2-Methyl-5-Nitrophenol supplier

Name
2-Methyl-5-nitrophenol
EINECS 226-580-7
CAS No. 5428-54-6
Article Data15
CAS DataBase
Density 1.32 g/cm³
Solubility
Melting Point 111-115 °C(lit.)
Formula C₇H₇NO₃
Boiling Point 293.3 °C at 760 mmHg
Molecular Weight 153.137
Flash Point 134.2 °C
Transport Information UN 2446 6.1/PG 3
Appearance Brown solid
Safety 26-36-37/39
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xi, Xn
Synonyms o-Cresol,5-nitro- (8CI);2-Hydroxy-4-nitrotoluene;5-Nitro-2-cresol;5-Nitro-2-methylphenol;5-Nitro-o-cresol;5-Nitro-o-methylphenol;NSC 12987;NSC 41203;NSC 50664;
PSA 66.05000
LogP 2.13200

Synthetic route

: 99-55-8
2-methyl-5-nitroaniline

: 5428-54-6
2-methyl-5-nitrophenol

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite In water for 0.333333h; Heating;	93%
With sulfuric acid; sodium nitrite In water Heating;	87%
Diazotization.Reaktion ueber mehrere Stufen;

: 21565-00-4
5-Nitroso-o-kresol

: 5428-54-6
2-methyl-5-nitrophenol

Conditions

Conditions	Yield
With sodium hydroxide; water; dihydrogen peroxide; sodium tungstate for 3h;	61%

: 99-55-8
2-methyl-5-nitroaniline

A: 5428-54-6
2-methyl-5-nitrophenol

B: 7597-18-4
6-nitroindazole

Conditions

Conditions	Yield
With sulfuric acid; water; sodium nitrite Diazotization;

: 7664-93-9
sulfuric acid

: 99-55-8
2-methyl-5-nitroaniline

sodium nitrite: sodium nitrite

A: 5428-54-6
2-methyl-5-nitrophenol

B: 7597-18-4
6-nitroindazole

Conditions

Conditions	Yield
Diazotization;

...Expand

: 7664-93-9
sulfuric acid

: 617-09-4
di-o-tolyl carbonate

: 7697-37-2
nitric acid

A: 99-53-6
2-methyl-4-nitrophenol

B: 5428-54-6
2-methyl-5-nitrophenol

C: 13073-29-5
2-methyl-6-nitrophenol

Conditions

Conditions	Yield
at -15 - 0℃; Kochen des Reaktionsprodukts mit wss. K2CO3-Loesung;

...Expand

: N-(2-methyl-5-nitro-phenyl)-N'-p-tolyl-triazene

acid: acid

A: 5428-54-6
2-methyl-5-nitrophenol

B: 106-49-0
p-toluidine

C nitrogen: nitrogen

...Expand

: 7647-01-0
hydrogenchloride

: 861519-76-8
N-(2-methyl-5-nitro-phenyl)-N'-o-tolyl-triazene

A: 5428-54-6
2-methyl-5-nitrophenol

B: 95-53-4
o-toluidine

C nitrogen: nitrogen

...Expand

: 7664-93-9
sulfuric acid

: 861519-76-8
N-(2-methyl-5-nitro-phenyl)-N'-o-tolyl-triazene

A: 5428-54-6
2-methyl-5-nitrophenol

B: 95-53-4
o-toluidine

C nitrogen: nitrogen

...Expand

: 861519-76-8
N-(2-methyl-5-nitro-phenyl)-N'-o-tolyl-triazene

: 64-19-7
acetic acid

A: 5428-54-6
2-methyl-5-nitrophenol

B: 95-53-4
o-toluidine

C nitrogen: nitrogen

...Expand

: 7647-01-0
hydrogenchloride

: 861519-76-8
N-(2-methyl-5-nitro-phenyl)-N'-o-tolyl-triazene

: 135-19-3
β-naphthol

A: 5428-54-6
2-methyl-5-nitrophenol

B: 95-53-4
o-toluidine

C: 6410-15-7
pigment orange 3

D nitrogen: nitrogen

...Expand

: 95-53-4
o-toluidine

ester of glycine: ester of glycine

: 5428-54-6
2-methyl-5-nitrophenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 36 percent / conc. HNO3, conc. H2SO4 / 2 - 5 °C 2: 1.) H2SO4, NaNO2 / 1.) 2-5 deg C, 2.) heating View Scheme

: 120-66-1
N-(2-methylphenyl)acetamide

: 5428-54-6
2-methyl-5-nitrophenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuric acid; HNO3+H2SO4 / Verseifung der Acetylverbindung 2: concentrated sulfuric acid; water; NaNO2 / Diazotization View Scheme

: 95-53-4
o-toluidine

: 5428-54-6
2-methyl-5-nitrophenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuric acid; nitric acid 2: concentrated sulfuric acid; water; NaNO2 / Diazotization View Scheme

: 121-14-2
2,4-dinitrotoluene

A: 5428-54-6
2-methyl-5-nitrophenol

B: 119-32-4
4-Methyl-3-nitroanilin

C: 99-55-8
2-methyl-5-nitroaniline

Conditions

Conditions	Yield
With hydrogen In methanol at 36℃; under 760.051 Torr; for 0.25h;

...Expand

: 5428-54-6
2-methyl-5-nitrophenol

: 108-24-7
acetic anhydride

: 54362-24-2
2-acetoxy-4-nitrotoluene

Conditions

Conditions	Yield
With sodium hydroxide In water at 20℃; for 0.666667h;	100%
With dmap; triethylamine In dichloromethane at 20℃; for 2h; Inert atmosphere;	99%
With pyridine at 20℃; for 6h;	91%
With pyridine at 0 - 20℃; for 6h;	91%
With pyridine at 20℃; for 24h;	86%

: 544-77-4
1-iodohexadecane

: 5428-54-6
2-methyl-5-nitrophenol

: 915711-10-3
2-hexadecyloxy-4-nitrotoluene

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In tetrahydrofuran Reflux;	100%
With 18-crown-6 ether; potassium carbonate In tetrahydrofuran at 80℃;	95%

: 5428-54-6
2-methyl-5-nitrophenol

: 54362-24-2
2-acetoxy-4-nitrotoluene

Conditions

Conditions	Yield
With acetic anhydride; sodium hydroxide In water at 20℃; for 0.666667h;	100%

: 5428-54-6
2-methyl-5-nitrophenol

A: 61995-11-7
3-acetoxy-4-methylaniline

B: 54362-24-2
2-acetoxy-4-nitrotoluene

Conditions

Conditions	Yield
With sodium hydroxide; acetic anhydride; palladium In ethyl acetate	A 94% B 100%
With sodium hydroxide; acetic anhydride	A 94% B 100%

: 5428-54-6
2-methyl-5-nitrophenol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 3-tert-butyldiphenylsilyloxy-4-methylnitrobenzene

Conditions

Conditions	Yield
Stage #1: 2-methyl-5-nitrophenol With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: tert-butylchlorodiphenylsilane In N,N-dimethyl-formamide at 20℃; for 4h;	100%
With 1H-imidazole In dichloromethane at 20℃; for 5h;	88%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; under 3750.38 Torr; for 4h;
With 1H-imidazole In dichloromethane

: 5428-54-6
2-methyl-5-nitrophenol

: 75-03-6
ethyl iodide

: 2486-63-7
2-ethoxy-1-methyl-4-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 40℃; Inert atmosphere;	100%
With potassium carbonate In acetone for 48h; Reflux;

: 5428-54-6
2-methyl-5-nitrophenol

: 100-39-0
benzyl bromide

: 219492-11-2
2-(benzyloxy)-1-methyl-4-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone for 2h; Inert atmosphere; Reflux;	99%
With potassium carbonate In acetonitrile at 80℃; for 2h;	97%
With potassium carbonate In N,N-dimethyl-formamide at 60℃; Inert atmosphere;	90%
With sodium carbonate In acetone	1.06 g (33%)

: 5428-54-6
2-methyl-5-nitrophenol

: 320-98-9
5-fluoro-2-nitrobenzoic acid

: 878743-92-1
5-(2-methyl-5-nitrophenoxy)-2-nitrobenzoic acid

Conditions

Conditions	Yield
Stage #1: 2-methyl-5-nitrophenol; 5-fluoro-2-nitrobenzoic acid With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 48h; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide	99%

: 5428-54-6
2-methyl-5-nitrophenol

: 78-95-5
chloroacetone

: 107188-56-7
4-Methyl-1-nitro-3-(2'-oxopropyloxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In acetone Heating;	98%

: 5428-54-6
2-methyl-5-nitrophenol

: 4091-39-8
3-chloro-2-butanone

: 203940-76-5
1-methyl-2-(1-methyl-2-oxoprop-1-yloxy)-4-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone for 10h; Heating;	98%

: 5428-54-6
2-methyl-5-nitrophenol

: 39183-20-5
2-chloro-6-methyl-3-nitro-phenol

Conditions

Conditions	Yield
With chlorine In chloroform for 0.5h; Heating;	96%
With chloroform; chlorine

: 5428-54-6
2-methyl-5-nitrophenol

: 74-88-4
methyl iodide

: 13120-77-9
2-methyl-5-nitroanisole

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide In water; toluene at 20℃;	96%
With potassium carbonate In N,N-dimethyl-formamide at 40℃; Inert atmosphere;	96%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 9h;	74%
With potassium carbonate In acetone for 5h; Heating / reflux;	72%

: 5428-54-6
2-methyl-5-nitrophenol

: 107-08-4
1-iodo-propane

: 854256-33-0
1-methyl-4-nitro-2-n-propoxybenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 40℃; Inert atmosphere;	96%

: 5428-54-6
2-methyl-5-nitrophenol

: 589-10-6
phenoxyethyl bromide

: 1-methyl-4-nitro-2-(2-phenoxyethoxy)benzene

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 40℃;	96%

: 5428-54-6
2-methyl-5-nitrophenol

: 624-65-7
2-propynyl chloride

: 136187-53-6
4-methyl-1-nitro-3-propargyloxybenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone Heating;	95%

: 5428-54-6
2-methyl-5-nitrophenol

: 61570-79-4
1,1-dimethyl-2-propynyl trifluoroacetate

: 184896-34-2
1-methyl-2-[(2-methylbut-3-yn-2-yl)oxy]-4-nitrobenzene

Conditions

Conditions	Yield
With copper(II) choride dihydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at -10 - 20℃; Inert atmosphere;	95%
With copper(II) chloride dihydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 0℃; for 7h;

: 542-69-8
1-iodo-butane

: 5428-54-6
2-methyl-5-nitrophenol

: 57264-52-5
2-butoxy-1-methyl-4-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 40℃; Inert atmosphere;	93%

: 5428-54-6
2-methyl-5-nitrophenol

: 75-26-3
isopropyl bromide

: 136187-51-4
2-isopropyloxy-1-methyl-4-nitrobenzene

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide at 90℃; for 2.5h;	92%

: 5428-54-6
2-methyl-5-nitrophenol

: 115-19-5
2-methyl-but-3-yn-2-ol

: 184896-34-2
1-methyl-2-[(2-methylbut-3-yn-2-yl)oxy]-4-nitrobenzene

Conditions

Conditions	Yield
Stage #1: 2-methyl-but-3-yn-2-ol With 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic anhydride In acetonitrile at -10℃; Inert atmosphere; Stage #2: 2-methyl-5-nitrophenol With copper(II) choride dihydrate at -10 - 20℃; Inert atmosphere;	92%

: 5428-54-6
2-methyl-5-nitrophenol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1226973-96-1
tert-butyldimethyl(2-methyl-5-nitrophenoxy)silane

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 16h;	91%

: 13154-24-0
triisopropylsilyl chloride

: 5428-54-6
2-methyl-5-nitrophenol

: 582322-76-7
4-methyl-3-(triisopropylsilyloxy)aniline

Conditions

Conditions	Yield
Stage #1: triisopropylsilyl chloride; 2-methyl-5-nitrophenol With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 21h; Inert atmosphere; Stage #2: With iron; acetic acid at 40℃; for 4h;	90%

: 5428-54-6
2-methyl-5-nitrophenol

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

: 4-(2-methyl-5-nitrophenoxy)piperidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80 - 85℃;	89%
With potassium carbonate In N,N-dimethyl-formamide at 80℃;	89%
With potassium carbonate In N,N-dimethyl-formamide at 80℃;	89%
With potassium carbonate In N,N-dimethyl-formamide at 90℃;

: 5428-54-6
2-methyl-5-nitrophenol

: 14000-67-0
benzyl 4-(2-hydroxyethyl)-1-piperazinecarboxylate

: 1257423-70-3
benzyl 4-[2-(2-methyl-5-nitrophenoxy)ethyl]piperazine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 2-methyl-5-nitrophenol; benzyl 4-(2-hydroxyethyl)-1-piperazinecarboxylate With triphenylphosphine In tetrahydrofuran at 0℃; for 0.166667h; Mitsunobu reaction; Inert atmosphere; Stage #2: With diethylazodicarboxylate In tetrahydrofuran; toluene at 0 - 20℃; for 2h; Mitsunobu reaction; Inert atmosphere;	86%

: 5428-54-6
2-methyl-5-nitrophenol

: 77-78-1
dimethyl sulfate

: 13120-77-9
2-methyl-5-nitroanisole

Conditions

Conditions	Yield
With sodium hydroxide In water at 70 - 75℃; for 2h;	86%

: 109-65-9
1-bromo-butane

: 5428-54-6
2-methyl-5-nitrophenol

: 57264-52-5
2-butoxy-1-methyl-4-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 4h; Heating;	81%
With sodium ethanolate

: 1111-97-3
3-chloro-3-methylbut-1-yne

: 5428-54-6
2-methyl-5-nitrophenol

: 184896-34-2
1-methyl-2-[(2-methylbut-3-yn-2-yl)oxy]-4-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile at 82℃; for 48h;	81%
With tetrabutylammomium bromide; potassium carbonate In acetonitrile at 70℃;	80%

: 5428-54-6
2-methyl-5-nitrophenol

: 2032-35-1
Bromoacetaldehyde diethyl acetal

: 185684-93-9
3-(2,2-Diethoxyethoxy)-4-methylnitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 153℃; for 3.5h;	81%
With potassium carbonate In N,N-dimethyl-formamide at 153℃;	81%
With potassium carbonate In N,N-dimethyl-formamide for 3.5h; Reflux;	81%

: 5428-54-6
2-methyl-5-nitrophenol

: 1895-39-2
sodium chlorodifluoroacetate

: 2-(difluoromethoxy)-1-methyl-4-nitrobenzene

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 100℃; for 2h;	81%

: 7252-83-7
1-bromo-2,2-dimethoxyethane

: 5428-54-6
2-methyl-5-nitrophenol

: 603305-53-9
2-(2,2-dimethoxyethoxy)-1-methyl-4-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) for 2.5h; Heating / reflux;	77%
With potassium carbonate In DMF (N,N-dimethyl-formamide) for 2.5h; Heating / reflux;	77%

2-Methyl-5-Nitrophenol Chemical Properties

Molecular Structure:

Molecular Formula: C₇H₇NO₃
Molecular Weight: 153.1354
IUPAC Name: 2-Methyl-5-nitrophenol
Synonyms of 2-Methyl-5-Nitrophenol (CAS NO.5428-54-6): 2-Hydroxy-4-nitrotoluene ; 5-Nitro-2-cresol ; EINECS 226-580-7 ; NSC 12987 ; NSC 41203 ; NSC 50664 ; Phenol, 2-methyl-5-nitro- ; o-Cresol, 5-nitro-
CAS NO: 5428-54-6
Product Categories: Intermediates of Dyes and Pigments ; Aromatic Phenols ; Phenol&Thiophenol&Mercaptan ; Phenoles and thiophenoles
Melting point: 111-115 °C
Index of Refraction: 1.596
Molar Refractivity: 39.5 cm³
Molar Volume: 115.9 cm³
Surface Tension: 54.7 dyne/cm
Density: 1.32 g/cm³
Flash Point: 134.2 °C
Enthalpy of Vaporization: 55.42 kJ/mol
Boiling Point: 293.3 °C at 760 mmHg
Vapour Pressure: 0.00099 mmHg at 25°C

2-Methyl-5-Nitrophenol Uses

2-Methyl-5-Nitrophenol (CAS NO.5428-54-6) is used as an intermediate for organic synthesis and dyestuff.

2-Methyl-5-Nitrophenol Safety Profile

Hazard Codes of 2-Methyl-5-Nitrophenol (CAS NO.5428-54-6): Irritant Xi,Xn
Risk Statements: 36/37/38-20/21/22
R36/37/38: Irritating to eyes, respiratory system and skin.
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
S37/39: Wear suitable gloves and eye/face protection.
RIDADR: UN 2446 6.1/PG 3
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III

Product Name

2-Methyl-5-nitrophenol

Synthetic route

2-Methyl-5-Nitrophenol Chemical Properties

2-Methyl-5-Nitrophenol Uses

2-Methyl-5-Nitrophenol Safety Profile

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