3-Chloro-1-(N,N-dimethyl)propylamine supplier

Name
3-Chloro-1-(N,N-dimethyl)propylamine
EINECS 203-679-3
CAS No. 109-54-6
Article Data51
CAS DataBase
Density 0.937 g/cm³
Solubility Slightly soluble in water.
Melting Point 168℃
Formula C₅H₁₂ClN
Boiling Point 130.7 °C at 760 mmHg
Molecular Weight 121.61
Flash Point 32.8 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Propylamine,3-chloro-N,N-dimethyl- (6CI,7CI,8CI);(3-Chloropropyl)dimethylamine;1-Chloro-3-(dimethylamino)propane;1-Dimethylamino-3-chloropropane;3-(Dimethylamino)-1-propyl chloride;3-(Dimethylamino)propyl chloride;3-(N,N-Dimethylamino)propyl chloride;3-Chloro-1-(dimethylamino)propane;3-Chloro-N,N-dimethylpropanamine;3-Dimethylamino-1-chloropropane;3-Dimethylaminopropan-1-yl chloride;Dimethyl(3-chloropropyl)amine;N,N-Dimethyl-3-chloro-1-propanamine;N,N-Dimethyl-3-chloropropanamine;N-(3-Chloropropyl)-N,N-dimethylamine;g-Chloropropyldimethylamine;g-Dimethylaminopropyl chloride;
PSA 3.24000
LogP 1.17690

Synthetic route

: 5407-04-5
3-(dimethylamino)propyl chloride hydrochloride

: 109-54-6
3-(Dimethylamino)propyl chloride

Conditions

Conditions	Yield
With sodium hydroxide In water at 45℃; for 2h;	91.07%
With triethylamine In diethyl ether at 20℃;	83%
With sodium hydroxide In water at 45 - 50℃; for 2h;	80%

: 3179-63-3
3-Dimethylamino-1-propanol

: 109-54-6
3-(Dimethylamino)propyl chloride

Conditions

Conditions	Yield
With thionyl chloride for 4h; Reflux;	91%
With thionyl chloride In chloroform at 0 - 70℃; for 4h; Inert atmosphere;	83%
With thionyl chloride; benzene zuletzt bei Siedetemperatur;
With thionyl chloride
With thionyl chloride In toluene for 2h; Reflux;

: 20904-57-8
N,N-dimethyl-3-phenoxypropan-1-amine

: 109-54-6
3-(Dimethylamino)propyl chloride

Conditions

Conditions	Yield
With hydrogenchloride at 170 - 180℃;

: 124-40-3
dimethyl amine

: 109-70-6
1,3-chlorobromopropane

: 109-54-6
3-(Dimethylamino)propyl chloride

Conditions

Conditions	Yield
With diethyl ether at 40℃;
With benzene
With Petroleum ether at 40℃;

: 17268-49-4
3-chloro-N,N-dimethylpropionamide

: 109-54-6
3-(Dimethylamino)propyl chloride

Conditions

Conditions	Yield
With lithium aluminium tetrahydride

: 30340-95-5
N,N-Dimethylazetidinium-chlorid

: 109-54-6
3-(Dimethylamino)propyl chloride

Conditions

Conditions	Yield
(pyrolysis);

: 110129-11-8
5-chloro-5,7-dihydrodibenzothiepin

A: N,N-dimethyl-3-(9-phenanthrylthio)propylamine

B: 110129-14-1
N,N-dimethyl-3-(9,10-dihydro-9-phenanthrylthio)propylamine

C: 109-54-6
3-(Dimethylamino)propyl chloride

Conditions

Conditions	Yield
With magnesium 1) tetrahydrofuran, 2) benzene, 4 h, reflux; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

dimethyl-propyl-amine hydrochloride: dimethyl-propyl-amine hydrochloride

: 109-54-6
3-(Dimethylamino)propyl chloride

Conditions

Conditions	Yield
With chloroform; chlorine Irradiation.mit Gluehlampenlicht;
With chloroform; phosphorus pentoxide; chlorine Irradiation.mit Gluehlampenlicht;

: 926-63-6
N,N-dimethylaminopropane

: 67-66-3
chloroform

: 7782-50-5
chlorine

A: 108-14-5
2-chloro-1-dimethylaminopropane

B: 109-54-6
3-(Dimethylamino)propyl chloride

Conditions

Conditions	Yield
bei der Reaktion des Hydrochlorids; mit Gluehlampenlicht.Irradiation;

...Expand

: 926-63-6
N,N-dimethylaminopropane

: 67-66-3
chloroform

: 7782-50-5
chlorine

phosphorus (V)-oxide: phosphorus (V)-oxide

A: 108-14-5
2-chloro-1-dimethylaminopropane

B: 109-54-6
3-(Dimethylamino)propyl chloride

Conditions

Conditions	Yield
bei der Reaktion des Hydrochlorids; mit Gluehlampenlicht.Irradiation;

...Expand

: 7647-01-0
hydrogenchloride

: 20904-57-8
N,N-dimethyl-3-phenoxypropan-1-amine

A: 109-54-6
3-(Dimethylamino)propyl chloride

B: 108-95-2
phenol

Conditions

Conditions	Yield
at 170 - 180℃;

...Expand

: 5-(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one

A: 3-dimethylaminopropyl-5(3,4-dimethoxyphenyl)-3,6-dihydro-1,3,4-thiadiazin-2-one

B: 109-54-6
3-(Dimethylamino)propyl chloride

: 37968-01-7
9,10-dihydro-4H-thieno<3,2,b>benzazepine

: 109-54-6
3-(Dimethylamino)propyl chloride

: 37968-12-0
[3-(9,10-dihydro-benzo[b]thieno[2,3-f]azepin-4-yl)-propyl]-dimethyl-amine

Conditions

Conditions	Yield
With sodium hydride In xylene Heating;	100%

: 2-bromo-4-(2-azidoethyl)phenol

: 109-54-6
3-(Dimethylamino)propyl chloride

: 3-(4-(2-azidoethyl)phenoxy)-N,N-dimethylpropan-1-amine

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In acetone for 15h; Reflux;	98%

: 5447-86-9
10,10-dimethyl-9,10-dihydroanthracen-9-one

: 109-54-6
3-(Dimethylamino)propyl chloride

: C20H25NO

Conditions

Conditions	Yield
Stage #1: 3-(Dimethylamino)propyl chloride With iodine; magnesium In diethyl ether; ethylene dibromide at 30 - 35℃; for 9h; Reflux; Large scale; Stage #2: 10,10-dimethyl-9,10-dihydroanthracen-9-one In diethyl ether; ethylene dibromide at 10 - 35℃; for 1h; Reflux; Large scale;	97.2%

: 22799-57-1
2-chloro-7-nitro-10H-phenothiazine

: 109-54-6
3-(Dimethylamino)propyl chloride

: 2-chloro-7-nitro-10-(3-(dimethylamino)propyl)-10H-phenothiazine hydrochloride

Conditions

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate In toluene Heating;	97%

: 27567-85-7
4-protoadamantanone

: 109-54-6
3-(Dimethylamino)propyl chloride

: 4-[3-(dimethylamino)propyl]-4-tricyclo[4.3.1.0(3,8)]decanol

Conditions

Conditions	Yield
Stage #1: 3-(Dimethylamino)propyl chloride With magnesium In benzene Heating; Stage #2: 4-protoadamantanone In benzene for 4h; Reflux; Stage #3: With water; ammonium chloride In benzene Cooling with ice;	97%

: 1507401-82-2
2-(5-bromo-2-methoxyphenyl)-2-(4-fluorophenyl)acetonitrile

: 109-54-6
3-(Dimethylamino)propyl chloride

: 1507401-83-3
2-(5-bromo-2-methoxyphenyl)-5-(dimethylamino)-2-(4-fluorophenyl)pentanenitrile

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran; diethyl ether at -44 - 0℃; for 1.5h; Reflux;	94%

: 41422-67-7
sodium phenyltelluride

: 109-54-6
3-(Dimethylamino)propyl chloride

: C11H17NTe

Conditions

Conditions	Yield
In methanol; benzene at 20℃; for 15h; Inert atmosphere; Schlenk technique;	94%

: 338409-28-2
5-methyl-2-(pyrazin-2-yl)thiazol-4-ol

: 109-54-6
3-(Dimethylamino)propyl chloride

: N,N-dimethyl-3-((5-methyl-2-(pyrazin-2-yl)thiazol-4-yl)oxy)propan-1-amine

Conditions

Conditions	Yield
Stage #1: 5-methyl-2-(pyrazin-2-yl)thiazol-4-ol With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 0.5h; Stage #2: 3-(Dimethylamino)propyl chloride With potassium iodide In N,N-dimethyl-formamide at 60℃; for 8h;	94%

: 64169-67-1
1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

: 109-54-6
3-(Dimethylamino)propyl chloride

: 59729-33-8
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Conditions

Conditions	Yield
Stage #1: 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile; 3-(Dimethylamino)propyl chloride With sodium hydride In 1,3-dimethyl-2-imidazolidinone; toluene at 40 - 50℃; for 0.666667h; Stage #2: With hydrogenchloride; water at 65 - 70℃; for 3h; Stage #3: With sodium hydroxide In water; toluene Product distribution / selectivity;	93%
Stage #1: 1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile; 3-(Dimethylamino)propyl chloride With sodium hydride In tetrahydrofuran; toluene at 40 - 50℃; for 0.666667h; Stage #2: With dimethyl sulfoxide at 65 - 70℃; for 3h; Stage #3: With acetic acid In water; toluene Product distribution / selectivity;	51.6%
With sodium hydride In dimethyl sulfoxide; toluene at 20 - 25℃; for 3h; Product distribution / selectivity;

: 26306-64-9
2,4-dichloro-1-(2-aminophenoxy)benzene

: 109-54-6
3-(Dimethylamino)propyl chloride

: 89279-19-6
N,N-Dimethyl-N'-<2-(2,4-dichlorophenoxy)phenyl>-1,3-propanediamine

Conditions

Conditions	Yield
With sodium amide In benzene	92%

: (+/-)-trans-5a,6,7,8,9,10,10a,11-octahydrobenzo[e]cyclohepta[b][1,4]thiazine

: 109-54-6
3-(Dimethylamino)propyl chloride

: (+/-)trans-3-(6,7,8,9,10,10a-hexahydrobenzo[e]cyclohepta[b][1,4]thiazin-11(5aH)-yl)-N,N-dimethylpropan-1-amine

Conditions

Conditions	Yield
Stage #1: (+/-)-trans-5a,6,7,8,9,10,10a,11-octahydrobenzo[e]cyclohepta[b][1,4]thiazine With sodium amide In toluene for 1.5h; Reflux; Inert atmosphere; Stage #2: 3-(Dimethylamino)propyl chloride In toluene Inert atmosphere;	92%

: 3169-77-5
2-(2,5-dichlorophenoxy)aniline

: 109-54-6
3-(Dimethylamino)propyl chloride

: 89279-20-9
N,N-Dimethyl-N'-<2-(2,5-dichlorophenoxy)phenyl>-1,3-propanediamine

Conditions

Conditions	Yield
With sodium amide In benzene	91%

: 4583-55-5
5-bromo-2,3-dimethyl-1H-indole

: 109-54-6
3-(Dimethylamino)propyl chloride

: 3-(5-bromo-2,3-dimethyl-1H-indol-1-yl)-N,N-dimethylpropan-1-amine

Conditions

Conditions	Yield
Stage #1: 5-bromo-2,3-dimethyl-1H-indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.333333h; Stage #2: 3-(Dimethylamino)propyl chloride In N,N-dimethyl-formamide; mineral oil at 0 - 50℃;	91%

: 119-61-9
benzophenone

: 109-54-6
3-(Dimethylamino)propyl chloride

: 791-37-7
DHP-361

Conditions

Conditions	Yield
Stage #1: benzophenone With 1,2-diphenyl-1,2-disodiumethane In tetrahydrofuran at 0℃; Inert atmosphere; Stage #2: 3-(Dimethylamino)propyl chloride In tetrahydrofuran; diethyl ether at 0℃; Inert atmosphere; Stage #3: With water In tetrahydrofuran; diethyl ether at 0℃; Inert atmosphere;	90%
Stage #1: 3-(Dimethylamino)propyl chloride With iodine; magnesium In tetrahydrofuran Heating; Stage #2: benzophenone In tetrahydrofuran at 0 - 20℃; Grignard reaction; Further stages.;	61%
With iodine; magnesium In tetrahydrofuran	61%
(i) Mg, EtBr, (ii) /BRN= 1238185/; Multistep reaction;
With 1,1-Dibromoethane; ammonium chloride; magnesium 1) THF, reflux, 15 min; 2) THF, reflux, 1 h; 3) overnight, CH2Cl2; Yield given. Multistep reaction;

: 109-54-6
3-(Dimethylamino)propyl chloride

: 156400-55-4
3β-mercapto-14β-hydroxy-5β-card-20(22)-enolide

: 4-[(3S,5R,8R,9S,10S,13R,14S,17R)-3-(3-Dimethylamino-propylsulfanyl)-14-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-5H-furan-2-one

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; Alkylation;	90%

: 109-54-6
3-(Dimethylamino)propyl chloride

: 193747-17-0
5-tert-Butyl-1-phenyl-1H-pyrazole-4-carbaldehyde

: 1-(5-tert-butyl-1-phenyl-1H-pyrazol-4-yl)-4-dimethylamino-butan-1-ol

Conditions

Conditions	Yield
Stage #1: 3-(Dimethylamino)propyl chloride With magnesium In tetrahydrofuran Metallation; Stage #2: 5-tert-Butyl-1-phenyl-1H-pyrazole-4-carbaldehyde In tetrahydrofuran Grignard reaction; Heating;	90%

: 109-54-6
3-(Dimethylamino)propyl chloride

: 79-06-1
2-propenamide

: 5205-93-6
2-methyl-acrylic acid 3-dimethylamino-propyl amide

Conditions

Conditions	Yield
Stage #1: 2-propenamide With sodium hydride In N,N-dimethyl-formamide; mineral oil at 60℃; for 1h; Stage #2: 3-(Dimethylamino)propyl chloride In N,N-dimethyl-formamide; mineral oil at 80℃; for 4h;	90%

: 82386-95-6
11H-Dibenz-1,4-oxathiepin

: 109-54-6
3-(Dimethylamino)propyl chloride

: 82387-04-0
11-(3-Dimethylaminopropyl)-11H-dibenz-1,4-oxathiepin

Conditions

Conditions	Yield
With n-butyllithium In hexane	89%

: C11H12N2O3

: 109-54-6
3-(Dimethylamino)propyl chloride

: C15H20N2O

Conditions

Conditions	Yield
Stage #1: 3-(Dimethylamino)propyl chloride With magnesium In tetrahydrofuran; ethylene dibromide; toluene for 5h; Stage #2: C11H12N2O3 In tetrahydrofuran; ethylene dibromide; toluene at 50℃; for 12h; Temperature;	88.8%

: 109-54-6
3-(Dimethylamino)propyl chloride

: 261-92-7
10H-pyrido<4,3-b><1,4>benzothiazine

: 94037-18-0
(3-benzo[b]pyrido[3,4-e][1,4]thiazin-10-yl-propyl)-dimethyl-amine

Conditions

Conditions	Yield
With sodium hydride In 1,4-dioxane; toluene Heating; 1.) 2 h;;	88%
With sodium amide

: 56966-48-4
2-(o-Chlorophenoxy)-5-chloroaniline

: 109-54-6
3-(Dimethylamino)propyl chloride

: 89279-18-5
N,N-Dimethyl-N'-<2-(o-chlorophenoxy)-5-chlorophenyl>-1,3-propanediamine

Conditions

Conditions	Yield
With sodium amide In benzene	87%

: 113194-07-3
2,2-dimethyl-5-nitro-2,3-dihydro-benzofuran-7-ol

: 109-54-6
3-(Dimethylamino)propyl chloride

: 1089187-65-4
2,2-dimethyl-5-nitro-7-(3-dimethylamino-propoxy)-2,3-dihydro-benzofuran

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide; xylene at 20 - 110℃; for 0.666667h; Product distribution / selectivity;	87%

: 5464-08-4
N-(4-methoxy-2-nitrophenyl)benzenesulfonamide

: 109-54-6
3-(Dimethylamino)propyl chloride

: N-[4-methoxy-2-nitrophenyl]-N-[3-(dimethylamino)propyl]benzenesulfonamide

Conditions

Conditions	Yield
With sodium carbonate In N,N-dimethyl-formamide at 130℃; for 0.166667h;	87%

: 5,5-dimethyl-3-(E)-[(2'-chloro-phenyl)-vinyl]-2-cyclohexene-1-one-(E)-oxime

: 109-54-6
3-(Dimethylamino)propyl chloride

: 5,5-Dimethyl-3-(E)-[(2'-chloro-phenyl)-vinyl]-1-(E)-(3"-dimethylamino-propoxyimino)-2-cyclohexene

Conditions

Conditions	Yield
With potassium hydroxide; sodium hydroxide; dimethyl sulfoxide In water	86.7%

: 82354-35-6
des-N-methylnoracronycine

: 109-54-6
3-(Dimethylamino)propyl chloride

: 6-O-(3-N,N-dimethylaminopropyl)glyfoline hydrochloride

Conditions

Conditions	Yield
With potassium carbonate In acetone Heating;	86%

: 1616475-42-3
N-(5-hydroxy-1-phenyl-1H-benzo[d]imidazol-2-yl)benzamide

: 109-54-6
3-(Dimethylamino)propyl chloride

: 1616475-44-5
N-(5-(3-(dimethylamino)propoxy)-1-phenyl-1H-benzo[d]imidazol-2-yl)benzamide

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile for 6h; Inert atmosphere; Reflux;	86%
With caesium carbonate In acetonitrile for 6h; Reflux; Inert atmosphere;	86%

: 16807-13-9
3-iodocarbazole

: 109-54-6
3-(Dimethylamino)propyl chloride

: C17H19IN2

Conditions

Conditions	Yield
Stage #1: 3-iodocarbazole With sodium hydride In tetrahydrofuran at 20℃; for 2h; Cooling with ice; Inert atmosphere; Stage #2: 3-(Dimethylamino)propyl chloride In tetrahydrofuran; dichloromethane for 12h; Reflux;	86%

: 486-84-0
harmane

: 109-54-6
3-(Dimethylamino)propyl chloride

: 9-(3-dimethylamino-propyl)-1-methyl-9H-β-carboline

Conditions

Conditions	Yield
With potassium hydroxide; 18-crown-6 ether; potassium carbonate In toluene for 2h; Heating;	85%
With xylene

3-Chloro-1-(N,N-dimethyl)propylamine Chemical Properties

IUPAC Name: 3-chloro-N,N-dimethylpropan-1-amine
Synonyms of 3-Chloro-1-(N,N-dimethyl)propylamine (CAS NO.109-54-6): 3-Dimethylaminopropyl chloride
CAS NO: 109-54-6
Molecular Formula: C₅H₁₂ClN
Molecular Weight: 121.61
Molecular Structure:
H bond acceptors: 1
H bond donors: 0
Freely Rotating Bonds: 3
Polar Surface Area: 3.24 Å²
Index of Refraction: 1.434
Molar Refractivity: 33.78 cm³
Molar Volume: 129.7 cm³
Surface Tension: 26.8 dyne/cm
Density: 0.937 g/cm³
Flash Point: 32.8 °C
Enthalpy of Vaporization: 36.83 kJ/mol
Boiling Point: 130.7 °C at 760 mmHg
Vapour Pressure: 9.61 mmHg at 25°C
EINECS: 203-679-3
SMILES: ClCCCN(C)C
InChI: InChI=1/C5H12ClN/c1-7(2)5-3-4-6/h3-5H2,1-2H3
InChIKey: NYYRRBOMNHUCLB-UHFFFAOYAP
Std. InChI: InChI=1S/C5H12ClN/c1-7(2)5-3-4-6/h3-5H2,1-2H3
Std. InChIKey: NYYRRBOMNHUCLB-UHFFFAOYSA-N
Product Categories of 3-Chloro-1-(N,N-dimethyl)propylamine (CAS NO.109-54-6): Polyamines

Product Name

3-Chloro-1-(N,N-dimethyl)propylamine

Synthetic route

3-Chloro-1-(N,N-dimethyl)propylamine Chemical Properties

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