2-Chlorobenzoyl chloride supplier

Name
2-Chlorobenzoyl chloride
EINECS 210-194-0
CAS No. 609-65-4
Article Data145
CAS DataBase
Density 1.369 g/cm³
Solubility Soluble in acetone, ether, and alcohol. Solubility in water it decomposes.
Melting Point -4 °C
Formula C₇H₄Cl₂O
Boiling Point 238 °C at 760 mmHg
Molecular Weight 175.014
Flash Point 91.2 °C
Transport Information UN 3265 8/PG 2
Appearance clear colourless to very slightly yellow liquid
Safety 26-36/37/39-45-28A
Risk Codes 34
Molecular Structure
Hazard Symbols
Synonyms Benzoylchloride, o-chloro- (6CI,7CI,8CI);NSC 93897;o-Chlorobenzoyl chloride;
PSA 17.07000
LogP 2.71900

Synthetic route

: 118-91-2
ortho-chlorobenzoic acid

: 609-65-4
o-chlorobenzoyl chloride

Conditions

Conditions	Yield
With thionyl chloride In toluene at 75℃;	100%
With thionyl chloride Reflux;	100%
With thionyl chloride at 100℃;	100%

: 201230-82-2
carbon monoxide

: 615-41-8
2-iodochlorobenzene

: 609-65-4
o-chlorobenzoyl chloride

Conditions

Conditions	Yield
With bis(tri-t-butylphosphine)palladium(0); benzyltriphenylphosphonium chloride In toluene at 110℃; under 38002.6 Torr; for 24h; Glovebox; Autoclave; Inert atmosphere;	93%

: 115377-62-3
1-benzyl-4-amino-1H-imidazole-5-carboxamide

A: 219935-35-0
4-(2-chlorobenzoylamino)-1-benzyl-5-imidazolecarboxamide

B: 609-65-4
o-chlorobenzoyl chloride

Conditions

Conditions	Yield
	A 92% B n/a

: 89-98-5
2-chloro-benzaldehyde

: 609-65-4
o-chlorobenzoyl chloride

Conditions

Conditions	Yield
With iron(III) chloride; Benzotrichlorid In benzene at 60℃; Rate constant; Mechanism; Thermodynamic data; various concentration ratios;
With chlorine at 140 - 160℃;
With phosphorus pentachloride; chlorine

: 98-88-4
benzoyl chloride

: 609-65-4
o-chlorobenzoyl chloride

Conditions

Conditions	Yield
With chlorine; iron(III) chloride at 35℃;

: 5814-05-1
2-chlorobenzoylhydrazide

: 609-65-4
o-chlorobenzoyl chloride

Conditions

Conditions	Yield
With hydrogenchloride; nitromethane; chlorine

: 133-59-5
Toluene-2-sulfonyl chloride

: 609-65-4
o-chlorobenzoyl chloride

Conditions

Conditions	Yield
With thionyl chloride at 240℃;

: 4342-61-4
1,2-dichlorotetramethylsilane

: 88-95-9
Phthaloyl dichloride

A: 609-65-4
o-chlorobenzoyl chloride

B: 119288-75-4
2-chlorodimethylsilylbenzoylchloride

Conditions

Conditions	Yield
bis(benzonitrile)palladium(II) dichloride; triphenylphosphine at 145℃; for 15h; Title compound not separated from byproducts;	A 18 % Chromat. B 19 % Chromat.

...Expand

2-chloro-trichloromethyl-benzene: 2-chloro-trichloromethyl-benzene

: 609-65-4
o-chlorobenzoyl chloride

Conditions

Conditions	Yield
With steam; iron(III) chloride at 100 - 120℃;

: 89-98-5
2-chloro-benzaldehyde

: 7782-50-5
chlorine

: 609-65-4
o-chlorobenzoyl chloride

Conditions

Conditions	Yield
at 140 - 160℃;

: 7719-09-7
thionyl chloride

: 118-91-2
ortho-chlorobenzoic acid

: 609-65-4
o-chlorobenzoyl chloride

dichloride of/the/ benzoic acid sulfonic acid-(2): dichloride of/the/ benzoic acid sulfonic acid-(2)

: 609-65-4
o-chlorobenzoyl chloride

Conditions

Conditions	Yield
durch Destillation;

: 69-72-7
salicylic acid

A: 609-65-4
o-chlorobenzoyl chloride

B salicylic acid chloride ; 2-chloro-trichloromethyl-benzene: salicylic acid chloride ; 2-chloro-trichloromethyl-benzene

Conditions

Conditions	Yield
With phosphorus pentachloride

: 95-49-8
2-methylchlorobenzene

: 609-65-4
o-chlorobenzoyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: permanganate 2: PCl5 View Scheme

: 79-37-8
oxalyl dichloride

: 118-91-2
ortho-chlorobenzoic acid

: 609-65-4
o-chlorobenzoyl chloride

Conditions

Conditions	Yield
N,N-dimethyl-formamide In 1,1-dichloroethane at 20℃; for 0.5h;

: 104-86-9
4-chlorobenzylamine

: 118-91-2
ortho-chlorobenzoic acid

: 609-65-4
o-chlorobenzoyl chloride

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20 - 25℃; for 4h;

: 186581-53-3, 908094-01-9
diazomethane

: 609-65-4
o-chlorobenzoyl chloride

: 50878-84-7
1-(2-chlorophenyl)-2-diazoethan-1-one

Conditions

Conditions	Yield
In diethyl ether for 2h; Ambient temperature;	100%
With diethyl ether
In diethyl ether at 0℃; Substitution;

: 609-65-4
o-chlorobenzoyl chloride

: 71-43-2
benzene

: 5162-03-8
(2-chlorophenyl)(phenyl)methanone

Conditions

Conditions	Yield
With aluminium trichloride for 19.5h; Heating;	100%
Friedel-Crafts reaction;	90%
iron(III) chloride at 109℃; for 0.458333h; Product distribution / selectivity; Irradiation;	83%

: 95-16-9
1,3-Benzothiazole

: 7677-24-9
trimethylsilyl cyanide

: 609-65-4
o-chlorobenzoyl chloride

: 2-Cyano-3-(o-chlorobenzoyl)-2,3-dihydrobenzothiazole

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane	100%

...Expand

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 609-65-4
o-chlorobenzoyl chloride

: 6183-25-1
2-Chloro-benzoic acid 2-dimethylamino-ethyl ester; hydrochloride

Conditions

Conditions	Yield
In benzene for 0.5h;	100%

: 3179-63-3
3-Dimethylamino-1-propanol

: 609-65-4
o-chlorobenzoyl chloride

: 87686-58-6
2-Chloro-benzoic acid 3-dimethylamino-propyl ester; hydrochloride

Conditions

Conditions	Yield
In benzene for 0.5h;	100%

: 1147550-11-5
ammonium thiocyanate

: 609-65-4
o-chlorobenzoyl chloride

: 5067-90-3
2-chlorobenzoyl isothiocyanate

Conditions

Conditions	Yield
With PEG-400 In ethyl acetate at 20℃;	100%
In acetone for 1h; Heating;
With polyethylene glycol-400 In dichloromethane for 1h; Ambient temperature;

: 609-65-4
o-chlorobenzoyl chloride

: 75-55-8, 41927-28-0, 76612-76-5, 76612-77-6, 205537-16-2
2-Methylaziridine

: 21384-45-2
1-(2-chlorobenzoyl)-2-methylaziridine

Conditions

Conditions	Yield
With sodium hydroxide In diethyl ether at 0℃;	100%
With sodium hydroxide In diethyl ether; water at 0℃; Schotten-Baumann reaction;

: 103505-49-3
6-chloro-N4-(4-chlorophenyl)-4,5-pyrimidinediamine

: 609-65-4
o-chlorobenzoyl chloride

: 686344-48-9
2-chloro-N-[4-chloro-6-(4-chlorophenylamino)pyrimidin-5-yl]benzamide

Conditions

Conditions	Yield
In N,N-dimethyl acetamide at 0 - 20℃;	100%
In N,N-dimethyl acetamide at 5 - 20℃; for 4h;	82%
In N,N-dimethyl acetamide at 5 - 20℃;	82%
In ISOPROPYLAMIDE at 5 - 20℃; for 4h;	82%
In ISOPROPYLAMIDE at 5 - 20℃; for 4.01667h;	82%

: 582-33-2
3-aminobenzoic acid ethyl ester

: 609-65-4
o-chlorobenzoyl chloride

: 300827-69-4
3-(2-chloro-benzoylamino)-benzoic acid ethyl ester

Conditions

Conditions	Yield
With triethylamine In chloroform	100%
With pyridine In tetrahydrofuran at 0℃; for 1h;

: 5398-36-7
2-aminothiazole-4-carboxylate

: 609-65-4
o-chlorobenzoyl chloride

: 324538-40-1
ethyl 2-(2-chlorobenzoyl)amino-1,3-thiazole-4-carboxylate

Conditions

Conditions	Yield
Stage #1: 2-aminothiazole-4-carboxylate With dmap In dichloromethane for 0.166667h; Stage #2: o-chlorobenzoyl chloride In dichloromethane at 50℃; for 12h;	100%
With pyridine In tetrahydrofuran at 0 - 20℃; for 1h;

: 609-65-4
o-chlorobenzoyl chloride

: ammonium thiocyanate

: 5067-90-3
2-chlorobenzoyl isothiocyanate

Conditions

Conditions	Yield
With PEG-400 In ethyl acetate at 20℃;	100%
In benzene for 2h; Reflux;

: 587-03-1
3-methylbenzyl alcohol

: 609-65-4
o-chlorobenzoyl chloride

: 1070881-30-9
3-methylbenzyl 2'-chlorolbenzoate

Conditions

Conditions	Yield
With pyridine at 0℃; for 1.5h;	100%

: methyl 4-amino-3-(methoxymethoxy)benzoate

: 609-65-4
o-chlorobenzoyl chloride

: methyl 4-(2-chlorobenzamido)-3-(methoxymethoxy)benzoate

Conditions

Conditions	Yield
With pyridine at 10 - 35℃;	100%

: 609-65-4
o-chlorobenzoyl chloride

: 177760-52-0
ethyl 2-aminooxazole-4-carboxylate

: C13H11ClN2O4

Conditions

Conditions	Yield
Stage #1: ethyl 2-aminooxazole-4-carboxylate With dmap In dichloromethane for 0.166667h; Stage #2: o-chlorobenzoyl chloride In dichloromethane at 50℃; for 12h;	100%

: 609-65-4
o-chlorobenzoyl chloride

: 62-53-3
aniline

: 6833-13-2
2-chlorobenzanilide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃;	99%
With pyridine; dmap at 0 - 20℃;	97%
With triethylamine In ethyl acetate at 20℃; for 8.66667h;	94%

: 609-65-4
o-chlorobenzoyl chloride

: 95-74-9
3-chloro-p-toluidine

: 7017-26-7
2-chloro-N-(3-chloro-4-methylphenyl)benzamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃;	99%
With ammonia; N,N-dimethyl-aniline In benzene

: 609-65-4
o-chlorobenzoyl chloride

: 106-47-8
4-chloro-aniline

: 319-39-1
2-chloro-N-(4-chlorophenyl)benzamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃;	99%

: 609-65-4
o-chlorobenzoyl chloride

: 73672-75-0
4-hydroxy-2-phenyl-6H-1,3-thiazin-6-one sodium salt

: 73672-81-8
2-Chloro-benzoic acid 6-oxo-2-phenyl-6H-[1,3]thiazin-4-yl ester

Conditions

Conditions	Yield
In benzene for 5h; Heating;	99%

: 609-65-4
o-chlorobenzoyl chloride

: 371-40-4
4-fluoroaniline

: 153386-06-2
2-chloro-N-(4-fluorophenyl)benzamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃;	99%
With pyridine at 0℃; for 12h;
With dmap In dichloromethane at 20℃; for 12h; Inert atmosphere;

: 931-51-1
cyclohexylmagnesiumchloride

: 609-65-4
o-chlorobenzoyl chloride

: cyclohexyl-(2-cyclohexyl-phenyl)-methanone

Conditions

Conditions	Yield
Stage #1: cyclohexylmagnesiumchloride With lithium chloride; manganese(ll) chloride In tetrahydrofuran at -30℃; Stage #2: o-chlorobenzoyl chloride In tetrahydrofuran at -30 - 0℃;	99%

: 100-59-4
phenylmagnesium chloride

: 609-65-4
o-chlorobenzoyl chloride

: 1985-32-6
2-phenylbenzophenone

Conditions

Conditions	Yield
Stage #1: phenylmagnesium chloride With lithium chloride; manganese(ll) chloride In tetrahydrofuran at -30℃; Stage #2: o-chlorobenzoyl chloride In tetrahydrofuran at -30 - 0℃;	99%

: 693-04-9
butyl magnesium bromide

: 609-65-4
o-chlorobenzoyl chloride

: 103562-92-1
1-(2-butyl-phenyl)-pentan-1-one

Conditions

Conditions	Yield
Stage #1: butyl magnesium bromide With lithium chloride; manganese(ll) chloride In tetrahydrofuran at -30℃; Stage #2: o-chlorobenzoyl chloride In tetrahydrofuran at -30℃; for 0.333333h;	99%

: 5307-14-2
2-nitro-1,4-phenylenediamine

: 609-65-4
o-chlorobenzoyl chloride

: 911211-57-9
N-(4-amino-3-nitro-phenyl)-2-chloro-benzamide

Conditions

Conditions	Yield
In dichloromethane at 20℃;	99%

: 699-83-2
2,6-dihydroxylacetophenone

: 609-65-4
o-chlorobenzoyl chloride

: 920006-37-7
2',6'-bis(2-chlorobenzoyloxy)acetophenone

Conditions

Conditions	Yield
With pyridine; dmap at 20℃; for 2h;	99%

: 1450-72-2
5-methyl-2-hydroxyacetophenone

: 609-65-4
o-chlorobenzoyl chloride

: 106551-35-3
2-acetyl-4-methylphenyl 2-Chlorobenzoate

Conditions

Conditions	Yield
With pyridine at 70℃;	99%
In pyridine at 20℃; for 2h; Inert atmosphere;	93%

: 35748-34-6
methyl 3-aminosalicylate

: 609-65-4
o-chlorobenzoyl chloride

: 533898-14-5
C15H12ClNO4

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 24h;	99%

: 1666-13-3
diphenyl diselenide

: 609-65-4
o-chlorobenzoyl chloride

: 62247-17-0
2-chlorobenzenecarboselenoic acid Se-phenyl ester

Conditions

Conditions	Yield
Stage #1: diphenyl diselenide With hydrogenchloride; zinc In water; acetone at 20℃; Schlenk technique; Inert atmosphere; Green chemistry; Stage #2: o-chlorobenzoyl chloride In water; acetone at 20℃; for 0.5h; Schlenk technique; Inert atmosphere; Green chemistry;	99%
With hydrogenchloride; zinc In water at 20℃; for 0.05h; Ionic liquid; Inert atmosphere;	94%
With magnesium; iron(II) chloride In 1,4-dioxane at 100℃; for 12h; Air;	91%

: 609-65-4
o-chlorobenzoyl chloride

: 60022-62-0
L-serine benzyl ester hydrochloride

: 1227492-08-1
(S)-benzyl 2-(2-chlorobenzamido)-3-hydroxypropanoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 50℃;	99%

: 609-65-4
o-chlorobenzoyl chloride

: 615-36-1
2-bromoaniline

: 299954-54-4
2-chlorobenzoic acid 2-bromoanilide

Conditions

Conditions	Yield
With triethylamine In diethyl ether at 0 - 20℃; Inert atmosphere;	99%

2-Chlorobenzoyl chloride Chemical Properties

Product Name: 2-Chlorobenzoyl chloride (CAS NO.609-65-4)
IUPAC Name: 2-chlorobenzoyl chloride
Molecular formula: C₇H₄Cl₂O
Molecular Weight: 175.01

EINECS: 210-194-0
Melting point: -4 °C
Boiling point: 238 °C(lit.)
Density: 1.382 g/mL at 25 °C(lit.)
Refractive index: n20/D 1.572(lit.)
Flash point: >230 ^°F
Sensitive: Moisture Sensitive
Index of Refraction: 1.561
Molar Refractivity: 41.39 cm³
Molar Volume: 127.7 cm³
Surface Tension: 42.8 dyne/cm
Enthalpy of Vaporization: 47.48 kJ/mol
Vapour Pressure: 0.0434 mmHg at 25°C
Product Categories: ACIDHALIDE; Aromatic Halides (substituted); Acid Halides; Carbonyl Compounds; Organic Building Blocks

2-Chlorobenzoyl chloride Safety Profile

The Hazard Codes: C Corrosive
The Risk Statements information:
34: Causes burns
The Safety Statements information:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
F: 19-21
Hazard Note: Corrosive/Moisture Sensitive
HazardClass: 8
RIDADR: UN 3265 8/PG 2
WGK Germany: 1

2-Chlorobenzoyl chloride Specification

2-Chlorobenzoyl chloride , its CAS NO. is 609-65-4, the synonyms are 2-chloro-benzoylchlorid ; Benzoylchloride,2-chloro- ; chlorobenzoylchloride ; Benzoyl chloride, o-chloro- ; o-Chlorobenzonyl chloride .

Product Name

2-Chlorobenzoyl chloride

Synthetic route

2-Chlorobenzoyl chloride Chemical Properties

2-Chlorobenzoyl chloride Safety Profile

2-Chlorobenzoyl chloride Specification

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