Conditions | Yield |
---|---|
With quinoline; sulfuric acid; copper(II) oxide at 220℃; for 3h; | 95% |
Conditions | Yield |
---|---|
Stage #1: o-toluidine hydrochloride With isopentyl nitrite In acetone at 0 - 15℃; Stage #2: With copper dichloride In ethanol; acetone at 5 - 20℃; for 2h; Reagent/catalyst; Solvent; Temperature; Sandmeyer Reaction; | 87% |
tri-tert-butyl phosphine
2-methylchlorobenzene
Conditions | Yield |
---|---|
In benzene-d6 at 70℃; Equilibrium constant; | 76% |
carbon monoxide
1-chloro-2-(chloromethyl)benzene
A
2-methylchlorobenzene
B
1,2-bis(2-chlorophenyl)ethane
C
1,3-bis(2-chlorophenyl)propan-2-one
Conditions | Yield |
---|---|
With [2,2]bipyridinyl; tetrabutylammonium tetrafluoroborate; iron(II) chloride; Fe64/Ni36 anode In N,N-dimethyl-formamide Ambient temperature; electrolysis; | A 2 % Chromat. B 10 % Chromat. C 75% |
Conditions | Yield |
---|---|
With iron(III) chloride In ethanol at 50 - 80℃; for 14h; Temperature; Inert atmosphere; | A 26.8% B 72.3% |
Conditions | Yield |
---|---|
With chlorine; natural kaolinitic clay In tetrachloromethane for 2h; Heating; | A 72% B 23% |
With aluminum (III) chloride; chlorine at 50℃; for 6h; Temperature; Inert atmosphere; | A 71.3% B 27.8% |
With hydrogenchloride; 1-(n-butyl)-3-methylimidazolium triflate at 100℃; for 96h; | A 38% B 60% |
Conditions | Yield |
---|---|
With chloro-trimethyl-silane; N-benzyl-N,N,N-triethylammonium chloride; sodium nitrite In tetrachloromethane 1.) 0 deg C, 1.5 h, 2.) r.t., 17 h; | 70% |
With hydrogenchloride Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuCl; | |
Reaktion ueber mehrere Stufen; |
Conditions | Yield |
---|---|
With potassium hydrogensulfate; potassium chloride; isoquinolinium dichromate In water at 20℃; Catalytic behavior; Reagent/catalyst; Temperature; Sonication; Green chemistry; regioselective reaction; | 69% |
With chlorine; iron im diffusen Licht; |
Conditions | Yield |
---|---|
at 180℃; under 0.5 Torr; for 3h; | A 30% B 65% |
Dithiopivalinsaeure-2-chlorbenzylester
A
2-(tert-butyl)benzo[b]thiophene
B
methyl dithiopivalate
C
2-methylchlorobenzene
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide Mechanism; cathodic reduction, Hg cathode; | A n/a B 63% C 62% |
toluene
A
para-chlorotoluene
B
2-methylchlorobenzene
C
2,4-dichlorotoluene
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hypochlorite In water at 20℃; Product distribution; Further Variations:; Temperatures; molar quantity of reagents; Chlorination; oxidative chlorination; | A 29% B 63% C 3.5% |
With oxone; potassium chloride In acetonitrile at 20℃; for 24h; Product distribution; Further Variations:; Reagents ratio; | |
With sulfuric acid; [BMIM]Cl; chlorine at 70℃; for 8h; |
2-methylenesuccinic acid
o-toluene-diazonium chloride
A
2-methylchlorobenzene
B
2-chloro-2-(2-methylbenzyl)butanedioic acid
Conditions | Yield |
---|---|
With copper(II) choride dihydrate In [(2)H6]acetone; water at 25℃; for 2.5h; Meerwein Arylation; | A n/a B 58% |
1,1-dimethoxyethylene
2-bromo-1-chlorobenzene
A
2-methylchlorobenzene
B
7,7-Dimethoxybicyclo<4.2.0>octa-1,3,5-triene
Conditions | Yield |
---|---|
With methyllithium In diethyl ether Heating; | A 10% B 54% |
2-methylchlorobenzene
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; copper In acetonitrile at 20℃; for 0.75h; Substitution; | 51% |
2,6-dimethylphenyl chloroformic acid ester
A
2-methylchlorobenzene
B
2,6-dimethyl-1-chlorobenzene
Conditions | Yield |
---|---|
With aluminum (III) chloride at 80 - 110℃; for 3h; | A n/a B 43.8% |
toluene
A
para-chlorotoluene
B
2-methylchlorobenzene
C
benzyl chloride
Conditions | Yield |
---|---|
With iron(III)porphyrinate; boron trifluoride diethyl etherate In dichloromethane | A 14% B 11% C 38% |
With sulfuryl dichloride; chromium(0) hexacarbonyl at 120℃; for 20h; Product distribution; with various metal complexes at various temperatures; | A 5.6% B 3.4% C 25.6% |
With chlorine for 2h; Irradiation; | A n/a B n/a C 12% |
toluene
A
para-chlorotoluene
B
2-methylchlorobenzene
C
2,2,3,3,4,4,5,5,6,6,7,7,7-Tridecafluoro-heptanoic acid p-tolyl ester
Conditions | Yield |
---|---|
With lead(IV) acetate; C6F13COOH; lithium chloride at 80℃; for 7h; | A n/a B n/a C 21.2% |
Conditions | Yield |
---|---|
at 200℃; under 2 Torr; for 3h; | A 5% B 15% |
(2)H8-toluene
bis(4-chlorophenyl)(4-methylphenyl)-selenonium chloride
A
para-chlorotoluene
B
2-methylchlorobenzene
C
C7(2)H7Cl
D
C7(2)H7Cl
Conditions | Yield |
---|---|
aluminium trichloride at 20℃; for 4h; other Lewis acids, other rct.-temp., other yields; | A 0.53% B 2.27% C 1.15% D 1.31% |
aluminium trichloride at 20℃; for 4h; Product distribution; Mechanism; other lewis acids (FeCl3, SbCl5, SbCl3, SbF3), other temp. (50 deg C), other yields; | A 0.53% B 2.27% C 1.15% D 1.31% |
methylmagnesium chloride
1,2-dichloro-benzene
A
o-xylene
B
2-methylchlorobenzene
Conditions | Yield |
---|---|
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In tetrahydrofuran at 105℃; for 1h; | A 2% B 93 % Chromat. |
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In tetrahydrofuran at 105℃; for 1h; Product distribution; other substrates, other Grignard reagent, other catalysts, other time, other temperature; | A 2 % Chromat. B 93 % Chromat. |
Conditions | Yield |
---|---|
With copper dichloride |
3-chloro-4-methylbenzenesulfonyl chloride
2-methylchlorobenzene
Conditions | Yield |
---|---|
With sulfuric acid anschliessend Kochen mit H2SO4; | |
Multi-step reaction with 2 steps 1: aqueous alkali View Scheme |
dichloro-tris-o-tolyloxy-phosphorane
2-methylchlorobenzene
Conditions | Yield |
---|---|
at 180℃; | |
at 180℃; |
Conditions | Yield |
---|---|
With copper(l) chloride | |
With hydrogenchloride; copper hydride at 0℃; | |
With hydrogenchloride |
Conditions | Yield |
---|---|
With hydrazine hydrate; diethylene glycol Erhitzen des mit Kaliumhydroxid versetzten Reaktionsgemisches; |
Conditions | Yield |
---|---|
With sulfuric acid; chlorine; iron(III) chloride |
acetic acid-(2,4,6,N-tetrachloro-anilide)
acetic acid
toluene
A
para-chlorotoluene
B
2-methylchlorobenzene
Conditions | Yield |
---|---|
im Dunkeln; |
methyl radical
chlorobenzene
A
1-chloro-3-methylbenzene
B
para-chlorotoluene
C
2-methylchlorobenzene
Conditions | Yield |
---|---|
at 130℃; |
carbon dioxide
2,4-dichlorotoluene
A
ortho-methylbenzoic acid
B
2-methylchlorobenzene
C
3-chloro-4-methylbenzoic acid
D
5-chloro-2-methylbenzoic acid
Conditions | Yield |
---|---|
With tetrabutylammomium bromide In N,N-dimethyl-formamide at 5℃; electrolysis (I=0.4 A); Yield given. Further byproducts given. Yields of byproduct given; |
18-crown-6/o-methylbenzenediazonium tetrafluoroborate complex
A
18-crown-6 ether
B
2-methylchlorobenzene
Conditions | Yield |
---|---|
In 1,2-dichloro-ethane at 20℃; Rate constant; Kinetics; Thermodynamic data; var. crown ethers, ΔH(excit.), ΔS(excit.); |
Conditions | Yield |
---|---|
With Cs2O3; PCy3 adduct of cyclopalladated ferrocenylimine In 1,4-dioxane at 100℃; for 15h; Suzuki cross-coupling reaction; | 100% |
With potassium phosphate; C50H63Cl2N3Pd In ethanol at 80℃; for 4h; Catalytic behavior; Reagent/catalyst; Solvent; Suzuki-Miyaura Coupling; | 100% |
With potassium carbonate In water; isopropyl alcohol at 100℃; for 18h; Suzuki-Miyaura Coupling; Inert atmosphere; | 100% |
2-methylchlorobenzene
2,6-dimethylbenzene boronic acid
2,2',6'-trimethylbiphenyl
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate In 1,4-dioxane for 12h; Suzuki coupling; Inert atmosphere; Reflux; | 100% |
With potassium phosphate; C22H23Br2N3Pd In water; isopropyl alcohol at 20℃; for 44h; Reagent/catalyst; Suzuki-Miyaura Coupling; | 98% |
With potassium phosphate monohydrate; R-Phos; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane at 100℃; for 0.666667h; Suzuki-Miyaura reaction; Inert atmosphere; | 95% |
2-methylchlorobenzene
2,6-diisopropylbenzenamine
Conditions | Yield |
---|---|
With di-μ-bromobis-(tritert-butylphosphine)dipalladium(I); sodium t-butanolate In toluene at 100℃; for 0.75h; Catalytic behavior; Time; Buchwald-Hartwig Coupling; | 100% |
With C34H39N3O4Pd; sodium t-butanolate In 1,4-dioxane at 100℃; for 0.166667h; Buchwald-Hartwig Coupling; Schlenk technique; Inert atmosphere; | 99% |
With C28H29Cl2N3OPd; potassium tert-butylate In toluene at 110℃; for 15h; Buchwald-Hartwig Coupling; Schlenk technique; Inert atmosphere; | 99% |
2-methylchlorobenzene
2,3,3-trimethyl-4-penten-2-ol
1-methyl-2-(3-methylbut-2-en-1-yl)benzene
Conditions | Yield |
---|---|
With palladium diacetate; caesium carbonate; tricyclohexylphosphine In toluene for 17h; Inert atmosphere; Reflux; | 100% |
Conditions | Yield |
---|---|
With copper(I) oxide; caesium carbonate In tetrahydrofuran at 150℃; for 3h; Ullmann condensation; | 100% |
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 12h; | 69% |
With copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 20 - 110℃; | 33% |
2,2-difluorethylamine
2-methylchlorobenzene
N-(2,2-difluoro-ethyl)-o-toluidine
Conditions | Yield |
---|---|
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Sealed tube; Inert atmosphere; | 99% |
With copper(I) oxide; copper |
Conditions | Yield |
---|---|
With C35H44Cl2N4Pd; potassium tert-butylate In tetrahydrofuran at 130℃; for 12h; Inert atmosphere; Sealed tube; | 99% |
With C36H43Cl2N3Pd; potassium tert-butylate In 1,4-dioxane at 110℃; for 12h; Buchwald-Hartwig Coupling; Inert atmosphere; Schlenk technique; | 94% |
With C40H44ClN3Pd; potassium tert-butylate In toluene at 110℃; for 24h; Buchwald-Hartwig Coupling; Inert atmosphere; | 87% |
2-methylchlorobenzene
2-Methylphenylboronic acid
2,2'-dimethyl-1,1'-biphenyl
Conditions | Yield |
---|---|
With PdCl2(TMes)2; caesium carbonate In ethanol at 90℃; for 15h; Suzuki coupling; Inert atmosphere; Reflux; | 99% |
With potassium phosphate; C22H23Br2N3Pd In water; isopropyl alcohol at 20℃; for 44h; Reagent/catalyst; Suzuki-Miyaura Coupling; | 99% |
With potassium fluoride; 18-crown-6 ether; bis-phenanthrylimidazolium chloride; palladium diacetate In tetrahydrofuran at 50℃; for 8h; Suzuki-Miyaura coupling; | 98% |
Conditions | Yield |
---|---|
With C41H50ClN3Pd; sodium t-butanolate In 1,4-dioxane at 100℃; for 4h; | 99% |
With C34H36ClN3Pd; sodium t-butanolate In 1,4-dioxane at 100℃; for 4h; Reagent/catalyst; | 97% |
With (C5H5)Fe(C5H3C(CH3)NC6H4CH3)PdCl(CN2(C6H3(CH(CH3)2)2)2C2H2); potassium tert-butylate In toluene for 2h; Inert atmosphere; Reflux; | 96% |
2-methylchlorobenzene
1-phenyl-propan-1-one
2-(2-methylphenyl)-1-phenylpropan-1-one
Conditions | Yield |
---|---|
With C41H50ClN3Pd; sodium t-butanolate In 1,4-dioxane at 100℃; for 4h; | 99% |
Stage #1: 2-methylchlorobenzene; 1-phenyl-propan-1-one With sodium t-butanolate In tetrahydrofuran at 20℃; for 0.0333333h; Glovebox; Inert atmosphere; Stage #2: With C26H42ClNPd In tetrahydrofuran at 20℃; for 4h; Glovebox; Inert atmosphere; | 97% |
With N-heterocyclic carbene-palladacycle; sodium t-butanolate In tetrahydrofuran at 70℃; for 2h; | 94% |
2-methylchlorobenzene
4-methoxyphenyl magnesium bromide
4'-methoxy-2-methylbiphenyl
Conditions | Yield |
---|---|
With C35H31BrN4NiP In tetrahydrofuran at 70℃; for 17h; Schlenk technique; Inert atmosphere; | 99% |
Stage #1: 2-methylchlorobenzene With Ni(PPh3)(1,3-di-tert-butylimidazol-2-ylidene)Br2 In tetrahydrofuran at 0℃; for 0.0333333h; Inert atmosphere; Schlenk technique; Stage #2: 4-methoxyphenyl magnesium bromide In tetrahydrofuran at 0 - 25℃; for 4h; Inert atmosphere; Schlenk technique; | 98% |
With C46H55ClFeN3Pd; lithium chloride In tetrahydrofuran at 60℃; for 12h; Kumada coupling reaction; Inert atmosphere; | 92% |
2-methylchlorobenzene
2,6-dimethylaniline
2,6-dimethyl-N-(o-tolyl)aniline
Conditions | Yield |
---|---|
With potassium tert-butylate In 1,4-dioxane at 110℃; for 3h; | 99% |
With tris-(dibenzylideneacetone)dipalladium(0); 1-methyl-2-(2-(dicyclohexylphosphino)phenyl)-1H-benzoimidazole; sodium t-butanolate In toluene at 20 - 135℃; for 20h; Buchwald-Hartwig reaction; Inert atmosphere; | 99% |
With C35H44Cl2N4Pd; potassium tert-butylate In tetrahydrofuran at 110℃; for 1h; Inert atmosphere; Sealed tube; | 98% |
Conditions | Yield |
---|---|
With palladium diacetate; sodium t-butanolate; ruphos In neat (no solvent) at 110℃; for 12h; Buchwald-Hartwig Coupling; Green chemistry; | 99% |
With C16H34ClPPd; sodium t-butanolate In toluene at 100℃; Buchwald-Hartwig amination; Inert atmosphere; | 98% |
With [Pd(N,N′-bis(2,6-bis(diphenylmethyl)-4-methoxyphenyl)imidazol-2-ylidene)(acac)Cl]; potassium 2-methylbutan-2-olate In 1,4-dioxane at 110℃; for 21h; Buchwald-Hartwig Coupling; Glovebox; Inert atmosphere; | 98% |
Conditions | Yield |
---|---|
With potassium tert-butylate In 1,4-dioxane at 110℃; for 3h; | 99% |
With (1,3-bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene)Pd(cinnamyl, 3-phenylallyl)Cl; sodium t-butanolate In neat (no solvent) at 110℃; for 12h; Buchwald-Hartwig Coupling; Inert atmosphere; Green chemistry; | 99% |
With C28H29Cl2N3OPd; potassium tert-butylate In toluene at 110℃; for 15h; Buchwald-Hartwig Coupling; Schlenk technique; Inert atmosphere; | 99% |
2-methylchlorobenzene
4-methoxyphenylboronic acid
4'-methoxy-2-methylbiphenyl
Conditions | Yield |
---|---|
With NHC-Pd(II)-Im; potassium tert-butylate In water at 80℃; for 24h; Suzuki-Miyaura coupling; | 99% |
With potassium phosphate tribasic trihydrate; PdCl2(C3H3N2(CH3))(C3H2N2(C6H3(C3H7)2)2) In tetrahydrofuran; water at 20℃; for 24h; Suzuki-Miyaura coupling reaction; Inert atmosphere; | 99% |
With potassium dihydrogen phosphate trihydrate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-yl-isoquinolin-2-yl]palladium dichloride In tetrahydrofuran; water at 50℃; for 6h; Inert atmosphere; | 99% |
2-methylchlorobenzene
4-methoxy-aniline
N-(4-methoxyphenyl)-2-methylbenzenamine
Conditions | Yield |
---|---|
With sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0); P(i-BuNCH2CH2)3N In toluene at 100℃; for 24h; Buchwald-Hartwig amination; | 99% |
With sodium hydride; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; tert-butyl alcohol; bis(acetylacetonate)nickel(II) In 1,4-dioxane at 100℃; | 99% |
With bis(η3-allyl-μ-chloropalladium(II)); potassium tert-butylate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride In 1,4-dioxane at 100℃; for 1.5h; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With sodium t-butanolate; tris(dibenzylideneacetone)dipalladium (0); P(i-BuNCH2CH2)3N In toluene at 100℃; for 20h; Buchwald-Hartwig amination; | 99% |
With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene at 80℃; for 21h; | 99% |
With 4-di-tert-butylphosphanyl-1-phenyl-5-(2-methoxyphenyl)-1H-[1,2,3]triazole; sodium t-butanolate; bis(dibenzylideneacetone)-palladium(0) In toluene at 110℃; for 20h; | 96% |
Conditions | Yield |
---|---|
With dichloro(3-chloropyridinyl)(1,3-(diisopropylphenyl)-4,5-bis(dimethylamino)imidazol-2-ylidene)palladium(II); caesium carbonate In 1,2-dimethoxyethane at 80℃; for 24h; Buchwald-Hartwig Coupling; Schlenk technique; Sealed tube; Inert atmosphere; | 99% |
With C28H29Cl2N3OPd; potassium tert-butylate In toluene at 110℃; for 15h; Buchwald-Hartwig Coupling; Schlenk technique; Inert atmosphere; | 99% |
With C36H45Cl2N3OPd; potassium tert-butylate In 1,4-dioxane at 90℃; for 1h; Buchwald-Hartwig Coupling; Inert atmosphere; Schlenk technique; | 98% |
Conditions | Yield |
---|---|
With potassium tert-butylate In 1,4-dioxane at 110℃; for 3h; | 99% |
With C35H44Cl2N4Pd; potassium tert-butylate In tetrahydrofuran at 110℃; for 3h; Inert atmosphere; Sealed tube; | 98% |
With C33H40ClN3O2Pd; potassium tert-butylate In toluene at 110℃; for 12h; Buchwald-Hartwig Coupling; Inert atmosphere; Schlenk technique; Sealed tube; | 94% |
Conditions | Yield |
---|---|
With C38H49N2P*C9H10ClPd In 1,4-dioxane at 20℃; for 18h; Inert atmosphere; Schlenk technique; | 99% |
With (R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl di-t-butylphosphine; sodium t-butanolate; palladium diacetate In 1,2-dimethoxyethane at 100℃; for 48h; | 98% |
With sodium t-butanolate; palladium diacetate; (R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl di-t-butylphosphine In 1,2-dimethoxyethane at 100℃; for 48h; | 98% |
Conditions | Yield |
---|---|
With bis(η3-allyl-μ-chloropalladium(II)); potassium tert-butylate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride In 1,4-dioxane at 100℃; for 1.5h; Inert atmosphere; | 99% |
With C35H44Cl2N4Pd; potassium tert-butylate In tetrahydrofuran at 130℃; for 12h; Inert atmosphere; Sealed tube; | 98% |
With C33H40ClN3O2Pd; potassium tert-butylate In toluene at 110℃; for 12h; Buchwald-Hartwig Coupling; Inert atmosphere; Schlenk technique; Sealed tube; | 97% |
Conditions | Yield |
---|---|
With potassium tert-butylate In 1,4-dioxane at 110℃; for 3h; | 99% |
With [PdCl{[(η5-C5H5)]Fe[(η5-C5H3)-N2C4H2-Cl]}(DCPAB)]; potassium tert-butylate at 120℃; for 12h; Buchwald-Hartwig reaction; | 95% |
With [PdCl(η5-C5H5)Fe((η5-C5H3)-NC5H3Br)C3H2N2(C6H4-2,6-iPr2)2]; potassium tert-butylate In poly(ethylene glycol-400) at 120℃; for 24h; Buchwald-Hartwig amination; Inert atmosphere; | 92% |
With C37H44ClN2O3PPd; potassium hydroxide; tert-butyl alcohol In water at 100℃; for 12h; Buchwald-Hartwig Coupling; Schlenk technique; Inert atmosphere; | 91% |
Conditions | Yield |
---|---|
With potassium tert-butylate In 1,4-dioxane at 110℃; for 3h; | 99% |
ortho-tolylmagnesium bromide
2-methylchlorobenzene
2,2'-dimethyl-1,1'-biphenyl
Conditions | Yield |
---|---|
amido pincer complex of nickel chloride catalyst In tetrahydrofuran at 20℃; for 28h; Kumada cross-coupling reaction; | 99% |
Conditions | Yield |
---|---|
With C28H29Cl2N3OPd; potassium tert-butylate In toluene at 110℃; for 15h; Buchwald-Hartwig Coupling; Schlenk technique; Inert atmosphere; | 99% |
With C35H44Cl2N4Pd; potassium tert-butylate In tetrahydrofuran at 110℃; for 1h; Inert atmosphere; Sealed tube; | 98% |
With C36H43Cl2N3Pd; potassium tert-butylate In 1,4-dioxane at 110℃; for 1h; Buchwald-Hartwig Coupling; Inert atmosphere; Schlenk technique; | 98% |
2-methylchlorobenzene
2,4,6-trimethylaniline
2,4,6-trimethyl-N-(2-methylphenyl)aniline
Conditions | Yield |
---|---|
With C28H29Cl2N3OPd; potassium tert-butylate In toluene at 110℃; for 15h; Buchwald-Hartwig Coupling; Schlenk technique; Inert atmosphere; | 99% |
With C35H44Cl2N4Pd; potassium tert-butylate In tetrahydrofuran at 110℃; for 1h; Inert atmosphere; Sealed tube; | 98% |
With bis{1,1’-diphenyl-3,3’-methylenediimidazoline-2,2’-diylidene}nickel(II) dibromide; potassium tert-butylate In 1,4-dioxane at 90℃; for 4h; Catalytic behavior; Reagent/catalyst; Buchwald-Hartwig Coupling; Inert atmosphere; Schlenk technique; | 98% |
2-methylchlorobenzene
1-Phenylethanol
2-(2-methylphenyl)-1-phenyl-1-ethanone
Conditions | Yield |
---|---|
Stage #1: 1-Phenylethanol With allylchloro[1,3-bis(2,6-di-isopropylphenyl)imidazol-2-ylidine]palladium(II); para-chlorotoluene; potassium tert-butylate In toluene at 40℃; for 3h; Inert atmosphere; Stage #2: 2-methylchlorobenzene In toluene at 80℃; for 6h; Inert atmosphere; | 99% |
2-methylchlorobenzene
rac-1-(4-methoxyphenyl)-ethanol
1-(4-methoxyphenyl)-2-(2-methylphenyl)ethanone
Conditions | Yield |
---|---|
Stage #1: rac-1-(4-methoxyphenyl)-ethanol With allylchloro[1,3-bis(2,6-di-isopropylphenyl)imidazol-2-ylidine]palladium(II); para-chlorotoluene; potassium tert-butylate In toluene at 40℃; for 3h; Inert atmosphere; Stage #2: 2-methylchlorobenzene In toluene at 80℃; for 3h; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With 4-diphenylphosphino-13-dicyclohexylphosphino-[2.2]paracyclophane; water; palladium diacetate; caesium carbonate In 1,4-dioxane at 125℃; for 24h; Buchwald-Hartwig coupling; | 99% |
With 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; potassium carbonate In 1,4-dioxane at 90℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Glovebox; | 99% |
With copper(I) oxide; potassium phosphate; N1,N2-bis(thiophen-2-ylmethyl)oxalamide In tert-butyl alcohol at 130℃; for 24h; Schlenk technique; | 79% |
With potassium carbonate; N,N`-dimethylethylenediamine at 130℃; for 23h; Neat (no solvent); | 78% |
Stage #1: 2-methylchlorobenzene; benzamide With copper(l) iodide; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine In acetonitrile for 0.00277778h; Inert atmosphere; Glovebox; Stage #2: In acetonitrile at 200℃; for 1h; Microwave irradiation; | 38 %Chromat. |
Conditions | Yield |
---|---|
With bis[dicyclohexyl(2,4,6-triisopropyl-[1,1':3',1''-terphenyl]-2-yl)phosphane]palladium(II) dichloride; caesium carbonate In tetrahydrofuran at 80℃; for 2.5h; | 99% |
With [Pd((η5-C5H5)Fe[(η5-C5H3)C(Me)=N(C6H4-4-Me)])(μ-Cl)]2; potassium carbonate; XPhos In 5,5-dimethyl-1,3-cyclohexadiene; water at 120℃; for 3h; | 88% |
With (R)-1-[(SP)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; palladium diacetate; caesium carbonate In dimethyl sulfoxide at 130℃; for 12h; | 31% |
The Molecular Structure of 2-Chlorotoluene (CAS NO.95-49-8):
Molecular Formula: C7H7Cl
Molecular Weight: 126.58
EINECS: 202-424-3
Melting point: -36 °C
Boiling point: 157-159 °C(lit.)
Density: 1.083 g/mL at 25 °C(lit.)
Vapor density: 4.38 (vs air)
Vapor pressure: 10 mm Hg ( 43 °C)
Refractive index: n20/D 1.525(lit.)
Flash point: 117 °F
Storage temp.: 0-6°C
Water Solubility: slightly soluble
Appearance: clear liquid
Synonyms: o-Chlorotoluene ; 1-chloro-2-methyl-benzen ; 2-Chloro-1-methylbenzene,o-tolylchloride ; 2-Chlortoluol ; 2-Methylchlorobenzene ; Benzene,1-chloro-2-methyl- ; Halso 99 ; halso99 ; o-chloro-toluen
2-Chlorotoluene (CAS NO.95-49-8) is commonly used in the medicine and pesticide products.
1. | ihl-rat LCLo:17,500 ppm | DTLVS* Documentation of Threshold Limit Values for Substances in Workroom Air. 4 (1980),95. | ||
2. | unr-rat LD50:5700 mg/kg | GISAAA Gigiena i Sanitariya. 45 (12)(1980),64. | ||
3. | unr-mus LD50:4400 mg/kg | GISAAA Gigiena i Sanitariya. 45 (12)(1980),64. | ||
4. | unr-gpg LD50:3000 mg/kg | GISAAA Gigiena i Sanitariya. 46 (2)(1981),14. |
Reported in EPA TSCA Inventory.
Moderately toxic by unspecified routes. Flammable when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Cl−.
Hazard Codes:XnXiNFT
Risk Statements: 20-51/53-39/23/24/25-23/24/25-11
R20: Harmful by inhalation
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed
R11: Highly flammable
Safety Statements: 24/25-61-45-36/37-16-7
S24/25: Avoid contact with skin and eyes
S61: Avoid release to the environment. Refer to special instructions / safety data sheets
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37: Wear suitable protective clothing and gloves
S16: Keep away from sources of ignition
RIDADR: UN 2238 3/PG 3
WGK Germany: 2
RTECS: XS9000000
Hazard Note: Irritant/Flammable
HazardClass: 3
PackingGroup: III
HS Code: 29036990
OSHA PEL: TWA 50 ppm
ACGIH TLV: TWA 50 ppm
DOT Classification: 3; Label: Flammable Liquid
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