Conditions | Yield |
---|---|
With methyl tributylammonium chloride; sodium hydroxide at 150℃; for 5h; | 99.1% |
With hydrogen bromide Behandeln des Reaktionsprodukts mit Soda; | |
With ferulic acid decarboxylase from Saccharomyces cerevisiae In aq. phosphate buffer; dimethyl sulfoxide at 25℃; pH=7.4; Kinetics; Enzymatic reaction; |
Conditions | Yield |
---|---|
Stage #1: para-bromotoluene With magnesium; lithium chloride In tetrahydrofuran at 0 - 20℃; for 2h; Schlenk technique; Inert atmosphere; Stage #2: vinyl acetate With iron(III) chloride In tetrahydrofuran at 0℃; for 3h; Schlenk technique; Inert atmosphere; | 99% |
Stage #1: para-bromotoluene With magnesium; lithium chloride In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; Stage #2: vinyl acetate With iron(III) chloride; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at 0 - 20℃; for 4h; | 99% |
With [2,2]bipyridinyl; tetrabutylammonium tetrafluoroborate; cobalt(II) bromide In pyridine; acetonitrile at 20℃; Electrolysis; | 53% |
Stage #1: para-bromotoluene With magnesium; lithium chloride In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere; Stage #2: vinyl acetate With iron(III) chloride In tetrahydrofuran at 0℃; for 2h; Inert atmosphere; | 49% |
Conditions | Yield |
---|---|
With sodium dodecylbenzenesulfonate; hydrogen; palladium diacetate In water at 25℃; under 760.051 Torr; for 0.75h; | 99% |
With piperazine; NiO doped titania In methanol at 20℃; for 3h; Inert atmosphere; Sealed tube; UV-irradiation; | 97% |
With hydrogen In ethanol at 100℃; under 4500.45 Torr; for 24h; chemoselective reaction; | 93% |
vinyl methanesulfonate
4-methylphenylboronic acid
1-ethenyl-4-methylbenzene
Conditions | Yield |
---|---|
With sodium tetrachloropalladate(II); cataCXium F sulf; potassium carbonate In water at 100℃; for 16h; Suzuki Miyaura coupling; Inert atmosphere; | 99% |
vinyl 4-methylbenzenesulfonate
4-methylphenylboronic acid
1-ethenyl-4-methylbenzene
Conditions | Yield |
---|---|
With sodium tetrachloropalladate(II); cataCXium F sulf; potassium carbonate In water at 100℃; for 16h; Suzuki Miyaura coupling; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With sodium hydride In mineral oil at 135℃; for 10h; Inert atmosphere; Schlenk technique; | 99% |
Conditions | Yield |
---|---|
With palladium diacetate; N,N′-bis(2,6-diisopropylphenyl)imidazol-2-ylidene hydrochloride; tetrabutyl ammonium fluoride In tetrahydrofuran; 1,4-dioxane at 80℃; for 48h; | 98% |
With Pd/Fe3O4; cesium fluoride In 1,4-dioxane at 100℃; for 24h; Stille Cross Coupling; | 75% |
Conditions | Yield |
---|---|
With 1-butyl-3-methyl-3H-imidazol-1-ium fluoride In acetonitrile at 70℃; Hiyama Coupling; Inert atmosphere; | 98% |
With sodium hydroxide In water at 100℃; for 10h; Hiyama Coupling; | 75% |
4-n-methylphenylacetylene
A
1-ethenyl-4-methylbenzene
B
4-methylethylbenzene
Conditions | Yield |
---|---|
With hydrogen In hexane at 40℃; under 760.051 Torr; for 3h; | A 96% B 4% |
With hydrogen; platinum nanoparticles In methanol at 90℃; under 10343.2 Torr; for 4.5h; Title compound not separated from byproducts.; | A 88 % Spectr. B 12 % Spectr. |
With hydrogen In hexane under 760.051 Torr; chemoselective reaction; |
1-(chloroethynyl)-4-methylbenzene
1-ethenyl-4-methylbenzene
Conditions | Yield |
---|---|
Stage #1: 1-(chloroethynyl)-4-methylbenzene With titanium(IV) isopropylate; isopropylmagnesium bromide In diethyl ether at -50℃; Metallation; Stage #2: With hydrogenchloride; water Hydrolysis; | 95% |
Methyltriphenylphosphonium bromide
4-methyl-benzaldehyde
1-ethenyl-4-methylbenzene
Conditions | Yield |
---|---|
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: 4-methyl-benzaldehyde In tetrahydrofuran at 20℃; Inert atmosphere; | 95% |
With potassium carbonate In 1,4-dioxane for 16h; Reflux; | 92% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene for 16h; Wittig reaction; Heating; | 81% |
Conditions | Yield |
---|---|
With potassium fluoride; Pd (3 wt%)/C In N,N-dimethyl-formamide at 130℃; under 1500.15 Torr; for 3h; Reagent/catalyst; Time; Hiyama Coupling; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
Stage #1: 4-Methylbenzyl alcohol With triethylphosphine hydrobromide at 100℃; for 0.166667h; Microwave irradiation; Stage #2: formaldehyd With potassium carbonate In water at 100℃; for 0.0833333h; Microwave irradiation; | 95% |
Conditions | Yield |
---|---|
With Hoveyda-Grubbs catalyst second generation; di-μ-bromobis-(tritert-butylphosphine)dipalladium(I) In tetrahydrofuran at 60℃; under 7500.75 Torr; for 16h; Autoclave; | 94% |
Conditions | Yield |
---|---|
With C17H36ClN6NiP2(1+)*Cl(1-) In tetrahydrofuran for 6h; Kumada Cross-Coupling; Inert atmosphere; | 94% |
Conditions | Yield |
---|---|
With C17H36ClN6NiP2(1+)*Cl(1-); potassium tert-butylate In toluene at 120℃; for 16h; Suzuki-Miyaura Coupling; Inert atmosphere; | 93% |
With caesium carbonate; triphenylphosphine; palladium dichloride In tetrahydrofuran; water at 85℃; for 7h; Suzuki-Miyaura reaction; | 79% |
Conditions | Yield |
---|---|
Stage #1: vinyl magnesium bromide With indium(III) chloride In tetrahydrofuran; hexane at -78 - 20℃; Stage #2: 4-tolyl iodide With tetrakis(triphenylphosphine) palladium(0); carbon monoxide In tetrahydrofuran; hexane at 60℃; for 1h; | 92% |
Stage #1: vinyl magnesium bromide With indium(III) chloride In tetrahydrofuran at -78 - 20℃; Stage #2: 4-tolyl iodide; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran for 0.5h; Heating; Further stages.; | 89% |
Stage #1: vinyl magnesium bromide With indium(III) chloride In tetrahydrofuran Stage #2: 4-tolyl iodide With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran Heating; | 68% |
1-(1,2-dibromoethyl)-4-methylbenzene
1-ethenyl-4-methylbenzene
Conditions | Yield |
---|---|
With indium; niobium pentachloride In tetrahydrofuran at 20℃; for 0.166667h; Sonication; chemoselective reaction; | 92% |
With 1,1'-bis(trimethylsilyl)-1,1',4,4'-tetrahydro-4,4'-bipyridylidene In acetonitrile at 20℃; for 2h; Inert atmosphere; | 92% |
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; sodium carbonate In dimethyl sulfoxide at 20℃; for 1.5h; Inert atmosphere; Irradiation; | 86% |
2-(4-methylphenyl)oxirane
1-ethenyl-4-methylbenzene
Conditions | Yield |
---|---|
With carbon monoxide In tetrahydrofuran; water at 110℃; under 6840.46 Torr; for 2h; Autoclave; chemoselective reaction; | 90% |
With sodium iodide; tin(ll) chloride In ethanol for 0.0833333h; Reflux; Green chemistry; | 90% |
With hydrogen; triethyl phosphite In isopropyl alcohol at 100℃; under 4500.45 Torr; for 12h; Glovebox; chemoselective reaction; | 89% |
Conditions | Yield |
---|---|
With aluminum (III) chloride; triphenylphosphine In nitromethane at 80℃; for 2h; | 89% |
With potassium pyrosulfate bei der Destillation; | |
at 120℃; for 0.25h; Microwave irradiation; Ionic liquid; |
Conditions | Yield |
---|---|
With bis(η3-allyl-μ-chloropalladium(II)); tris(diethylamino)sulfonium difluorotrimethylsiliconate In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide at 50℃; for 2h; | 89% |
With potassium fluoride; Pd (0.87 wt%)/MgO In N,N-dimethyl-formamide at 130℃; under 1500.15 Torr; for 7h; Time; Reagent/catalyst; Hiyama Coupling; Inert atmosphere; | 78% |
With TEA; palladium diacetate; triphenylphosphine In N,N-dimethyl-formamide at 85℃; for 24h; | 51 % Chromat. |
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran for 0.5h; Heating; | 89% |
4-Methylbenzyl chloride
Chloromethyltrimethylsilane
1-ethenyl-4-methylbenzene
Conditions | Yield |
---|---|
Stage #1: 4-Methylbenzyl chloride With polymer bound α-sulfonyl monocarbanions In tetrahydrofuran; N,N-dimethyl-formamide at 80℃; solid-phase synthesis; Stage #2: Chloromethyltrimethylsilane With Lithium dimsyl In tetrahydrofuran at 20℃; Stage #3: With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; | 89% |
Conditions | Yield |
---|---|
layered double hydroxide-supported nanoplatinum In 1-methyl-pyrrolidin-2-one at 100℃; for 8h; Stille coupling reaction; | 88% |
With palladium; N,N-dimethyl-formamide In 1-methyl-pyrrolidin-2-one at 120℃; for 15h; | 65% |
4-methylphenyl tosylate
vinyl magnesium bromide
1-ethenyl-4-methylbenzene
Conditions | Yield |
---|---|
With C17H36ClN6NiP2(1+)*Cl(1-) In tetrahydrofuran for 6h; Kumada Cross-Coupling; Inert atmosphere; | 87% |
Conditions | Yield |
---|---|
With 10H-phenothiazine; bis(μ-chloro)bis{(2-(1-(hydroxyimino)methyl)phenyl-C1,N)palladium(II)}; potassium acetate In N,N-dimethyl acetamide at 105℃; under 1551.49 Torr; for 24h; Heck-Mizoroki reaction; Inert atmosphere; | 86% |
With 1-ethyl-piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; PdCl2{P(OC6H5)3}2 In carbon dioxide at 130℃; under 7600 Torr; for 18h; Mizoroki-Heck reaction; | |
With tributyl-amine; potassium carbonate; palladium In N,N-dimethyl-formamide at 150℃; under 7757.43 Torr; for 1h; Heck reaction; microwave irradiation; | |
With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine In acetonitrile at 60℃; under 3345.86 Torr; Heck Reaction; Sealed tube; |
Conditions | Yield |
---|---|
With platinum on carbon; potassium tert-butylate; hydrogen In toluene under 1875.19 Torr; for 10h; Inert atmosphere; Reflux; | 86% |
Conditions | Yield |
---|---|
With 1-butyl-3-methylimidazolium Tetrafluoroborate; azapalladacycle catalyst In methanol at 20℃; for 0.166667h; | 83% |
azamacrocyclic palladium(0) In 1,4-dioxane at 20℃; for 3.5h; Suzuki-Miyaura cross-coupling; | 36% |
4-tolyl iodide
4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane
1-ethenyl-4-methylbenzene
Conditions | Yield |
---|---|
With silver(l) oxide; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 67℃; for 24h; Suzuki-Miyaura reaction; | 83% |
1-ethenyl-4-methylbenzene
2-(4-methylphenyl)oxirane
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide; C15H12ClMoN3O7 In methanol; dichloromethane for 1h; Reagent/catalyst; | 100% |
With tert.-butylhydroperoxide; cis-[MoO2(N'-(3-ethoxy-2-hydroxybenzylidene)-2-methoxybenzohydrazide-2H)(OH2)] In methanol; dichloromethane for 1h; Catalytic behavior; Reflux; | 100% |
With tert.-butylhydroperoxide; C22H22Br4N6O7S2V2 In methanol; dichloromethane for 1h; | 100% |
Conditions | Yield |
---|---|
With C28H18Co(1-)*K(1+)*2C4H10O2; hydrogen In toluene at 20℃; under 1500.15 Torr; for 3h; Reagent/catalyst; Time; chemoselective reaction; | 100% |
With hydrogen In ethanol at 20℃; under 760.051 Torr; for 0.833333h; Green chemistry; | 99% |
With hydrazine hydrate In tetrahydrofuran at 20℃; for 24h; Irradiation; | 99% |
1-ethenyl-4-methylbenzene
1-(1,2-dibromoethyl)-4-methylbenzene
Conditions | Yield |
---|---|
With bromine In chloroform at 0℃; Inert atmosphere; | 100% |
With bromine In chloroform at 0 - 20℃; for 1h; Inert atmosphere; | 100% |
With [bis(acetoxy)iodo]benzene; potassium bromide In dichloromethane; water at 20℃; for 0.25h; | 98% |
triethylsilane
1-ethenyl-4-methylbenzene
(E)-1-(p-methylphenyl)-2-(triethylsilyl)ethylene
Conditions | Yield |
---|---|
dodecacarbonyl-triangulo-triruthenium In benzene at 80℃; for 5h; | 100% |
With dimanganese decacarbonyl; N,N-bis(diphenylphosphino)isopropylamine at 140℃; for 24h; Sealed tube; | 82% |
With norborn-2-ene; chloro(1,5-cyclooctadiene)rhodium(I) dimer; triphenylphosphine In tetrahydrofuran at 100℃; for 2h; Schlenk technique; Inert atmosphere; Sealed tube; | 82% |
Trichloromethanesulfonyl chloride
1-ethenyl-4-methylbenzene
1,1,1,3-tetrachloro-3-(4-methylphenyl)propane
Conditions | Yield |
---|---|
Ru2Cl4((+)-diop)3 In benzene at 100℃; | 100% |
dichlorotris(triphenylphosphine)ruthenium(II) In benzene at 100℃; for 24h; | 55% |
1-ethenyl-4-methylbenzene
2-bromo-1-(p-tolyl)ethanol
Conditions | Yield |
---|---|
With N-Bromosuccinimide; water In acetonitrile at 20℃; | 100% |
With potassium bromate; sulfuric acid; water; potassium bromide In dimethyl sulfoxide at 70 - 80℃; for 0.5h; | 97% |
With sodium periodate; sulfuric acid; lithium bromide In water; acetonitrile at 25℃; pH=6.12; | 95% |
Conditions | Yield |
---|---|
With LutClO4; potassium carbonate In dichloromethane electrolysis (20 mA; current density; 1 mA/cm-2); | 100% |
1-ethenyl-4-methylbenzene
(E)-4,4'-dimethylstilbene
Conditions | Yield |
---|---|
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In dichloromethane for 2h; Heating; | 100% |
With 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; Grubbs-type ruthenium at 20℃; for 4h; | 89% |
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In methanol; dichloromethane; water at 45℃; for 8.5h; Ionic liquid; Inert atmosphere; Catalyst solution in CH2Cl2/BMIM incapsulated within polydimethylsiloxane thimble; | 76% |
Conditions | Yield |
---|---|
With sodium periodate; C31H29Br2N3Ru*CH2Cl2 In water; ethyl acetate; acetonitrile at 25℃; for 0.5h; Inert atmosphere; Schlenk technique; | 100% |
With tert.-butylhydroperoxide; manganese(II,III) oxide In acetonitrile at 70℃; for 3h; | 98% |
With iron(III) trifluoromethanesulfonate; 2-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)-6-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)pyridine; oxygen In 1,2-dichloro-ethane at 70℃; under 760.051 Torr; for 6h; Reagent/catalyst; Solvent; Green chemistry; chemoselective reaction; | 96% |
1-ethenyl-4-methylbenzene
Conditions | Yield |
---|---|
[Ni(η3-CH2C(Me)CH2)(κ1P-PPh2CH2CH=CH2)][BAr'4] In 1,2-dichloro-ethane at 25℃; for 22h; | 100% |
1-ethenyl-4-methylbenzene
[Pd(CH3)(carbonyl)(1,4-diisopropyl-1,4-diaza-1,3-butadiene)](1+)[B(3,5-(CF3)2C6H3)4](1-)
CH3C6H4CHCH2COCH3Pd(CH3)2CHNCHCHNCH(CH3)2(1+)*B[C6H3(CF3)2]4(1-)=CH3C6H4CHCH2COCH3Pd(CH3)2CHNCHCHNCH(CH3)2B[C6H3(CF3)2]4
Conditions | Yield |
---|---|
In chloroform-d1 addn. of p-methylstyrene to complex soln. at -10°C, gentle heating to 20°C; | 100% |
In chloroform addn. of p-methylstyrene to complex soln. at -10°C, gentle heating to 20°C; | 100% |
In dichloromethane (N2); addn. of p-methylstyrene to a soln. of palladium complex in CH2Cl2at -15°C, slow warming to 25°C; addn. of hexane, washing with hexane, drying in vac.; elem. anal.; | 96% |
1-ethenyl-4-methylbenzene
2-hydroxy-2-methylpropanenitrile
(+/-)-2-(4'-methylphenyl)-propionitrile
Conditions | Yield |
---|---|
With 3-[bis-(4-methoxy-phenyl)-phosphanyl]-2H-isoquinolin-1-one; N-{6-[bis-(4-methoxy-phenyl)-phosphanyl]-pyridin-2-yl}-2,2-dimethyl-propionamide; bis(1,5-cyclooctadiene)nickel (0) In toluene at 35℃; for 25h; Inert atmosphere; regioselective reaction; | 100% |
1-ethenyl-4-methylbenzene
Conditions | Yield |
---|---|
With 1,1,1,3',3',3'-hexafluoro-propanol; Pentafluorobenzoic acid In dichloromethane at 20℃; for 1h; regioselective reaction; | 100% |
1-oxothiolane
1-ethenyl-4-methylbenzene
trifluoromethylsulfonic anhydride
Conditions | Yield |
---|---|
In dichloromethane at -40 - 20℃; Inert atmosphere; | 100% |
1-ethenyl-4-methylbenzene
pyridin-2-yl sulfenyl chloride
Conditions | Yield |
---|---|
Stage #1: pyridin-2-yl sulfenyl chloride With sulfuryl dichloride In dichloromethane at 20℃; for 0.166667h; Stage #2: 1-ethenyl-4-methylbenzene In dichloromethane at 20℃; for 20h; regioselective reaction; | 100% |
1-ethenyl-4-methylbenzene
2-pyridineselenenyl chloride
Conditions | Yield |
---|---|
Stage #1: 2-pyridineselenenyl chloride With bromine In chloroform at 20℃; for 0.333333h; Stage #2: 1-ethenyl-4-methylbenzene In chloroform at 20℃; for 6h; Reflux; regioselective reaction; | 100% |
1-ethenyl-4-methylbenzene
[N-(p-tolylsulfonyl)imino]phenyliodinane
N-tosyl-2-(p-tolyl)aziridine
Conditions | Yield |
---|---|
With [CuI(tris[(tetramethylguanidino)-phenyl]amine)][PF6] In acetonitrile for 2h; Inert atmosphere; Molecular sieve; | 99% |
With [PhB{CH2P(p-CF3Ph)2}3]Cu(PPh3) In dichloromethane at 20℃; for 5h; Inert atmosphere; Schlenk technique; | 97% |
With iodine In water at 20℃; for 10h; Green chemistry; | 91% |
1-ethenyl-4-methylbenzene
phenylboronic acid
E-1-methyl-4-styryl-benzene
Conditions | Yield |
---|---|
With palladium diacetate; acetic anhydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetic acid at 90℃; for 27h; Heck reaction; | 99% |
With [2,2]bipyridinyl; methanesulfonic acid; palladium(II) trifluoroacetate In N,N-dimethyl-formamide at 100℃; for 24h; Schlenk technique; | 92% |
With C38H36Cl2Fe2N2Pd2; oxygen In N,N-dimethyl-formamide at 50℃; for 3h; Heck reaction; | 87% |
With N-Bromosuccinimide; palladium diacetate In toluene at 20℃; for 12h; Heck Reaction; Inert atmosphere; Schlenk technique; | 70% |
With palladium diacetate; sodium acetate In acetic acid at 25℃; for 20h; | 99 % Chromat. |
1-ethenyl-4-methylbenzene
ethene
1-methyl-4-(1-methyl-2-propenyl)benzene
Conditions | Yield |
---|---|
With 2-benzyloxymethylphenyldiphenylphosphine; bi(allylnickel bromide); sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate In dichloromethane at 23℃; under 760.051 Torr; for 11h; Schlenk technique; | 99% |
With hexakis(acetonitrile)nickel(II) tetrafluoroborate; diethylaluminium chloride; triphenylphosphine In dichloromethane; toluene at 20℃; under 7500.6 Torr; for 1h; hydrovinylation; | 84% |
With 2; diethylaluminium chloride; triphenylphosphine In dichloromethane; toluene under 7500.6 Torr; for 0.5h; Yield given; | |
With silver trifluoromethanesulfonate; triphenylphosphine; bi(allylnickel bromide) In dichloromethane at -55℃; under 760 Torr; for 2h; | |
With C33H63ClOP2Ru; silver trifluoromethanesulfonate In dichloromethane for 6h; Inert atmosphere; |
1-ethenyl-4-methylbenzene
2-carbonyl-3-butenenitrile
Conditions | Yield |
---|---|
In acetonitrile at 81℃; for 24h; hetero-Diels-Alder cycloaddition; | 99% |
1-ethenyl-4-methylbenzene
2,3-dimethyl-2,3-butane diol
(R)-pinacol (1-(p-methylphenyl)ethyl) boronate
Conditions | Yield |
---|---|
Stage #1: 1-ethenyl-4-methylbenzene With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; benzo[1,3,2]dioxaborole In 1,2-dimethoxyethane at -66 - -65℃; for 7h; hydroboration; Stage #2: 2,3-dimethyl-2,3-butane diol In 1,2-dimethoxyethane at -66 - 20℃; Substitution; | 99% |
Stage #1: 1-ethenyl-4-methylbenzene With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; benzo[1,3,2]dioxaborole In 1,2-dimethoxyethane at -68℃; for 7h; Inert atmosphere; Stage #2: 2,3-dimethyl-2,3-butane diol In 1,2-dimethoxyethane at -68 - 20℃; optical yield given as %ee; | 65% |
Conditions | Yield |
---|---|
Stage #1: 1-ethenyl-4-methylbenzene; 4-nitrobenzaldehdye With phenylborondichloride In dichloromethane at 25℃; for 6h; Stage #2: With water | 99% |
1-ethenyl-4-methylbenzene
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane
Conditions | Yield |
---|---|
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,2-bis-(diphenylphosphino)ethane In dichloromethane at 20℃; for 24h; | 99% |
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,4-di(diphenylphosphino)-butane In tetrahydrofuran at 20℃; for 24h; | 95% |
With bis(diphenylphosphino)butane; bis(1,5-cyclooctadiene)diiridium(I) dichloride In tetrahydrofuran under N2; pinacol borane was reacted with ligand in THF at room temp. for 24 h in the presence of Ir-complex and bis(diphenylphosphino)butane; chromy.; | 95% |
Conditions | Yield |
---|---|
With potassium phosphate tribasic trihydrate In N,N-dimethyl-formamide at 120℃; for 2h; Heck Reaction; | 99% |
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 0.133333h; Catalytic behavior; Heck Reaction; Sonication; Green chemistry; | 97% |
With triethylamine In water; acetonitrile at 60℃; for 2h; Heck Reaction; | 97% |
1-ethenyl-4-methylbenzene
Conditions | Yield |
---|---|
In not given | 99% |
1-ethenyl-4-methylbenzene
Conditions | Yield |
---|---|
In not given | 99% |
1-ethenyl-4-methylbenzene
t-butyl diazoacetate
Conditions | Yield |
---|---|
With C67H51IrN2O2 In tetrahydrofuran at -78℃; for 24.1667h; optical yield given as %ee; enantioselective reaction; | 99% |
Empirical Formula: C9H10
Molecular Weight: 118.1757
EINECS: 210-762-8
Melting point: -34 °C
Storage temp: 2-8°C
Index of Refraction: 1.55
Density: 0.897 g/cm3
Flash Point: 48.7 °C
Enthalpy of Vaporization: 39.16 kJ/mol
Boiling Point: 172 °C at 760 mmHg
Vapour Pressure: 1.81 mmHg at 25 °C
Appearance: A clear colorless liquid with an aromatic odor
Structure of 4-Methylstyrene (CAS.622-97-9):
4-Methylstyrene (CAS.622-97-9) can be used in making plastics, especially as a monomer for polyesters.
1. | cyt-hmn:lyms 330 µmol/L | CRNGDP Carcinogenesis. 2 (1981),237. | ||
2. | sce-hmn:lyms 330 µmol/L | CRNGDP Carcinogenesis. 2 (1981),237. | ||
3. | orl-rat LD50:2255 mg/kg | JACTDZ Journal of the American College of Toxicology. 1 (1990),77. | ||
4. | ipr-rat LD50:2324 mg/kg | JACTDZ Journal of the American College of Toxicology. 1 (1990),77. | ||
5. | orl-mus LD50:1072 mg/kg | JACTDZ Journal of the American College of Toxicology. 1 (1990),76. | ||
6. | ipr-mus LD50:581 mg/kg | JACTDZ Journal of the American College of Toxicology. 1 (1990),76. | ||
7. | ivn-mus LD50:280 mg/kg | JACTDZ Journal of the American College of Toxicology. 1 (1990),76. | ||
8. | orl-dog LD50:>5 g/kg | JACTDZ Journal of the American College of Toxicology. 1 (1990),77. | ||
9. | skn-rbt LD50:>5 g/kg | JACTDZ Journal of the American College of Toxicology. 1 (1990),77. |
Reported in EPA TSCA Inventory.
Poison by intravenous route. Moderately toxic by ingestion. Slightly toxic by skin contact. Human mutation data reported.
Risk Statements: 10-36/37/38-65
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin.
R65:Harmful: may cause lung damage if swallowed.
Safety Statements: 26-36-62
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S62:If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label.
4-Methylstyrene (CAS.622-97-9) also can be called 4-Vinyltoluene ; Styrene, p-methyl- ; and; Benzene, 1-ethenyl-4-methyl- . It may react vigorously with strong oxidizing agents. May react exothermically with reducing agents to release hydrogen gas. In the presence of various catalysts (such as acids) or initiators, may undergo exothermic addition polymerization reactions. May undergo autoxidation upon exposure to the air to form peroxides. These peroxides and polyperoxides are usually extremely unstable and liable to detonation. If polymerization takes place inside a closed container, the container may rupture violently. Vapors irritate the mucous membranes. Less dense than water and insoluble in water.
4-Methylstyrene (CAS.622-97-9) is hazardous,so the first aid measures and others should be known.Such as: When on the skin: first,should flush skin with plenty of water immediatelyfor at least 15 minutes while removing contaminated clothing. Secondly,Get shoesmedical aid . Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.Then get medical aid soon.While ,it's Inhaled: Remove from exposure and move to fresh air immediately.Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : Wash mouth out with water,and get medical aid immediately.Notes to physician: Treat supportively and symptomatically.
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