2-Fluorotoluene supplier

Name
2-Fluorotoluene
EINECS 202-428-5
CAS No. 95-52-3
Article Data90
CAS DataBase
Density 1.001 g/cm³
Solubility immiscible with water
Melting Point -62 °C
Formula C₇H₇F
Boiling Point 116.3 °C at 760 mmHg
Molecular Weight 110.131
Flash Point 11.4 °C
Transport Information UN 2388 3/PG 2
Appearance clear colorless to slightly yellow liquid
Safety 16-26-33-36-37/39
Risk Codes 11-36/37/38
Molecular Structure
Hazard Symbols F,Xi
Synonyms Benzene, 1-fluoro-2-methyl-;Toluene, o-fluoro-;1/C7H7F/c1-6-4-2-3-5-7(6)8/h2-5H,1H;1-Methyl-2-fluorobenzene;4-05-00-00799 (Beilstein Handbook Reference);1-fluoro-2-methylbenzene;1-fluoro-2-methyl-benzene;o-Fluorotoluene [UN2388] [Flammable liquid];
PSA 0.00000
LogP 2.13410

Synthetic route

: 95-53-4
o-toluidine

: 95-52-3
2-Fluorotoluene

Conditions

Conditions	Yield
With pyridine hydrogenfluoride; sodium nitrite 1.) O deg C, 20 min, 2.) 55 deg C, 1 h;	99%
With hydrogen fluoride; sodium nitrite at -1 - 3℃; for 1h;	99.5%
Stage #1: o-toluidine With hydrogen fluoride at -15 - 0.5℃; Flow reactor; Large scale; Stage #2: With nitrosylsulfuric acid at -5 - 0.5℃; Flow reactor; Large scale;	98.1%

: 615-37-2
ortho-methylphenyl iodide

: 95-52-3
2-Fluorotoluene

Conditions

Conditions	Yield
With copper(I) trifluoromethanesulfonate bis(trimethylacetonitrile) complex; silver fluoride In N,N-dimethyl-formamide at 140℃; for 22h; Inert atmosphere;	96%

: 446-48-0
o-fluorobenzyl bromide

A: 95-52-3
2-Fluorotoluene

B: 776-35-2
9,10-dihydrophenanthrene

C: 349-38-2
1,2-bis(2-fluorophenyl)ethane

Conditions

Conditions	Yield
With magnesium at 600℃;	A 11% B 3% C 80%

...Expand

: 1493-13-6
trifluorormethanesulfonic acid

: 2093-46-1
2-methylphenyl diazonium tetrafluoroborate

A: 95-52-3
2-Fluorotoluene

B: 66107-34-4
2-methylphenyl triflate

Conditions

Conditions	Yield
at 90℃; for 1h;	A n/a B 75%

...Expand

: 345-35-7
2-fluorobenzyl chloride

A: 95-52-3
2-Fluorotoluene

B: 776-35-2
9,10-dihydrophenanthrene

C: 349-38-2
1,2-bis(2-fluorophenyl)ethane

Conditions

Conditions	Yield
With magnesium at 600℃;	A 7% B 5% C 73%

...Expand

: 19296-22-1
toluene-2-diazonium ; hexafluoro phosphate

: 95-52-3
2-Fluorotoluene

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate at 120 - 125℃; for 1h;	72%

: 95-48-7
ortho-cresol

: 95-52-3
2-Fluorotoluene

Conditions

Conditions	Yield
With 1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole; cesium fluoride; diphenylzinc In 1,4-dioxane at 110℃; for 20h; Product distribution / selectivity; Sealed vial;	72%
With 1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole; diphenylzinc; cesium fluoride In 1,4-dioxane at 23 - 110℃; for 20.5h; Inert atmosphere;	87 %Spectr.

: 106-43-4
para-chlorotoluene

A: 352-32-9
p-fluorotoluene

B: 95-52-3
2-Fluorotoluene

C: 352-70-5
m-Fluorotoluene

Conditions

Conditions	Yield
With Al2CuF8 Gas phase; Inert atmosphere;	A 71% B 5% C 10%
With silver fluoride at 350℃; Product distribution / selectivity; Gas phase;	A 20.8% B 0.6% C 35.8%

...Expand

: potassium o-tolyltrifluoroborate

A: 95-52-3
2-Fluorotoluene

B: 108-88-3
toluene

Conditions

Conditions	Yield
With lithium hydroxide monohydrate; silver trifluoromethanesulfonate; Selectfluor In ethyl acetate at 55℃; Sealed tube;	A 71% B n/a

: 95-49-8
2-methylchlorobenzene

A: 95-52-3
2-Fluorotoluene

B: 352-70-5
m-Fluorotoluene

Conditions

Conditions	Yield
With Al2CuF8 Gas phase; Inert atmosphere;	A 60% B 7%

: 68971-87-9
(2-tolyl)tributyltin

: 95-52-3
2-Fluorotoluene

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate); tetrabutylammonium triphenyldifluorosilicate In acetonitrile at 60℃; for 3h; Sealed tube; regiospecific reaction;	50%
With copper(I) trifluoromethanesulfonate bis(trimethylacetonitrile) complex; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate In ethyl acetate at 25℃; for 12h; Inert atmosphere; Glovebox;	76 %Spectr.

: 546-67-8
lead(IV) tetraacetate

: 109-63-7
trifluoroborane diethyl ether

: 108-88-3
toluene

A: 352-32-9
p-fluorotoluene

B: 95-52-3
2-Fluorotoluene

C: 352-70-5
m-Fluorotoluene

Conditions

Conditions	Yield
mercury(II) diacetate Stirring of toluene in BF3*Et2O contg. Pb(OAc)4 and overnight at room temp.; GC anal. 13% recovery of toluene.;	A 43% B 12% C 4%

...Expand

: 66107-34-4
2-methylphenyl triflate

: 95-52-3
2-Fluorotoluene

Conditions

Conditions	Yield
With bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II); t-BuBrettPhos; cesium fluoride In toluene at 130℃; for 12h;	42%
With bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II); t-BuBrettPhos; cesium fluoride In toluene at 130℃; for 12h;	42 %Chromat.

: 446-52-6
2-Fluorobenzaldehyde

A: 271-44-3
benzimidazole

B: 95-52-3
2-Fluorotoluene

Conditions

Conditions	Yield
With hydrazine hydrate In 1,2-dimethoxyethane for 15h; Heating;	A 29% B 45 % Chromat.

: 108-41-8
1-chloro-3-methylbenzene

A: 352-32-9
p-fluorotoluene

B: 95-52-3
2-Fluorotoluene

C: 352-70-5
m-Fluorotoluene

Conditions

Conditions	Yield
With silver fluoride at 350℃; Product distribution / selectivity; Gas phase;	A 15% B 6.7% C 25.7%

...Expand

: 95-49-8
2-methylchlorobenzene

A: 352-32-9
p-fluorotoluene

B: 95-52-3
2-Fluorotoluene

C: 352-70-5
m-Fluorotoluene

Conditions

Conditions	Yield
With silver fluoride at 350℃; Product distribution / selectivity; Gas phase;	A 0.5% B 13.9% C 14.4%

...Expand

: 462-06-6
fluorobenzene

: 593-53-3
Methyl fluoride

A: 352-32-9
p-fluorotoluene

B: 95-52-3
2-Fluorotoluene

C: 352-70-5
m-Fluorotoluene

Conditions

Conditions	Yield
at 37.5℃; Product distribution; Irradiation; various fluorobenzenes, other conditions;

...Expand

: 75-45-6
Chlorodifluoromethane

A: 462-06-6
fluorobenzene

B: 352-32-9
p-fluorotoluene

C: 95-52-3
2-Fluorotoluene

D: 352-70-5
m-Fluorotoluene

E: 71-43-2
benzene

Conditions

Conditions	Yield
With methylcyclopentadiene at 650.9℃; Product distribution; Mechanism; conditions of pulse gas compression, other temperatures;

...Expand

: 107-31-3
Methyl formate

: 138850-94-9
C7H7F*H(1+)

A: 95-52-3
2-Fluorotoluene

B: 39014-35-2, 380649-05-8, 52067-01-3
C2H4O2*H(1+)

Conditions

Conditions	Yield
Thermodynamic data;

...Expand

: 770-09-2
benzyltrimethylsilane

: 95-52-3
2-Fluorotoluene

Conditions

Conditions	Yield
With fluorine In trichlorofluoromethane at -78℃;

: 138850-94-9
C7H7F*H(1+)

: 108-88-3
toluene

A: 95-52-3
2-Fluorotoluene

B: 52809-63-9
C7H8*H(1+)

Conditions

Conditions	Yield
Thermodynamic data;

...Expand

: 1-Fluoro-2-methyl-benzene; compound with GENERIC INORGANIC NEUTRAL COMPONENT

: 108-88-3
toluene

A: 95-52-3
2-Fluorotoluene

B: 77406-15-6
Toluene; compound with GENERIC INORGANIC NEUTRAL COMPONENT

Conditions

Conditions	Yield
Thermodynamic data;

...Expand

: 108-88-3
toluene

A: 352-32-9
p-fluorotoluene

B: 95-52-3
2-Fluorotoluene

Conditions

Conditions	Yield
With Selectfluor In acetonitrile for 16h; Heating; also fluorination of other aromatic compounds;	A 20 % Spectr. B 60 % Spectr.
With potassium hydroxide; nitrogen; fluorine In methanol at -40℃; Product distribution; different educt and reagent concentration, different temperatures, different fluorine/nitrogen ratio, different solvents, without or with different additives;	A 57.0 % Chromat. B 32.7 % Chromat.
With acetyl hypofluorite for 2h;
With trifluorormethanesulfonic acid; Selectfluor In dichloromethane at 40℃; for 24h; Fluorination; Title compound not separated from byproducts;

: 108-88-3
toluene

A: 352-32-9
p-fluorotoluene

B: 95-52-3
2-Fluorotoluene

C: 352-70-5
m-Fluorotoluene

Conditions

Conditions	Yield
With fluorine In trichlorofluoromethane at -78℃; for 1h; Rate constant; Product distribution; competitive reaction with benzene, other solvent;	A 29 % Chromat. B 60 % Chromat. C 11 % Chromat.
With lead(IV) acetate; boron trifluoride diethyl etherate; mercury(II) diacetate Ambient temperature;	A 43 % Chromat. B 12 % Chromat. C 4 % Chromat.
With caesium fluoroxysulphate; trifluorormethanesulfonic acid In acetonitrile Ambient temperature; Yield given;

...Expand

: 108-88-3
toluene

A: 352-32-9
p-fluorotoluene

B: 95-52-3
2-Fluorotoluene

C: 352-70-5
m-Fluorotoluene

D: 350-50-5
benzyl fluoride

Conditions

Conditions	Yield
With acetyl hypofluorite In acetic acid for 0.0833333h; Ambient temperature; Yield given. Yields of byproduct given;
With fluorine In acetonitrile at 0℃; Flow reactor;

...Expand

: 108-88-3
toluene

A: 352-32-9
p-fluorotoluene

B: 95-52-3
2-Fluorotoluene

C: 352-70-5
m-Fluorotoluene

D: 452-76-6
2,4-difluorotoluene

Conditions

Conditions	Yield
With tetrafluoroammonium tetrafluoroborate In hydrogen fluoride at 0℃; Further byproducts given. Title compound not separated from byproducts;	A 15 % Spectr. B 15 % Spectr. C 8 % Spectr. D 30 % Spectr.

...Expand

: 108-88-3
toluene

A: 352-32-9
p-fluorotoluene

B: 95-52-3
2-Fluorotoluene

C: 352-70-5
m-Fluorotoluene

D: 452-76-6
2,4-difluorotoluene

E: 2,3,4,6-tetrafluorotoluene

Conditions

Conditions	Yield
With tetrafluoroammonium tetrafluoroborate In hydrogen fluoride at 0℃; Product distribution;	A 15 % Spectr. B 15 % Spectr. C 8 % Spectr. D 30 % Spectr. E 7 % Spectr.

...Expand

: 108-88-3
toluene

A: 352-32-9
p-fluorotoluene

B: 95-52-3
2-Fluorotoluene

C: 352-70-5
m-Fluorotoluene

D: 2,3,4,6-tetrafluorotoluene

Conditions

Conditions	Yield
With tetrafluoroammonium tetrafluoroborate In hydrogen fluoride at 0℃; Further byproducts given. Title compound not separated from byproducts;	A 15 % Spectr. B 15 % Spectr. C 8 % Spectr. D 7 % Spectr.

...Expand

: 108-88-3
toluene

A: 352-32-9
p-fluorotoluene

B: 95-52-3
2-Fluorotoluene

C: 350-50-5
benzyl fluoride

Conditions

Conditions	Yield
With caesium fluoroxysulphate In acetonitrile at 25℃; Product distribution; Rate constant; reagents ratio, presence of 1,3,5-trinitrobenzene;	A 2 % Chromat. B 4 % Chromat. C 67 % Chromat.
With caesium fluoroxysulphate In acetonitrile Ambient temperature; Yield given. Yields of byproduct given;

...Expand

: 95-52-3
2-Fluorotoluene

: 124-38-9
carbon dioxide

: 315-31-1
2-fluoro-3-methylbenzoic acid

Conditions

Conditions	Yield
Stage #1: 2-Fluorotoluene With sec.-butyllithium In tetrahydrofuran at -78℃; for 0.5h; Stage #2: carbon dioxide In tetrahydrofuran under 760.051 Torr;	100%
Stage #1: 2-Fluorotoluene With n-butyllithium Metallation; Stage #2: carbon dioxide Carboxylation;

: 51-17-2
benzoimidazole

: 95-52-3
2-Fluorotoluene

: 34734-23-1
N-(2-methyl-1-phenyl)-1H-benzimidazole

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl acetamide at 210℃; for 12h; Microwave irradiation;	100%

: 95-52-3
2-Fluorotoluene

: 320-11-6
1-(tert-butyl)-2-fluorobenzene

Conditions

Conditions	Yield
With triethanolamine; 2,2'-azobis(isobutyronitrile); chlorine at 90 - 115℃; for 5h;	99%

: 95-52-3
2-Fluorotoluene

: 65-85-0
benzoic acid

: 478970-84-2
2-fluorobenzyl benzoate

Conditions

Conditions	Yield
With di-tert-butyl peroxide; C11H23N2(1+)*Br4Fe(1-) at 110℃; for 24h;	98%

: 95-52-3
2-Fluorotoluene

: phenylmagnesium bromide

: 643-58-3
2-methylbiphenyl

Conditions

Conditions	Yield
With 1-[2-(diphenylphosphino)phenyl]ethanol; bis(acetylacetonate)nickel(II) In diethyl ether at 20℃; for 5h;	96%
With 1,3-bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazolium tetrafluoroborate; Ni(acac) In tetrahydrofuran at 20℃; for 18h; Kumada-Corriu cross-coupling;	53 % Chromat.

: 95-52-3
2-Fluorotoluene

: 100-58-3
phenylmagnesium bromide

: 643-58-3
2-methylbiphenyl

Conditions

Conditions	Yield
Stage #1: 2-Fluorotoluene; phenylmagnesium bromide; 1-[2-(diphenylphosphino)phenyl]ethanol; bis(acetylacetonate)nickel(II) In diethyl ether for 5h; Stage #2: With methanol In diethyl ether Product distribution / selectivity;	96%
Stage #1: 2-Fluorotoluene; phenylmagnesium bromide; bis(acetylacetonate)nickel(II); ((2-hydroxymethyl)phenyl)diphenylphosphine In diethyl ether for 48h; Stage #2: With methanol In diethyl ether Product distribution / selectivity;	95%
With C28H32ClN2NiP In tetrahydrofuran at 20℃; for 24h; Time; Schlenk technique; Inert atmosphere;	16 %Chromat.

: 95-52-3
2-Fluorotoluene

: 7353-91-5
4-dimethylaminophenylmagnesium bromide

: 2′-methyl-N,N-dimethylbiphenyl-4-amine

Conditions

Conditions	Yield
With C26H24ClN2NiP*0.1C7H8 In toluene at 25℃; for 24h; Kumada Cross-Coupling; Schlenk technique; Inert atmosphere;	95%

: 95-52-3
2-Fluorotoluene

: 104-82-5
4-Methylbenzyl chloride

: 21895-17-0
p-(2-methylbenzyl)toluene

Conditions

Conditions	Yield
With C23H40Br2N2NiO5P; magnesium In tetrahydrofuran at 60℃; for 12h; Inert atmosphere;	95%

: 95-52-3
2-Fluorotoluene

: 446-52-6
2-Fluorobenzaldehyde

Conditions

Conditions	Yield
With Xylaria polymorpha laccase; 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonate) diammonium salt In 1,4-dioxane at 20℃; for 1.91667h; pH=4.5; Green chemistry; Enzymatic reaction;	94%
With laccase of Pleurotus ostreatus MTCC-1801; 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt In 1,4-dioxane at 20℃; pH=4.5; Enzymatic reaction;	90%
With tert.-butylhydroperoxide; C29H25Cl2N4Ru(1+)*F6P(1-) In acetonitrile at 60℃; for 2h; Schlenk technique; Inert atmosphere;	74%

: ammonium hexafluorophosphate

: 102-54-5
ferrocene

: 95-52-3
2-Fluorotoluene

: 165681-07-2
η-pentadienyl-η-1,2-fluoromethylbenzeneiron(II) hexafluorophosphate

Conditions

Conditions	Yield
With aluminium trichloride; aluminium In water other Radiation; 0.02 mol metal addn. to arene, Fe- and Al-salts mixt. in 1,2,4-C6H3Cl3 (ratio arene:Fe:AlCl3:Al=2:1:2:1.1), homogenization (stirring), mixt. irradiation in microwave oven (850 W) for 3 min, ice addn. (AlCl3 decompn.), filtration, filtrate washing (Et2O); filtration, treating with aq. NH4-salt, ppt. filtration off through sinter, washing (i-PrOH, Et2O); elem. anal.;	94%

Yield

With aluminium trichloride; aluminium In water other Radiation; 0.02 mol metal addn. to arene, Fe- and Al-salts mixt. in 1,2,4-C6H3Cl3 (ratio arene:Fe:AlCl3:Al=2:1:2:1.1), homogenization (stirring), mixt. irradiation in microwave oven (850 W) for 3 min, ice addn. (AlCl3 decompn.), filtration, filtrate washing (Et2O); filtration, treating with aq. NH4-salt, ppt. filtration off through sinter, washing (i-PrOH, Et2O); elem. anal.;

94%

...Expand

: 95-52-3
2-Fluorotoluene

: 824-94-2
p-methoxybenzyl chloride

: 53039-52-4
1-methyl-2-(4-methoxybenzyl) benzene

Conditions

Conditions	Yield
With Ni(PPh3)(1,3-di-tert-butylimidazol-2-ylidene)Br2; magnesium In tetrahydrofuran at 0 - 35℃; for 24h; Schlenk technique; Inert atmosphere;	93%

: 42142-52-9
3-methylamino-1-phenylpropan-1-ol

: 95-52-3
2-Fluorotoluene

: 17199-29-0
(S)-Mandelic acid

: R-(-)-atomoxetine-S-(+)-mandelate

Conditions

Conditions	Yield
Stage #1: 3-methylamino-1-phenylpropan-1-ol With potassium hydroxide In Triethylene glycol dimethyl ether; toluene at 20 - 120℃; for 1h; Large scale; Stage #2: 2-Fluorotoluene In Triethylene glycol dimethyl ether; toluene for 3h; Large scale; Stage #3: (S)-Mandelic acid at 20 - 75℃; for 1h; Temperature; Large scale;	93%

...Expand

: 100-02-7
4-nitro-phenol

: 95-52-3
2-Fluorotoluene

: C13H10FNO2

Conditions

Conditions	Yield
With di-tert-butyl peroxide; 1,3-di-tert-butylimidazolium at 130℃; for 24h; Green chemistry;	93%

: 100-02-7
4-nitro-phenol

: 95-52-3
2-Fluorotoluene

: 891-75-8
1-fluoro-2-((4-nitrophenoxy)methyl)benzene

Conditions

Conditions	Yield
With di-tert-butyl peroxide; 1,3-di-tert-butylimidazolium at 130℃; for 24h;	93%

: 95-52-3
2-Fluorotoluene

: 63940-51-2
(+/-)-atomoxetine

Conditions

Conditions	Yield
Stage #1: 3-methylamino-1-phenylpropan-1-ol With potassium hydroxide In dimethyl sulfoxide at 110℃; Stage #2: 2-Fluorotoluene In dimethyl sulfoxide at 145 - 147℃; for 1h; Heating / reflux;	92.7%

: 95-52-3
2-Fluorotoluene

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 92495-54-0
4'-methoxy-2-methylbiphenyl

Conditions

Conditions	Yield
Stage #1: 2-Fluorotoluene With Ni(PPh3)(1,3-di-tert-butylimidazol-2-ylidene)Br2 In tetrahydrofuran at 0℃; for 0.0333333h; Inert atmosphere; Schlenk technique; Stage #2: 4-methoxyphenyl magnesium bromide In tetrahydrofuran at 0 - 25℃; for 10h; Inert atmosphere; Schlenk technique;	92%
With palladium diacetate; DavePhos In 1,2-dimethoxyethane at 80℃; for 12h;	73%

: 95-52-3
2-Fluorotoluene

: 124-38-9
carbon dioxide

: 118-90-1
ortho-methylbenzoic acid

Conditions

Conditions	Yield
Stage #1: 2-Fluorotoluene With C78H70Al2Cl4N6P4Rh2; magnesium; ethylene dibromide In tetrahydrofuran at 20℃; for 22h; Inert atmosphere; Glovebox; Stage #2: carbon dioxide In tetrahydrofuran at 20℃; under 760.051 Torr; for 0.5h;	92%

: 95-52-3
2-Fluorotoluene

: 75-36-5
acetyl chloride

: 369-32-4
1-(4-fluoro-3-methylphenyl)ethanone

Conditions

Conditions	Yield
With aluminum (III) chloride In chloroform at -5 - 20℃; for 2h; Solvent; Reagent/catalyst; Temperature;	91%
With aluminium trichloride In dichloromethane at 20℃; for 24h; Friedel-Krafts reaction;	82%
With aluminium trichloride
Stage #1: 2-Fluorotoluene; acetyl chloride With aluminum (III) chloride In dichloromethane at 20℃; for 26h; Reflux; Stage #2: With water; sodium carbonate In dichloromethane
With aluminum (III) chloride In dichloromethane at 20℃; for 26h; Reflux;

: 95-52-3
2-Fluorotoluene

: 100-47-0
benzonitrile

: 948-65-2
2-phenyl-indole

Conditions

Conditions	Yield
With cesium fluoride; lithium hexamethyldisilazane at 110℃; for 12h; Reagent/catalyst; Temperature; Green chemistry;	90%
With cesium fluoride; lithium hexamethyldisilazane at 110℃; for 12h; Reagent/catalyst; Concentration; Sealed tube; Inert atmosphere;	90%

: 95-52-3
2-Fluorotoluene

: 115290-81-8
(R)-N-methyl-3-phenyl-3-hydroxypropylamine

: 105314-52-1, 105314-53-2, 63940-51-2, 83015-26-3
(R)-tomoxetine

Conditions

Conditions	Yield
Stage #1: (R)-N-methyl-3-phenyl-3-hydroxypropylamine With potassium hydroxide In dimethyl sulfoxide at 130℃; for 1h; Stage #2: 2-Fluorotoluene In dimethyl sulfoxide at 130℃;	89.51%
Stage #1: (R)-N-methyl-3-phenyl-3-hydroxypropylamine With sodium hydride In dimethyl sulfoxide for 0.25h; Stage #2: With Potassium benzoate In dimethyl sulfoxide at 50 - 55℃; for 1h; Stage #3: 2-Fluorotoluene In dimethyl sulfoxide at 50 - 120℃; for 6.25 - 7.25h;
With potassium tert-butylate In dimethyl sulfoxide at 60℃; for 8h;

: 95-52-3
2-Fluorotoluene

: 4210-32-6
4-tert-butyl benzonitrile

: 521295-49-8
2-(4-(tert-butyl)phenyl)-1H-indole

Conditions

Conditions	Yield
With cesium fluoride; lithium hexamethyldisilazane at 110℃; for 12h; Sealed tube; Inert atmosphere;	89%

: 95-52-3
2-Fluorotoluene

: 455-88-9
5-nitro-2-fluorotoluene

Conditions

Conditions	Yield
With 2C2H3F3O*BF3; potassium nitrate at 20℃; for 5h;	88%
With nitric acid
With nitric acid; Nitrogen dioxide
With nitric acid

: 95-52-3
2-Fluorotoluene

: C15H25AlO

: 92495-54-0
4'-methoxy-2-methylbiphenyl

Conditions

Conditions	Yield
With bis(tricyclohexylphosphine)nickel(II) dichloride In tetrahydrofuran at 50℃; for 24h; Inert atmosphere;	88%

: cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate

: 95-52-3
2-Fluorotoluene

: C12H12FRu(1+)*F6P(1-)

Conditions

Conditions	Yield
In 1,2-dichloro-ethane at 90℃; for 18h; Inert atmosphere;	88%

: 95-52-3
2-Fluorotoluene

: (E)-N-(2-(4-methoxyphenyl)propan-2-yl)-1-phenylmethanimine

: N-(2-(2-fluorophenyl)-1-phenylethyl)-2-(4-methoxyphenyl)propan-2-amine

Conditions

Conditions	Yield
With potassium tert-butylate; 2,2,6,6-tetramethylpiperidinyl-lithium at -40℃; for 18h; Glovebox; Inert atmosphere;	88%

: 613-46-7
2-naphthalenecarbonitrile

: 95-52-3
2-Fluorotoluene

: 23746-81-8
2-(2-naphthyl)indole

Conditions

Conditions	Yield
With cesium fluoride; lithium hexamethyldisilazane In 1,4-dioxane at 110℃; for 12h; Green chemistry;	88%
With cesium fluoride; lithium hexamethyldisilazane In 1,2-dimethoxyethane at 110℃; for 12h; Solvent; Sealed tube; Inert atmosphere;	88%

: 95-52-3
2-Fluorotoluene

: 73183-34-3
bis(pinacol)diborane

: 195062-59-0
2-methylphenylboronic acid pinacol ester

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel (0); copper(l) iodide; cesium fluoride; tricyclohexylphosphine In toluene at 80℃; for 24h; Inert atmosphere;	87.6%
With chlorobis(tricyclohexylphosphine)copper(I); cesium fluoride In toluene at 80℃; for 24h;	79%
With tetramethylammonium fluoride; 2-mercaptopyridine sodium salt In acetonitrile at 30 - 35℃; for 24h; Irradiation; Inert atmosphere;	57%

: 95-52-3
2-Fluorotoluene

: C19H13CrO3

: 32913-59-0
(η6-1-fluoro-2-methylbenzene)tricarbonylchromium(0)

Conditions

Conditions	Yield
In 1,4-dioxane at 90℃; for 16h;	86%

2-Fluorotoluene Chemical Properties

Molecule structure of o-Fluorotoluene (CAS NO.95-52-3):

IUPAC Name: 1-Fluoro-2-methylbenzene
Molecular Formula: C₇H₇F
Molecular Weight: 110.13 g/mol
Density: 1.001 g/cm³
Melting Point: -62 °C
Boiling Point: 116.3 °C at 760 mmHg
Flash Point: 11.4 °C
Index of Refraction: 1.477
Molar Refractivity: 31.07 cm³
Molar Volume: 109.9 cm³
Surface Tension: 27.6 dyne/cm
Enthalpy of Vaporization: 33.99 kJ/mol
Vapour Pressure: 21.8 mmHg at 25 °C
Storage Temp.: flammables area
Water Solubility: immiscible
XLogP3: 2.9
H-Bond Acceptor: 1
Exact Mass: 110.053178
MonoIsotopic Mass: 110.053178
Canonical SMILES: CC1=CC=CC=C1F
InChI: InChI=1S/C7H7F/c1-6-4-2-3-5-7(6)8/h2-5H,1H3
InChIKey: MMZYCBHLNZVROM-UHFFFAOYSA-N
EINECS: 202-428-5
Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives; Organics; Aryl; C7; Halogenated Hydrocarbons

2-Fluorotoluene Uses

o-Fluorotoluene (CAS NO.95-52-3) can be used for intermediates of medicine and pesticide.

2-Fluorotoluene Toxicity Data With Reference

orl-brd LD50:100 mg/kg

AECTCV Archives of Environmental Contamination and Toxicology. 12 (1983),355.

2-Fluorotoluene Consensus Reports

Reported in EPA TSCA Inventory.

2-Fluorotoluene Safety Profile

Hazard Codes: F, Irritant Xi
Risk Statements: 11-36/37/38
R11:Highly flammable.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 16-26-33-36-37/39
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S33:Take precautionary measures against static discharges.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
RIDADR: UN 2388 3/PG 2
WGK Germany: 3
RTECS: XT2579000
Hazard Note: Flammable/Irritant
HazardClass: 3
PackingGroup: II
HS Code: 29036990

2-Fluorotoluene Specification

o-Fluorotoluene (CAS NO.95-52-3) is also named as 1-Fluoro-2-methylbenzene ; 1-Methyl-2-fluorobenzene ; 2-Fluorotoluene ; 4-05-00-00799 (Beilstein Handbook Reference) ; BRN 1853362 ; NSC 8859 . o-Fluorotoluene (CAS NO.95-52-3) is clear colorless to slightly yellow liquid with an aromatic odor. It is highly flammable and insoluble in water.
o-Fluorotoluene has generally low reactivity. It reacts with strong oxidizing agents and strong reducing agents. Also it may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. Inhalation of vapor may cause respiratory irritation. Prolonged and repeated vapor exposures may produce systemic toxic effects.

Product Name

2-Fluorotoluene

Synthetic route

2-Fluorotoluene Chemical Properties

2-Fluorotoluene Uses

2-Fluorotoluene Toxicity Data With Reference

2-Fluorotoluene Consensus Reports

2-Fluorotoluene Safety Profile

2-Fluorotoluene Specification

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