3,5-Dimethylaniline supplier

Name
3,5-Dimethylaniline
EINECS 203-607-0
CAS No. 108-69-0
Article Data71
CAS DataBase
Density 0.972 g/cm³
Solubility <0.1 g/100 mL at 19 °C in water
Melting Point 7-9 °C
Formula C₈H₁₁N
Boiling Point 218.5 °C at 760 mmHg
Molecular Weight 121.182
Flash Point 93.3 °C
Transport Information UN 1711 6.1/PG 2
Appearance clear yellow-brown to brown liquid
Safety 28-36/37-45-61-28A
Risk Codes 23/24/25-33-51/53
Molecular Structure
Hazard Symbols T,N
Synonyms 3,5-Dimethylbenzeneamine;3,5-Xylidine;3,5-Dimethy Iani line;3,5-Dimethyl aniline;Product Name: 3,5-dimethylaniline;3,5-Xylidene;3,5-Xylylamine;5-Amino-1,3-xylene;3, 5-Dimethylbenzeneamine;benzenamine, 3,5-dimethyl-;1-Amino-3,5-dimethylbenzene;5-Amino-1,3-dimethylbenzene;Benzene, 1-amino-3,5-dimethyl-;3,5-Xylidine;3, 5-Xylylamine;3,5-Dimethylphenylamine;3,5-Dimethylbenzenamine;
PSA 26.02000
LogP 2.46680

Synthetic route

: 556-96-7
5-bromo-1,3-xylene

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With copper(I) oxide; ammonium hydroxide In 1-methyl-pyrrolidin-2-one at 80℃; for 15h;	100%
With copper(l) iodide; 2-carboxyquinoline N-oxide; potassium carbonate; ammonium hydroxide In dimethyl sulfoxide at 80℃; for 23h; Inert atmosphere;	91%
With copper(l) iodide; ammonia; sodium phosphate In water at 100℃; for 24h;	86%
With diethylenetriaminopentaacetic acid; ammonia; copper(II) oxide; potassium hydroxide In water at 100℃; for 6h;	74%
Stage #1: 5-bromo-1,3-xylene With magnesium In tetrahydrofuran Inert atmosphere; Stage #2: With C10H17NO In tetrahydrofuran; toluene at -78℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water; toluene Inert atmosphere;	74%

: 99-12-7
5-nitro-m-xylene

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With borane-ammonia complex In methanol; water at 49.84℃; for 0.166667h; Catalytic behavior;	99%
With sodium tetrahydroborate In water at 60℃; for 0.0166667h;	96%
Stage #1: 5-nitro-m-xylene With Cu(OH)x impregnated on Fe3O4 In water for 0.0833333h; Green chemistry; Stage #2: With sodium tetrahydroborate In water at 55 - 60℃; for 0.116667h; Green chemistry;	95%

: 22445-41-6
3,5-dimethylphenyl iodide

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With copper(I) oxide; ammonium hydroxide In 1-methyl-pyrrolidin-2-one at 80℃; for 15h;	99%
With potassium phosphate; copper(l) iodide; N-((1-oxy-pyridin-2-yl)methyl)oxalamic acid; ammonia In water; dimethyl sulfoxide at 25℃; Schlenk technique; Inert atmosphere; Sealed tube; chemoselective reaction;	95%
With copper(l) iodide; 2-carboxyquinoline N-oxide; potassium carbonate; ammonium hydroxide In dimethyl sulfoxide at 50℃; for 23h; Inert atmosphere;	92%

: 556-97-8
1-chloro-3,5-dimethylbenzene

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With ammonium hydroxide; potassium phosphate In dimethyl sulfoxide at 80℃; UV-irradiation;	99%
Multi-step reaction with 2 steps 1.1: sulfuric acid; nitric acid / 30 °C / Cooling with ice 2.1: palladium on activated charcoal / ethanol / 0.5 h / 50 °C / Autoclave 2.2: 0.83 h / 65 °C / 2250.23 Torr / Autoclave View Scheme

: 62034-72-4
N-hydroxy-3,5-dimethylbenzamide

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 90℃; for 4h; Lossen Rearrangement;	97%

: 108-68-9
3,5-Dimethylphenol

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With palladium/alumina; ammonia; hydrogen In toluene at 250℃; under 2250.23 Torr; Temperature; Pressure; Solvent;	95%
With 5%-palladium/activated carbon; hydrazine hydrate; lithium hydroxide In 1,4-dioxane at 170℃; for 16h; Molecular sieve; Inert atmosphere;	71%
With ammonia at 350℃; under 117681 - 183877 Torr;
With aluminum oxide; nitrogen; ammonia; hydrogen at 450℃; under 147102 Torr;

: 101252-04-4
3,5-dimethyl-cyclohexanone oxime

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With Pd(OH)x/LDH In N,N-dimethyl acetamide at 130℃; for 11h; Schlenk technique; Inert atmosphere;	91%

: 5-[(3,5-dimethylphenyl)imino]-5H-5γ4-dibenzo[b,d]thiophene-5-oxide

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane In toluene at 100℃; Sealed tube;	88%

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 99-12-7
5-nitro-m-xylene

A: 91-22-5
quinoline

B: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With nickel-nitrogen-doped carbon framework In water at 145℃; for 18h; Inert atmosphere; Sealed tube; Green chemistry;	A 73% B 76%

...Expand

: 99-12-7
5-nitro-m-xylene

: 6872-06-6
2-methyl indoline

A: 95-20-5
2-methyl-1H-indole

B: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With nickel-nitrogen-doped carbon framework In water at 145℃; for 18h; Inert atmosphere; Sealed tube; Green chemistry;	A 74% B 76%

...Expand

: 2320-30-1
3,5-dimethylcyclohexanone

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With ethene; 5%-palladium/activated carbon; ammonium acetate In acetonitrile at 90℃; under 760.051 Torr; for 15h; Schlenk technique;	71%

: 64-17-5
ethanol

: 99-12-7
5-nitro-m-xylene

A: 102871-67-0
2,5,7-trimethylquinoline

B: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With platinum-loaded TiO2 at 30℃; for 5h; UV-irradiation;	A 68% B 16%

...Expand

: 105-67-9
2,4-Xylenol

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
Stage #1: 2,4-Xylenol With Nonafluorobutanesulfonyl fluoride; tris(trimethylsilyl)amine; potassium hexamethylsilazane In tetrahydrofuran at 60℃; for 5h; Schlenk technique; Inert atmosphere; Stage #2: With hydrogenchloride In water at 20℃; for 0.0833333h; pH=3 - 4;	67%

: 21857-45-4
5-methoxyindoline

: 99-12-7
5-nitro-m-xylene

A: 1006-94-6
5-methoxylindole

B: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With nickel-nitrogen-doped carbon framework In water at 145℃; for 18h; Inert atmosphere; Sealed tube; Green chemistry;	A 62% B 61%

...Expand

: 108-38-3
m-xylene

A: 108-69-0
3,5-dimethylaminoaniline

B: 95-68-1
2,4-Xylidine

C: 87-62-7
2,6-dimethylaniline

Conditions

Conditions	Yield
With tris-(2-chloro-ethyl)-amine; trifluorormethanesulfonic acid; trifluoroacetic acid In chloroform at 25℃; for 1h;	A 2% B 58% C 15%
With hydrogenchloride; aluminium trichloride; sodium azide In various solvent(s) at 20℃;
With sodium azide; trifluorormethanesulfonic acid at 20℃; Ultrasonic irradiation;
Stage #1: m-xylene With sulfuric acid; hydroxylamine hydrochloride In acetonitrile at 25℃; for 0.166667h; Stage #2: With hydrogenchloride; titanium(III) chloride In water; acetonitrile at 25℃; Inert atmosphere; Sealed tube; Overall yield = 60 percent; Overall yield = 72 mg;

...Expand

: 499-06-9
3,5-dimethylbenzoic acid

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With hydrogenchloride; PPA; hydroxylamine

: 5692-35-3
3,5-dimethylbenzamide

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With alkaline sodium hypobromite

: 10272-10-3
2-amino-4,6-dimethylbenzene-1,3-dicarbonitrile

A: 875241-52-4
2-amino-4,6-dimethyl benzamide

B: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With sulfuric acid

: 67543-92-4
3,5-dimethyl-cyclohex-2-enone oxime

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With hydrogenchloride at 170℃;

: 108-68-9
3,5-Dimethylphenol

A: 5369-25-5
bis-(3,5-dimethylphenyl)-amine

B: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With ammonium chloride at 350℃; under 36775.4 Torr;

5-nitro-m-xylene: 5-nitro-m-xylene

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With hydrogenchloride; tin(ll) chloride
With iron; acetic acid
With hydrogenchloride; tin

: 7664-41-7
ammonia

: 108-68-9
3,5-Dimethylphenol

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
at 350℃; under 117681 Torr;

: ammonium chloride

: 108-68-9
3,5-Dimethylphenol

A: 5369-25-5
bis-(3,5-dimethylphenyl)-amine

B: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
at 350℃; under 36775.4 - 44130.5 Torr;

...Expand

: 5692-35-3
3,5-dimethylbenzamide

alkaline hypobromite: alkaline hypobromite

: 108-69-0
3,5-dimethylaminoaniline

: 42205-08-3
1,2,3-triethylbenzene

: 83186-90-7
bis-(3,5-dimethyl-cyclohex-2-enylidene)-hydrazine

palladium/charcoal: palladium/charcoal

: 108-69-0
3,5-dimethylaminoaniline

...Expand

: 7647-01-0
hydrogenchloride

: 91536-77-5
4-(3,5-dimethyl-phenylazo)-3,5-dimethyl-aniline

tin: tin

A: 108-69-0
3,5-dimethylaminoaniline

B 2.5-diamino-m-xylene: 2.5-diamino-m-xylene

...Expand

: [Pd((CH3)2C6H3NH2)4](2+)*2CF3COCHCOCF3(1-)=[Pd((CH3)2C6H3NH2)4](CF3COCHCOCF3)2

: [Pd(CF3COCHCOCF3)((CH3)2C6H3NH2)2](1+)*CF3COCHCOCF3(1-)=[Pd(CF3COCHCOCF3)((CH3)2C6H3NH2)2](CF3COCHCOCF3)

B: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
In chloroform-d1 not isolated; detected by NMR;

: (E)-cyclooct-2-en-1-yl (3,5-dimethylphenyl)carbamate

: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With 3,6-dimethyl-1,2,4,5-tetrazine; formic acid In acetonitrile at 20℃; for 1h; Reagent/catalyst; Solvent;
With 3,6-dimethyl-1,2,4,5-tetrazine; formic acid In acetonitrile at 20℃; for 1h; Reagent/catalyst; Solvent;

: 1558-23-2
3,6-dimethyl-1,2,4,5-tetrazine

: C17H23NO2

A: 86997-05-9
C12H18N2

B: 108-69-0
3,5-dimethylaminoaniline

Conditions

Conditions	Yield
With pyridine In acetonitrile at 20℃; for 1h; Reagent/catalyst;

...Expand

: 108-69-0
3,5-dimethylaminoaniline

: 98-59-9
p-toluenesulfonyl chloride

: 114097-28-8
N-(3,5-dimethylphenyl)-4-methyl-benzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 4℃;	100%
With silica gel at 20℃;	95%
With triethylamine In dichloromethane at 0 - 20℃;	82%

: 108-69-0
3,5-dimethylaminoaniline

: 75-98-9
Trimethylacetic acid

: 86489-67-0
N-(3,5-dimethylphenyl)pivalamide

Conditions

Conditions	Yield
With diphosphorus tetraiodide In tetrachloromethane; dichloromethane Heating;	100%

: 108-69-0
3,5-dimethylaminoaniline

: 762-42-5
dimethyl acetylenedicarboxylate

: 92952-51-7
dimethyl (Z)-N-(3,5-dimethylphenyl)aminofumarate

Conditions

Conditions	Yield
at 20℃; for 0.133333h; Michael addition;	100%
In diethyl ether at 0℃;	75%

: 123-11-5
4-methoxy-benzaldehyde

: 108-69-0
3,5-dimethylaminoaniline

: 199435-31-9
3,5-dimethyl-N-(4-methoxybenzylidene)aniline

Conditions

Conditions	Yield
at 20℃;	100%
With acetic acid In methanol at 20℃;

: 4755-77-5
Ethyl oxalyl chloride

: 108-69-0
3,5-dimethylaminoaniline

: 333441-77-3
2-(3,5-dimethylphenylamino)-2-oxoacetic acidethyl ester

Conditions

Conditions	Yield
With pyridine at 20℃; for 1.5h; Inert atmosphere;	100%
With triethylamine In tetrahydrofuran at 0 - 20℃;	68%

: 108-69-0
3,5-dimethylaminoaniline

: 857070-85-0
3-(3,5-dimethyl-phenylamino)-propionamide

Conditions

Conditions	Yield
With ammonia In methanol at 80℃;	100%

: 864460-87-7
2-(2-tert-butoxycarbonylaminopyridin-4-ylmethylthio)pyridine-3-carboxylic acid

: 108-69-0
3,5-dimethylaminoaniline

: 2-(2-tert-Butoxycarbonylaminopyridin-4-ylmethylthio)-N-(3,5-dimethylphenyl)pyridine-3-carboxamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 12h;	100%

: 1009646-49-4
{4-[6-formyl-1-(3-hydroxy-6-methylpyridin-2-ylmethyl)-1H-benzoimidazol-2-ylamino]piperidin-1-yl}acetic acid ethyl ester

: 108-69-0
3,5-dimethylaminoaniline

: 1009646-54-1
{4-[6-[(3,5-dimethylphenylamino)methyl]-1-(3-hydroxy-6-methylpyridin-2-ylmethyl)-1H-benzoimidazol-2-ylamino]piperidin-1-yl}acetic acid ethyl ester

Conditions

Conditions	Yield
With sodium cyanoborohydride; acetic acid In acetonitrile at 20℃; for 12h;	100%

: 108-69-0
3,5-dimethylaminoaniline

: 583-53-9
1,2-dibromobenzene

: 1068437-89-7
N,N'-di(3,5-dimethylphenyl)benzene-1,2-diamine

Conditions

Conditions	Yield
With ammonium chloride; sodium t-butanolate; palladium diacetate In water; argon; toluene	100%
With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate In toluene at 110℃; for 14h; Inert atmosphere;	100 %Chromat.

: 37630-26-5, 4735-49-3
β-(1-naphthyl)nitroethylene

: 108-69-0
3,5-dimethylaminoaniline

: 1268482-47-8
C20H20N2O2

Conditions

Conditions	Yield
at 20℃; for 0.1h; Michael addition; neat (no solvent);	100%

: 5670-66-6, 5670-67-7, 3156-39-6
1-nitro-2-(2-nitrovinyl)benzene

: 108-69-0
3,5-dimethylaminoaniline

: 1268482-40-1
C16H17N3O4

Conditions

Conditions	Yield
at 20℃; for 0.1h; Michael addition; neat (no solvent);	100%

: 102-96-5
(2-nitroethenyl)benzene

: 108-69-0
3,5-dimethylaminoaniline

: 1266995-18-9
C16H18N2O2

Conditions

Conditions	Yield
at 20℃; for 0.1h; Michael addition; neat (no solvent);	100%

: 882-26-8
3-nitro-β-nitrostyrene

: 108-69-0
3,5-dimethylaminoaniline

: 108836-94-8
3,5-dimethyl-N-[2-nitro-1-(3-nitro-phenyl)-ethyl]-aniline

Conditions

Conditions	Yield
at 20℃; for 0.1h; Michael addition; neat (no solvent);	100%

: 706-07-0
1-chloro-4-(2-nitrovinyl)benzene

: 108-69-0
3,5-dimethylaminoaniline

: 1268482-45-6
C16H17ClN2O2

Conditions

Conditions	Yield
at 20℃; for 0.1h; Michael addition; neat (no solvent);	100%

: 108-69-0
3,5-dimethylaminoaniline

: 762-21-0
acetylenedicarboxylic acid diethyl ester

: 1349802-62-5
diethyl (Z)-N-(3,5-dimethylphenyl)aminofumarate

Conditions

Conditions	Yield
at 20℃; for 0.15h; Michael addition;	100%

: 100-52-7
benzaldehyde

: 108-69-0
3,5-dimethylaminoaniline

: 91000-43-0
3,5-dimethyl-N-benzylideneaniline

Conditions

Conditions	Yield
at 20℃;	100%
In methanol	99%
In ethanol for 3h; Reflux;

: 104-87-0
4-methyl-benzaldehyde

: 108-69-0
3,5-dimethylaminoaniline

: 107399-20-2
3,5-dimethyl-N-(4-methylbenzylidene)aniline

Conditions

Conditions	Yield
at 20℃;	100%

: 104-88-1
4-chlorobenzaldehyde

: 108-69-0
3,5-dimethylaminoaniline

: 180569-73-7
3,5-dimethyl-N-(4-chlorobenzylidene)aniline

Conditions

Conditions	Yield
at 20℃;	100%
In neat (no solvent) at 20℃; for 0.5h; Schlenk technique; Molecular sieve; Inert atmosphere;

: 108-69-0
3,5-dimethylaminoaniline

: 1122-91-4
4-bromo-benzaldehyde

: 348601-49-0
3,5-dimethyl-N-(4-bromobenzylidene)aniline

Conditions

Conditions	Yield
at 20℃;	100%

: 626-19-7
Isophthalaldehyde

: 108-69-0
3,5-dimethylaminoaniline

: C24H26N2

Conditions

Conditions	Yield
at 20℃;	100%

: 26074-52-2
2-bromo-butyryl bromide

: 108-69-0
3,5-dimethylaminoaniline

: 2-bromo-N-(3,5-dimethylphenyl)butanamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%

: 625-08-1
3-Hydroxy-3-methylbutyric acid

: 108-69-0
3,5-dimethylaminoaniline

: C13H19NO2

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 14h;	100%

: 108-24-7
acetic anhydride

: 108-69-0
3,5-dimethylaminoaniline

: 2050-45-5
N-acetyl-3,5-dimethylaniline

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	99%
Stage #1: acetic anhydride; 3,5-dimethylaminoaniline In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Stage #2: With sodium hydroxide In tetrahydrofuran; water pH=12 - 14; Cooling with ice;	99%
Stage #1: acetic anhydride; 3,5-dimethylaminoaniline In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Stage #2: With sodium hydroxide In tetrahydrofuran; water pH=12 - 14; Cooling with ice;	99%

: 108-69-0
3,5-dimethylaminoaniline

: 75-36-5
acetyl chloride

: 2050-45-5
N-acetyl-3,5-dimethylaniline

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 201℃; for 1h;	99%
Stage #1: 3,5-dimethylaminoaniline With potassium carbonate In dichloromethane at 0℃; for 0.5h; Inert atmosphere; Stage #2: acetyl chloride for 2h; Inert atmosphere;	99%
With potassium carbonate In dichloromethane at 20℃; for 2.5h; Cooling with ice;	98.8%

: 156-38-7
4-hydroxyphenylacetate

: 108-69-0
3,5-dimethylaminoaniline

: 131179-77-6
N-(3,5-dimethylphenyl)-4-hydroxyphenylacetamide

Conditions

Conditions	Yield
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 5h;	99%
With boric acid In toluene for 18h; Heating;	95%
With pyridine; FI-750-M; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 60℃; for 0.75h; Sealed tube;	86%

: 2009-81-6
2-dimethylaminomethylene-1,3-bis(dimethylimonio)propane diperchlorate

: 108-69-0
3,5-dimethylaminoaniline

: 3-(3,5-dimethylphenylamino)-2-(dimethylphenyliminomethyl)propenal hydrogenperchlorate

Conditions

Conditions	Yield
With perchloric acid In ethanol at 105℃; for 1.5h;	99%

: 15761-39-4
1-(tert-butoxycarbonyl)-L-proline

: 108-69-0
3,5-dimethylaminoaniline

: 137496-70-9
(S)-tert-butyl 2-((3,5-dimethylphenyl)carbamoyl)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With chloroformic acid ethyl ester; triethylamine In dichloromethane at 20℃; for 1h;	99%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 12h;	85%
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane for 12h; Ambient temperature;	65%

: 106-43-4
para-chlorotoluene

: 108-69-0
3,5-dimethylaminoaniline

: 34160-16-2
3,5-dimethyl-N-p-tolylbenzenamine

Conditions

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); potassium tert-butylate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride In 1,4-dioxane at 100℃; for 1.5h; Inert atmosphere;	99%
With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; potassium hydroxide; sodium t-butanolate In water at 110℃; for 22h; Buchwald-Hartwig amination; Inert atmosphere; chemoselective reaction;	95%
With sodium t-butanolate; [Na2PdCl4]; dicyclohexyl-(9-ethyl-9H-fluoren-9-yl)phosphane*HBF4 In toluene at 120℃; for 12h; Buchwald-Hartwig coupling reaction;
With sodium t-butanolate; palladium diacetate; dicyclohexyl(9-ethyl-9H-fluorene-9-yl)-phosphine·HBF4 In toluene at 120℃; for 12h; Product distribution / selectivity; Buchwald-Hartwig Amination;

3,5-Dimethylaniline Chemical Properties

Molecular Formula:C₈H₁₁N
Molar mass:121.17964g/mol
Structure:

Synonyms :3,5-Xylidene;3,5-Dimethylbenzenamine;Benzenamine, 3,5-dimethyl-;5-Amino-1,3-xylene;3,5-Xylylamine;5-Amino-m-xylene;m-Xylidine
Density:0.975 g/cm³
Flash Point:93.3 °C
Boiling Point:218.5 °C at 760 mmHg
Index of Refraction:1.559
Vapour Pressure:0.126 mmHg at 25°C
Melting point:7-9°C
Solubility: Not dissolve in water
Water solubility:<0.1 g/100 mL at 19°C

3,5-Dimethylaniline Uses

3,5-Dimethylaniline(108-69-0) is used for production of pesticides, dyes, and other chemicals.

3,5-Dimethylaniline Toxicity Data With Reference

1.	mmo-sat 1 mg/plate	EMMUEG Environmental and Molecular Mutagenesis. 11 (Suppl 12)(1988),1.
2.	orl-rat LD50:707 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB214-270 .
3.	orl-mus LD50:421 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB214-270 .

4. Carcinogenicity:3,5-Dimethylaniline(108-69-0)- Not listed as a carcinogen by NTP, IARC,ACGIH, or CA Prop 65.
Other: See actual entry in RTECS for complete information.

3,5-Dimethylaniline Consensus Reports

Reported in EPA TSCA Inventory.

3,5-Dimethylaniline Safety Profile

Suspected carcinogen. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also XYLIDINE; 2,3-XYLIDINE; 2,4-XYLIDINE; 2,5-XYLIDINE; 2,6-XYLIDINE; 3,4-XYLIDINE; 2,4-XYLIDINE HYDROCHLORIDE; 2,5-XYLIDINE HYDROCHLORIDE.
Hazard Codes:T,N
Risk Statements:
23: Toxic by inhalation
24: Toxic in contact with skin
25: Toxic if swallowed
33: Danger of cumulative effects
51: Toxic to aquatic organisms
53: May cause long-term adverse effects in the aquatic environment
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
61: Avoid release to the environment. Refer to special instructions safety data sheet

3,5-Dimethylaniline Standards and Recommendations

DFG MAK: (all isomers except 2,4-xylidene) Confirmed Animal Carcinogen with Unknown Relevance to Humans

3,5-Dimethylaniline Specification

Stability and Reactivity of 3,5-Dimethylaniline(108-69-0):
Conditions to Avoid:Incompatible materials, light, exposure to air, excess heat.
Chemical Stability:Stable under normal pressures and temperatures. Darkens on exposure to light and air.
Incompatibilities with Other Materials: Excess heat, chloroformates, acids, acid chlorides,acid anhydrides,halogens,coatings, plastics, rubber, hypochlorite.
Hazardous Decomposition Products: carbon dioxide,nitrogen oxides,Carbon monoxide.

Product Name

3,5-Dimethylaniline

Synthetic route

3,5-Dimethylaniline Chemical Properties

3,5-Dimethylaniline Uses

3,5-Dimethylaniline Toxicity Data With Reference

3,5-Dimethylaniline Consensus Reports

3,5-Dimethylaniline Safety Profile

3,5-Dimethylaniline Standards and Recommendations

3,5-Dimethylaniline Specification

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