4-Chlorophenol supplier | CasNO.106-48-9

Name
4-Chlorophenol
EINECS 203-402-6
CAS No. 106-48-9
Article Data660
CAS DataBase
Density 1.287 g/cm³
Solubility 2.7 g/100 mL (20 ºC) in water
Melting Point 40-45 ºC
Formula C₆H₅ClO
Boiling Point 220 ºC at 760 mmHg
Molecular Weight 128.558
Flash Point 80.1 ºC
Transport Information UN 2020 6.1/PG 3
Appearance off-white to light tan crystals or powder
Safety 28-61-28A-24/25-60
Risk Codes 20/21/22-51/53-50
Molecular Structure
Hazard Symbols Xn,N
Synonyms Phenol,p-chloro- (8CI);4-Hydroxychlorobenzene;Applied 3-78;Phenol,4-chloro-;p-Chlorophenic acid;p-Chlorophenol;
PSA 20.23000
LogP 2.04560

Synthetic route

: 623-12-1
4-chloromethoxybenzene

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With sodium; diphenyldisulfane In 1-methyl-pyrrolidin-2-one for 0.5h; Heating;	100%
With calcium hydride; diphenyldisulfane In 1-methyl-pyrrolidin-2-one at 220℃; for 0.5h;	99%
With copper(I) oxide; sodium methylate In methanol at 185℃; for 12h; Autoclave;	96%

: 109-72-8, 29786-93-4
n-butyllithium

: 73040-88-7
(4-Chlorophenoxy)dimethylsulfoxonium Tetrafluoroborate

A: 51241-35-1
n-butyl 4-chlorophenyl ether

B: [(18)O]dimethyl sulfone

C: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With 18O-labeled water In 1,2-dimethoxyethane at -11 - 25℃; Product distribution; Mechanism;	A 5% B 100% C 79%

...Expand

: 945-51-7
1,1'-sulfinylbisbenzene

A: 95-57-8
2-monochlorophenol

B: 139-66-2
diphenyl sulfide

C: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With hydrogenchloride; phenol In dichloromethane at 0 - 25℃;	A n/a B 100% C n/a

...Expand

: 951-92-8
1-methoxyl-4-(phenylsulfinyl)benzene

A: 95-57-8
2-monochlorophenol

B: 5633-57-8
1-methoxy-4-(phenylsulfanyl)benzene

C: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With hydrogenchloride; phenol In dichloromethane at 0 - 25℃;	A n/a B 100% C n/a

...Expand

: ammonium thiocyanate

: 117971-97-8
4-chlorophenyl 1-chloroethylcarbonate

A: 117972-05-1
4-chlorophenyl 1-thiocyanoethylcarbonate

B: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
In formamide at 50℃; for 20h;	A 100% B n/a

...Expand

: 126644-72-2
1-<(tert-butyldimethylsilyl)oxy>-4-chlorobenzene

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 20℃; for 0.3h;	99%
With sodium phosphate dodecahydrate In N,N-dimethyl-formamide at 20℃; for 0.3h;	98%
With hafnium tetrakis(trifluoromethanesulfonate) In methanol at 20℃; for 8h;	96%
With P(MeNCH2CH2)3N In dimethyl sulfoxide at 80℃; for 24h; desilylation;	94%

: 1679-18-1
4-Chlorophenylboronic acid

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With 2,5-dimethylfuran; zinc(II) phthalocyanine; oxygen In tetrahydrofuran at 25℃; under 760.051 Torr; for 1.5h; Irradiation; Sealed tube; Schlenk technique;	99%
With water In tetrahydrofuran at 100℃; for 12h;	99%
With dihydrogen peroxide In acetonitrile at 30 - 35℃; for 0.0833333h; Schlenk technique;	98%

: 17005-59-3
4-chlorophenoxytrimethylsilane

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In methanol at 20℃; for 0.0333333h;	99%
With nano magnetic sulfated zirconia (Fe3O4 at ZrO2/SO42-) In neat (no solvent) at 20℃; for 0.75h; Green chemistry;	91%
With K5 In acetonitrile at 20℃; for 1.25h;	5 % Chromat.
With (NH4)8[CeW10O36]*20H2O In acetonitrile at 20℃; for 0.5h;	55 %Chromat.

: 126644-72-2
1-<(tert-butyldimethylsilyl)oxy>-4-chlorobenzene

Cs2CO3: Cs2CO3

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
In water; N,N-dimethyl-formamide at 20℃; for 1h;	99%

: 637-87-6
1-Chloro-4-iodobenzene

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With glycolic Acid; copper hydroxide; sodium hydroxide In water; dimethyl sulfoxide at 120℃; for 6h; Inert atmosphere; Schlenk technique;	99%
Stage #1: 1-Chloro-4-iodobenzene With copper(l) iodide; cesiumhydroxide monohydrate; 1,3-diphenylpropanedione In water; dimethyl sulfoxide at 130℃; for 36h; Inert atmosphere; Stage #2: With hydrogenchloride In dichloromethane; water; dimethyl sulfoxide at 20℃; Inert atmosphere; chemoselective reaction;	95%
With copper(l) iodide; potassium hydroxide In water at 100℃; Inert atmosphere;	94%

: potassium (4-chlorophenyl)trifluoroborate

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With Oxone; water In acetone at 20℃; for 0.0333333h;	99%
With rose bengal; triethylamine In ethanol at 25℃; for 12h; Schlenk technique; Irradiation;	60%

: 1892-43-9
2-(4-chlorophenoxy)ethanol

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 100℃; for 3h; Schlenk technique;	99%

: 95-14-7
1,2,3-Benzotriazole

: 50798-82-8
p-chlorophenyl 2-benzoxazolyl ether

A: 106-48-9
4-chloro-phenol

B: 25124-80-5
1-(2-benzoxazolyl)-1H-benzotriazole

Conditions

Conditions	Yield
With hydridotetakis(triphenylphosphine)rhodium(I); o-phenylenebis(diphenylphosphine) In chlorobenzene for 5h; Inert atmosphere; Reflux;	A 95% B 99%

...Expand

: 876-27-7
4-chlorophenyl acetate

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
silica gel; toluene-4-sulfonic acid In water; benzene at 80℃; for 40h;	98%
With sodium tetrahydroborate; cobalt(II) chloride In ethanol at 0 - 25℃; for 10h;	97%
With sodium hydrogencarbonate In water at 20℃; for 4h;	97%

: 13997-70-1
1-allyloxy-4-chlorobenzene

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With chloro-trimethyl-silane; sodium iodide In acetonitrile for 0.0333333h;	98%
With iodine at 20℃; Reagent/catalyst;	96%
With sodium tetrahydroborate; nickel(II) chloride hexahydrate In methanol at 0℃;	90%

: 1329689-03-3
4-chloro-N-[2,2-dichloro-1-(4-chlorophenoxy)-2-phenylethyl]benzenesulfonamide

A: 106-48-9
4-chloro-phenol

B: 360564-14-3
4-chloro-N-(2,2-dichloro-1-hydroxy-2-phenylethyl)benzenesulfonamide

Conditions

Conditions	Yield
With water	A n/a B 98%

: 1679-18-1
4-Chlorophenylboronic acid

: 7722-84-1
dihydrogen peroxide

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With ammonium bicarbonate In water at 20℃; for 2h; Schlenk technique;	98%

: 1768-32-7
sulfur bis(trifluoromethyl)amide chloride

: 108-95-2
phenol

A: 1913-85-5
sulfur bis{bis(trifluoromethyl)amide}

B: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 24h;	A 95% B 97%

...Expand

: 20443-90-7
4-chlorophenyl tetrahydro-2H-pyran-2-yl ether

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With methanol at 20℃; for 0.5h;	97%
With aluminium(III) iodide; N,N-dimethyl-formamide dimethyl acetal In acetonitrile at 80℃; for 18h;	96%
With aluminium(III) iodide; N,N-dimethyl-formamide dimethyl acetal In acetonitrile at 80℃;	96%

: 108-95-2
phenol

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With N-chloro-succinimide; 2C5HN10(3-)2Mn(2+)Cu(2+)*5H2O In acetonitrile at 90℃; for 6h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; regioselective reaction;	95%
With chloro(dimethyl)sulfonium chloride In dichloromethane at -25℃; for 4h;	84%
Stage #1: phenol In acetonitrile at 80℃; for 0.166667h; Stage #2: With N-chloro-succinimide In acetonitrile at 80℃; for 8h; regioselective reaction;	77%

: 1774-35-2
di(p-tolyl) sulfoxide

A: 620-94-0
di-(p-tolyl)sulfane

B: 95-57-8
2-monochlorophenol

C: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With hydrogenchloride; phenol In dichloromethane at 0 - 25℃;	A 95% B n/a C n/a

...Expand

: 3272-95-5
Z-L-Phe p-chlorophenyl ester

: 598-41-4
H-Gly-NH2

A: 17187-05-2
Z-L-phenylalanylglycinamide

B: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With thiolsubtilisin In water; N,N-dimethyl-formamide Ambient temperature; pH 8.0 phosphate buffer containing PhB(OH)2 traces;	A 95% B n/a
With thiolsubtilisin In water; N,N-dimethyl-formamide Ambient temperature; further acyl donors and acyl acceptors; method for enzymic peptid segment coupling;	A 95% B n/a

...Expand

: 2005-08-5
4-chlorophenyl benzoate

: 137-07-5
2-amino-benzenethiol

A: 883-93-2
2-Phenylbenzothiazole

B: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With 1-methyl-pyrrolidin-2-one; potassium carbonate at 100℃; for 0.75h; Hydrolysis; cyclization; debenzoylation;	A n/a B 95%

...Expand

: 1679-18-1
4-Chlorophenylboronic acid

: acetonitrile complex of hypofluorous acid

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
In dichloromethane at 20℃;	95%

: 1679-18-1
4-Chlorophenylboronic acid

: 80937-33-3
oxygen

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With triethanolamine In water at 20℃; for 18h; Sonication; Irradiation; Green chemistry;	95%
With methylene blue; N-ethyl-N,N-diisopropylamine In water; acetonitrile at 20℃; for 7h; Schlenk technique; Irradiation;

: 89488-25-5
(5‐chloro‐2‐hydroxyphenyl)boronic acid

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
In dimethyl sulfoxide at 120℃; for 18h;	95%

: 18673-04-6
3-(4-chlorophenoxy)-1-propanol

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 100℃; for 3h; Schlenk technique;	95%

: 1-chloro-4-((2-methoxyethoxy)methoxy)benzene

: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With aluminium(III) iodide; N,N-dimethyl-formamide dimethyl acetal In acetonitrile at 80℃; for 18h;	94%
With aluminium(III) iodide; N,N-dimethyl-formamide dimethyl acetal In acetonitrile at 80℃; for 18h;	94%

: 3085-42-5
bis(4-chlorophenyl)sulfoxide

A: 5181-10-2
bis(4-chlorophenyl)sulfide

B: 95-57-8
2-monochlorophenol

C: 106-48-9
4-chloro-phenol

Conditions

Conditions	Yield
With hydrogenchloride; phenol In dichloromethane at 0 - 25℃;	A 93% B n/a C n/a

...Expand

: 108-24-7
acetic anhydride

: 106-48-9
4-chloro-phenol

: 876-27-7
4-chlorophenyl acetate

Conditions

Conditions	Yield
K5 In acetonitrile at 20℃; for 0.25h;	100%
With magnesium(II) perchlorate at 80℃; for 0.25h;	100%
With sodium hydroxide for 0.0125h; microwave irradiation;	99%

: 106-48-9
4-chloro-phenol

: 350-46-9
4-Fluoronitrobenzene

: 1836-74-4
4-(4-chlorophenoxy)nitrobenzene

Conditions

Conditions	Yield
With cesium fluoride/clinoptilolite In dimethyl sulfoxide at 110℃; for 0.15h; Ullmann Condensation;	100%
With potassium fluoride supported on Clinoptilolite In dimethyl sulfoxide at 110 - 115℃; for 1.66667h;	95%
With potassium carbonate In dimethyl sulfoxide at 70℃;	92%

: 106-48-9
4-chloro-phenol

: 88-87-9
4-chloro-2,6-dinitrophenol

Conditions

Conditions	Yield
With dinitrogen tetraoxide; ferric nitrate In ethyl acetate for 0.0833333h; Heating;	100%
With chromium(III) nitrate; dinitrogen tetraoxide In ethyl acetate for 0.166667h; Nitration; reflux;	98%
With Tetraethylene glycol; silica gel; dinitrogen tetraoxide In ethyl acetate for 0.833333h; Heating;	98%

: 106-48-9
4-chloro-phenol

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 17005-59-3
4-chlorophenoxytrimethylsilane

Conditions

Conditions	Yield
With aluminum potassium sulfate dodecahydrate In acetonitrile at 20℃; for 0.333333h;	100%
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione at 20℃; for 0.25h;	98%
With melamine-N2,N4,N6-trisulfonic acid at 20℃; for 0.166667h; neat (no solvent); chemoselective reaction;	98%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 106-48-9
4-chloro-phenol

: 126644-72-2
1-<(tert-butyldimethylsilyl)oxy>-4-chlorobenzene

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;	100%
With dmap; triethylamine In [D3]acetonitrile at 25℃; for 0.2h;	99%
With triethylamine at 20℃; for 0.166667h; Inert atmosphere;	95%

: 75-09-2
dichloromethane

: 106-48-9
4-chloro-phenol

: 555-89-5
bis(p-chlorophenoxy)methane

Conditions

Conditions	Yield
With potassium hydroxide; benzyltrimethylammonium chloride In water at 40℃; for 72h;	100%
With potassium hydroxide; benzyltrimethylammonium chloride In dichloromethane at 40℃; for 72h;	100%
Stage #1: 4-chloro-phenol With sodium hydride In 1-methyl-pyrrolidin-2-one Stage #2: dichloromethane In 1-methyl-pyrrolidin-2-one at 40℃; for 9h;	98%
With 1-methyl-pyrrolidin-2-one; sodium hydride at 40℃; for 9h;	98%
With sodium hydroxide; Amberlite IRA-400 (Cl-) 2.) reflux, 15 h; Yield given. Multistep reaction;

: 56512-49-3
dabsyl chloride

: 106-48-9
4-chloro-phenol

: 146303-65-3
4-(4-Dimethylamino-phenylazo)-benzenesulfonic acid 4-chloro-phenyl ester

Conditions

Conditions	Yield
With carbonate-bicarbonate In acetone; acetonitrile for 0.25h; Product distribution; other (mono-, di- and trihydric) phenols; effect of reaction time, pH, molar ratio, concentration;	100%
With carbonate-bicarbonate buffer In acetone; acetonitrile 1.) 15 min, 2.) reflux;	100%
With carbonate-bicarbonate buffer In acetone for 0.5h; Heating;

: 106-48-9
4-chloro-phenol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 30342-25-7
(4-Chloro-phenoxy)-dimethyl-silane

Conditions

Conditions	Yield
	100%
at 20 - 160℃; for 2h; Inert atmosphere;

: 106-48-9
4-chloro-phenol

: 108-95-2
phenol

Conditions

Conditions	Yield
With hydrogen; sodium hydroxide In water under 760.051 Torr; for 0.833333h; Kinetics; Reagent/catalyst; Solvent; Green chemistry;	100%
With hydrogen; sodium hydroxide In water at 20℃; for 2h; Kinetics; Catalytic behavior; Solvent; Reagent/catalyst;	99.1%
With hydrogen; sodium hydroxide In water at 25℃; under 760.051 Torr; for 2h; Reagent/catalyst; Solvent;	99.9%

: 401-99-0
3,5-dinitrobenzotrifluoride

: 106-48-9
4-chloro-phenol

: 1-(4-chlorophenoxy)-3-nitro-5-trifluoromethylbenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 98℃; for 3h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 3h; Activation energy; Inert atmosphere;	54%
With potassium carbonate In N,N-dimethyl-formamide

: 1194-02-1
4-fluorobenzonitrile

: 106-48-9
4-chloro-phenol

: 74448-92-3
4-(4'-chlorophenoxy)benzonitrile

Conditions

Conditions	Yield
With sodium carbonate In N,N-dimethyl-formamide for 24h; Reflux;	100%
With potassium carbonate In N,N-dimethyl-formamide Reflux;	96%
With sodium carbonate In N,N-dimethyl-formamide for 24h; Reflux;	95%

: 335148-89-5
bisphenol AF bisoxalyl chloride adduct

: 106-48-9
4-chloro-phenol

: bisphenol-AF bis(4-chlorophenyl oxalate)

Conditions

Conditions	Yield
In dichloromethane at -20℃; Heating / reflux;	100%

: {Ni(Al(O-i-Pr)4)2}

: 106-48-9
4-chloro-phenol

: {Ni(Al(O-i-Pr)(p-ClC6H4O)3)2}

Conditions

Conditions	Yield
In benzene byproducts: isopropanol; anhyd. conditions; Ni(Al(OC3H7)4)2 : p-chlorophenol = 1 : 6; refluxed (4 h); solvent removed (reduced pressure);	100%

: {Co(Al(O-i-Pr)4)2}

: 106-48-9
4-chloro-phenol

: {Co(Al(O-i-Pr)2(p-ClC6H4O)2)2}

Conditions

Conditions	Yield
In benzene byproducts: isopropanol; anhyd. conditions; Co(Al(OC3H7)4)2 : p-chlorophenol = 1 : 4; refluxed (2 h); solvent removed (reduced pressure); elem.anal.;	100%

: 40400-13-3
2-Iodobenzyl bromide

: 106-48-9
4-chloro-phenol

: 1332326-20-1
4-(2-iodobenzyloxy)-1-chlorobenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone at 50℃;	100%

: 106-48-9
4-chloro-phenol

: 1523-15-5
2,4-dinitrophenyl benzoate

A: 2005-08-5
4-chlorophenyl benzoate

B: 14314-69-3
potassium 2,4-dinitrophenolate

Conditions

Conditions	Yield
With potassium hydrogencarbonate In N,N-dimethyl-formamide at 25℃; for 5h;	A 100% B n/a

...Expand

: 858124-04-6
ethyl 3-(chloromethyl)-4-methoxybenzoate

: 106-48-9
4-chloro-phenol

: 1360060-15-6
ethyl 3-[(4-chlorophenoxy)methyl]-4-methoxybenzoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 13h;	100%

: 54795-27-6
5-methyl-3,4-hexadien-1-ol

: 106-48-9
4-chloro-phenol

: 1376520-79-4
1-chloro-4-(5-methylhexa-3,4-dienyloxy)benzene

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	100%

: 106-48-9
4-chloro-phenol

: 13360-57-1
dimethylamino sulfonyl chloride

: 1135-05-3
4-chlorophenyl N,N-dimethylsulfamate

Conditions

Conditions	Yield
Stage #1: 4-chloro-phenol With sodium hydride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃; for 0.166667h; Stage #2: dimethylamino sulfonyl chloride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃; for 16h;	100%
Stage #1: 4-chloro-phenol With sodium hydride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃; for 10h; Stage #2: dimethylamino sulfonyl chloride In 1,2-dimethoxyethane; mineral oil at 0 - 20℃;	83%

: 73686-46-1
2-methylbenzoic acid 2-pyridinyl ester

: 106-48-9
4-chloro-phenol

: 500285-59-6
2-methyl-benzoic acid-(4-chloro-phenyl ester)

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane at 60℃; for 48h; Green chemistry;	100%

: 4858-85-9
2,3-dichloropyrazine

: 106-48-9
4-chloro-phenol

: C9H5Cl2N3O

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 15h;	100%

: 4858-85-9
2,3-dichloropyrazine

: 106-48-9
4-chloro-phenol

: 2-chloro-3-(4-chlorophenoxy)pyrazine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 15h;	100%

: 350-30-1
3-chloro-4-fluoronitrobenzene

: 106-48-9
4-chloro-phenol

: 22544-07-6
4-(4'-chlorophenoxy)-3-chloronitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 17h;	100%
With caesium carbonate In dimethyl sulfoxide for 4h;

: C16H11I

: 106-48-9
4-chloro-phenol

: C22H15ClO

Conditions

Conditions	Yield
Stage #1: 4-chloro-phenol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.0833333h; Stage #2: C16H11I In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 12h;	100%

: 353-49-1
fluoroformyl chloride

: 106-48-9
4-chloro-phenol

: 1644-73-1
4-chlorophenyl fluoroformate

Conditions

Conditions	Yield
With triethylamine In toluene at 60℃;	99.8%

4-Chlorophenol Consensus Reports

Reported in EPA TSCA Inventory. Chlorophenol compounds are on the Community Right-To-Know List.

4-Chlorophenol Specification

The 4-Chlorophenol, with the CAS registry number 106-48-9,is also known as 4-Hydroxychlorobenzene. It belongs to the product categories of Analytical Reagents;Analytical/Chromatography. This chemical's molecular formula is C₆H₅ClO and molecular weight is 128.56. Its EINECS number is 200-349-0.What's more,Its systematic name is 4-Chlorophenol.It is a off-white powder which is stable, but readily decomposed by moderately strong alkaline solutions. Corrodes iron and zinc and attacks some types of polymer. Incompatible with strong oxidizing agents.It is White crystals with a strong phenol odor Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible. Used as an intermediate in organic synthesis of dyes and drugs.

Physical properties about 4-Chlorophenol are:
(1)ACD/LogP: 2.426; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.43; (4)ACD/LogD (pH 7.4): 2.42; (5)ACD/BCF (pH 5.5): 41.07; (6)ACD/BCF (pH 7.4): 40.7; (7)ACD/KOC (pH 5.5): 497.25; (8)ACD/KOC (pH 7.4): 493.09; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.575; (13)Molar Refractivity: 33.029 cm3; (14)Molar Volume: 99.814 cm3; (15)Surface Tension: 44.7470016479492 dyne/cm; (16)Density: 1.288 g/cm3; (17)Flash Point: 80.113 °C; (18)Enthalpy of Vaporization: 47.5 kJ/mol ; (19)Boiling Point: 219.999 °C at 760 mmHg; (20)Vapour Pressure: 0.0780000016093254 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:Oc1ccc(Cl)cc1;
(2)Std. InChI:InChI=1S/C6H5ClO/c7-5-1-3-6(8)4-2-5/h1-4,8H;
(3)Std. InChIKey:WXNZTHHGJRFXKQ-UHFFFAOYSA-N.

Safety Information of 4-Chlorophenol:
The 4-Chlorophenol is harmful by inhalation, in contact with skin and if swallowed and toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.And it is very toxic to aquatic organisms.So it should avoid release to the environment. Refer to special instructions / safety data sheets. After contact with skin, wash immediately with plenty of soap-suds. When you use it , you should avoid contact with skin and eyes. This material and its container must be disposed of as hazardous waste.

The toxicity data of 4-Chlorophenol as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TCLo	inhalation	10gm/m3/8H (10000mg/m3)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: IRRITABILITY	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 29(10), Pg. 37, 1964.
mammal (species unspecified)	LD50	oral	500mg/kg (500mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
mammal (species unspecified)	LD50	skin	1gm/kg (1000mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(10), Pg. 16, 1980.
mouse	LCLo	inhalation	3200mg/m3/2H (3200mg/m3)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: OTHER CHANGES	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 57(7-8), Pg. 9, 1992.
mouse	LD50	intraperitoneal	332mg/kg (332mg/kg)		Journal of Medicinal Chemistry. Vol. 18, Pg. 868, 1975.
mouse	LD50	oral	367mg/kg (367mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: COMA	Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny. Journal of Experimental and Clinical Medicine. Vol. 25, Pg. 339, 1985.
mouse	LD50	unreported	605mg/kg (605mg/kg)	AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 54(1), Pg. 68, 1989.
rat	LC50	inhalation	11mg/m3 (11mg/m3)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 29(10), Pg. 37, 1964.
rat	LD50	intraperitoneal	281mg/kg (281mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	British Journal of Pharmacology and Chemotherapy. Vol. 13, Pg. 20, 1958.
rat	LD50	oral	670mg/kg (670mg/kg)		Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 2, Pg. 76, 1943.
rat	LD50	skin	1500mg/kg (1500mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 29(10), Pg. 37, 1964.
rat	LD50	subcutaneous	1030mg/kg (1030mg/kg)		Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 2, Pg. 76, 1943.
rat	LD50	unreported	625mg/kg (625mg/kg)	AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 54(1), Pg. 68, 1989.

Product Name

4-Chlorophenol

Synthetic route

4-Chlorophenol Consensus Reports

4-Chlorophenol Specification

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