ethyl 3-(N,N-dimethylamino)propionate
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
With C13H34BFeNOP2; hydrogen In tetrahydrofuran at 100℃; under 22502.3 Torr; for 18h; Autoclave; Inert atmosphere; | 86% |
Conditions | Yield |
---|---|
In tetrahydrofuran; water at 50℃; for 24h; Inert atmosphere; | 73.5% |
With water |
(E)-3-(dimethylamino)acrolein
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
With 1,2,3-trimethoxybenzene; hydrogen In ethyl acetate at 60℃; under 750.075 Torr; Flow reactor; Green chemistry; | 70% |
sodium allyloxide
dimethyl amine
allyl alcohol
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
at 130℃; |
Conditions | Yield |
---|---|
With sodium hydroxide | |
With sodium 2-propenoate at 120 - 140℃; |
Conditions | Yield |
---|---|
With benzene | |
In toluene for 3h; Reflux; |
Conditions | Yield |
---|---|
With formic acid; water | |
With formic acid | |
With formic acid |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In diethyl ether | |
With hydrogen; C40H39BN2P2Ru In tetrahydrofuran at 80℃; under 37503.8 Torr; for 16h; Product distribution / selectivity; | |
With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); hydrogen; sodium methylate In methanol at 100℃; under 37503.8 Torr; for 16h; Autoclave; Inert atmosphere; | < 10 %Spectr. |
(3-hydroxy-propyl)-trimethyl-ammonium; hydroxide
3-Dimethylamino-1-propanol
2,2-dimethyl-isoxazolidinium; iodide
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
(electrochemical reduction); |
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
In tetrahydrofuran Heating; |
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
With sodium hydroxide; dihydrogen peroxide In tetrahydrofuran |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium tetrahydroborate; dihydrogen peroxide; sodium carbonate 1.) ether 2.) THF, reflux, 3h; Yield given. Multistep reaction; |
Fluxema
A
3-Dimethylamino-1-propanol
B
1-Benzylcycloheptene
C
1-benzylcycloheptan-1-ol
D
(Cycloheptylidenmethyl)benzol
Conditions | Yield |
---|---|
In water at 95℃; Mechanism; Rate constant; Thermodynamic data; further temperatures and different pH-s; ΔE(excit.); |
(3-Hydroxy-propyl)-methoxymethyl-dimethyl-ammonium; bromide
A
3-Dimethylamino-1-propanol
B
(3-Methoxymethoxy-propyl)-dimethyl-amine
Conditions | Yield |
---|---|
With 2,3-dimercapto-succinic acid at 50℃; |
dimethyl sulfate
propan-1-ol-3-amine
A
N-methyl-3-hydroxypropylamine
B
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
With lithium hydride 1.) THF, room temp., 1 h; 2.) room temp., 1 h; Yield given. Multistep reaction; | |
With calcium hydride 1.) THF, room temp., 2.) room temp., 1 h; Yield given. Multistep reaction; |
A
3-Dimethylamino-1-propanol
B
4-ethenyl-1-methylpyridinium iodide
Conditions | Yield |
---|---|
In water at 25℃; Rate constant; ionic strength 0.1 mol dm-3; |
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
With sodium hydroxide durch Verseifung; |
methanol
propan-1-ol-3-amine
A
N-methyl-3-hydroxypropylamine
B
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
With Cs-P-Si mixed-oxide at 300℃; under 61504.9 Torr; Title compound not separated from byproducts; |
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
With naphthalene; lithium In tetrahydrofuran at -78℃; for 4.3h; | 47 % Chromat. |
dimethyl amine
acrolein
A
3-Dimethylamino-1-propanol
B
1-amino-3-(dimethylamino)propane
Conditions | Yield |
---|---|
Stage #1: dimethyl amine; acrolein at 4℃; for 1.25h; autoclave; Stage #2: With ammonia; hydrogen; Raney cobalt In water at 80℃; under 45004.5 Torr; for 2h; Product distribution / selectivity; autoclave; | A 13.9 %Chromat. B 80.3 %Chromat. |
Stage #1: dimethyl amine; acrolein at 4℃; for 1.25h; Autoclave; Stage #2: With ammonia; hydrogen; Ra-Co In tetrahydrofuran; water at 40℃; under 45004.5 Torr; for 2h; Product distribution / selectivity; Autoclave; | |
Stage #1: dimethyl amine; acrolein at 4℃; for 1.25h; Autoclave; Stage #2: With ammonia; hydrogen; Ra-Co In tetrahydrofuran; water at 40℃; under 45004.5 Torr; for 3h; Product distribution / selectivity; Autoclave; |
Conditions | Yield |
---|---|
Stage #1: dimethyl amine; acrolein In tetrahydrofuran at 4℃; for 1.25h; Autoclave; Stage #2: With ammonia; hydrogen; Ra-Co In tetrahydrofuran at 40℃; under 45004.5 Torr; for 3h; Product distribution / selectivity; Autoclave; |
Conditions | Yield |
---|---|
With formic acid; 5%-palladium/activated carbon In water at 20℃; for 3h; Reagent/catalyst; Cooling with ice; | |
With 5%-palladium/activated carbon; hydrogen; acetic acid In water under 3087.28 Torr; for 13h; Concentration; Reagent/catalyst; |
N,N-dimethylammonium chloride
dimethyl amine
3-Hydroxypropionitrile
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In water at 50℃; under 3087.28 Torr; for 4h; Concentration; Temperature; Reagent/catalyst; |
N,N-dimethylammonium chloride
3-Hydroxypropionitrile
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In water under 3087.28 Torr; for 3h; |
3-Dimethylamino-1-propanol
o-chlorobenzoyl chloride
2-Chloro-benzoic acid 3-dimethylamino-propyl ester; hydrochloride
Conditions | Yield |
---|---|
In benzene for 0.5h; | 100% |
3-Dimethylamino-1-propanol
methanesulfonyl chloride
3-(N,N'-dimethylamino)propyl methanesulfonate hydrochloride
Conditions | Yield |
---|---|
In dichloromethane for 6h; Ambient temperature; | 100% |
In dichloromethane at 20℃; for 24h; | 97% |
In dichloromethane at 20℃; for 24h; | 97% |
3-Dimethylamino-1-propanol
2,4-dichlorobenzoyl chloride
2,4-Dichloro-benzoic acid 3-dimethylamino-propyl ester; hydrochloride
Conditions | Yield |
---|---|
In benzene for 0.5h; | 100% |
1-fluoro-9-methylphenazine
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 100℃; for 2h; | 100% |
hexakis[μ-(2-propanolato)]hexakis(2-propanolato)tetraaluminum
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
In benzene to Al(OPri)3 added Me2NCH2CH2CH2OH (molar ratio 1:3), followed by benzene, contens shaken and refluxed for 6 h; benzene-isopropanol azeotrope removed at 80°C, excess solvent removed under reduced pressure (4 mm); elem. anal.; | 100% |
3-Dimethylamino-1-propanol
2,6-dichloropyrazine
3-(6-chloropyrazin-2-yloxy)-N,N-diethylpropan-1-amine
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 20℃; | 100% |
3-Dimethylamino-1-propanol
2,6-dichloropyrazine
3-(6-chloropyrazin-2-yl)oxy-N,N-dimethylpropan-1-amine
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran at 20℃; | 100% |
Stage #1: 3-Dimethylamino-1-propanol With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.333333h; Inert atmosphere; Stage #2: 2,6-dichloropyrazine In N,N-dimethyl-formamide at 20℃; Inert atmosphere; | 79% |
Stage #1: 3-Dimethylamino-1-propanol With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h; Stage #2: 2,6-dichloropyrazine In tetrahydrofuran at 50℃; for 0.166667h; Microwave irradiation; | 77% |
Stage #1: 3-Dimethylamino-1-propanol With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Microwave irradiation; Stage #2: 2,6-dichloropyrazine In tetrahydrofuran for 0.166667h; Microwave irradiation; |
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 0 - 20℃; for 1h; | 99% |
bromethyl methyl ether
3-Dimethylamino-1-propanol
(3-Hydroxy-propyl)-methoxymethyl-dimethyl-ammonium; bromide
Conditions | Yield |
---|---|
In diethyl ether temperature not higher than 5 deg C; | 98% |
Conditions | Yield |
---|---|
With sulfuryl dichloride In chloroform at 0℃; for 5h; Reflux; | 98% |
With thionyl chloride In chloroform Reflux; Cooling with ice; | |
With thionyl chloride In dichloromethane at 0 - 60℃; for 2h; |
2-Amino-4,6-dichloropyrimidine
3-Dimethylamino-1-propanol
4-chloro-6-(3-(dimethylamino)propoxy)pyrimidin-2-amine
Conditions | Yield |
---|---|
With sodium hydride for 0.166667h; Microwave irradiation; | 98% |
Conditions | Yield |
---|---|
Stage #1: bis(trichloromethyl) carbonate; (5R,7Z,24Z,27R)-5,27-dihexyl-2,2,3,3,29,29,30,30-octamethyl-4,28-dioxa-3,29-disilahentriaconta-7,24-dien-16-ol With pyridine In toluene at 20℃; for 2h; Stage #2: 3-Dimethylamino-1-propanol In toluene at 20℃; for 3h; | 98% |
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 2h; Inert atmosphere; Schlenk technique; | 98% |
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 2h; Inert atmosphere; Schlenk technique; | 98% |
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 2h; Inert atmosphere; Schlenk technique; | 98% |
1,3-dihydro-1-hydroxy-6-hydroxymethyl-2,1-benzoxaborole
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
Stage #1: 1,3-dihydro-1-hydroxy-6-hydroxymethyl-2,1-benzoxaborole With sodium sulfate In diethyl ether; acetone Stage #2: 3-Dimethylamino-1-propanol at 20℃; for 5.5h; | 98% |
With sodium sulfate In diethyl ether; acetone at 20℃; for 5.5h; | 98% |
Conditions | Yield |
---|---|
Stage #1: 3H-benzo[c][1,2]oxaborol-1-ol With sodium sulfate In diethyl ether; acetone Stage #2: 3-Dimethylamino-1-propanol at 20℃; for 5.5h; | 98% |
With sodium sulfate In diethyl ether; acetone at 20℃; for 5.5h; | 98% |
3-Dimethylamino-1-propanol
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 75℃; for 1.5h; Inert atmosphere; | 98% |
3-Dimethylamino-1-propanol
p-toluenesulfonyl chloride
p-toluenesulfonic acid 3-dimethylamino-n-propyl ester
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20 - 50℃; for 6h; | 97% |
With triethylamine In dichloromethane at 0 - 20℃; for 1h; | 40% |
3-Dimethylamino-1-propanol
methacrylic acid methyl ester
3-(N,N-dimethylamino)propyl methacrylate
Conditions | Yield |
---|---|
With 4-methoxy-phenol; potassium dihydrogenphosphate at 95℃; under 225.023 Torr; for 6h; | 97% |
With tetrabutoxytitanium; 10H-phenothiazine | |
With di(n-butyl)tin oxide | |
With potassium phosphate; 4-methoxy-phenol at 95℃; under 225.023 Torr; Large scale; | 1517 g |
3-Dimethylamino-1-propanol
diethylzinc
[Ethylzink-(3-dimethylaminopropanolat)]3
Conditions | Yield |
---|---|
In hexane 3-dimethylaminopropanol slowly added dropwise under stirring at 0°C to diethylzinc in hexane; heated slowly to room temp.; stirred for 5 h; left at -5°C; filtrated; dried in vacuum; elem. anal.; | 97% |
3-Dimethylamino-1-propanol
4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid
4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminopropyl ester
Conditions | Yield |
---|---|
Stage #1: 4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 40℃; Inert atmosphere; Stage #2: 3-Dimethylamino-1-propanol With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 40℃; Inert atmosphere; | 97% |
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 2h; Inert atmosphere; Schlenk technique; | 97% |
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 2h; Inert atmosphere; Schlenk technique; | 97% |
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 2h; Inert atmosphere; Schlenk technique; | 97% |
3-Dimethylamino-1-propanol
5-Bromo-2-chloropyrimidine
3-((5-bromopyrimidin-2-yl)oxy)-N,N-dimethylpropan-1-amine
Conditions | Yield |
---|---|
Stage #1: 3-Dimethylamino-1-propanol With sodium hydride In tetrahydrofuran; mineral oil at 0 - 25℃; for 1h; Inert atmosphere; Stage #2: 5-Bromo-2-chloropyrimidine In tetrahydrofuran; mineral oil at 0 - 25℃; for 1.5h; Inert atmosphere; | 96% |
Stage #1: 3-Dimethylamino-1-propanol With sodium hydride In tetrahydrofuran at 20℃; for 0.25h; Stage #2: 5-Bromo-2-chloropyrimidine In tetrahydrofuran at 20℃; for 16h; |
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 2h; Inert atmosphere; Schlenk technique; | 96% |
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 2h; Inert atmosphere; Schlenk technique; | 96% |
3-Dimethylamino-1-propanol
3'H-cyclopropa[1,9][5,6]fullereno-C60-Ih-3'-carboxylic acid N-hydroxysuccinimide ester
Conditions | Yield |
---|---|
In chloroform at 20℃; for 2h; | 96% |
Conditions | Yield |
---|---|
Stage #1: 3-Dimethylamino-1-propanol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: 3-bromo-2-chloro-5-nitropyridine In tetrahydrofuran; mineral oil at 25℃; for 2h; Inert atmosphere; | 96% |
Molecular structure of Dimethylaminopropanol (CAS NO.3179-63-3) is:
Product Name: Dimethylaminopropanol
CAS Registry Number: 3179-63-3
IUPAC Name: 3-(dimethylamino)propan-1-ol
Molecular Weight: 103.16282 [g/mol]
Molecular Formula: C5H13NO
XLogP3-AA: -0.1
H-Bond Donor: 1
H-Bond Acceptor: 2
EINECS: 221-659-2
Melting Point: -35 °C
Refractive index: n20/D 1.436(lit.)
Storage temp.: Flammables area
Water Solubility: miscible
Stability: Stable. Flammable. Incompatible with strong oxidizing agents.
Surface Tension: 31 dyne/cm
Density: 0.89 g/cm3
Flash Point: 36.1 °C
Enthalpy of Vaporization: 46.58 kJ/mol
Boiling Point: 163.5 °C at 760 mmHg
Vapour Pressure: 0.7 mmHg at 25°C
Product Categories: Amino Alcohols;Organic Building Blocks;Oxygen Compounds
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | oral | 1650mg/kg (1650mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Toksikologicheskii Vestnik. Vol. (2), Pg. 34, 1996. |
rat | LD50 | oral | 2130mg/kg (2130mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Toksikologicheskii Vestnik. Vol. (2), Pg. 34, 1996. |
Safty information about Dimethylaminopropanol (CAS NO.3179-63-3) is:
Hazard Codes: Xi, C
Risk Statements: 10-41-34-22
R10:Flammable.
R41:Risk of serious damage to the eyes.
R34:Causes burns.
R22:Harmful if swallowed.
Safety Statements: 26-39-45-36/37/39-16
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39:Wear eye / face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S16:Keep away from sources of ignition.
RIDADR: UN 1987 3/PG 3
WGK Germany: 1
RTECS: UB3155000
F: 34
HazardClass: 8
PackingGroup: II
HS Code: 29221980
Dimethylaminopropanol , its cas register number is 3179-63-3. It also can be called 1-Dimethylamino-3-propanol ; 3-(Dimethlyamino)propanol ; 3-(Dimethylamino)-1-propanol ; 3-(N,N-Dimethylamino)-1-propanol ; N,N-Dimethyl-3-hydroxypropylamine ; N,N-Dimethyl-gamma-aminopropanol ; N,N-Dimethylpropanolamine ; 1-Propanol, 3-(dimethylamino)- .It is a colourless to yellow liquid.
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