 1-ethyl-2-pyrrolidinone; palladium diacetate In tetrahydrofuran at 50℃; for 2h; Inert atmosphere;
90%
2,3-Lutidine
583-61-9

2,3-Lutidine

2-oxo-2H-chromene-3-carboxylic acid
531-81-7

2-oxo-2H-chromene-3-carboxylic acid

4-((3-methylpyridin-2-yl)methyl)chroman-2-one
1542158-10-0

4-((3-methylpyridin-2-yl)methyl)chroman-2-one

Conditions
ConditionsYield
In 1,4-dioxane at 120℃; for 48h;90%
2,3-Lutidine
583-61-9

2,3-Lutidine

1-cyanoethyl trifluoromethanesulfonate
1403873-31-3

1-cyanoethyl trifluoromethanesulfonate

1-(1-cyanoethyl)-2,3-dimethylpyridinium triflate

1-(1-cyanoethyl)-2,3-dimethylpyridinium triflate

Conditions
ConditionsYield
In diethyl ether at 20℃; for 48h; Inert atmosphere;90%
2,3-Lutidine
583-61-9

2,3-Lutidine

ethyl 2-bromomethyl-2-propenoate
17435-72-2

ethyl 2-bromomethyl-2-propenoate

C13H17NO2

C13H17NO2

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl acetamide at 150℃; for 16h; Inert atmosphere;90%
2,3-Lutidine
583-61-9

2,3-Lutidine

1-adamantyl bromomethyl ketone
5122-82-7

1-adamantyl bromomethyl ketone

2,3-dimethyl-1-[2-oxo-2-(tricyclo[3.3.1.13,7]dec-1-yl)ethyl]pyridinium bromide

2,3-dimethyl-1-[2-oxo-2-(tricyclo[3.3.1.13,7]dec-1-yl)ethyl]pyridinium bromide

Conditions
ConditionsYield
In acetonitrile at 20℃;90%
2,3-Lutidine
583-61-9

2,3-Lutidine

inden-1-one
83-33-0

inden-1-one

1-(3-Methylpyridin-2-ylmethyl)-1-indanol

1-(3-Methylpyridin-2-ylmethyl)-1-indanol

Conditions
ConditionsYield
With n-butyllithium89%
2,3-Lutidine
583-61-9

2,3-Lutidine

Dimethyldisulphide
624-92-0

Dimethyldisulphide

2-bis(methylthio)methyl-3-methylpyridine

2-bis(methylthio)methyl-3-methylpyridine

Conditions
ConditionsYield
Stage #1: 2,3-Lutidine With n-butyllithium; N-ethyl-N,N-diisopropylamine; sodium t-butanolate In tetrahydrofuran; hexane at -78℃;
Stage #2: Dimethyldisulphide In tetrahydrofuran; hexane at -78℃; Further stages.;
89%
2,3-Lutidine
583-61-9

2,3-Lutidine

ruthenium(II) phthalocyanine
27636-56-2

ruthenium(II) phthalocyanine

(phthalocyaninato)(2,3-lutidine)2-ruthenium(II)
133776-65-5

(phthalocyaninato)(2,3-lutidine)2-ruthenium(II)

Conditions
ConditionsYield
In neat (no solvent) under N2; refluxed for 5 h; addn. of hexane to hot soln.; slowly cooled down to room temp.; filtered; washed (MeOH); chromy. (Al2O3, CHCl3); dried (70°C); elem. anal.; UV; IR;89%
2,3-Lutidine
583-61-9

2,3-Lutidine

2-oxo-2H-thiochromene-3-carboxylic acid
66253-08-5

2-oxo-2H-thiochromene-3-carboxylic acid

4-((3-methylpyridin-2-yl)methyl)thiochroman-2-one
1542158-28-0

4-((3-methylpyridin-2-yl)methyl)thiochroman-2-one

Conditions
ConditionsYield
In 1,4-dioxane at 120℃; for 48h;89%
2,3-Lutidine
583-61-9

2,3-Lutidine

5,6-dimethylpicolinamide

5,6-dimethylpicolinamide

Conditions
ConditionsYield
With dipotassium peroxodisulfate; oxygen; sodium formate; silver nitrate In water at 80℃; for 4h; Schlenk technique; regioselective reaction;89%
With dipotassium peroxodisulfate; oxygen; sodium acetate; silver nitrate In water at 80℃; for 4h; Green chemistry;89%

2,3-Lutidine Chemical Properties

Molecule structure of 2,3-Lutidine (CAS NO.583-61-9):

IUPAC Name: 2,3-Dimethylpyridine 
Molecular Weight: 107.15306 g/mol
Molecular Formula: C7H9
Density: 0.93 g/cm3 
Melting Point: −15 °C(lit.)
Boiling Point: 160.7 °C at 760 mmHg 
Flash Point: 45.4 °C
Index of Refraction: 1.501
Molar Refractivity: 33.99 cm3
Molar Volume: 115.2 cm3
Surface Tension: 33.2 dyne/cm 
Enthalpy of Vaporization: 39.08 kJ/mol
Vapour Pressure: 3.07 mmHg at 25 °C 
Storage Temp.: flammables area
Water Solubility: 95 g/L (26 °C)
XLogP3-AA: 1.6
H-Bond Acceptor: 1
Exact Mass: 107.073499
MonoIsotopic Mass: 107.073499
Topological Polar Surface Area: 12.9
Heavy Atom Count: 8
Canonical SMILES: CC1=C(N=CC=C1)C
InChI: InChI=1S/C7H9N/c1-6-4-3-5-8-7(6)2/h3-5H,1-2H3
InChIKey: HPYNZHMRTTWQTB-UHFFFAOYSA-N
EINECS: 209-514-1
Product Categories: Pyridines derivates; Heterocyclic Compounds; Biochemistry; Reagents for Oligosaccharide Synthesis

2,3-Lutidine Safety Profile

Hazard Codes: HarmfulXn, FlammableF, IrritantXi
Risk Statements: 10-22-37/38-41-20/21/22-36/37/38 
R10:Flammable. 
R22:Harmful if swallowed. 
R37/38:Irritating to respiratory system and skin. 
R41:Risk of serious damage to the eyes. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 16-26-39-36/37-36/37/39 
S16:Keep away from sources of ignition. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S39:Wear eye / face protection. 
S36/37:Wear suitable protective clothing and gloves. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
HazardClass: 6.1
PackingGroup: II

2,3-Lutidine Specification

 2,3-Lutidine (CAS NO.583-61-9) is also named as 2,3-Dimethylpyridine ; AI3-24280 ; NSC 2157 ; 2,3-Lutidine (8CI) ; Pyridine, 2,3-dimethyl- . 2,3-Lutidine (CAS NO.583-61-9) is clear colorless to slightly yellow liquid.

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