Product Name

  • Name

    (2-Chlorophenyl)phenyl-methanone

  • EINECS 225-936-9
  • CAS No. 5162-03-8
  • Article Data115
  • CAS DataBase
  • Density 1.207 g/cm3
  • Solubility Insoluble AUTOIGNITION
  • Melting Point 44-47 °C(lit.)
  • Formula C13H9ClO
  • Boiling Point 330.6 °C at 760 mmHg
  • Molecular Weight 216.667
  • Flash Point 175.2 °C
  • Transport Information 25kgs
  • Appearance white to yellow crystalline powder
  • Safety 37/39-26-24/25-36
  • Risk Codes 36/37/38-20/21/22
  • Molecular Structure Molecular Structure of 5162-03-8 ((2-Chlorophenyl)phenyl-methanone)
  • Hazard Symbols HarmfulXn, IrritantXi
  • Synonyms Benzophenone,2-chloro- (6CI,7CI,8CI);(2-Chlorophenyl)(phenyl)methanone;2-Benzoylphenylchloride;Methanone,(2-chlorophenyl)phenyl-;2-Chlorophenyl phenyl ketone;NSC 62529;o-Chlorobenzophenone;
  • PSA 17.07000
  • LogP 3.57100

Synthetic route

o-chlorobenzoyl chloride
609-65-4

o-chlorobenzoyl chloride

benzene
71-43-2

benzene

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With aluminium trichloride for 19.5h; Heating;100%
Friedel-Crafts reaction;90%
iron(III) chloride at 109℃; for 0.458333h; Product distribution / selectivity; Irradiation;83%
(2-chlorophenyl)phenylmethanone oxime
71225-69-9

(2-chlorophenyl)phenylmethanone oxime

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With toluene-4-sulfonic acid at 20℃; for 0.0166667h; neat (no solvent);98%
With periodic acid at 20℃; for 0.3h;86%
benzoyl chloride
98-88-4

benzoyl chloride

chlorobenzene
108-90-7

chlorobenzene

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With C4F9SO3H at 130℃; for 0.333333h; Product distribution; var. of time, conc. of reagent;96%
With aluminum (III) chloride for 6h; Friedel-Crafts Acylation; Reflux;
sodium tetraphenyl borate
143-66-8

sodium tetraphenyl borate

o-chlorobenzoyl chloride
609-65-4

o-chlorobenzoyl chloride

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With potassium fluoride; bis-triphenylphosphine-palladium(II) chloride In acetone for 0.15h; microwave irradiation (525 W);94%
With aluminum oxide; bis-triphenylphosphine-palladium(II) chloride; potassium fluoride In acetone for 0.0833333h; MW-irradiation;90%
With silica-supported diphenylphosphine palladium(0) In tetrahydrofuran at 40℃; for 48h;74%
(2-chlorophenyl)(phenyl)methanol
6954-45-6, 16071-25-3, 16071-26-4, 134236-27-4

(2-chlorophenyl)(phenyl)methanol

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With cobalt(III) acetate; sodium bromide In acetic acid at 60℃; for 1h;93%
With peracetic acid; 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy In acetonitrile at 20℃; for 9h;93%
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione at 80℃; for 0.5h; Reagent/catalyst;92%
(o-benzyl)chlorobenzene
29921-41-3

(o-benzyl)chlorobenzene

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With pyridine; tert.-butylhydroperoxide; iodine In water at 80℃; chemoselective reaction;93%
With N-Bromosuccinimide; water In chloroform for 3h; Reflux;92%
With lithium perchlorate In water; acetonitrile at 20℃; for 5h; Electrolysis;67%
2-Chlorobenzeneboronic acid
3900-89-8

2-Chlorobenzeneboronic acid

benzoyl chloride
98-88-4

benzoyl chloride

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With 2C60H80NaO12(2+)*Cl6Pd2(2-); potassium carbonate; triphenylphosphine In toluene at 70℃; for 12h; Suzuki Coupling;93%
With [Pd(η(5)-C5H5)Fe(η(5)-C5H3-C(CH3)=N-C6H4-4-CH3)Cl(P(C6H5)3)]; potassium carbonate In toluene at 60℃; for 12h; Inert atmosphere;90%
1-(o-chlorophenyl)-1-phenylethylene
24892-81-7

1-(o-chlorophenyl)-1-phenylethylene

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With oxygen at 110℃; for 8h; Schlenk technique; Green chemistry;91%
With oxygen at 110℃; for 8h; Sealed tube;90.9%
With cerium(III) chloride; 1,1,1-trichloroethanol In acetonitrile at 25℃; for 40h; Irradiation;78%
(E)-2-chlorostilbene
1657-52-9

(E)-2-chlorostilbene

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With sodium periodate; tetraethylammonium iodide In water; acetonitrile at 105℃; for 12h; Sealed tube;89%
iodobenzene
591-50-4

iodobenzene

carbon monoxide
201230-82-2

carbon monoxide

chlorophenyltriethoxysilane

chlorophenyltriethoxysilane

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With dichloro bis(acetonitrile) palladium(II); cesium fluoride In 1-methyl-pyrrolidin-2-one at 80℃; under 760.051 Torr; for 6h; Hiyama Coupling;88%
...Expand
2-Chlorobenzeneboronic acid
3900-89-8

2-Chlorobenzeneboronic acid

Benzoylformic acid
611-73-4

Benzoylformic acid

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With silver carbonate In acetonitrile at 60℃; for 1h;87%
carbon monoxide
201230-82-2

carbon monoxide

Phenyl triflate
17763-67-6

Phenyl triflate

2-Chlorobenzeneboronic acid
3900-89-8

2-Chlorobenzeneboronic acid

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium(II) trifluoroacetate In tert-butyl methyl ether at 80℃; under 760.051 Torr; for 6h; Suzuki-Miyaura Coupling;87%
...Expand
iodobenzene
591-50-4

iodobenzene

C8H4ClO3(1-)*K(1+)

C8H4ClO3(1-)*K(1+)

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With copper(l) iodide; palladium(II) iodide at 120℃; for 3h;85%
ortho-chlorobenzoic acid
118-91-2

ortho-chlorobenzoic acid

phenylboronic acid
98-80-6

phenylboronic acid

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); water; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline In N,N-dimethyl-formamide at 60℃; for 15h; Inert atmosphere;84%
2-Chlorobenzeneboronic acid
3900-89-8

2-Chlorobenzeneboronic acid

benzaldehyde
100-52-7

benzaldehyde

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With [Pd(2-((1-naphthalenyl)methylene)-N-phenylhydrazinecarbothioamide)Cl(PPh3)]; caesium carbonate In toluene at 110℃; for 12h;84%
With potassium phosphate; 3,3-dimethyl-butan-2-one; C14H10Cl2N2O2Ru; tri tert-butylphosphoniumtetrafluoroborate In water; toluene at 100℃; for 24h;65%
benzophenone
119-61-9

benzophenone

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With dipotassium peroxodisulfate; N-chloro-succinimide; trifluorormethanesulfonic acid; palladium diacetate In 1,2-dichloro-ethane at 80℃; for 10h; Reagent/catalyst;83%
carbon monoxide
201230-82-2

carbon monoxide

2-iodochlorobenzene
615-41-8

2-iodochlorobenzene

triethoxyphenylsilane
780-69-8

triethoxyphenylsilane

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With dichloro bis(acetonitrile) palladium(II); cesium fluoride In 1-methyl-pyrrolidin-2-one at 80℃; under 760.051 Torr; for 6h; Hiyama Coupling;83%
...Expand
carbon monoxide
201230-82-2

carbon monoxide

toluene-4-sulfonic acid phenyl ester
640-60-8

toluene-4-sulfonic acid phenyl ester

2-Chlorobenzeneboronic acid
3900-89-8

2-Chlorobenzeneboronic acid

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; 1,2-bis-(diphenylphosphino)ethane In N,N-dimethyl acetamide at 80℃; under 760.051 Torr; for 6h; Suzuki-Miyaura Coupling;83%
...Expand
2-chloro-benzaldehyde
89-98-5

2-chloro-benzaldehyde

phenylboronic acid
98-80-6

phenylboronic acid

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With [Pd(2-((1-naphthalenyl)methylene)-N-phenylhydrazinecarbothioamide)Cl(PPh3)]; caesium carbonate In toluene at 110℃; for 12h;83%
With C36H28NO2PPd; caesium carbonate In toluene for 18h; Reagent/catalyst; Reflux;79%
o-chlorobenzoyl chloride
609-65-4

o-chlorobenzoyl chloride

phenylboronic acid
98-80-6

phenylboronic acid

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With potassium carbonate; (t-Bu2POH)2PdCl2 In 1,4-dioxane; toluene at 80℃; for 1h; Suzuki cross-coupling reaction;82%
With water; sodium carbonate; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; palladium diacetate at 60℃; for 3h; Suzuki reaction;80%
With C28H40Br4N4Pd2; potassium carbonate In ethanol; water at 50℃; for 5h; Suzuki Coupling;78%
With sodium dodecyl-sulfate; potassium carbonate; palladium dichloride In water at 60℃; for 6h;40%
2-chlorobenzoic anhydride
49619-43-4

2-chlorobenzoic anhydride

phenylboronic acid
98-80-6

phenylboronic acid

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With PEG200; sodium carbonate; palladium diacetate at 60℃; for 3h; Suzuki reaction;82%
With sodium carbonate; palladium dichloride In water; acetone at 20℃; for 1.5h; Suzuki type reaction; Inert atmosphere;78%
With sodium dodecyl-sulfate; potassium carbonate; palladium dichloride In water at 60℃; for 6h;68%
N-amino-o-chlorobenzenesulfonamide
5906-98-9

N-amino-o-chlorobenzenesulfonamide

benzonitrile
100-47-0

benzonitrile

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With 2,2'-biquinoline; water; palladium diacetate In dimethyl sulfoxide at 80℃; under 760.051 Torr; for 6h;82%
bromobenzene
108-86-1

bromobenzene

carbon monoxide
201230-82-2

carbon monoxide

chlorophenyltriethoxysilane

chlorophenyltriethoxysilane

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With dichloro bis(acetonitrile) palladium(II); cesium fluoride In 1-methyl-pyrrolidin-2-one at 100℃; under 760.051 Torr; for 6h; Hiyama Coupling;81%
...Expand
o-(α,α-dichlorobenzyl)phenyl phosphochloridate
5381-96-4

o-(α,α-dichlorobenzyl)phenyl phosphochloridate

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With trichlorophosphate at 220℃; under 1 Torr;80%
potassium (2-chlorophenyl)trifluoroborate

potassium (2-chlorophenyl)trifluoroborate

phenylglyoxylic acid potassium salt
63468-90-6

phenylglyoxylic acid potassium salt

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With dipotassium peroxodisulfate; silver nitrate In water at 25℃; for 1h; Green chemistry;79%
carbon monoxide
201230-82-2

carbon monoxide

2-iodochlorobenzene
615-41-8

2-iodochlorobenzene

benzene
71-43-2

benzene

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); silver trifluoromethanesulfonate In 1,2-dichloro-ethane at 100℃; under 3040.2 Torr; for 24h; Inert atmosphere; Sealed tube; Glovebox; Schlenk technique; Green chemistry; chemoselective reaction;79%
...Expand
(2-Chloro-phenyl)-phenyl-methanethione
100108-97-2

(2-Chloro-phenyl)-phenyl-methanethione

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With clay supported ferric nitrate; Clayfen In dichloromethane for 8h; Ambient temperature;78%
2-bromo-1-chlorobenzene
694-80-4

2-bromo-1-chlorobenzene

carbon monoxide
201230-82-2

carbon monoxide

triethoxyphenylsilane
780-69-8

triethoxyphenylsilane

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With dichloro bis(acetonitrile) palladium(II); cesium fluoride In 1-methyl-pyrrolidin-2-one at 100℃; under 760.051 Torr; for 6h; Hiyama Coupling;78%
...Expand
2-Hydroxybenzophenone
117-99-7

2-Hydroxybenzophenone

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Conditions
ConditionsYield
With phosphorus pentachloride at 215 - 220℃;77.2%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

(2-chlorophenyl)(phenyl)methanol
6954-45-6, 16071-25-3, 16071-26-4, 134236-27-4

(2-chlorophenyl)(phenyl)methanol

Conditions
ConditionsYield
With N-methylpyrrolidine zinc borohydride In tetrahydrofuran for 0.5h; Heating;100%
With [(OC-6-13)-RuCl2[P(p-CH3C6H5)3]2(en)]; potassium tert-butylate; hydrogen In isopropyl alcohol; tert-butyl alcohol at 28℃; under 6080.41 Torr; for 12h; Catalytic hydrogenation;95%
With sodium tetrahydroborate In ethanol at 20℃; for 3h;94.1%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

(S)-2-chlorobenzhydrol
16071-25-3

(S)-2-chlorobenzhydrol

Conditions
ConditionsYield
Stage #1: (2-chlorophenyl)(phenyl)methanone With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; polymethylhydrosiloxane; copper(l) chloride; sodium t-butanolate In toluene at -30℃; for 13h; Inert atmosphere;
Stage #2: With sodium hydroxide; water In ethyl acetate; toluene for 1h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;		99%
With formic acid; ((R,R)-Ts-DENEB)RuCl; triethylamine at 40℃; for 17h; Reagent/catalyst; Inert atmosphere; enantioselective reaction;99%
With C32H39BrMnN2O2P; potassium tert-butylate; hydrogen In methanol at 20℃; under 22502.3 Torr; for 16h; Glovebox; Autoclave; enantioselective reaction;99%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

p-tolylzinc(II) chloride
90252-89-4

p-tolylzinc(II) chloride

(4′-methylbiphenyl-2-yl)(phenyl)methanone
13124-61-3

(4′-methylbiphenyl-2-yl)(phenyl)methanone

Conditions
ConditionsYield
With C26H24ClN2NiP*0.1C7H8 In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Negishi Coupling; Schlenk technique; Inert atmosphere;99%
With Ni(Cl){2-(Ph2P(O))C6H4NCH(Ph)PPh2} In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 25℃; for 24h; Negishi coupling reaction; Inert atmosphere;98%
With C27H22Cl2N3NiP In tetrahydrofuran; 1-methyl-pyrrolidin-2-one for 24h; Inert atmosphere; Schlenk technique; Heating;91%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

(R)-(2-chlorophenyl)phenylmethanol

(R)-(2-chlorophenyl)phenylmethanol

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C43H53FeN2O2PS; hydrogen; lithium tert-butoxide In isopropyl alcohol at 25 - 30℃; under 22801.5 Torr; for 12h; Autoclave; enantioselective reaction;98%
With potassium tert-butylate; hydrogen; triphenylphosphine In toluene; tert-butyl alcohol at 25℃; under 15201 Torr; for 24h; Product distribution / selectivity;95%
With hydrogen; C34H63ClIrNP2; lithium tert-butoxide In hexane; toluene at 20℃; under 38002.6 Torr; for 24h; Autoclave; enantioselective reaction;95%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

4-methoxyphenyl magnesium bromide
13139-86-1

4-methoxyphenyl magnesium bromide

(4′-methoxylbiphenyl-2-yl)(phenyl)methanone
851591-16-7

(4′-methoxylbiphenyl-2-yl)(phenyl)methanone

Conditions
ConditionsYield
Stage #1: 4-methoxyphenyl magnesium bromide In tetrahydrofuran at -20℃; for 0.166667h;
Stage #2: (2-chlorophenyl)(phenyl)methanone With para-fluorostyrene; tetra-(n-butyl)ammonium iodide; cobalt acetylacetonate In tetrahydrofuran; 1,2-dimethoxyethane at 25℃; for 1h;		98%
Stage #1: 4-methoxyphenyl magnesium bromide In tetrahydrofuran at -20℃; for 0.166667h;
Stage #2: (2-chlorophenyl)(phenyl)methanone With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; para-fluorostyrene; tetra-(n-butyl)ammonium iodide; cobalt acetylacetonate In tetrahydrofuran; 1,2-dimethoxyethane at 25℃; for 1h; Further stages.;		98%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

para-bromotoluene
106-38-7

para-bromotoluene

(4′-methylbiphenyl-2-yl)(phenyl)methanone
13124-61-3

(4′-methylbiphenyl-2-yl)(phenyl)methanone

Conditions
ConditionsYield
Stage #1: para-bromotoluene With lithium
Stage #2: With zinc(II) chloride
Stage #3: (2-chlorophenyl)(phenyl)methanone; nickel amido phosphine pincer complex In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 100℃; for 24h; Negishi cross-coupling; Further stages.;		98%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

(4-(trifluoromethyl)phenyl)zinc(II) chloride
125102-17-2

(4-(trifluoromethyl)phenyl)zinc(II) chloride

phenyl(4′-(trifluoromethyl)-[1,1′-biphenyl]-2-yl)methanone

phenyl(4′-(trifluoromethyl)-[1,1′-biphenyl]-2-yl)methanone

Conditions
ConditionsYield
With C26H24ClN2NiP*0.1C7H8 In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 80℃; for 24h; Negishi Coupling; Schlenk technique; Inert atmosphere;98%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

(4-cyano-3-fluorophenyl)zinc chloride

(4-cyano-3-fluorophenyl)zinc chloride

2'-benzoyl-3-fluoro-[1,1'-biphenyl]-4-carbonitrile

2'-benzoyl-3-fluoro-[1,1'-biphenyl]-4-carbonitrile

Conditions
ConditionsYield
With Li2CoCl4; sodium formate In tetrahydrofuran at 25℃; Negishi Coupling; Inert atmosphere; Schlenk technique;98%
trifluoromethan
75-46-7

trifluoromethan

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

2,2,2-trifluoro-1-(2-chlorophenyl)-1-phenylethanol
730-63-2

2,2,2-trifluoro-1-(2-chlorophenyl)-1-phenylethanol

Conditions
ConditionsYield
Stage #1: trifluoromethan; (2-chlorophenyl)(phenyl)methanone With tris(trimethylsilyl)amine; phosphazene base-P4-tert-butyl In tetrahydrofuran at 20℃; for 10h; Schlenk technique;
Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 1h; Schlenk technique;		98%
With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; under 750.075 Torr; for 0.000138889h; Flow reactor;74%
3-cyanobromobenzene
6952-59-6

3-cyanobromobenzene

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

2'-benzoyl-[1,1'-biphenyl]-3-carbonitrile

2'-benzoyl-[1,1'-biphenyl]-3-carbonitrile

Conditions
ConditionsYield
Stage #1: 3-cyanobromobenzene With TurboGrignard In tetrahydrofuran at 0℃; for 3h;
Stage #2: In tetrahydrofuran at -20℃; for 0.166667h;
Stage #3: (2-chlorophenyl)(phenyl)methanone With para-fluorostyrene; tetra-(n-butyl)ammonium iodide; cobalt acetylacetonate In tetrahydrofuran; 1,2-dimethoxyethane at 25℃; for 1.5h;		96%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

phenylmagnesium bromide

phenylmagnesium bromide

2-phenylbenzophenone
1985-32-6

2-phenylbenzophenone

Conditions
ConditionsYield
Stage #1: phenylmagnesium bromide In tetrahydrofuran at -20℃; for 0.166667h;
Stage #2: (2-chlorophenyl)(phenyl)methanone With para-fluorostyrene; tetra-(n-butyl)ammonium iodide; cobalt acetylacetonate In tetrahydrofuran; 1,2-dimethoxyethane at 25℃; for 0.25h;		95%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

PhCu(CN)MgX, X = Br or Cl

PhCu(CN)MgX, X = Br or Cl

2-phenylbenzophenone
1985-32-6

2-phenylbenzophenone

Conditions
ConditionsYield
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; para-fluorostyrene; tetra-(n-butyl)ammonium iodide; cobalt acetylacetonate In tetrahydrofuran; 1,2-dimethoxyethane at 25℃; for 0.25h;95%
N,N-diethyl-2,2-difluoroacetamide
686-11-3

N,N-diethyl-2,2-difluoroacetamide

(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

N,N-diethyl-3-(2-chlorophenyl)-3-phenyl-2,2-difluoro-3-hydroxypropanamide

N,N-diethyl-3-(2-chlorophenyl)-3-phenyl-2,2-difluoro-3-hydroxypropanamide

Conditions
ConditionsYield
With potassium hexamethylsilazane In toluene at 20℃; for 0.25h; Inert atmosphere;95%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

butyl magnesium bromide
693-04-9

butyl magnesium bromide

(2-butyl-phenyl)-phenyl-methanone
59137-63-2

(2-butyl-phenyl)-phenyl-methanone

Conditions
ConditionsYield
Stage #1: butyl magnesium bromide With lithium chloride; manganese(ll) chloride In tetrahydrofuran at -10℃;
Stage #2: (2-chlorophenyl)(phenyl)methanone In tetrahydrofuran at -5℃; for 0.75h;		94%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

C13H10(2)HClO

C13H10(2)HClO

Conditions
ConditionsYield
With N-Methyldicyclohexylamine; [iridium(2-(4-fluorophenyl)pyridinato)2(2,2'-bipyridine)]hexafluorophosphate; water-d2; lithium carbonate In acetonitrile Irradiation;94%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

4-(N,N-dimethylamino)phenylmagnesium bromide lithium chloride complex

4-(N,N-dimethylamino)phenylmagnesium bromide lithium chloride complex

(4'-(dimethylamino)-[1,1'-biphenyl]-2-yl)(phenyl)methanone

(4'-(dimethylamino)-[1,1'-biphenyl]-2-yl)(phenyl)methanone

Conditions
ConditionsYield
With chromium dichloride In tetrahydrofuran at 25℃; for 0.25h; Inert atmosphere;93%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

((triisopropylsilyl)ethynyl)zinc pivalate

((triisopropylsilyl)ethynyl)zinc pivalate

phenyl(2-((triisopropylsilyl)ethynyl)phenyl)methanone

phenyl(2-((triisopropylsilyl)ethynyl)phenyl)methanone

Conditions
ConditionsYield
With Li2CoCl4; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran; 1,4-dioxane at 20℃; for 8h; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere; Schlenk technique;93%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

para-methylphenylmagnesium bromide
4294-57-9

para-methylphenylmagnesium bromide

A

(4,4'-dimethyl-1,1'-biphenyl)
613-33-2

(4,4'-dimethyl-1,1'-biphenyl)

B

(4′-methylbiphenyl-2-yl)(phenyl)methanone
13124-61-3

(4′-methylbiphenyl-2-yl)(phenyl)methanone

Conditions
ConditionsYield
With C80H88Cl2N6NiP2; water; lithium chloride; zinc(II) chloride In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 55℃; Kumada coupling reaction; Inert atmosphere;A n/a
B 92%
...Expand
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

2-phenylbenzophenone
1985-32-6

2-phenylbenzophenone

Conditions
ConditionsYield
Stage #1: phenylmagnesium bromide With titanium(IV) tetraethanolate In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere;
Stage #2: (2-chlorophenyl)(phenyl)methanone With tributylphosphine; cobalt(II) chloride In tetrahydrofuran at 20℃; Inert atmosphere; chemoselective reaction;		92%
Stage #1: (2-chlorophenyl)(phenyl)methanone With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate In tetrahydrofuran; toluene Kumada Cross-Coupling; Inert atmosphere; Sealed tube;
Stage #2: phenylmagnesium bromide In tetrahydrofuran; toluene at 20℃; for 2h; Kumada Cross-Coupling; Inert atmosphere; Sealed tube; chemoselective reaction;		82%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

Diphenylmethane
101-81-5

Diphenylmethane

Conditions
ConditionsYield
With W-7 Raney-Nickel In ethanol for 6h; Heating;91%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

(3-dimethylaminopropyl)-triphenylphosphoniumbromide
18355-96-9

(3-dimethylaminopropyl)-triphenylphosphoniumbromide

(4-(2-chlorophenyl)-4-phenyl-but-3-enyl)-dimethyl-amine

(4-(2-chlorophenyl)-4-phenyl-but-3-enyl)-dimethyl-amine

Conditions
ConditionsYield
Stage #1: (3-dimethylaminopropyl)-triphenylphosphoniumbromide With n-butyllithium In tetrahydrofuran; hexane at 0℃; Wittig reaction;
Stage #2: (2-chlorophenyl)(phenyl)methanone In tetrahydrofuran; hexane at 0 - 20℃; Further stages.;		91%
(2-chlorophenyl)(phenyl)methanone
5162-03-8

(2-chlorophenyl)(phenyl)methanone

phenyllithium
591-51-5

phenyllithium

2-phenylbenzophenone
1985-32-6

2-phenylbenzophenone

Conditions
ConditionsYield
Stage #1: phenyllithium With titanium(IV) tetraethanolate In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere;
Stage #2: (2-chlorophenyl)(phenyl)methanone With tributylphosphine; cobalt(II) chloride In tetrahydrofuran at 20℃; Inert atmosphere; chemoselective reaction;		91%

2-Chlorobenzophenone Chemical Properties

Structure of 2-Chlorobenzophenone (CAS NO.5162-03-8):

IUPAC Name: (2-Chlorophenyl)-phenylmethanone
Molecular Formula: C13H9ClO
Molar mass: 216.663 g/mol
Density: 1.207 g/cm3
Flash Point: 175.2 °C
Index of Refraction: 1.594
Melting Point: 44-47 °C(lit.)
Boiling Point: 330.6 °C at 760 mmHg
Vapour Pressure: 0.000164 mmHg at 25 °C 
XLogP3: 4
H-Bond Acceptor: 1
Rotatable Bond Count: 2
Exact Mass: 216.034193
MonoIsotopic Mass: 216.034193
Topological Polar Surface Area: 17.1
Heavy Atom Count: 15 
Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=CC=CC=C2Cl
InChI: InChI=1S/C13H9ClO/c14-12-9-5-4-8-11(12)13(15)10-6-2-1-3-7-10/h1-9H
InChIKey: VMHYWKBKHMYRNF-UHFFFAOYSA-N
EINECS: 225-936-9
Product Categories: Aromatic Benzophenones & Derivatives (substituted); Functional Materials; Photopolymerization Initiators; C13 to C14; Carbonyl Compounds; Ketones

2-Chlorobenzophenone Uses

 2-Chlorobenzophenone (CAS NO.5162-03-8) can be used as pharmaceutical intermediates.

2-Chlorobenzophenone Toxicity Data With Reference

mouse LD oral > 500mg/kg (500mg/kg) BEHAVIORAL: MUSCLE WEAKNESS National Technical Information Service. Vol. OTS0544006,

2-Chlorobenzophenone Safety Profile

Hazard Codes: IrritantXi, HarmfulXn
Risk Statements: 36/37/38-20/21/22 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 37/39-26-24/25-36 
S37/39:Wear suitable gloves and eye/face protection. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S24/25:Avoid contact with skin and eyes. 
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: PC4945633
Hazard Note: Irritant

2-Chlorobenzophenone Specification

 2-Chlorobenzophenone (CAS NO.5162-03-8) is also named as (2-Chlorophenyl)phenylmethanone ; 2-Chlorobenyl phenyl ketone ; AI3-22112 ; NSC 62529 ; o-Chlorobenzophenone ; Benzophenone, 2-chloro- (6CI,7CI,8CI) ; Methanone, (2-chlorophenyl)phenyl- . 2-Chlorobenzophenone (CAS NO.5162-03-8) is white to yellow crystalline powder.

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