4-Chlorobenzoic acid supplier

Name
4-Chlorobenzoic acid
EINECS 200-805-9
CAS No. 74-11-3
Article Data989
CAS DataBase
Density 1.374 g/cm³
Solubility soluble in hot water
Melting Point 238-241 °C
Formula C₇H₅ClO₂
Boiling Point 287.2 °C at 760 mmHg
Molecular Weight 156.569
Flash Point 127.5 °C
Transport Information
Appearance white to off-white crystalline flakes
Safety 26-36-37/39
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms Benzoicacid, p-chloro- (7CI,8CI);4-CBA;Mycosid;NSC 143358;NSC 32738;NSC 8444;p-Carboxychlorobenzene;p-Chlorbenzoic acid;p-Chlorobenzoic acid;
PSA 37.30000
LogP 2.03820

Synthetic route

: 104-88-1
4-chlorobenzaldehyde

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With sodium perborate In acetic acid for 1.5h; steam bath;	100%
With hydrogen bromide; oxygen In acetonitrile at 20℃; for 5h; UV-irradiation;	100%
With C4H11FeMo6NO24(3-)*3C16H36N(1+); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 8h; Green chemistry;	99%

: 67483-73-2
benzyl p-chlorobenzoate

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With hydrogen In ethyl acetate at 60℃; for 24h; Reagent/catalyst;	100%
With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 20℃; for 0.0833333h; chemoselective reaction;	87%
With ammonium cerium(IV) nitrate In water; acetonitrile for 6h; Mechanism; Heating; other esters react in the same way;	65%

: 15784-28-8
allyl 4-chlorobenzoate

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With formic acid; triethylamine In acetonitrile at 80℃; for 1h; Inert atmosphere;	100%
With toluene-4-sulfonic acid for 0.0666667h; microwave irradiation;	86%
With iodine; dimethyl sulfoxide for 0.2h; Heating;	76%
With ammonium cerium(IV) nitrate In water; acetonitrile for 6h; Mechanism; Heating; other esters react in the same way;	74%

: 873-76-7
para-Chlorobenzyl alcohol

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With bromine; oxygen In acetonitrile for 10h; Irradiation;	100%
With periodic acid; tripropylammonium fluorochromate (VI) In acetonitrile at 0℃;	99%
With silica-supported Jones reagent In dichloromethane for 0.035h;	99.4%

: 790-41-0
4-chlorobenzoic anhydride

A: 873-76-7
para-Chlorobenzyl alcohol

B: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate In tetrahydrofuran for 1h; Ambient temperature;	A 94% B 100%

: 79606-45-4
4-chloro-N,N-diisopropylbenzamide

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With hydrogenchloride; zinc(II) chloride at 160℃; for 72h;	100%

: 106-43-4
para-chlorotoluene

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With Oxone; potassium bromide In dichloromethane; water at 20℃; for 24h; visible light irradiation;	99%
With ruthenium trichloride; sodium hypochlorite; tetrabutylammomium bromide In 1,2-dichloro-ethane at 25℃; for 2h;	98%
With ruthenium trichloride; sodium hypochlorite; tetrabutylammomium bromide In 1,2-dichloro-ethane at 25℃; for 2h; Rate constant; Mechanism; pH 9: other methylbenzenes; var. concentration of aq. NaOCl, ruthenium and tetrabutylammonium bromide;	98%

: 1126-46-1
Methyl 4-chlorobenzoate

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With iodine; aluminium In acetonitrile at 80℃; for 18h;	99%
With potassium hydroxide In toluene at 150℃; for 0.166667h; microwave irradiation;	94%
With sodium hydroxide In N,N-dimethyl-formamide for 0.5h; Ambient temperature;	93%

: 637-87-6
1-Chloro-4-iodobenzene

: 201230-82-2
carbon monoxide

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With amphiphilic resin-supported phosphine-palladium; water; potassium carbonate at 25℃; under 760 Torr; for 12h; hydroxycarbonylation;	99%
With dichloro bis(acetonitrile) palladium(II); potassium hydroxide; sodium dodecyl-sulfate In water; butan-1-ol at 70℃; under 760 Torr; for 4h;	94%
With potassium carbonate; palladium diacetate In water; N,N-dimethyl-formamide at 25℃; under 760 Torr; for 2h;	92%

cobalt (II) acetate·4 H2O: cobalt (II) acetate·4 H2O

: 106-43-4
para-chlorotoluene

: 143435-52-3
1N,3N,5N-trihydroxy-1,3,5-triazin-2,4,6[1H,3H,5H]-trione

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With acetic acid	99%

...Expand

: 27032-10-6
4-chlorobenzyl azide

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; vanadia In water at 100℃; for 6h;	99%

: 3395-72-0
1-chloro-4-{[(phenylmethyl)oxy]methyl}benzene

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With Oxone; potassium bromide In acetonitrile at 0 - 30℃; for 24.5h; Green chemistry;	99%

: 1875-88-3
2-(4-Chlorophenyl)ethanol

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With oxygen; sodium t-butanolate In tetrahydrofuran at 20℃; under 750.075 Torr; for 17h; chemoselective reaction;	99%

: 106-39-8
bromochlorobenzene

: 201230-82-2
carbon monoxide

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With tetrabutylammomium bromide; dicobalt octacarbonyl In sodium hydroxide; benzene at 65℃; for 1h; Irradiation;	98%
With sodium hydroxide; tetrabutylammomium bromide; dicobalt octacarbonyl In water; benzene at 65℃; under 760 Torr; for 1h; Irradiation;	98%

: 7335-27-5
ethyl 4-chlorobenzoate

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
Stage #1: ethyl 4-chlorobenzoate With iron(III) chloride In tetrachloromethane at 85℃; for 24h; Inert atmosphere; Stage #2: With hydrogenchloride; water In tetrachloromethane Inert atmosphere;	98%
With potassium hydroxide In methanol at 35℃; for 0.333333h;	89%
With ammonium cerium(IV) nitrate In water; acetonitrile for 6h; Mechanism; Heating; other esters react in the same way;	58%
Stage #1: ethyl 4-chlorobenzoate With sodium hydroxide In water at 20℃; Stage #2: With hydrogenchloride In water
With water; lithium hydroxide In tetrahydrofuran at 25℃; for 6h; Reagent/catalyst; Solvent;	92 %Chromat.

: 98554-12-2
p-chlorobenzoylmethanesulfonic acid

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With water; sodium hydroxide for 5h; Heating;	98%

: 99-91-2
para-chloroacetophenone

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With 1,10-Phenanthroline; oxygen; copper diacetate; potassium hydroxide In dimethyl sulfoxide at 130℃; under 3000.3 Torr; for 12h; Autoclave;	97%
Stage #1: para-chloroacetophenone With tert.-butylhydroperoxide; sodium hydroxide; tungsten(VI) oxide In water at 80℃; for 8h; Stage #2: With hydrogenchloride In water	94%
With copper(II) nitrate trihydrate; oxygen In acetonitrile at 120℃; under 4500.45 Torr; for 10h; Autoclave;	93%

: 150-13-0
4-amino-benzoic acid

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With t-butyl thionitrite; copper dichloride In acetonitrile at 25℃; for 0.0333333h;	97%
Stage #1: 4-amino-benzoic acid With tert.-butylnitrite In acetonitrile at 20℃; Sandmeyer Reaction; Flow reactor; Stage #2: With copper dichloride In ethylene glycol; acetonitrile at 82℃; Sandmeyer Reaction; Flow reactor;	50%
With hydrogenchloride; potassium nitrite; dimethyl sulfoxide; copper(l) chloride In water at 35℃; for 0.5h;	77 % Chromat.

: 4-chloro-benzoic acid 3-methyl-but-2-enyl ester

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With Montmorillonite K-10 clay; toluene for 0.333333h; Dealkylation; Microwave irradiation;	97%
With toluene-4-sulfonic acid for 0.0666667h; microwave irradiation;	84%

: 67483-73-2
benzyl p-chlorobenzoate

: 108-88-3
toluene

A: 620-47-3
1-methyl-3-(phenylmethyl)-benzene

B: 620-83-7
1-methyl-4-(phenylmethyl)benzene

C: 713-36-0
2-benzyltoluene

D: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate; water at 80℃; for 2h; regioselective reaction;	A n/a B n/a C n/a D 97%

...Expand

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With sodium hydroxide In water; tert-butyl alcohol at 70℃; Ni-anode, 16 mA/cm2;	96%

: 622-95-7
4-chlorobenzyl bromide

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With Oxone In water; acetonitrile for 9h; Reflux;	96%
With sodium periodate; sulfuric acid In water at 95℃; for 12h;	79%
With tert.-butylhydroperoxide In water at 80℃; for 12h; Green chemistry;
Multi-step reaction with 2 steps 1: silver(I) nitrite / diethyl ether / 5 h / 0 °C / Reflux 2: tetra-(n-butyl)ammonium iodide; zinc diacetate; water / 24 h / 80 °C View Scheme

: 106-43-4
para-chlorotoluene

A N-acetoxy-1,8-naphthalenedicarboximide: N-acetoxy-1,8-naphthalenedicarboximide

B: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With acetic acid In titanium	A n/a B 96%

: 3391-10-4
1-(p-chlorophenyl)ethyl alcohol

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With sodium nitrate; water; oxygen In dimethyl sulfoxide at 130℃; for 24h;	96%
With 1,10-Phenanthroline; oxygen; copper diacetate; potassium hydroxide In dimethyl sulfoxide at 130℃; under 3000.3 Torr; for 12h; Autoclave;	93%
With iron(III) chloride; cerium(III) chloride; tetrabutyl-ammonium chloride; oxygen In acetonitrile at 20℃; under 760.051 Torr; for 24h; Schlenk technique; Irradiation;	90%

: 106-43-4
para-chlorotoluene

A: 104-88-1
4-chlorobenzaldehyde

B: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With hydrogenchloride; oxygen; 9-(2-mesityl)-10-methylacridinium perchlorate In acetonitrile at 4.84℃; for 12h; Irradiation;	A 5% B 95%
With N-hydroxyphthalimide; oxygen; cobalt(II) acetate In acetic acid at 25℃; under 760 Torr; for 20h;	A 3% B 67%
With sulfuric acid bei der elektrolytischen Oxydation;

: 106-46-7
para-dichlorobenzene

: 124-38-9
carbon dioxide

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With magnesium In tetrahydrofuran for 0.5h; Heating;	95%
With Al-anode In N,N-dimethyl-formamide at 20℃; electrocarboxylation;	78%
With tetrabutylammonium tetrafluoroborate In N,N-dimethyl-formamide at 20℃; under 760.051 Torr; for 4h; Electrolysis;	66%
Stage #1: para-dichlorobenzene With bis(cyclopentadienyl)titanium dichloride; butyl magnesium bromide In tetrahydrofuran at 40℃; for 6h; Inert atmosphere; Schlenk technique; Stage #2: carbon dioxide In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; Schlenk technique;	44%

: 104-88-1
4-chlorobenzaldehyde

A: 873-76-7
para-Chlorobenzyl alcohol

B: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
Stage #1: 4-chlorobenzaldehyde With potassium hydroxide for 0.0833333h; Cannizzaro Reaction; Milling; Inert atmosphere; Sealed tube; Green chemistry; Stage #2: With hydrogenchloride In water Green chemistry;	A 95% B 95%
With sodium hydroxide In water at 20℃; for 3.5h; Cannizzaro Reaction;	A n/a B 89%
With TEA; magnesium bromide In dichloromethane at 20℃; for 48h; Cannizzaro reaction;	A 88% B n/a

: cinnamyl 4-chlorobenzoate

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With Montmorillonite K-10 clay; methoxybenzene for 0.333333h; Dealkylation; Microwave irradiation;	95%
With methoxybenzene In toluene for 15h; Heating;	5%

: 29540-84-9
4-chlorophenyl trifluoromethanesulfonate

molybdenum hexacarbonyl: molybdenum hexacarbonyl

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate at 150℃; for 0.333333h; microwave irradiation;	95%

: C16H25ClO2Si

: 74-11-3
para-chlorobenzoic acid

Conditions

Conditions	Yield
With water; N,N-dimethyl-formamide at 70℃; for 1h; Green chemistry; chemoselective reaction;	95%

: 67-56-1
methanol

: 74-11-3
para-chlorobenzoic acid

: 1126-46-1
Methyl 4-chlorobenzoate

Conditions

Conditions	Yield
With sulfuric acid for 4h; Reflux;	100%
With sulfuric acid Fischer-Speier esterification method; Reflux;	100%
With di(methoxycarbonyl)methylene tri-n-butylphosphorane In toluene at 70℃; for 24h;	98%

: 74-11-3
para-chlorobenzoic acid

: 122-01-0
4-chloro-benzoyl chloride

Conditions

Conditions	Yield
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃;	100%
With thionyl chloride for 2h; Reflux;	100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h; Reflux;	100%

: 74-11-3
para-chlorobenzoic acid

: 873-76-7
para-Chlorobenzyl alcohol

Conditions

Conditions	Yield
With C25H42N6Rh(1+)*CF3O3S(1-); phenylsilane In tetrahydrofuran at 30℃; for 20h; Inert atmosphere;	100%
With samarium diiodide; benzaldehyde; samarium(III) trifluoromethanesulfonate In tetrahydrofuran; methanol; water at 20℃; for 0.0166667h; Reduction;	99%
With samarium diiodide; phosphoric acid In tetrahydrofuran for 0.000833333h; Ambient temperature;	94%

: 100-51-6
benzyl alcohol

: 74-11-3
para-chlorobenzoic acid

: 67483-73-2
benzyl p-chlorobenzoate

Conditions

Conditions	Yield
With N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride In acetonitrile for 1.5h; Heating;	100%
Stage #1: para-chlorobenzoic acid With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine In neat (no solvent) at 20℃; for 0.0166667h; Stage #2: benzyl alcohol In neat (no solvent) at 20℃; for 0.216667h;	90%
Stage #1: para-chlorobenzoic acid With N-chlorobenzotriazole; triphenylphosphine In dichloromethane for 0.25h; Cooling; Stage #2: benzyl alcohol With triethylamine In dichloromethane at 20℃; for 0.583333h;	85%
With 2-butyl-1,3-diphenyl-1,3,2-diazaphospholidine; 1,1'-azodicarbonyl-dipiperidine In 1,2-dichloro-ethane at 40℃; under 760.051 Torr; Mitsunobu Displacement;	85%

: 74-11-3
para-chlorobenzoic acid

: 65-85-0
benzoic acid

Conditions

Conditions	Yield
Stage #1: para-chlorobenzoic acid With palladium/alumina; hydrogen; potassium carbonate In water at 60℃; Stage #2: With hydrogenchloride In water	100%
With hydrogen; triethylamine; palladium on activated charcoal In methanol at 20℃; for 6h;	99%
With ammonium formate In water; isopropyl alcohol at 20℃; for 3h;	99%

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 74-11-3
para-chlorobenzoic acid

: 71320-77-9
moclobemide

Conditions

Conditions	Yield
With tetramethylorthosilicate In toluene at 110℃; for 1h; Inert atmosphere;	100%
With zirconocene dichloride In toluene at 110℃; for 24h; Inert atmosphere; sealed tube;	86%
With [((CH3)5Cp)2Zr(H2O)2OSO2C8F17]+[OSO2C8F17]-*THF In tetrahydrofuran at 100℃; for 12h; Catalytic behavior; Reagent/catalyst; Temperature;	85%

: 111-70-6
n-heptan1ol

: 74-11-3
para-chlorobenzoic acid

: 97222-05-4
heptyl 4-chlorobenzoate

Conditions

Conditions	Yield
With Candida antarctica lipase B immobilised in a macroporous DVB crosslinked polymer (Novozym 435) In cyclohexane at 80℃; for 24h; Enzymatic reaction;	100%

: 106-96-7
propargyl bromide

: 74-11-3
para-chlorobenzoic acid

: 79318-18-6
prop-2-yn-1-yl 4-chlorobenzoate

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene for 5h;	100%

: 64-17-5
ethanol

: 74-11-3
para-chlorobenzoic acid

: 7335-27-5
ethyl 4-chlorobenzoate

Conditions

Conditions	Yield
With sulfuric acid for 0.666667h; Reflux;	99.7%
With sulfuric acid for 5h; Reflux;	93.4%
With sulfuric acid for 3h; Heating;	87%

: 84471-16-9
4-(diazomethyl)-7-methoxycoumarin

: 74-11-3
para-chlorobenzoic acid

: 76196-61-7
4-Chloro-benzoic acid 7-methoxy-2-oxo-2H-chromen-4-ylmethyl ester

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 1h;	99.7%

: 62-53-3
aniline

: 74-11-3
para-chlorobenzoic acid

: 6833-15-4
4-chlorobenzanilide

Conditions

Conditions	Yield
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 5h;	99%
With nano sulfated-TiO2 at 115℃; under 760.051 Torr; for 4h; Neat (no solvent);	98%
With triethylamine; Phenyl N-phenylphosphoramidochloridate In dichloromethane for 0.333333h; Ambient temperature;	93%

: 74-11-3
para-chlorobenzoic acid

: 790-41-0
4-chlorobenzoic anhydride

Conditions

Conditions	Yield
With iodine; triethylamine; triphenylphosphine In dichloromethane at 0 - 20℃;	99%
With N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; tributyl-amine In acetonitrile at 20℃; for 0.5h;	97%
With thionyl chloride In dichloromethane at 22 - 25℃; for 1h;	96.9%

: 100-46-9
benzylamine

: 74-11-3
para-chlorobenzoic acid

: 7461-34-9
N-benzyl-p-chlorobenzamide

Conditions

Conditions	Yield
With Bromotrichloromethane; 4-(diphenylphosphino)-benzyltrimethylammonium bromide; triethylamine In tetrahydrofuran at 60℃; for 6h; Inert atmosphere;	99%
With borane-ammonia complex In 5,5-dimethyl-1,3-cyclohexadiene for 6h; Reflux;	99%
With nickel ferrite nanoparticle In neat (no solvent) for 0.166667h; Irradiation; Sealed tube;	92%

: 188290-36-0
thiophene

: 74-11-3
para-chlorobenzoic acid

: 4153-45-1
2-(4-chlorobenzoyl)thiophene

Conditions

Conditions	Yield
With pyridin-2-yl trifluoromethanesulfonate; trifluoroacetic acid for 4h; Heating;	99%
With phosphoric acid; trifluoroacetic anhydride In water at 20℃; for 2h;	87%

: 100-39-0
benzyl bromide

: 74-11-3
para-chlorobenzoic acid

: 67483-73-2
benzyl p-chlorobenzoate

Conditions

Conditions	Yield
With N(Et)4(1+)*(2-pyrrolidone-anion) In N,N-dimethyl-formamide for 1h; Ambient temperature;	99%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 74-11-3
para-chlorobenzoic acid

: 122334-37-6
4-chloro-N-methoxy-N-methylbenzamide

Conditions

Conditions	Yield
With 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In methanol at 20℃; for 0.5h;	99%
Stage #1: para-chlorobenzoic acid With 1,1'-carbonyldiimidazole In dichloromethane at 0℃; for 0.5h; Stage #2: N,O-dimethylhydroxylamine*hydrochloride With triethylamine In dichloromethane at 0 - 20℃;	99%
Stage #1: para-chlorobenzoic acid With triethylamine; trichloromethyl chloroformate In dichloromethane at 0℃; Stage #2: N,O-dimethylhydroxylamine*hydrochloride In dichloromethane at 25℃; for 1h;	96%

: 1117-97-1
N,0-dimethylhydroxylamine

: 74-11-3
para-chlorobenzoic acid

: 122334-37-6
4-chloro-N-methoxy-N-methylbenzamide

Conditions

Conditions	Yield
Stage #1: N,0-dimethylhydroxylamine; para-chlorobenzoic acid In toluene at 0℃; for 0.166667h; Stage #2: With phosphorus trichloride In toluene at 20 - 60℃; for 0.5h;	99%
With 1,1'-carbonyldiimidazole
With triethylamine; 1,1'-carbonyldiimidazole

: 159000-71-2
Boc-Apns-Dmt-NHtBu

: 74-11-3
para-chlorobenzoic acid

: (1S,2S)-2-[(tert-butoxycarbonyl)amino]-1-({(4R)-4-[(tert-butylamino)carbonyl]-5,5-dimethyl-1,3-thiazolan-3-yl}carbonyl)-3-phenylpropyl 4-chlorobenzoate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃;	99%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;

: 143-33-9
sodium cyanide

: 74-11-3
para-chlorobenzoic acid

: 619-65-8
4-cyanobenzoic Acid

Conditions

Conditions	Yield
With nickel dibromide In 1-methyl-pyrrolidin-2-one at 200℃; under 10343 Torr; for 0.166667h; microwave irradiation;	99%

: 74-11-3
para-chlorobenzoic acid

: 98-80-6
phenylboronic acid

: 92-92-2
biphenyl-4-carboxylic acid

Conditions

Conditions	Yield
With potassium hydroxide In water at 80℃; for 2h; Suzuki Coupling; Green chemistry;	99%
With glucosamine-based dicyclohexylarylphosphine; sodium carbonate; palladium diacetate In ethanol; water; toluene at 80℃; Suzuki-Miyaura cross coupling reaction;	97%
With sodium hydroxide; polyaniline-supported palladium In water at 80℃; for 4h; Suzuki coupling;	97%

: 25487-66-5
3-Carboxyphenylboronic acid

: 74-11-3
para-chlorobenzoic acid

: 92152-01-7
biphenyl-3,4′-dicarboxylic acid

Conditions

Conditions	Yield
With sodium 2'‐(dicyclohexylphosphaneyl)‐2,6‐diisopropyl‐[1,1'‐biphenyl]‐3‐sulfonate; palladium diacetate; potassium carbonate In water at 50℃; for 8h; Suzuki-Miyaura coupling;	99%

4-Chlorobenzoic acid Chemical Properties

IUPAC Name: 4-Chlorobenzoic acid
Synonyms of 4-Chlorobenzoic acid (CAS NO.74-11-3): 4-Chlorobenzoic acid ; Acido p-clorobenzoico ; Benzoic acid, 4-chloro- ; Benzoic acid, p-chloro- ; Chlorodracylic acid ; p-Carboxychlorobenzene ; p-Chlorbenzoic acid ; p-Chlorobenzoic acid ; para-Chlorobenzoic acid
CAS NO: 74-11-3
Molecular Formula: C₇H₅ClO₂
Molecular Weight: 156.57
Molecular Structure:
EINECS : 200-805-9
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 1
Polar Surface Area: 26.3 Å²
Index of Refraction: 1.583
Molar Refractivity: 38.07 cm³
Molar Volume: 113.9 cm³
Surface Tension: 51.5 dyne/cm
Density: 1.374 g/cm³
Flash Point: 127.5 °C
Enthalpy of Vaporization: 55.6 kJ/mol
Boiling Point: 287.2 °C at 760 mmHg
Vapour Pressure: 0.00117 mmHg at 25°C
Melting Point: 238-241 °C(lit.)
Water Solubility: soluble in hot water
Stability: Stable. Combustible. Incompatible with bases, strong oxidizing agents.
Appearance: Triclinic crystals or light fluffy white powder.
Product Categories: Benzoic acid;Organic acids;Absolute Configuration Determination (Exciton Chirality CD Method);Analytical Chemistry;Enantiomer Excess & Absolute Configuration Determination;Exciton Chirality CD Method (for Hydroxyl Groups);Alpha sort;C;CAlphabetic;CH;Pesticides&Metabolites;C7;Carbonyl Compounds;Carboxylic Acids

4-Chlorobenzoic acid Uses

4-Chlorobenzoic acid (CAS NO.74-11-3) is used as dyes, pesticides, medicine intermediates.

4-Chlorobenzoic acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	oral	1170mg/kg (1170mg/kg)	Journal of Agricultural and Food Chemistry. Vol. 23, Pg. 724, 1975.
rat	LD50	intraperitoneal	1gm/kg (1000mg/kg)	Bollettino Chimico Farmaceutico. Vol. 112, Pg. 53, 1973.
rat	LD50	oral	1170mg/kg (1170mg/kg)	Journal of Agricultural and Food Chemistry. Vol. 21, Pg. 794, 1973.

4-Chlorobenzoic acid Consensus Reports

Reported in EPA TSCA Inventory.

4-Chlorobenzoic acid Safety Profile

The Hazard Codes: Xn
Risk Statements: 22-36/37/38
R22: 4-Chlorobenzoic acid (CAS NO.74-11-3) is harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36: Wear suitable protective clothing
S37/39: Wear suitable gloves and eye/face protection
WGK Germany: 2
RTECS: DG4976010
HS Code: 29163900

Product Name

4-Chlorobenzoic acid

Synthetic route

4-Chlorobenzoic acid Chemical Properties

4-Chlorobenzoic acid Uses

4-Chlorobenzoic acid Toxicity Data With Reference

4-Chlorobenzoic acid Consensus Reports

4-Chlorobenzoic acid Safety Profile

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