3-Aminopropanol supplier | CasNO.156-87-6

Name
3-Aminopropanol
EINECS 205-864-4
CAS No. 156-87-6
Article Data70
CAS DataBase
Density 0.947 g/cm³
Solubility miscible
Melting Point 10-12 °C(lit.)
Formula C₃H₉NO
Boiling Point 187.5 °C at 760 mmHg
Molecular Weight 75.1106
Flash Point 79.4 °C
Transport Information UN 2735 8/PG 2
Appearance clear colourless to very slightly yellow liquid
Safety 26-36/37/39-45
Risk Codes 22-34-20/21/22
Molecular Structure
Hazard Symbols C
Synonyms 1,3-Propanolamine;1-Amino-3-hydroxypropane;1-Amino-3-propanol;3-Amino-1-propanol;3-Aminopropyl alcohol;3-Hydroxy-1-aminopropane;N-(3-Hydroxypropyl)amine;NSC 7766;Propanolamine;g-Aminopropanol;g-Hydroxy-1-propylamine;
PSA 46.25000
LogP 0.02780

Synthetic route

: 98642-44-5
tert-butyl (3-hydroxypropyl)methylcarbamate

: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
With hydrogenchloride for 2h;	99%

: 109-78-4
3-Hydroxypropionitrile

: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
With ammonium hydroxide; hydrogen; silver nitrate In methanol at 45 - 75℃; under 1500.15 Torr; Temperature; High pressure; Inert atmosphere; Autoclave;	98%
With hydrogen; nickel In isopropyl alcohol at 60℃; under 3102.9 Torr; 20-24 h;	88%
With ammonium hydroxide; hydrogen at 80℃; under 60006 Torr; for 6h; Sealed tube;	80%

: 4720-29-0
3-(benzylamino)propan-1-ol

: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
With ammonium formate; palladium on activated charcoal In methanol for 0.166667h; Heating;	95%

: 6328-48-9
3-benzyloxypropionitrile

: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
With palladium on activated charcoal; hydrogen In dichloromethane; water at 40℃; under 3375.34 Torr; for 4h; Temperature; Pressure; Solvent; Autoclave;	93.8%

: 107-95-9
3-amino propanoic acid

: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
With sulfuric acid; hydrogen In water at 79.84℃; under 60006 Torr;	90%
With ruthenium trichloride; sulfuric acid; hydrogen In water at 95℃; for 10h; pH=4; Temperature; Reagent/catalyst; Autoclave;	88.09%
With tetrahydrofuran; lithium aluminium tetrahydride

: 98748-92-6
3-trimethylsiloxy-1-phenylpropyl isocyanide

: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
With hydrogenchloride In methanol at 24℃; for 12h;	65%

: 7688-51-9
N,N-bis(trimethylsilyl)allylamine

: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
	55%

: 289-95-2
PYRIMIDINE

: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
With water; nickel at 140℃; under 51485.6 Torr; Hydrogenation;

: 924-73-2
3-amino-propionic acid ethyl ester

: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

: 1656-48-0
2-cyanoethyl ether

: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
With ammonia; nickel at 110 - 115℃; Hydrogenation.unter Druck;

: 25182-84-7
3-nitropropan-1-ol

: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
With hydrogenchloride; tin

: 78-96-6, 1674-56-2
3-amino-2-propanol

: 156-87-6
propan-1-ol-3-amine

: 20907-32-8
sodium allyloxide

: 107-18-6
allyl alcohol

: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
With methanol; ammonia at 110 - 140℃;

: 109-78-4
3-Hydroxypropionitrile

A: 14002-34-7
tripropanolamine

B: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
With nickel kieselguhr at 60 - 70℃; Hydrogenation.unter Druck;

: 503-29-7
azetidine

: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
With perchloric acid at 25℃; Rate constant; Thermodynamic data; E(a);

: 107-10-8
propylamine

A: 352-92-1
3-aminopropanal

B: 144-62-7
oxalic acid

C: 802294-64-0
propionic acid

D: 56-40-6
glycine

E: 156-87-6
propan-1-ol-3-amine

F: 107-95-9
3-amino propanoic acid

Conditions

Conditions	Yield
With argon arc plasma; water at 30℃; Product distribution; cathode: tungsten rod; anode: copper nozzle; 40 A; 10 V; pH= 3.0; variation of concentration of substrate and time;

...Expand

: 107-10-8
propylamine

A: 6168-72-5
2-Amino-1-propanol

B: 632-12-2
(RS)-isoserine

C: 56-40-6
glycine

D: 156-87-6
propan-1-ol-3-amine

E: 107-95-9
3-amino propanoic acid

Conditions

Conditions	Yield
In water at 10 - 20℃; Product distribution; pH=2.7 and pH=12.0, various reaction times, contact glow discharge electrolysis;

...Expand

: 107-10-8
propylamine

A: 632-12-2
(RS)-isoserine

B: 56-40-6
glycine

C: 156-87-6
propan-1-ol-3-amine

D: 107-95-9
3-amino propanoic acid

Conditions

Conditions	Yield
In water at 10 - 20℃; contact glow discharge electrolysis, pH=2.7; Yield given. Further byproducts given;

...Expand

: 107-10-8
propylamine

A: 352-92-1
3-aminopropanal

B: 56-40-6
glycine

C: 156-87-6
propan-1-ol-3-amine

D: 107-95-9
3-amino propanoic acid

Conditions

Conditions	Yield
town gas-oxigen flame In water at 40 - 50℃; for 0.25h;	A 7.1 % Chromat. B n/a C 8.9 % Chromat. D n/a

...Expand

: 14753-26-5
3-chloropropan-1-amine

A: 503-29-7
azetidine

B: 40226-15-1
3-(3-aminopropylamino)propan-1-ol

C: 54262-75-8
N-γ-aminopropyltrimethyleneimine

D: 129157-76-2
N1-(3-Azetidin-1-yl-propyl)-propane-1,3-diamine

E: 107-11-9
1-amino-2-propene

F: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
With sodium hydroxide In water at 80℃; Product distribution;	A n/a B 6 % Chromat. C 50 % Chromat. D 25 % Chromat. E n/a F 15 % Chromat.

...Expand

: 84508-22-5
3-hydroxypropan-1-aminium

: 114444-46-1
C14H13NO

A: 124225-44-1
1-methyl-4-(phenylacetyl)pyridinium cation

B: 156-87-6
propan-1-ol-3-amine

Conditions

Conditions	Yield
In water at 25℃; Equilibrium constant; Rate constant;

...Expand

: 104053-83-0
N-3-phenoxypropylacetamide

A: 64-19-7
acetic acid

B: 156-87-6
propan-1-ol-3-amine

C: 7617-76-7
3-phenoxypropanamine

D: 108-95-2
phenol

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 94.5℃; Product distribution; Mechanism; Kinetics; velocity const; different HCl conc.;var. temp.;

...Expand

: 104053-84-1
N-3-phenoxypropylpropionamide

A: 802294-64-0
propionic acid

B: 156-87-6
propan-1-ol-3-amine

C: 7617-76-7
3-phenoxypropanamine

D: 108-95-2
phenol

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 94.5℃; Product distribution; Mechanism; Kinetics; velocity const; different HCl conc.; var. temp.;

...Expand

: 96-49-1
[1,3]-dioxolan-2-one

: 156-87-6
propan-1-ol-3-amine

: 69506-93-0
(3-hydroxy-propyl)-carbamic acid-(2-hydroxy-ethyl ester)

Conditions

Conditions	Yield
1) 50-55 deg C, 1 h; 2) r.t., overnight;	100%

: 85-44-9
phthalic anhydride

: 156-87-6
propan-1-ol-3-amine

: 883-44-3
N-(3-hydroxypropyl)phthalimide

Conditions

Conditions	Yield
In toluene at 125℃; for 6.5h; Inert atmosphere;	100%
With triethylamine In toluene at 125℃; for 3h; Inert atmosphere; Dean-Stark;	99%
With triethylamine In toluene at 130℃; for 3h;	95%

: 156-87-6
propan-1-ol-3-amine

: 109-94-4
formic acid ethyl ester

: 49807-74-1
3-(N-formylamino)propan-1-ol

Conditions

Conditions	Yield
	100%
Reflux;	100%
at 50℃; for 2.25h; Cooling with ice;	95%

: 762-04-9
phosphonic acid diethyl ester

: 156-87-6
propan-1-ol-3-amine

: 58474-49-0
(3-hydroxy-propyl)-phosphoramidic acid diethyl ester

Conditions

Conditions	Yield
With potassium carbonate; potassium hydrogencarbonate; tetrabutylammomium bromide In tetrachloromethane; dichloromethane at 15 - 20℃; for 2h;	100%
With triethylamine In tetrachloromethane; benzene
With sodium hypochlorite In water at 0℃; Temperature;	8.6 g

: 98-59-9
p-toluenesulfonyl chloride

: 156-87-6
propan-1-ol-3-amine

: 13379-98-1
3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h; Inert atmosphere;	100%
With triethylamine In dichloromethane at 0℃; for 17h;	99%
With triethylamine In chloroform at 0 - 20℃; for 18h; Inert atmosphere;	99%

: 1121-60-4
pyridine-2-carbaldehyde

: 156-87-6
propan-1-ol-3-amine

: 134777-96-1
tetrahydro-2-(2-pyridinyl)-2H-1,3-oxazine

Conditions

Conditions	Yield
In ethanol for 2h; Product distribution; Ambient temperature; other aminoalcohols, other pyridinecarbaldehydes;	100%
In ethanol for 2h; Ambient temperature;	100%

: 156-87-6
propan-1-ol-3-amine

: 60759-49-1
N-acetyl-1,3-oxazol-2-one

: 10601-73-7
N-(3-hydroxypropyl)acetamide

Conditions

Conditions	Yield
In tetrahydrofuran for 1h; Ambient temperature;	100%

: 156-87-6
propan-1-ol-3-amine

: 5332-06-9
4-bromobutanenitrile

: 159791-11-4
4-(3-Hydroxy-propylamino)-butyronitrile

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 20h; Heating;	100%
With potassium carbonate; sodium iodide In acetonitrile for 20h; Alkylation; Heating;	6.70 g

: 18162-48-6
tert-butyldimethylsilyl chloride

: 156-87-6
propan-1-ol-3-amine

: 115306-75-7
3-(tertbutyldimethylsiloxyl)propylamine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	100%
With 1H-imidazole In dichloromethane at 20℃;	99%
With triethylamine In dichloromethane at 20℃; for 12h;	97%

: 156-87-6
propan-1-ol-3-amine

: 4-Benzenesulfonyl-butyryl chloride

: 191475-21-5
4-Benzenesulfonyl-N-(3-hydroxy-propyl)-butyramide

Conditions

Conditions	Yield
In dichloromethane at 0℃;	100%

: 156-87-6
propan-1-ol-3-amine

: 5-Benzenesulfonyl-pentanoyl chloride

: 191475-22-6
5-Benzenesulfonyl-pentanoic acid (3-hydroxy-propyl)-amide

Conditions

Conditions	Yield
In dichloromethane at 0℃;	100%

: 156-87-6
propan-1-ol-3-amine

: 6-Benzenesulfonyl-hexanoyl chloride

: 191475-23-7
6-Benzenesulfonyl-hexanoic acid (3-hydroxy-propyl)-amide

Conditions

Conditions	Yield
In dichloromethane at 0℃;	100%

: 156-87-6
propan-1-ol-3-amine

: 7-Benzenesulfonyl-heptanoyl chloride

: 191475-24-8
7-Benzenesulfonyl-heptanoic acid (3-hydroxy-propyl)-amide

Conditions

Conditions	Yield
In dichloromethane at 0℃;	100%

: 81-84-5
1,8-Naphthalic anhydride

: 156-87-6
propan-1-ol-3-amine

: 6914-97-2
N-(3-hydroxypropyl)-1,8-naphthalimide

Conditions

Conditions	Yield
	100%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 85℃; for 4h; Inert atmosphere;	98%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 85℃; for 4h;	95%

: 50-00-0
formaldehyd

: 156-87-6
propan-1-ol-3-amine

: 61112-42-3
3-[3,5-bis(3-hydroxypropyl)[1,3,5]triazinan-1-yl]propan-1-ol

Conditions

Conditions	Yield
In methanol at 20℃; for 16h;	100%
In acetonitrile at 20℃;	92%
In ethanol Cyclization;

: 60835-69-0
4'-nitrobenzo-15-crown-5

: 156-87-6
propan-1-ol-3-amine

: 3-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-4-nitro-phenylamino]-propan-1-ol

Conditions

Conditions	Yield
In ethanol at 100℃; for 100h; Ring cleavage;	100%

: 112528-14-0, 112528-15-1, 98078-91-2
C23H28N4O2

: 156-87-6
propan-1-ol-3-amine

: 1-(3-hydroxypropyl)-3-{3-[3-(piperidinomethyl)phenoxy]propyl}guanidine-2-carbonitrile

Conditions

Conditions	Yield
at 20℃; for 1h; Substitution;	100%

: 1672-34-0
3,6-dimethylthio-1,2,4,5-tetrazine

: 156-87-6
propan-1-ol-3-amine

: 317350-80-4
3-((6-methylthio-1,2,4,5-tetrazin-3-yl)amino)propan-1-ol

Conditions

Conditions	Yield
With 3 Angstroem MS In methanol at 25℃; for 18h;	100%

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 156-87-6
propan-1-ol-3-amine

: 253453-32-6
2-(3,4,5-trimethoxy)phenyltetrahydro-(2H)-1,3-oxazine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene Heating;	100%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 156-87-6
propan-1-ol-3-amine

: 253453-31-5
2-(3,4-dimethoxy)phenyltetrahydro-(2H)-1,3-oxazine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene Heating;	100%

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 156-87-6
propan-1-ol-3-amine

: 864655-26-5
tert-butyl 4-[(3-hydroxypropyl)amino]piperidine-1-carboxylate

Conditions

Conditions	Yield
With hydrogen; palladium 10% on activated carbon In ethanol under 3361.55 Torr; for 1.5h;	100%
With hydrogen; palladium on activated charcoal In methanol at 20℃; under 760.051 Torr; for 24h;	99%
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane for 2h;
Stage #1: N-tert-butyloxycarbonylpiperidin-4-one; propan-1-ol-3-amine With acetic acid In dichloromethane at 20 - 27℃; for 3h; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20 - 27℃; Inert atmosphere;

3-Aminopropanol Chemical Properties

MF: C₃H₉NO
MW: 75.11
EINECS: 205-864-4
mp： 10-12 °C(lit.)
bp： 184-187 °C(lit.)
density： 0.987 g/mL at 20 °C(lit.)
vapor density： 2.59 (vs air)
vapor pressure： 2.1 mm Hg ( 20 °C)
refractive index： n20/D 1.4598(lit.)
Fp： 175 °F
Water Solubility： miscible
Sensitive： Hygroscopic
BRN： 741855
CAS DataBase Reference： 156-87-6(CAS DataBase Reference)
NIST Chemistry Reference： 156-87-6(NIST)
The structure of 3-PROPANOLAMINE is:

3-Aminopropanol Uses

3-PROPANOLAMINE is used as chemical intermediate for dexpanthenol and a gastrointestinal drug.

3-Aminopropanol Toxicity Data With Reference

1.	skn-rbt 10 mg/24H open SEV	AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95.
2.	eye-rbt 250 µg/24H SEV	85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,683.
3.	orl-rat LDLo:2830 mg/kg	AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95.
4.	skn-rbt LD50:1250 mg/kg	AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95.

3-Aminopropanol Consensus Reports

3-PROPANOLAMINE is reported in EPA TSCA Inventory.

3-Aminopropanol Safety Profile

Hazard Codes： C
RIDADR： UN 2735 8/PG 2
WGK Germany： 1
RTECS： UA5600000
HazardClass： 8
PackingGroup ： II
HS Code： 29221980
Hazardous Substances Data： 156-87-6(Hazardous Substances Data)
Moderately toxic by ingestion and skin contact. An experimental teratogen. A severe skin and eye irritant. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO₂, dry chemical. When heated to decomposition it emits toxic fumes of NO_x.

3-Aminopropanol Specification

1、Fire Fighting Measures
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
2、Handling and Storage
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area.

Product Name

3-Aminopropanol

Synthetic route

3-Aminopropanol Chemical Properties

3-Aminopropanol Uses

3-Aminopropanol Toxicity Data With Reference

3-Aminopropanol Consensus Reports

3-Aminopropanol Safety Profile

3-Aminopropanol Specification

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