4-Hydroxybenzyl alcohol supplier

Name
4-Hydroxybenzyl alcohol
EINECS 210-768-0
CAS No. 623-05-2
Article Data249
CAS DataBase
Density 1.22 g/cm³
Solubility Soluble in water (6.7 mg/ml at 20°C), dioxane (100 mg/ml), 1N NaOH (50 mg/ml), DMSO, and methanol.
Melting Point 110-112 °C
Formula C₇H₈O₂
Boiling Point 252 °C at 760 mmHg
Molecular Weight 124.139
Flash Point 145.8 °C
Transport Information
Appearance Pink to beige crystalline powder
Safety 26-24/25-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Benzylalcohol, p-hydroxy- (8CI);(4-Hydroxyphenyl)methanol;4-(Hydroxymethyl)phenol;4-Hydroxybenzenemethanol;4-Methylolphenol;Gastrodigenin;NSC 227926;p-(Hydroxymethyl)phenol;p-Hydroxybenzyl alcohol;p-Methoxytoluol;p-Methylolphenol;a-Hydroxy-p-cresol;
PSA 40.46000
LogP 0.88450

Synthetic route

: 123-08-0
4-hydroxy-benzaldehyde

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With N-methylpyrrolidine zinc borohydride In tetrahydrofuran at 20℃; for 4h;	100%
With sodium tetrahydroborate In methanol at 0℃;	100%
With triethylamine; 2-hydroxyethanethiol In acetonitrile for 23h; Irradiation;	100%

: C28H28BO8(1-)*Na(1+)

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With water	100%

: 3256-45-9
4-allyloxybenzyl alcohol

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With aniline; (ϖ-allyl)palladium triflate based catalyst at 30℃; for 0.333333h;	99%
With ammonium formate; palladium on activated charcoal In methanol for 0.5h; Heating;	96%

: 99-96-7
4-hydroxy-benzoic acid

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With sodium tetrahydroborate; Trimethyl borate; dimethyl sulfate In tetrahydrofuran at 20℃; for 4.5h; Product distribution; Further Variations:; Reagents; reagent ratios;	96%
With [Zn(BH4)2(py)] In tetrahydrofuran for 3.6h; Heating;	92%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 6h; Inert atmosphere;	86%

: 99-76-3
methyl 4-hydroxylbenzoate

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With zirconium(IV) borohydride In tetrahydrofuran at 25℃; for 2h; Reduction;	96%
With zinc(II) tetrahydroborate; cyclohexene In tetrahydrofuran for 4h; Heating;	72%
With lithium aluminium tetrahydride In diethyl ether
With sodium tetrahydroborate In methanol; 1,2-dimethoxyethane for 1h; Reduction; Heating;

: 117635-46-8
1-(tert-butyldimethylsilyloxy)-4-((tert-butyldimethylsilyloxy)methyl)benzene

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With methanol; trimethylsilyl bromide at 20℃; for 5h; chemoselective reaction;	96%
With methanesulfonic acid In methanol at 20℃; for 1.33333h;	94%
sulfated SnO2 In methanol at 20℃; for 16h;
With trifluoroacetic acid In methanol at 25℃; for 0.333333h; Reagent/catalyst;

: 59016-93-2
p-hydroxymethylphenylboronic acid

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With urea hydrogen peroxide adduct In acetonitrile at 27 - 29℃; for 0.5h; Green chemistry; chemoselective reaction;	95%
With 1-carboxymethyl-3-methylimidazolium tetrachloroferrate; dihydrogen peroxide In neat (no solvent) at 20℃; for 0.133333h;	91%
With 1,3-dimethyl-5-ethyl-4a-hydroperoxyalloxazine; oxygen; hydrazine hydrate In methanol; 2,2,2-trifluoroethanol at 20℃; under 760.051 Torr; for 2h;	74%

: 228106-33-0
4-trityloxymethyl-phenol

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With sodium hydrogen sulfate; silica gel In methanol; dichloromethane at 20℃; for 2h;	93%

: 166544-95-2
4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenol

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
ruthenium trichloride In water; acetonitrile at 20℃; for 0.416667h;	92%
With lithium borohydride In methanol at 20℃; for 0.5h;	90%
With sulfuric acid; silica gel In methanol at 20℃; for 2.16667h;	83%

: 18401-58-6
4-(trimethylsilyloxymethyl)phenoxytrimethylsilane

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With 1-butyl-3-methylimidazolium chloride at 20℃; for 12h;	92%

: 2937-64-6
4-(acetyloxy)benzyl acetate

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With aluminum oxide In neat (no solvent) at 35℃; for 0.0166667h; microwave irradiation;	89%

: 117635-46-8
1-(tert-butyldimethylsilyloxy)-4-((tert-butyldimethylsilyloxy)methyl)benzene

Cs2CO3: Cs2CO3

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
In water; N,N-dimethyl-formamide at 100℃; for 3h;	88%

: 1338215-45-4
[4-(2-trimethylsilanylethoxy)phenyl]methanol

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
Stage #1: [4-(2-trimethylsilanylethoxy)phenyl]methanol With cesium fluoride In N,N-dimethyl-formamide at 60℃; for 1h; Inert atmosphere; Stage #2: With water In N,N-dimethyl-formamide Inert atmosphere;	88%

: 302348-51-2
(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With sodium L-ascorbate; fluorescein free acid In aq. phosphate buffer for 0.5h; pH=7.4; Reagent/catalyst; Irradiation;	88%

: 1140923-99-4
(E)-6-(4-hydroxybenzyloxy)hex-3-en-2-one

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
Stage #1: (E)-6-(4-hydroxybenzyloxy)hex-3-en-2-one With sodium hydride In N,N-dimethyl-formamide at 22℃; for 1h; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide	87%

: 18282-51-4
4-iodo-benzyl alcohol

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With copper(l) iodide; triethanolamine; tetrabutylammomium bromide; water; potassium hydroxide at 120℃; for 24h; Inert atmosphere;	86%
With copper(l) iodide; triethanolamine; tetrabutylammomium bromide; potassium hydroxide In water at 120℃; for 24h; Inert atmosphere; Sealed tube; Green chemistry;	86%
With oxygen; triethylamine In acetonitrile at 32℃; for 24h; Schlenk technique; UV-irradiation;	53%

: 115255-87-3
4-trimethylsilyloxymethylphenol

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With water In dichloromethane at 20℃; for 0.916667h;	85%
With Kaolinitic clay; water for 0.025h; Irradiation; microwave;	82%

: 18401-58-6
4-(trimethylsilyloxymethyl)phenoxytrimethylsilane

A: 623-05-2
(4-hydroxyphenyl)methanol

B: 115255-86-2
(4-Trimethylsilanyloxy-phenyl)-methanol

Conditions

Conditions	Yield
With Dowex CCR-2 In ethanol for 10h; Ambient temperature;	A 19% B 82%
With Dowex CCR-2 resin In ethanol for 10h; Product distribution; Ambient temperature; competitive desilylation with other TMS ethers, investigation;	A 19% B 82%

: 330970-69-9
(S)-1-((S)-2-tert-Butoxycarbonylamino-propionyl)-pyrrolidine-2-carboxylic acid 4-phenylacetoxy-benzyl ester

A: 623-05-2
(4-hydroxyphenyl)methanol

B: 33300-72-0
N-tert-butoxycarbonyl-L-alanyl-L-proline

Conditions

Conditions	Yield
With penicillin G acylase In methanol; phosphate buffer pH=7; Enzymatic reaction;	A n/a B 82%

: 330970-68-8
(S)-2-((2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-phenyl-propionic acid 4-phenylacetoxy-benzyl ester

A: 623-05-2
(4-hydroxyphenyl)methanol

B: Boc-Thr-Phe-OH

Conditions

Conditions	Yield
With penicillin G acylase In methanol; phosphate buffer pH=7; Enzymatic reaction;	A n/a B 82%

: 50-00-0
formaldehyd

: 108-95-2
phenol

A: 623-05-2
(4-hydroxyphenyl)methanol

B: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With sodium metaborate tetrahydrate In water at 60℃; Green chemistry; regioselective reaction;	A 10% B 80%
With sodium hydroxide In water at 30℃; for 1h; Product distribution; other reagents, reagent concentrations, time and solvents;
With sodium hydroxide; HP-β-cyclodextrin In water at 4℃; for 240h; Product distribution; further additives;

...Expand

: 330970-66-6
(S)-2-((S)-2-Allyloxycarbonylamino-3-methyl-butyrylamino)-propionic acid 4-phenylacetoxy-benzyl ester

A: 623-05-2
(4-hydroxyphenyl)methanol

B: (S)-2-((S)-2-(((allyloxy)carbonyl)amino)-3-methylbutanamido)propanoic acid

Conditions

Conditions	Yield
With penicillin G acylase In methanol; phosphate buffer pH=7; Enzymatic reaction;	A n/a B 80%

: 330970-67-7
(2S,3S)-2-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionylamino)-3-methyl-pentanoic acid 4-phenylacetoxy-benzyl ester

A: 623-05-2
(4-hydroxyphenyl)methanol

B: 145435-25-2
N-Boc-L-Ser-Ile-OH

Conditions

Conditions	Yield
With penicillin G acylase In methanol; phosphate buffer pH=7; Enzymatic reaction;	A n/a B 80%

: 105-13-5
4-Methoxybenzyl alcohol

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With 1-N-ferrocenylmethyl benzimidazole tagged polymer In N,N-dimethyl-formamide Reflux;	79%
With 1-butylpyridinium bromide for 0.05h; microwave irradiation;	78%
With [2Fe-2S] ferredoxin HaPux; CYP199A4 from the rhodopseudomonas palustrisstrain HaA2 (S244D); flavin-dependent ferredoxin reductase HaPuR; oxygen; NADH In aq. buffer pH=7.4; Catalytic behavior; Reagent/catalyst; regioselective reaction;

: 52-90-4
L-Cysteine

: ferrocene carbamate phenyl acrylate

A: 1273-82-1
aminoferrocene

B: 623-05-2
(4-hydroxyphenyl)methanol

C: 108051-20-3
3-carboxy-5-oxoperhydro-1,4-thiazepine

Conditions

Conditions	Yield
With 2-amino-4-mercaptobutyric acid; GLUTATHIONE Electrochemical reaction;	A n/a B n/a C 79%

...Expand

: 59016-93-2
p-hydroxymethylphenylboronic acid

: 80937-33-3
oxygen

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With triethanolamine In water at 20℃; for 18h; Sonication; Irradiation; Green chemistry;	78%

: 72909-34-3
pyrroloquinoline quinone

: 556-02-5, 556-03-6, 34537-57-0, 55520-40-6, 96946-98-4, 60-18-4
›Tyr

A: 623-05-2
(4-hydroxyphenyl)methanol

B: 132847-84-8
C15H7N3O7

Conditions

Conditions	Yield
With air; cetyltrimethylammonim bromide at 30℃;	A n/a B 77%

...Expand

: 249284-23-9
4-tert-butyl-butyldimethylsilyloxybenzyl alcohol THP ether

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With iodine In methanol for 2h; desilylation; Heating;	75%

: 120-47-8
Ethyl 4-hydroxybenzoate

: 623-05-2
(4-hydroxyphenyl)methanol

Conditions

Conditions	Yield
With zinc(II) tetrahydroborate In tetrahydrofuran for 4h; Inert atmosphere; Reflux;	70%
With ethanol; potassium tert-butylate; C39H41FeMnN2O5P(1+)*Br(1-) In tert-butyl alcohol at 100℃; for 22h; Inert atmosphere; Schlenk technique; enantioselective reaction;	10%
With lithium aluminium tetrahydride; diethyl ether

: 50-00-0
formaldehyd

: 108-95-2
phenol

A: 254-27-3
4H-1,3,2-benzodioxin

B: 623-05-2
(4-hydroxyphenyl)methanol

C: 90-01-7
salicylic alcohol

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid at 65℃; for 20h;	A 3% B 68% C 7%

...Expand

: 108-05-4
vinyl acetate

: 623-05-2
(4-hydroxyphenyl)methanol

: 80767-12-0
4-hydroxybenzyl acetate

Conditions

Conditions	Yield
With Candida cylindracea lipase In hexane for 4h;	100%
novozyme 435 In acetonitrile at 20℃; for 6h; Enzymatic reaction;	99%
iodine at 20℃; for 2h;	95%
With porcine pancreatic lipase (PPL, Type II) In tetrahydrofuran at 42 - 45℃; for 48h; Acetylation;	80%
With Pseudomonas cepacia PS lipase In di-isopropyl ether at 25℃; for 0.5h;

: 623-05-2
(4-hydroxyphenyl)methanol

: 123-08-0
4-hydroxy-benzaldehyde

Conditions

Conditions	Yield
With Oxone In ethanol at 20℃; for 2h; Catalytic behavior;	100%
With tert.-butylhydroperoxide; V/SiO2 In decane; tert-butyl alcohol at 25℃; for 3h;	99.1%
With titanium(IV) oxide; oxygen at 29.84℃; under 760.051 Torr; for 6h; Sealed tube; Irradiation;	99%

: 623-05-2
(4-hydroxyphenyl)methanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 126070-20-0
4-((tert-butyldimethylsilyloxy)methyl)phenol

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 0.75h;	100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 1.5h; Cooling with ice;	95%
With sodium hydride In N,N-dimethyl-formamide	95.6%

: 79-46-9
2-nitropropane

: 623-05-2
(4-hydroxyphenyl)methanol

: 16066-97-0
1-nitro-1,1-dimethyl-2-(4-hydroxyphenyl]ethane

Conditions

Conditions	Yield
With potassium tert-butylate In diethylene glycol dimethyl ether at 20 - 137℃; for 6h;	99.6%
With potassium tert-butylate In diethylene glycol dimethyl ether Cooling with ice; Reflux;	83%
With tetrabutyl ammonium fluoride at 130℃; for 15h;	73%

: 623-05-2
(4-hydroxyphenyl)methanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 117635-46-8
1-(tert-butyldimethylsilyloxy)-4-((tert-butyldimethylsilyloxy)methyl)benzene

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 50℃; for 4h;	99%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 12h; Inert atmosphere;	99%
With 1H-imidazole In N,N-dimethyl-formamide Ambient temperature;	97%

: 2-phenylquinolin-4-yl-methylchloride hydrochloride

: 623-05-2
(4-hydroxyphenyl)methanol

: 926630-07-1
[4-(2-phenyl-quinolin-4-ylmethoxy)-phenyl]-methanol

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 20h;	99%

: 623-05-2
(4-hydroxyphenyl)methanol

: 2-chloro[1,3]thiazolo[4,5-b]pyridine hydrochloride

: 1190927-40-2
[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]methanol

Conditions

Conditions	Yield
Stage #1: 2-chloro[1,3]thiazolo[4,5-b]pyridine hydrochloride With potassium carbonate In acetonitrile at 50℃; for 3h; Inert atmosphere; Stage #2: (4-hydroxyphenyl)methanol In acetonitrile for 3h; Reflux;	99%

: 623-05-2
(4-hydroxyphenyl)methanol

: 100-51-6
benzyl alcohol

A: 100-52-7
benzaldehyde

B: 123-08-0
4-hydroxy-benzaldehyde

Conditions

Conditions	Yield
With air; potassium carbonate at 20℃; for 12h;	A 99% B 11%

...Expand

: 623-05-2
(4-hydroxyphenyl)methanol

A: 106-44-5
p-cresol

B: C6H10O

Conditions

Conditions	Yield
With palladium dichloride In methanol at 40℃; for 24h; Inert atmosphere; Green chemistry; chemoselective reaction;	A 99% B 99%

: 623-05-2
(4-hydroxyphenyl)methanol

: 64-19-7
acetic acid

: 80767-12-0
4-hydroxybenzyl acetate

Conditions

Conditions	Yield
With 50wtpercent Cs2.5H0.5PW12O40 supported on MCM-41 In acetonitrile at 50℃; for 0.5h;	98%
With potassium fluoride at 80℃; for 7h;	94%
With potassium fluoride at 20℃;	82%
With sulfuric acid
In ethyl acetate at 30℃; for 8h;

: 288-13-1
NH-pyrazole

: 623-05-2
(4-hydroxyphenyl)methanol

: 80200-09-5
4-((1H-pyrazol-1-yl)methyl)phenol

Conditions

Conditions	Yield
In water at 120℃; for 12h; Microwave irradiation; Sealed tube;	98%
at 160℃; for 0.5h;	47%

: 623-05-2
(4-hydroxyphenyl)methanol

: 106-95-6
allyl bromide

: 3256-45-9
4-allyloxybenzyl alcohol

Conditions

Conditions	Yield
With potassium carbonate In acetone Heating;	98%
With potassium carbonate In acetone for 12h; Reflux; Inert atmosphere;	91%
With potassium carbonate; potassium iodide In acetone for 24h; Etherification; Heating;	84%

: 623-05-2
(4-hydroxyphenyl)methanol

: 106-96-7
propargyl bromide

: 34905-02-7
(4-(prop-2-yn-1-yloxy)phenyl)methanol

Conditions

Conditions	Yield
With potassium carbonate In toluene; acetonitrile at 70℃; for 20h; Inert atmosphere;	98%
With potassium carbonate In toluene; acetonitrile at 50℃; for 48h;	95.5%
Stage #1: (4-hydroxyphenyl)methanol With potassium carbonate In acetonitrile at 20℃; for 0.5h; Stage #2: propargyl bromide In toluene; acetonitrile at 50℃; for 40h;	89%

: 623-05-2
(4-hydroxyphenyl)methanol

: 78-95-5
chloroacetone

: 1-(4-(hydroxymethyl)phenoxy)propan-2-one

Conditions

Conditions	Yield
With potassium carbonate In acetone for 20h; Heating / reflux;	98%
With potassium carbonate In acetone Reflux;	98%
With potassium carbonate In acetone Heating;

: 623-05-2
(4-hydroxyphenyl)methanol

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: methyl 4-((4-(hydroxymethyl)phenoxy)methyl)benzoate

Conditions

Conditions	Yield
With potassium carbonate In acetone Heating;	98%

: 623-05-2
(4-hydroxyphenyl)methanol

: 24424-99-5
di-tert-butyl dicarbonate

: 156281-11-7
tert-butyl (4-(hydroxymethyl)phenyl)carbonate

Conditions

Conditions	Yield
With carbon tetrabromide at 65℃; for 0.75h; Neat (no solvent); chemoselective reaction;	98%
With 6,7-dimethoxyisoquinoline In dichloromethane at 20℃; for 10h; Inert atmosphere; chemoselective reaction;	95%
triphenylphosphine at 65℃; for 1h;	85%

: 623-05-2
(4-hydroxyphenyl)methanol

: 1346226-17-2
(R)-dimethyl 2-(3-(chloromethyl)benzamido)pentanedioate

: 1346226-18-3
(R)-dimethyl 2-(3-((4-(hydroxymethyl)phenoxy)methyl)benzamido)pentanedioate

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile at 70℃; for 5h;	98%

: 623-05-2
(4-hydroxyphenyl)methanol

: 99-96-7
4-hydroxy-benzoic acid

Conditions

Conditions	Yield
With oxygen In acetonitrile at 20℃; for 7.5h; Catalytic behavior;	97%
With diethylene glycol dimethyl ether at 70℃; for 0.5h; Sonication;	94%
With tert.-butylhydroperoxide; ammonium cerium (IV) nitrate In water; acetonitrile at 20℃; for 24h; chemoselective reaction;	90%

: 765-69-5
2-Methylcyclopentane-1,3-dione

: 623-05-2
(4-hydroxyphenyl)methanol

: 112621-27-9
2-(4-hydroxybenzyl)-2-methyl-1,3-cyclopentanedione

Conditions

Conditions	Yield
In water at 80℃; for 12h;	97%
With water at 80℃; for 12h; Inert atmosphere;	80%

: 623-05-2
(4-hydroxyphenyl)methanol

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 115255-87-3
4-trimethylsilyloxymethylphenol

Conditions

Conditions	Yield
With silica-coated iron nanoparticles-supported RuIII (OTf)Salophen In dichloromethane at 20℃; for 0.0166667h; Catalytic behavior;	97%
With titanium(IV) dioxide In acetonitrile at 20℃; for 0.0833333h; chemoselective reaction;	95%
With nano Fe3O4 supported CeO2/SO4 2-bifunctional solid acidcatalyst In neat (no solvent) at 25℃; for 0.416667h;	91%
With poly(N-bromobenzene-1,3-disulfonamide) for 0.07h; Irradiation;	90%
With lithium perchlorate for 0.0166667h; Irradiation; microwave;	68%

: 623-05-2
(4-hydroxyphenyl)methanol

: 123-62-6
propionic acid anhydride

: 1092474-60-6
4-propionyloxybenzyl propionate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	97%

: 623-05-2
(4-hydroxyphenyl)methanol

: 767593-49-7
glutamic acid di-tert-butyl ester

: 4-formylphenyloxycarbonyl-glutamic acid di-tertbutyl ester

Conditions

Conditions	Yield
Stage #1: (4-hydroxyphenyl)methanol With phosgene; N-ethyl-N,N-diisopropylamine In dichloromethane; toluene; acetonitrile at 0℃; for 0.5h; Stage #2: glutamic acid di-tert-butyl ester With N-ethyl-N,N-diisopropylamine In dichloromethane; toluene; acetonitrile at 0℃;	97%

: 623-05-2
(4-hydroxyphenyl)methanol

: 6396-08-3, 139618-18-1
triphenylphosphine hydrogen iodide

: (4-hydroxybenzyl)triphenylphosphonium iodide

Conditions

Conditions	Yield
In acetonitrile at 90℃; for 12h;	97%

: 623-05-2
(4-hydroxyphenyl)methanol

: 108-24-7
acetic anhydride

: 2937-64-6
4-(acetyloxy)benzyl acetate

Conditions

Conditions	Yield
With nickel dichloride at 20℃; for 0.5h; Neat (no solvent);	96%
With dmap; triethylamine In dichloromethane for 2.5h;	95%
With iron zirconium phosphate In neat (no solvent) at 40℃; for 0.166667h; Green chemistry;	92%

: 623-05-2
(4-hydroxyphenyl)methanol

: 100-39-0
benzyl bromide

: 836-43-1
4-benzyloxybenzyl alcohol

Conditions

Conditions	Yield
With potassium carbonate In acetone for 4h; Heating;	96%
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 6h; Inert atmosphere;	93%
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 6h;	90%

4-Hydroxybenzyl alcohol Specification

The 4-Hydroxybenzyl alcohol, with the CAS registry number 623-05-2, is also known as Benzenemethanol, 4-hydroxy-. It belongs to the product categories of Alcohols; C7 to C8; Linkers; Peptide Synthesis; Aromatics; Benzhydrols, Benzyl & Special Alcohols; Alphabetical Listings; Flavors and Fragrances; G-H; Bifunctional Crosslinkers Oxygen Compounds. Its EINECS registry number is 210-768-0. This chemical's molecular formula is C₇H₈O₂ and molecular weight is 124.14. Its IUPAC name is called 4-(hydroxymethyl)phenol. The product should be sealed and stored in cool and dry place. What's more, it should be protected from strong oxides. It can be used as organic intermediates.

Physical properties of 4-Hydroxybenzyl alcohol: (1)ACD/LogP: 0.30; (2)ACD/LogD (pH 5.5): 0.3; (3)ACD/LogD (pH 7.4): 0.3; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 34.61; (7)ACD/KOC (pH 7.4): 34.45; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 3; (11)Index of Refraction: 1.595; (12)Molar Refractivity: 34.58 cm³; (13)Molar Volume: 101.6 cm³; (14)Surface Tension: 54.1 dyne/cm; (15)Density: 1.22 g/cm³; (16)Flash Point: 145.8 °C; (17)Enthalpy of Vaporization: 51.7 kJ/mol; (18)Boiling Point: 252 °C at 760 mmHg; (19)Vapour Pressure: 0.0104 mmHg at 25°C.

Preparation: this chemical can be prepared by 4-hydroxy-benzaldehyde. This reaction will need reagent Dowex1-x8, NaBH₄ and solvent tetrahydrofuran. The reaction time is 30 min with reaction temperature of 20 °C. The yield is about 92%.

Uses of 4-Hydroxybenzyl alcohol: it can be used to produce 4-Methoxymethyl-phenol at temperature of 80 °C. This reaction will need reagent Yb(OTf)₃ and solvent acetonitrile with reaction time of 5 hours. The yield is about 85%.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1=CC(=CC=C1CO)O
(2)InChI: InChI=1S/C7H8O2/c8-5-6-1-3-7(9)4-2-6/h1-4,8-9H,5H2
(3)InChIKey: BVJSUAQZOZWCKN-UHFFFAOYSA-N

Product Name

4-Hydroxybenzyl alcohol

Synthetic route

4-Hydroxybenzyl alcohol Specification

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